Pharmacy, Pharmacology, Toxicology and Pharmaceutics, General Pharmacology, Toxicology and Pharmaceutics, Pharmaceutical Science
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Scopus Publications
Scopus Publications
A Comprehensive Review of The Nanoparticulate Transdermal Drug Delivery Kalai Selvi L. Tamil, Tamang Rejoys, SagarLakshmi S., Bhattacharyya Sayani Nano Life, 2026 The present review focuses on the modern approaches of nanoparticulate transdermal delivery of drugs and biomaterials. The systemic delivery and targeting of the drugs at a predetermined rate through a non-invasive way is the main objective of transdermal delivery. The review highlights the principles of transdermal delivery and product development. It emphasizes the various nanoparticulate matters, their structural specificity, and their applications in the delivery of drugs and cosmeceuticals. The challenges associated with the development are also featured here. Therefore, the authors have tried to make a well-defined, comprehensive review to summarize the basic features and enlighten the researcher about the potential applications of the novel types of nanoparticles used for transdermal delivery.
An in vitro characterization and cytotoxic evaluation of mesoporous delivery of celecoxib on anticancer activity Sayani Bhattacharyya, Reena Inas Fernandaes European Journal of Parenteral and Pharmaceutical Sciences, 2025 Celecoxib has opened new avenues for its potential efficacy in the treatment of colorectal cancer. The low solubility of the drug is a major concern for its efficacy. The present research explores the possibility of enhancing the solubility of the drug using a mesoporous delivery system. A commercially available mesoporous silica (Syloid 244FP) was used as a carrier to load celecoxib by the solvent evaporation method. Three different formulations were prepared varying drug/silica ratio. The formulations were evaluated for drug loading, particle size, surface morphology, solid-state characterization, and drug release study. Cytotoxicity study was conducted on cancer cell lines. The formulations were found to be nano-sized, with a high loading of drugs in the porous network of silica. The dissolution efficiency of celecoxib in the formulations was improved remarkably. Formulation with the highest drug/silica ratio was found to be the best in terms of dissolution. The solid-state behaviour studies of the best formulation exhibited compatibility and amorphization of the drug and the same was further proved by surface morphology study. Surface area analysis study further proved the high loading of the drug in the silica. The cytotoxicity study revealed a significant reduction in the number of viable cancer cells following administration of the best formulation in comparison to the pure drug and standard drug doxorubicin. Hence it can be concluded that mesoporous nanoparticles loaded with celecoxib can make a valuable contribution to enhancement of solubility and anticancer activity.
Preparation and evaluation of mesoporous Celecoxib for improved antiarthritic activity in rodents Reena I Fernandaes, Sayani Bhattacharyya Thai Journal of Pharmaceutical Sciences, 2025 Background: Celecoxib, a model anti-inflammatory drug, used in the management of arthritis exhibits limited oral bioavailability and slow onset of action due to its poor solubility. Objective: The present study explores a mesoporous drug delivery of celecoxib to investigate the efficacy of its antiarthritic activity in animal models, and develops a low-oral dose therapy. Materials and Methods: The solvent evaporation method was employed for the preparation of mesoporous delivery of celecoxib, using Syloid®, and Neusilin®, at a molar ratio of silica/ drug 1:2.5. The formulations were characterized for drug loading, in vitro drug release, and material structure characteristics and bone mineral affinity. An in vivo study of the formulation was conducted on a diseased rat model. Investigation on hematological parameters, bone deformation through X-ray, and bone histopathology on the arthritic animals were conducted after oral administration of mesoporous celecoxib for 28 days. Histopathology studies of the liver and spleen were carried out as a measure of safety assessment of the new delivery of celecoxib. Results: The solvent evaporation method could yield 95–97% loading of celecoxib in the pores of silicas with significant enhancement in the dissolution efficiency of celecoxib. The formulations exhibited high bone mineral affinity compared to pure drugs. In vivo studies revealed a remarkable recovery of the cartilage over 28 days of treatment. The efficacy and safety of the mesoporous delivery of celecoxib were confirmed from the histopathology studies. Conclusion: The proposed delivery of celecoxib was found to be beneficial in the treatment of arthritis and the findings encourage its application.
