Pablo Scharf

Verified @gmail.com

School of Pharmaceutical Sciences - University of São Paulo
Sandra Farsky

Pablo Scharf


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https://researchid.co/scharfpablo

RESEARCH INTERESTS

inflammation, immunotoxicology, tobacco-induced diseases, autoimmune disorders, T cell biology
18

Scopus Publications

295

Scholar Citations

9

Scholar h-index

9

Scholar i10-index

Scopus Publications

  • Heated tobacco and cigarette smoke modulate CD4 + T cell activation and neuroinflammation in a context-dependent manner
    Pablo Scharf, Silvana Sandri, Pâmela Pacassa Borges, Tiago Francisco da Silva, Laura Caroline de Faria, Luana Filippi Xavier, Ana Victoria dos Santos Helfstein, Augusto César Penalva de Oliveira, Guilherme Sciacia do Olival, Jean Pierre Peron Schatzmann, Sandra Helena Poliselli Farsky
    Journal of Neuroinflammation, 2026
    Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS), driven by CD4⁺ T cell-mediated neuroinflammation and influenced by both genetic and environmental factors. Conventional cigarette (CC) smoking is a well-established environmental risk factor for MS, primarily due to its immunotoxic combustion byproducts. Heated tobacco products (HTPs), marketed as safer alternatives due to the absence of combustion, are increasingly adopted by young adults; however, their effects on immune responses and related diseases remain largely unknown. In this study, we evaluated the effects of HTP exposure on experimental neuroinflammation and CD4⁺ T cell responses. Experimental autoimmune encephalomyelitis (EAE)-induced animals were exposed twice daily for 7 days to HTP, CC, or air via a puff-based system delivering equivalent nicotine doses, either prior to disease onset or during the effector phase (7–13 days post-immunization). Pre-EAE exposure to either HTP or CC aggravated clinical symptoms, neurodegeneration, and increased Th1/Th17 cell infiltration into the CNS. During the effector phase, only HTP exposure exacerbated disease severity, neurodegeneration, and peripheral T-cell expansion through enhanced proliferation. In contrast, CC selectively promoted Th22 differentiation and activation of the aryl hydrocarbon receptor (AhR). Ex vivo studies showed that HTP and CC induced distinct T-cell response profiles. CD4⁺ T cells from healthy donors exhibited reduced activation and proliferation in response to HTP, whereas MS-derived cells displayed increased activation and proliferative capacity. CC exposure enhanced activation in both groups without affecting proliferation. These findings clearly demonstrate that HTP exacerbates neuroinflammation and modulates immune responses in a context-dependent manner, challenging their designation as safer tobacco products, particularly in individuals predisposed to autoimmune disorders.
  • ACR-16/α7-nicotinic receptor signaling mediates nicotine-induced mitochondrial dysfunction and suppression of host defense against gram-negative bacteria
    Pablo Scharf, Romina Deza-Ponzio, Stephanie Stransky, Simone Sidoli, Michael Aschner, Sandra Helena Poliselli Farsky
    Environmental Pollution, 2025
  • Metainflammation alters neutrophil function and migration in vivo in response to tissue injury
    Cassia Michael, Joaquín Cantón-Sandoval, María Feliz-Norberto, Pablo Scharf, Sofia de Oliveira
    Journal of Leukocyte Biology, 2025
