Dr Sarumathy S

@srmist.edu.in

Associate Professor, Department of Pharmacy Practice, Faculty of Medicine and Health Sciences
SRM institute of science and technology

Dr Sarumathy S


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https://researchid.co/sarumathy

RESEARCH INTERESTS

Clinical Research, Patient Counselling, Pharmacovigilance
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Scopus Publications

Scopus Publications

  • A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women
    K. Dhivya, S. Sarumathy, G. Manigandan
    Naunyn Schmiedeberg S Archives of Pharmacology, 2025
  • Advancements in Oral Drug Delivery of Insulin: A Review
    M. Balamurugan, S. Sarumathy
    International Journal of Diabetes in Developing Countries, 2025
  • Ten years survival outcome of breast cancer patients among South Indian population: A retrospective cohort study
    Journal of Medicinal and Pharmaceutical Chemistry Research, 2025
  • Pharmaceutical care impact on health-related quality of life (HRQOL) and pharmaco-economical burden on COVID recovered diabetic patients with comorbid condition
    Journal of Medicinal and Pharmaceutical Chemistry Research, 2025
  • Efficacy and safety of dapagliflozin in ameliorating anemia in heart failure patients: A randomized controlled trial
    Laxmi Sankalpa Bhaganagarapu, Sarumathy Sundararajan, Vengatesh Munusamy
    Journal of Pharmacy and Pharmacognosy Research, 2025
    Context: Originally developed for managing type-2 diabetes mellitus, sodium-glucose co-transporter 2 inhibitors have demonstrated the potential to manage heart failure (HF) and its associated comorbidities. Aims: To evaluate the hematopoietic and glycemic effects of dapagliflozin in addition to the standard treatment for HF. Methods: An open-label randomized control study was conducted on 46 patients who were randomly allocated to either of the treatment regimens. Group A received standard HF treatment along with oral hypoglycemic agents (biguanides or sulfonylureas), while Group B received the standard treatment + dapagliflozin (10 mg once daily). Hematologic and glycemic parameters were assessed at baseline, 3rd month, and 6th month. Results: At baseline, no significant differences were observed between the groups. After 12 weeks, Group B showed a significant improvement in the glycemic parameters like postprandial plasma glucose, fasting plasma glucose, and hematological parameters, namely hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, mean corpuscular volume, packed cell volume, and serum iron. At 24 weeks follow-up, further improvements in glycemic parameters, including HbA1c and hematologic parameters, such as serum iron, transferrin, and transferrin saturation, were observed. No significant changes in hematologic parameters while significant changes in glycemic parameters except HbA1c were noticed over 24 weeks of therapy in Group A. Conclusions: When used in conjunction with the standard treatment, dapagliflozin significantly improved glycemic control and alleviated anemia in HF patients.
  • Clinical trials in health‑care metaverse – A conceptual overview
    J. Mohammed Sulaiman Sait, S. Sarumathy
    Perspectives in Clinical Research, 2025
    Post-COVID-19, the emergence of newer technologies has taken center stage. One such technology is metaverse, which is an extension of existing technologies such as virtual reality (VR) and augmented reality (AR) that enables a fully immersive communication platform through the utilization of digital twins and avatars in a three-dimensional digital space. Literature review has shown that the adoption of such technologies in the field of clinical trials can help in improving the therapeutic outcomes in patients while having numerous other benefits. Despite its early stages of adoption, the application of metaverses in clinical trials through the use of AR, VR, and digital twins holds the ability to revolutionize key tasks in clinical trials, such as patient enrollment, engagement, monitoring, and counseling, by removing barriers to study participation. This review article focuses on the concepts of metaverse, its use in clinical trials, its inherent benefits, and limitations and serves as a starting point for clinical research organizations, pharmaceutical companies, and technology firms to conceptualize and develop metaverse solutions that stand to significantly benefit the broader landscape of clinical trials.
  • Unraveling the connection between reproductive factors and cognitive function of post-menopausal women in South India
    Dhivya Kothandan, Sarumathy S, Manigandan G
    Clinical Epidemiology and Global Health, 2025