Formulation and Evaluation of Orodispersible Tablet of Dolutegravir - Methionine Cocrystal Rejoys Tamang, Ammon Tamang, Sayani Bhattacharyya Fabad Journal of Pharmaceutical Sciences, 2025 Dolutegravir, a newly approved anti-HIV medication is insoluble in the normal gastric pH range and that results in slow onset of action. The research proposes cocrystallization process to increase the solubility of the drug and hence dissolution. The cocrystals of dolutegravir were formulated using methionine as coformers by solvent evaporation method. The cocrystals were evaluated for solubility, in vitro drug release, and solid-state characterization, study. The orodispersible tablets of dolutegravir cocrystal were successfully prepared by direct compression method. The solid-state characterization study showed the compatibility and amorphization of the drug in the cocrystal form. The cocrystal of drug: methionine (1:2) was found to enhance dissolution by 1.88 times compared to the pure drug. The orodispersible tablets disintegrated at 10.05 secs and 90% drug was released in 20 min. Hence, it can be concluded that the methionine-dolutegravir cocrystal can be a promising means to improve the solubility of the drug
Preparation and Evaluation of Nanolipid Carriers of Bedaquiline-In vitro Evaluation and in silico Prediction Nandhini Rajendhiran, Sayani Bhattacharyya Jordan Journal of Pharmaceutical Sciences, 2024 Background: Bedaquiline, a potent antitubercular drug used in the treatment of multidrug-resistant strains, suffers from low oral bioavailability, a slow onset of therapeutic action, and side effects. This investigation proposes the development of nanocarriers for the drug to improve drug release and estimate its effect on oral absorption through an in-silico model. Initially, a custom design was investigated to estimate the effects of composition and process on the entrapment and particle size of the carriers. The nanocarriers were subjected to studies on surface characteristics, surface morphology, thermal properties, drug release, ex vivo permeation, and antimicrobial efficacy. In silico predictions of bioavailability and pharmacokinetic parameters of the optimized formulation were conducted using GastroPlus® software. Results: The study revealed that bedaquiline entrapped in nano lipid carriers (65.5 nm) of glyceryl behenate and palm oil effectively increased the rate of drug release by more than 80% and led to a 3.5-fold increase in antimicrobial activity against Mycobacterium tuberculosis. Intestinal permeation was enhanced by 3.7 times. Predictions using GastroPlus® software indicated that the nano lipid carrier of bedaquiline could be a promising method for improving the drug's efficacy with better localization in the gastrointestinal compartments and improved pharmacokinetics, achieving 93% bioavailability. Conclusion: It can be concluded that bedaquiline nanocarriers in a lipid matrix can serve as an effective tool for enhancing the efficacy of bedaquiline in the treatment of tuberculosis.
Formulation and Evaluation of a Transferosomal Gel of Famciclovir for Transdermal Use Sayani Bhattacharyya, Kalai Tamilselvi L, Andhuvan Muthukumar Turkish Journal of Pharmaceutical Sciences, 2024 Objectives Famciclovir, the drug of choice for cold sores and recurrent genital herpes, has poor oral bioavailability and is associated with numerous side effects. The study aimed to explore the possibility of transdermal application of famciclovir through a transferosome-loaded gelling system to localize the drug at the site of application with improved penetrability, therapeutic effects, and comfort. Materials and Methods Transferosomes of famciclovir were prepared using tween 80, phospholipid, and cholesterol. To optimize drug entrapment and the vesicular size of the transferosomes, a central composite design was employed. The optimized formulation was evaluated for physicochemical characteristics, surface morphology, and degree of deformability. The optimized product was included in the Carbopol 940 gelling system. The gel was evaluated for ex vivo permeation, skin irritation, drug deposition at various skin layers, and histopathological analysis. Results The design optimization yielded an optimized product (FAMOPT) of nanosized (339 nm) stable vesicles of the transferosome of famciclovir. The surface morphology analysis revealed the formation of nanovesicles without aggregation. Compatibility between the drug and excipients was established. The elasticity of the vesicles demonstrated resistance to leakage. The permeation of the drug was enhanced by 2.8 times. The gel was found to be non-irritating and non-sensitizing to the animal skin. The drug deposition at various skin layers was remarkably improved, indicating effective drug penetration. The histopathological examination further demonstrated the penetration of nano-vesiculate drugs through deeper layers of the skin. Conclusion Hence, nano-vesicular famciclovir delivery is a promising alternative to conventional famciclovir delivery with enhanced local and systemic action for herpes treatment.