    Overnutrition and the consumption of Western-type diets lead to chronic low-grade systemic inflammation (ie metainflammation) and a dysfunctional immune response. Although neutrophils are affected by metainflammation, mechanistic evidence regarding the direct effects of dietary fat exposure on neutrophil function and migration in vivo, particularly in response to injury, remains limited. Here, we investigated how metainflammation induced by a high-cholesterol diet (HCD) influences neutrophil function and migration following tissue injury. We employed a tailfin transection model in juvenile zebrafish larvae with fluorescently tagged neutrophils fed an HCD and assessed neutrophil function and migration dynamics in vivo at the injury site and whole animal. We combined long-term, noninvasive intravital confocal microscopy with computational analysis to examine neutrophil behavior, and photoconversion techniques to track neutrophil mobilization across the larvae. Exposure to HCD resulted in a dysfunctional neutrophil response characterized by exacerbated recruitment, increased reactive oxygen species production and NETosis, impaired apoptosis, and delayed inflammation resolution. Neutrophil forward and reverse migration were also significantly impacted at the injury site. Moreover, we identified diet-inflamed regions such as the liver and intestine as sources of activated neutrophils that reverse migrate and respond to injuries at distant sites, contributing to interorgan transmission of inflammation. Finally, ameliorating steatosis and systemic chronic inflammation rescued the exaggerated neutrophil recruitment to injury. Overall, our study highlights the crucial role of neutrophil dysregulation and reverse migration from diet-induced inflamed tissues in driving exacerbated and dysfunctional inflammatory responses to injury, providing insight into potential therapeutic strategies to alleviate these effects in metabolic disease context.
  • Annexin A1 in neurological disorders: Neuroprotection and glial modulation
    Luiz Philipe de Souza Ferreira, Rafael André da Silva, Pâmela Pacassa Borges, Luana Filippi Xavier, Pablo Scharf, Silvana Sandri, Sonia M. Oliani, Sandra H.P. Farsky, Cristiane D. Gil
    Pharmacology and Therapeutics, 2025
  • Neutrophils in toxicology: a forgotten field
    Pablo Scharf, Michael Aschner, Sandra Farsky
    Journal of Toxicology and Environmental Health Part B Critical Reviews, 2025
    Neutrophils are the most abundant leukocytes in humans and essential for innate immune responses despite a short lifespan in the bloodstream. A complex and tightly regulated production of neutrophils is required to maintain host defense. This process involves intricate signaling between the bone marrow, blood, and tissue clearance. Deficiency or excessive neutrophil infiltration impairs host defenses. Historically, neutrophils were viewed as initial effectors in innate immune responses. Recent discoveries have expanded our understanding of neutrophil biology, identifying multiple activation states and subsets. These subsets may switch phenotypes based on the composition of the microenvironment and might exhibit reverse migratory behavior, moving from inflamed tissues back into the bloodstream. This versatility poses neutrophils as key players in (1) signaling for host defenses, (2) trained immunity, (3) tissue repair, and (4) cancer biology. Disturbances in neutrophil production, responsiveness, apoptosis, and cell removal significantly affect inflammatory diseases and cancer progression. Environmental factors may directly affect the immune system and trigger the onset of many diseases; however, the precise mechanisms underlying the impact of xenobiotics on neutrophil production and functions remain unclear. This review aimed to summarize the current knowledge on neutrophil ontogeny, plasticity, and roles in inflammation, tissue repair, and cancer, emphasizing their susceptibility to different sources of xenobiotic exposures.
  • Annexin A1 levels affect microbiota in health and DSS-induced colitis/inflammatory bowel disease development
    Luana Filippi Xavier, Ranko Gacesa, Gustavo Henrique Oliveira da Rocha, Milena Fronza Broering, Pablo Scharf, Fabiana da Silva Lima, Klaas Nico Faber, Hermie Harmsen, Christian Hoffmann, Sandra Helena Poliselli Farsky
    Frontiers in Immunology, 2025