    Background: This study is conducted to estimate the incidence of cognitive decline and analyze the correlation between reproductive factors and cognition in post-menopausal women.This study marks the first instance of community-focused research in the South Indian population, focusing on the link between cognition and reproductive factors in post-menopausal women using actual world data.Methods: This cross-sectional study was accomplished in the community setting of Vellore District, in association with the Rotary Club of Anaicut, for 6 months.The study included post-menopausal women, aged 45 years or above, who had proficiency in reading and writing in English or Tamil.We applied the Montreal Cognitive Assessment (MoCA) scale to appraise cognitive function.A self-administered questionnaire was utilized to collect the data.The serum estradiol level was measured.We interpreted the obtained data using IBM Statistical Package for the Social Sciences (SPSS) software version 24.Results: Of 300 post-menopausal women screened, about 256 participants met the required inclusion criteria.The average age of the participants was 55.88 6.38 years.Mild cognitive impairment (MCI) was present in 73 % of the study participants, with a mean MoCA score of 21.68 3.28.The present study findings revealed that the overall MoCA score declined with high parity (r = -0.123),earlier age at menopause (r = 0.311), lessened reproductive span (r = 0.337), and diminished estrogen levels (r = 0.425).Conclusion: This study posited a robust link between cognitive function and reproductive factors.Considering the increased occurrence of MCI in post-menopausal women, the outcomes of this research offer significant perspectives for healthcare specialists and decision-makers in devising evidence-based approaches to prevent the progression of dementia in post-menopausal women.
  • Cognitive decline in type II diabetes mellitus among post-menopausal women: A cross-sectional study in South India
    Dhivya K, Sarumathy S, Manigandan G
    Journal of Applied Pharmaceutical Science, 2024
    This study was contemplated to ascertain the occurrence of cognitive impairment and explore the relationship between cognition and diabetes mellitus type 2 (T2DM) in post-menopausal women. The present cross-sectional study was conducted in the community setting in and around Anaicut Panchayat, Vellore, over 6 months (July 2023 to Dec 2023). Post-menopausal women with T2DM in the age group of above 35 years were included. The Montreal Cognitive Assessment (MoCA) scale was utilized to evaluate the cognitive function. Glycated hemoglobin (HbA1c) was also measured. The acquired data were analyzed using IBM Statistical Package for the Social Sciences (SPSS) software version 23. The inclusion criteria were met by 188 subjects. The diabetic women who were involved in the study have an average age of 57 years. The current study population evinced a mean MoCA score of 20.91 ± 3.99 and a mean HbA1c level of 9.27 ± 2.45 suggesting a strong link between cognitive dysfunction and hyperglycemia. 67% of the study subjects exhibited mild cognitive impairment (MCI). A noticeable inverse relationship was found between MoCA score and duration of T2DM (r = −0.744) as well as between MoCA score and HbA1c (r = −0.769). This study suggested that the duration of T2DM and the level of HbA1c have an antithetical influence on cognitive function. Due to the higher prevalence exists for MCI in diabetic patients, it is recommended that healthcare professionals should assess cognitive function in diabetic patients in their routine clinical practice to prevent the progression of dementia.
  • EVOLUTION OF METFORMIN IN BREAST CANCER THERAPY IN LAST TWO DECADES: A REVIEW
    R. SARATHI, S. SARUMATHY, V.M. DURAI MAVALAVAN
    Experimental Oncology, 2024
    Among women, breast cancer is one of the most prevalent cancers. The disease has a complex etiology, with multiple biological pathways contributing to its development. As insulin signaling has mitogenic effects, glucose is a necessary cellular metabolic substrate, and the growth and metastasis of breast cancer are closely related to cellular glucose metabolism. Anti-diabetic medications have drawn increased attention as a potential treatment for breast cancer. Metformin lowers cancer incidence and death rates in patients with type 2 diabetes, according to epidemiologic studies. Preclinical studies conducted in vivo and in vitro offer fascinating new insights into the cellular mechanisms underlying metformin oncostatic action. We present an overview of the mechanisms of anticancer effects of metformin and discuss its potential function as an adjuvant in the treatment of breast cancer.
  • A review on status of drug disposal practice of unused and expired drugs among different countries
    Aakriti Aryal, Paulvarnan Anitha Anuba, Gopalan Ramalingam Arun, Sundararajan Sarumathy, Ramachandran Nanda kumar
    Journal of Applied Pharmaceutical Science, 2023
    Medicines are crucial in treating various diseases, but when they are not needed, it is essential to dispose of them correctly. This review aims to study the status of the disposal of unused and expired drugs in different countries. The study objectives included reviewing procedures adopted by the general public for disposing of pharmaceuticals and public awareness about the problem of incorrect disposal methods. The literature search was done from PubMed and Elsevier databases, by entering the keywords “unused medications,” “expired drugs,” and “drug disposal.” Articles were excluded if they did not focus specifically on drug disposal practices. In many nations, disposing of unwanted drugs has become a burden since pharmaceutical waste permeates the ecosystem, posing a severe risk to human and environmental health. As a need of the hour, public education on proper medication disposal is required. Furthermore, the government should promote the reverse distribution practice. Residents are urged to return undesired prescriptions to pharmacies, which are collected and destroyed by approved agents or bodies.
  • Safety and efficacy of Hemocare®LACT on breast milk production and prolactin levels in postpartum mothers: An open-label, placebo controlled, randomized trial