Novel Deformable Vesicle for the Transdermal Delivery of Terbinafine Hydrochloride-Formulation and Cytotoxic Evaluation Shaanya Johl, Sayani Bhattacharyya Indian Journal of Pharmaceutical Education and Research, 2024 Abstract: Aim/Background: According to estimates, about a billion people in the world have fungal infections of the skin, nails, and hair. Skin disorders are a significant contributor to disability, deformity, and misery among people. In the present study, a versatile vesicular delivery of terbinafine hydrochloride through the dermal route in a biocompatible platform consisting of glycerine, phospholipids, and cholesterol is proposed for the treatment of mycoses. Materials and Methods: The glycerosomes of terbinafine hydrochloride were formulated by thin film hydration technique using central composite design to explore the composition effects on the formation of nanosized stable glycerosomes and drug loading. The optimized formulation was evaluated for deformability, antifungal activity, compatibility by FTIR, surface morphology, in vitro and ex vivo drug diffusion, skin irritation, histopathology, and cytotoxicity studies on HaCaT cell lines. Results: Numerical optimization of the design revealed that the particle size and entrapment efficiency of the drug were remarkably affected by the composition. Surface imaging by TEM revealed the formation of well-defined vesicles with no aggregation. The elasticity of the vesicles was established by determining their deformability index. The in vitro and ex vivo drug release study revealed better permeation of the drug compared to the marketed formulation. The histopathology and cytotoxicity study conceded the suitability of the glycerosomal carrier system for the transdermal delivery of terbinafine hydrochloride. Conclusion: Hence it can be concluded that the glycerosomes of terbinafine hydrochloride possess a potential formulation approach for treating dermal infection. Keywords: Glycerosomes, Terbinafine hydrochloride, Transdermal delivery, Skin permeation, Cytotoxicity.
Experimental Design Supported Formulation and Evaluation of Nanostructured Lipid Carrier Loaded Oro mucosal Film of Tenofovir Disoproxil Fumarate Kavitha HK, Sayani BHATTACHARYYA Journal of Research in Pharmacy, 2024 : Antiretroviral medication tenofovir disoproxil fumarate (TDF) is frequently used to treat HIV and Hepatitis B virus infection and possesses low oral bioavailability due to low cellular penetration, and intestinal degradation. The present research focuses to develop nanoparticle-loaded oral film of TDF for the pediatric population with an aim to improve bioavailability and patient compliance. A high-shear homogenization process was employed to prepare nanostructured lipid carriers (NLCs) of TDF using an I-Optimal design. The consequences of proportions of solid and liquid lipid, and surfactant concentrations on drug entrapment, loading, and particle size were studied with a planned 14 experimental runs. The optimized formulation was loaded into an oromucosal film using hydroxy propyl methyl cellulose (HPMC) polymer. The films were evaluated for their physicochemical, and mechanical properties. The permeation of the drug from the films through goat oral mucosa was estimated. The design yielded an optimized product characterized by its nanosized (215 nm), stability (0.1 mV), and high entrapment (95.6%) of TDF in the carrier matrix. The surface morphology proved the irregular surface of the nano lipid carrier. The oro-mucosal film exhibited prolonged residence time and was released gradually over 24 h. The permeation of the drug from the nanocarriers loaded film was significantly improved compared to the pure drug. These findings support the idea that NLC-loaded oro-mucosal adhesive films may represent a promising strategy for increasing TDF's oral bioavailability.
Nonlinear pharmacokinetics Sayani Bhattacharyya, Falguni Patra, Subhabrata Ray Physico Chemical Aspects of Dosage Forms and Biopharmaceutics Recent and Future Trends in Pharmaceutics Volume 2, 2024
Multicompartment model Sayani Bhattacharyya, Falguni Patra, Subhabrata Ray Physico Chemical Aspects of Dosage Forms and Biopharmaceutics Recent and Future Trends in Pharmaceutics Volume 2, 2024
Analytical method validation of rizatriptan benzoate in fasted state simulated intestinal fluid using UV spectrophotometric method International Journal of Pharmaceutical Research, 2019
Optimization of process parameters for emulsion solvent evaporation technique in the preparation of nano lipid carriers using definitive screening design International Journal of Pharmaceutical Research, 2019
Formulation and evaluation of lorazepam microemulsion for parenteral delivery system Studia Universitatis Vasile Goldis Arad Seria Stiintele Vietii, 2014
Preparation and evaluation of orally disintegrating taste masking tablet of paracetamol with kollicoat smart seal 30 D Der Pharmacia Lettre, 2014
Design, evaluation and statistical optimisation of a controlled release multiparticulate acyclovir delivery system Latin American Journal of Pharmacy, 2007