    BackgroundInflammatory Bowel Diseases (IBDs) are characterized by intestinal dysbiosis and immune dysregulation. Annexin A1 (AnxA1) promotes epithelial repair and inhibits immune responses during IBD. However, AnxA1’s impact on gut microbiota during IBD remains unclear. Here, we experimentally investigated the microbiota profile during colitis in wild-type (WT) and AnxA1-deficient mice (AnxA1-/-), and evaluated an observational cohort in IBD patients with high or low AnxA1 expression.MethodsColitis was induced in C57BL/6 WT and AnxA1-/- mice via oral administration of 2% DSS for six days. Fecal samples were collected at baseline, peak inflammation (day 6), and during the recovery phase (day 10) for 16S rRNA sequencing. Human microbiota data from the Lifelines Dutch Microbiome Project cohort, including IBD and healthy subjects, were analyzed for AnxA1 expression using R software.ResultsHealthy AnxA1-/- mice exhibited reduced microbial richness and a distinct gut microbiota composition, marked by increased Proteobacteria and Parasutterella, and reduced Deferribacterota, Campylobacterota, and Verrucomicrobiota. During DSS-induced colitis, AnxA1-/- mice showed greater weight loss and heightened inflammation, displaying earlier and more pronounced microbial shifts, including increased Proteobacteria, Cyanobacteria, Parabacteroides, Bacteroides, and Escherichia-Shigella. In contrast, WT mice exhibited delayed changes, with expansion of Alloprevotella, Akkermansia, and Faecalibaculum after day 6. In human IBD samples, Crohn’s disease (CD) patients with low AnxA1 expression and active inflammation presented an altered microbiota enriched in Lachnoclostridium and Parabacteroides, while ulcerative colitis (UC) patients showed phylum-level shifts modulated by AnxA1 levels. Notably, non-inflamed CD and UC patients with low AnxA1 differed significantly in microbiota composition. Moreover, inflamed CD patients with high AnxA1 expression showed microbial profiles resembling those of healthy controls, while low AnxA1 expression was associated with a more pronounced dysbiotic state.ConclusionAnxA1 is implicated in microbiota control under healthy and IBD conditions. Accordingly, the microbiota of healthy AnxA1-/- mice, colitic AnxA1-/- mice, and IBD patients with low AnxA1 expression exhibit dysbiosis compared to their respective controls. Together, these unprecedented findings reveal AnxA1 as a potential regulatory protein in the immune–microbiota axis involved in IBD pathogenesis.
  • A single and short exposure to heated tobacco vapor or cigarette smoke affects macrophage activation and polarization
    Pablo Scharf, Silvana Sandri, Pâmela Pacassa Borges, Tiago Franco de Oliveira, Sandra Helena Poliselli Farsky
    Toxicology, 2024
  • GPCRs overexpression and impaired fMLP-induced functions in neutrophils from chronic kidney disease patients
    Pablo Scharf, Silvana Sandri, Felipe Rizzetto, Luana Filippi Xavier, Daniela Grosso, Rebeca D. Correia-Silva, Pedro S. Farsky, Cristiane D. Gil, Sandra Helena Poliselli Farsky
    Frontiers in Immunology, 2024
    IntroductionG-protein coupled receptors (GPCRs) expressed on neutrophils regulate their mobilization from the bone marrow into the blood, their half-live in the circulation, and their pro- and anti-inflammatory activities during inflammation. Chronic kidney disease (CKD) is associated with systemic inflammatory responses, and neutrophilia is a hallmark of CKD onset and progression. Nonetheless, the role of neutrophils in CKD is currently unclear.MethodsBlood and renal tissue were collected from non-dialysis CKD (grade 3 - 5) patients to evaluate GPCR neutrophil expressions and functions in CKD development.ResultsCKD patients presented a higher blood neutrophil-to-lymphocyte ratio (NLR), which was inversely correlated with the glomerular filtration rate (eGFR). A higher frequency of neutrophils expressing the senescent GPCR receptor (CXCR4) and activation markers (CD18+CD11b+CD62L+) was detected in CKD patients. Moreover, CKD neutrophils