    Sunita Samal, S Sarumathy, A Priyadharshini, Manali Sudhir, Fatema Juzer, Karthikeswari A, TM Vijayakumar, Madhu Madhuben
    Phytomedicine Plus, 2021
  • Pharmacist led intervention towards management of type 2 diabetes mellitus and assessment of patient satisfaction of care - A prospective, randomized controlled study
    Manithottiyle Angelo Simon, Bandaru Yeswanth Raja, Paulin C. Varughese, Linda Mary Daniel, Kolli Sowjanya, Kumar J. S, Sarumathy S, Kiran Kumar Rathinam, Pravin Kumar J
    Diabetes and Metabolic Syndrome Clinical Research and Reviews, 2021
  • The Effects of Clinical Pharmacist Education on Lifestyle Modifications of Postmyocardial Infarction Patients in South India: A Prospective Interventional Study
    Sarumathy Sundararajan, Shanmugarajan Thukani Sathanantham, Shanmugasundaram Palani
    Current Therapeutic Research Clinical and Experimental, 2020
  • Trends in management of congestive heart failure patients in a tertiary care hospital-a retrospective study
    S. Sarumathy, V. Madhumitha, M. Vishali, S. Janani, M. Englebert Rynjah, A. Priyadharshini
    Research Journal of Pharmacy and Technology, 2019
  • Effect of health education and iron supplementation on haemoglobin levels in adolescent girls
    Dinesh John Rajkumar, R. Manikandan, Mohammed Aboobacker Mathuf, Koripella Sree Aakash, Dolly k Pajapath, T. R. Ashok Kumar, S. Sarumathy, M Logaraj
    Research Journal of Pharmacy and Technology, 2018
  • Clinical study on assessment of lipid profile and renal function in type 2 diabetic patients- A retrospective study
    R Manikandan, S. Sarumathy
    Research Journal of Pharmacy and Technology, 2018
  • Significance of clinical laboratory values as early indicators of myocardial infarction - A retrospective study
    S. Sarumathy, T. S. Shanmugarajan, K. G. Suresh Rao, N. Benazeer Begum
    Research Journal of Pharmacy and Technology, 2018
  • A clinical study on safety and efficacy of formoterol and tiotropium combination compared to formoterol and tiotropium with roflumilast combination in treatment of moderate to severe chronic obstructive pulmonary disease patients
    Kavitha Devi M, Sarumathy S, Sarath Lal Sasidharan, Sarumathy S, Mehanaz Shaik, Gottimukkala Sandeep, Sarath Lal Sasidharan, Vunnam Rajasekhar, Mehanaz Shaik, Damodharan N, Gottimukkala Sandeep, Vunnam Rajasekhar, Damodharan N
    Asian Journal of Pharmaceutical and Clinical Research, 2018
  • Knowledge, attitude and practice of diabetic patients regarding diabetic retinopathy in a tertiary care hospital
    S Sarumathy, Leya Annie Johnson
    Research Journal of Pharmacy and Technology, 2017
  • A prospective study on incidence of anaemia in type 2 diabetes mellitus patients
    Vaddi Mounika, S. Sarumathy, J. Anisha Ebens, T. S. Shanmugarajan
    Research Journal of Pharmacy and Technology, 2017
  • Clinical assessment and comparison of lipid profiles among coronary artery disease and type 2 diabetes mellitus patients receiving statin therapy
    S Kalaivanan, S Sarumathy, J Anisha Ebens, K Naresh Kumar, A Roobena Parveen, M. Nasreen Ashraf
    Research Journal of Pharmacy and Technology, 2017
  • Assessment of health-related quality of lifeand predictors of risk factors in patients with knee osteoarthritis
    International Journal of Pharmtech Research, 2016
  • Study on the adverse reactions of antipsychotics and therapeutic drug monitoring of olanzapine in psychiatric patients
    K Menaka, S Sarumathy, T Sivakumar
    Research Journal of Pharmacy and Technology, 2016
  • Clinical comparison of serum lipids between cyclosporine and tacrolimus treated renal transplant recipients
    S. Sarumathy, P. Samuel Gideon George, B. Yeswanth Prasanna Kumar, V. Atheena Mukundan, T.S. Shanmugarajan, P. Maheshwari
    Research Journal of Pharmacy and Technology, 2016
  • Clinical comparison of the efficacy and safety of intra-articular injections of sodium hyaluronate and methylprednisolone in the treatment of osteoarthritis of knee
    S. Sarumathy, CH Haripriya, Muddala Vara Prasanna Rao, K. Gayathri, CH Bala Sudhakar, M. Divya, P. Shanmugasundaram
    Research Journal of Pharmacy and Technology, 2015
  • The prospective study on quality of life with assessment of Heamoglobin levels in chronic kidney disease patients
    Research Journal of Pharmaceutical Biological and Chemical Sciences, 2015
  • Antioxidant activity and cytotoxic potential ofhydroalcoholic extract of salacia fruticosa (root)-in vitro
    International Journal of Pharmacy and Pharmaceutical Sciences, 2015
  • A study on drug use pattern and adverse drug reactions of anti-psychiatric medications in a psychiatry specialized hospital
    International Journal of Pharmacy and Pharmaceutical Sciences, 2014
  • Study of drug utilization pattern in a tertiary care hospital during the inpatient admittance in the emergency care department
    Asian Journal of Pharmaceutical and Clinical Research, 2014
  • Patient awareness on ADR of drugs used in diabetes with hypertension
    Research Journal of Pharmaceutical Biological and Chemical Sciences, 2014
  • Evaluation of immunomodulatory activity of aqueous extract of a polyherbal formulation by IN-VIVO method
    Asian Journal of Pharmaceutical and Clinical Research, 2013
  • Efficacy and safety of oral glutamine in radiation induced oral mucositis in patients with head and neck cancer
    Asian Journal of Pharmaceutical and Clinical Research, 2012