expressed higher amounts of GPCR formyl peptide receptors (FPR) 1 and 2, known as neutrophil pro- and anti-inflammatory receptors, respectively. Cytoskeletal organization, migration, and production of reactive oxygen species (ROS) by CKD neutrophils were impaired in response to the FPR1 agonist (fMLP), despite the higher expression of FPR1. In addition, CKD neutrophils presented enhanced intracellular, but reduced membrane expression of the protein Annexin A1 (AnxA1), and an impaired ability to secrete it into the extracellular compartment. Secreted and phosphorylated AnxA1 is a recognized ligand of FPR2, pivotal in anti-inflammatory and efferocytosis effects. CKD renal tissue presented a low number of neutrophils, which were AnxA1+.ConclusionTogether, these data highlight that CKD neutrophils overexpress GPCRs, which may contribute to an unbalanced aging process in the circulation, migration into inflamed tissues, and efferocytosis.
  • Development of Ac2-26 Mesoporous Microparticle System as a Potential Therapeutic Agent for Inflammatory Bowel Diseases
    Milena Broering, Pedro Oseliero Filho, Pâmela Borges, Luis da Silva, Marcos Knirsch, Luana Xavier, Pablo Scharf, Silvana Sandri, Marco Stephano, Fernando de Oliveira, Ibrahim Sayed, Lionel Gamarra, Soumita Das, Márcia Fantini, Sandra Farsky
    International Journal of Nanomedicine, 2024
    Introduction Inflammatory bowel diseases (IBDs) disrupt the intestinal epithelium, leading to severe chronic inflammation. Current therapies cause adverse effects and are expensive, invasive, and ineffective for most patients. Annexin A1 (AnxA1) is a pivotal endogenous anti-inflammatory and tissue repair protein in IBD. Nanostructured compounds loading AnxA1 or its active N-terminal mimetic peptides improve IBD symptomatology. Methods To further explore their potential as a therapeutic candidate, the AnxA1 N-terminal mimetic peptide Ac2-26 was incorporated into SBA-15 ordered mesoporous silica and covered with EL30D-55 to deliver it by oral treatment into the inflamed gut. Results The systems SBA-Ac2-26 developed measurements revealed self-assembled rod-shaped particles, likely on the external surface of SBA-15, and 88% of peptide incorporation. SBA-15 carried the peptide Ac2-26 into cultured Raw 264.7 macrophages and Caco-2 epithelial cells. Moreover, oral administration of Eudragit-SBA-15-Ac2-26 (200 μg; once a day; for 4 days) reduced colitis clinical symptoms, inflammation, and improved epithelium recovery in mice under dextran-sodium sulfate-induced colitis. Discussion The absorption of SBA-15 in gut epithelial cells is typically low; however, the permeable inflamed barrier can enable microparticles to cross, being phagocyted by macrophages. These findings suggest that Ac2-26 is successfully delivered and binds to its receptors in both epithelial and immune cells, aligning with the clinical results. Conclusion Our findings demonstrate a simple and cost-effective approach to delivering Ac2-26 orally into the inflamed gut, highlighting its potential as non-invasive IBD therapy.
  • Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
    Airton C. Martins, Miriam B. Virgolini, Daiana Silva Ávila, Pablo Scharf, Jung Li, Alexey A. Tinkov, Anatoly V. Skalny, Aaron B. Bowman, João B. T. Rocha, Michael Aschner
    Cells, 2023
    Mitochondria play a crucial role in cellular respiration, ATP production, and the regulation of various cellular processes. Mitochondrial dysfunctions have been directly linked to pathophysiological conditions, making them a significant target of interest in toxicological research. In recent years, there has been a growing need to understand the intricate effects of xenobiotics on human health, necessitating the use of effective scientific research tools. Caenorhabditis elegans (C. elegans), a nonpathogenic nematode, has emerged as a powerful tool for investigating toxic mechanisms and mitochondrial dysfunction. With remarkable genetic homology to mammals, C. elegans has been used in studies to elucidate the impact of contaminants and drugs on mitochondrial function. This review focuses on the effects of several toxic metals and metalloids, drugs of abuse and pesticides on mitochondria, highlighting the utility of C. elegans as a model organism to investigate mitochondrial dysfunction induced by xenobiotics. Mitochondrial structure, function, and dynamics are discussed, emphasizing their essential role in cellular viability and the regulation of processes such as autophagy, apoptosis, and calcium homeostasis. Additionally, specific toxins and toxicants, such as arsenic, cadmium, and manganese are examined in the context of their impact on mitochondrial function and the utility of C. elegans in elucidating the underlying mechanisms. Furthermore, we demonstrate the utilization of C. elegans as an experimental model providing a promising platform for investigating the intricate relationships between xenobiotics and mitochondrial dysfunction. This knowledge could contribute to the development of strategies to mitigate the adverse effects of contaminants and drugs of abuse, ultimately enhancing our understanding of these complex processes and promoting human health.
  • Development of Annexin A1-surface-functionalized metal-complex multi-wall lipid core nanocapsules and effectiveness on experimental colitis
    Milena Fronza Broering, Matheus de Castro Leão, Gustavo Henrique Oliveira da Rocha, Pablo Scharf, Luana Fillipi Xavier, Aline de Cristo Soares Alves, Inar Castro, Chris Reutelingsperger, Mayara Klimuk Uchiyama, Koiti Araki, Sílvia Stanisçuaski Guterres, Adriana Raffin Pohlmann, Sandra Helena Poliselli Farsky
    European Journal of Pharmaceutics and Biopharmaceutics, 2022
  • Neutrophil depletion in the pre-implantation phase impairs pregnancy index, placenta and fetus development
    Cristina Bichels Hebeda, Anna Carolina Savioli, Pablo Scharf, Marina de Paula-Silva, Cristiane Damas Gil, Sandra Helena Poliselli Farsky, Silvana Sandri
    Frontiers in Immunology, 2022
  • Xenobiotics Delivered by Electronic Nicotine Delivery Systems: Potential Cellular and Molecular Mechanisms on the Pathogenesis of Chronic Kidney Disease
    Pablo Scharf, Felipe Rizzetto, Luana Filippi Xavier, Sandra Helena Poliselli Farsky
    International Journal of Molecular Sciences, 2022
  • Toxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor inhalation on rheumatoid arthritis
    Cintia Scucuglia Heluany, Pablo Scharf, Ayda Henriques Schneider, Paula Barbim Donate, Walter dos Reis Pedreira Filho, Tiago Franco de Oliveira, Fernando Queiroz Cunha, Sandra Helena Poliselli Farsky
    Science of the Total Environment, 2022
  • Immunotoxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor on Jurkat T cell functions
    Pablo Scharf, Gustavo H.O. da Rocha, Silvana Sandri, Cintia S. Heluany, Walter R. Pedreira Filho, Sandra H.P. Farsky
    Environmental Pollution, 2021
  • Pioglitazone-Mediated Attenuation of Experimental Colitis Relies on Cleaving of Annexin A1 Released by Macrophages
    Gustavo Henrique Oliveira da Rocha, Marina de Paula-Silva, Milena Fronza Broering, Pablo Rhasan dos Santos Scharf, Larissa Satiko Alcântara Sekimoto Matsuyama, Silvya Stuchi Maria-Engler, Sandra Helena Poliselli Farsky
    Frontiers in Pharmacology, 2020
  • Red light-emitting diode treatment improves tissue recovery in DSS-induced colitis in mice
    Marina de Paula-Silva, Milena Fronza Broering, Pablo Scharf, Gustavo Henrique Oliveira da Rocha, Sandra Farsky, Adriana Lino-dos-Santos-Franco
    Journal of Photochemistry and Photobiology B Biology, 2020
  • Cellular and molecular mechanisms of environmental pollutants on hematopoiesis
    Pablo Scharf, Milena Fronza Broering, Gustavo Henrique Oliveira da Rocha, Sandra Helena Poliselli Farsky
    International Journal of Molecular Sciences, 2020

RECENT SCHOLAR PUBLICATIONS

  • Heated tobacco and cigarette smoke modulate CD4+ T cell activation and neuroinflammation in a context-dependent manner
    P Scharf, S Sandri, PP Borges, T Francisco da Silva, LC de Faria, ...
    Journal of Neuroinflammation , 2026
    2026
  • Modulation of the neuroimmune interface by tobacco products: effects on innate immunity, neuroinflammation, and neurodegeneration
    PRS Scharf
    Universidade de São Paulo , 2026
    2026
  • Annexin A1 levels affect microbiota in health and DSS-induced colitis/inflammatory bowel disease development
    L Filippi Xavier, R Gacesa, GHO da Rocha, MF Broering, P Scharf, ...
    Frontiers in Immunology 16, 1679071 , 2025
    2025
    Citations: 2
  • ACR-16/α7-nicotinic receptor signaling mediates nicotine-induced mitochondrial dysfunction and suppression of host defense against gram-negative bacteria
    P Scharf, R Deza-Ponzio, S Stransky, S Sidoli, M Aschner, SHP Farsky
    Environmental Pollution, 127007 , 2025
    2025
    Citations: 1
  • Metainflammation alters neutrophil function and migration in vivo in response to tissue injury
    C Michael, J Cantón-Sandoval, M Feliz-Norberto, P Scharf, S de Oliveira
    Journal of Leukocyte Biology 117 (7), qiaf094 , 2025
    2025
    Citations: 4
  • Neutrophils in toxicology: a forgotten field
    P Scharf, M Aschner, S Farsky
    Journal of Toxicology and Environmental Health, Part B 28 (3), 151-182 , 2025
    2025
    Citations: 9
  • Annexin A1 in neurological disorders: neuroprotection and glial modulation
    LP de Souza Ferreira, RA da Silva, PP Borges, LF Xavier, P Scharf, ...
    Pharmacology & Therapeutics 267, 108809 , 2025
    2025
    Citations: 25
  • Development of Ac2-26 mesoporous microparticle system as a potential therapeutic agent for inflammatory bowel diseases
    MF Broering, PL Oseliero Filho, PP Borges, LCC da Silva, MC Knirsch, ...
    International Journal of Nanomedicine, 3537-3554 , 2024
    2024
    Citations: 8
  • GPCRs overexpression and impaired fMLP-induced functions in neutrophils from chronic kidney disease patients
    P Scharf, S Sandri, F Rizzetto, LF Xavier, D Grosso, RD Correia-Silva, ...
    Frontiers in Immunology 15, 1387566 , 2024
    2024
    Citations: 8
  • A single and short exposure to heated tobacco vapor or cigarette smoke affects macrophage activation and polarization
    P Scharf, S Sandri, PP Borges, TF de Oliveira, SHP Farsky
    Toxicology 506, 153859 , 2024
    2024
    Citations: 6
  • Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
    AC Martins, MB Virgolini, DS Ávila, P Scharf, J Li, AA Tinkov, AV Skalny, ...
    Cells 12 (17), 2124 , 2023
    2023
    Citations: 27
  • Development of Annexin A1-surface-functionalized metal-complex multi-wall lipid core nanocapsules and effectiveness on experimental colitis
    MF Broering, M de Castro Leão, GHO da Rocha, P Scharf, LF Xavier, ...
    European Journal of Pharmaceutics and Biopharmaceutics 181, 49-59 , 2022
    2022
    Citations: 4
  • Neutrophil depletion in the pre-implantation phase impairs pregnancy index, placenta and fetus development
    CB Hebeda, AC Savioli, P Scharf, M de Paula-Silva, CD Gil, SHP Farsky, ...
    Frontiers in immunology 13, 969336 , 2022
    2022
    Citations: 17
  • Xenobiotics delivered by electronic nicotine delivery systems: potential cellular and molecular mechanisms on the pathogenesis of chronic kidney disease
    P Scharf, F Rizzetto, LF Xavier, SHP Farsky
    International Journal of Molecular Sciences 23 (18), 10293 , 2022
    2022
    Citations: 14
  • Toxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor inhalation on rheumatoid arthritis
    CS Heluany, P Scharf, AH Schneider, PB Donate, ...
    Science of the Total Environment 809, 151097 , 2022
    2022
    Citations: 29
  • Immunotoxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor on Jurkat T cell functions
    P Scharf, GHO da Rocha, S Sandri, CS Heluany, WR Pedreira Filho, ...
    Environmental Pollution 268, 115863 , 2021
    2021
    Citations: 28
  • Pioglitazone-mediated attenuation of experimental colitis relies on cleaving of annexin A1 released by macrophages
    GHO Da Rocha, M de Paula-Silva, MF Broering, PRS Scharf, ...
    Frontiers in Pharmacology 11, 591561 , 2020
    2020
    Citations: 28
  • Red light-emitting diode treatment improves tissue recovery in DSS-induced colitis in mice
    M de Paula-Silva, MF Broering, P Scharf, GHO da Rocha, S Farsky, ...
    Journal of Photochemistry and Photobiology B: Biology 212, 112018 , 2020
    2020
    Citations: 19
  • Cellular and molecular mechanisms of environmental pollutants on hematopoiesis
    P Scharf, MF Broering, GH Oliveira da Rocha, SHP Farsky
    International Journal of Molecular Sciences 21 (19), 6996 , 2020
    2020
    Citations: 66

MOST CITED SCHOLAR PUBLICATIONS

  • Cellular and molecular mechanisms of environmental pollutants on hematopoiesis
    P Scharf, MF Broering, GH Oliveira da Rocha, SHP Farsky
    International Journal of Molecular Sciences 21 (19), 6996 , 2020
    2020
    Citations: 66
  • Toxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor inhalation on rheumatoid arthritis
    CS Heluany, P Scharf, AH Schneider, PB Donate, ...
    Science of the Total Environment 809, 151097 , 2022
    2022
    Citations: 29
  • Immunotoxic mechanisms of cigarette smoke and heat-not-burn tobacco vapor on Jurkat T cell functions
    P Scharf, GHO da Rocha, S Sandri, CS Heluany, WR Pedreira Filho, ...
    Environmental Pollution 268, 115863 , 2021
    2021
    Citations: 28
  • Pioglitazone-mediated attenuation of experimental colitis relies on cleaving of annexin A1 released by macrophages
    GHO Da Rocha, M de Paula-Silva, MF Broering, PRS Scharf, ...
    Frontiers in Pharmacology 11, 591561 , 2020
    2020
    Citations: 28
  • Mitochondria in the Spotlight: C. elegans as a Model Organism to Evaluate Xenobiotic-Induced Dysfunction
    AC Martins, MB Virgolini, DS Ávila, P Scharf, J Li, AA Tinkov, AV Skalny, ...
    Cells 12 (17), 2124 , 2023
    2023
    Citations: 27
  • Annexin A1 in neurological disorders: neuroprotection and glial modulation
    LP de Souza Ferreira, RA da Silva, PP Borges, LF Xavier, P Scharf, ...
    Pharmacology & Therapeutics 267, 108809 , 2025
    2025
    Citations: 25
  • Red light-emitting diode treatment improves tissue recovery in DSS-induced colitis in mice
    M de Paula-Silva, MF Broering, P Scharf, GHO da Rocha, S Farsky, ...
    Journal of Photochemistry and Photobiology B: Biology 212, 112018 , 2020
    2020
    Citations: 19
  • Neutrophil depletion in the pre-implantation phase impairs pregnancy index, placenta and fetus development
    CB Hebeda, AC Savioli, P Scharf, M de Paula-Silva, CD Gil, SHP Farsky, ...
    Frontiers in immunology 13, 969336 , 2022
    2022
    Citations: 17
  • Xenobiotics delivered by electronic nicotine delivery systems: potential cellular and molecular mechanisms on the pathogenesis of chronic kidney disease
    P Scharf, F Rizzetto, LF Xavier, SHP Farsky
    International Journal of Molecular Sciences 23 (18), 10293 , 2022
    2022
    Citations: 14
  • Neutrophils in toxicology: a forgotten field
    P Scharf, M Aschner, S Farsky
    Journal of Toxicology and Environmental Health, Part B 28 (3), 151-182 , 2025
    2025
    Citations: 9
  • Development of Ac2-26 mesoporous microparticle system as a potential therapeutic agent for inflammatory bowel diseases
    MF Broering, PL Oseliero Filho, PP Borges, LCC da Silva, MC Knirsch, ...
    International Journal of Nanomedicine, 3537-3554 , 2024
    2024
    Citations: 8
  • GPCRs overexpression and impaired fMLP-induced functions in neutrophils from chronic kidney disease patients
    P Scharf, S Sandri, F Rizzetto, LF Xavier, D Grosso, RD Correia-Silva, ...
    Frontiers in Immunology 15, 1387566 , 2024
    2024
    Citations: 8
  • A single and short exposure to heated tobacco vapor or cigarette smoke affects macrophage activation and polarization
    P Scharf, S Sandri, PP Borges, TF de Oliveira, SHP Farsky
    Toxicology 506, 153859 , 2024
    2024
    Citations: 6
  • Metainflammation alters neutrophil function and migration in vivo in response to tissue injury
    C Michael, J Cantón-Sandoval, M Feliz-Norberto, P Scharf, S de Oliveira
    Journal of Leukocyte Biology 117 (7), qiaf094 , 2025
    2025
    Citations: 4
  • Development of Annexin A1-surface-functionalized metal-complex multi-wall lipid core nanocapsules and effectiveness on experimental colitis
    MF Broering, M de Castro Leão, GHO da Rocha, P Scharf, LF Xavier, ...
    European Journal of Pharmaceutics and Biopharmaceutics 181, 49-59 , 2022
    2022
    Citations: 4
  • Annexin A1 levels affect microbiota in health and DSS-induced colitis/inflammatory bowel disease development
    L Filippi Xavier, R Gacesa, GHO da Rocha, MF Broering, P Scharf, ...
    Frontiers in Immunology 16, 1679071 , 2025
    2025
    Citations: 2
  • ACR-16/α7-nicotinic receptor signaling mediates nicotine-induced mitochondrial dysfunction and suppression of host defense against gram-negative bacteria
    P Scharf, R Deza-Ponzio, S Stransky, S Sidoli, M Aschner, SHP Farsky
    Environmental Pollution, 127007 , 2025
    2025
    Citations: 1
  • Heated tobacco and cigarette smoke modulate CD4+ T cell activation and neuroinflammation in a context-dependent manner
    P Scharf, S Sandri, PP Borges, T Francisco da Silva, LC de Faria, ...
    Journal of Neuroinflammation , 2026
    2026
  • Modulation of the neuroimmune interface by tobacco products: effects on innate immunity, neuroinflammation, and neurodegeneration
    PRS Scharf
    Universidade de São Paulo , 2026
    2026