Scott Mazurkewich

@chalmers.se

Division of Industrial Biotechnology at the Department of Life Sciences
Chalmers University of Technology

Scott Mazurkewich


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https://researchid.co/scott.mazurkewich

EDUCATION

Doctor of Philosophy in Biochemistry
University of Guelph, Ontario, Canada, 2010 – 2016
• Advisor: Dr. Stephen Y. K. Seah
• Structure-function characterizations of enzymes from the lignin degradative pathways of Pseudomonas putida, important pathways that could be harnessed for biomass utilization.


Honours Baccalaureate of Science in Biochemistry
University of Guelph, Ontario, Canada, 2005 – 2010
549

Scholar Citations

15

Scholar h-index

17

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • Interaction of a glucuronoyl esterase with complex fragments of the plant cell wall hemicellulose
    A Zaghini, EB Østberg, S Banerjee, S Mazurkewich, L Yu, P Dupree, ...
    International Journal of Biological Macromolecules, 151020 , 2026
    2026
  • Cyclization Decoded: Engineering Amylomaltase for Efficient α-Glucan Transformations
    H Liu, T Shang, S Mazurkewich, Z Zhang, J Hu, T Cai, X Luo, D Zhang, ...
    Journal of the American Chemical Society 147 (36), 33162-33176 , 2025
    2025
    Citations: 3
  • Structural and biochemical basis for activity of Aspergillus nidulans α-1,3-glucanases from glycoside hydrolase family 71
    S Mazurkewich, T Widén, H Karlsson, L Evenäs, P Ramamohan, ...
    Communications Biology 8 (1), 1298 , 2025
    2025
    Citations: 4
  • Genomic and secretomic analyses of Blastobotrys yeasts reveal key xylanases for biomass decomposition
    J Ravn, AS Ristinmaa, S Mazurkewich, GB Dias, J Larsbrink, C Geijer
    Applied Microbiology and Biotechnology 109 (1), 175 , 2025
    2025
    Citations: 1
  • Exploration of three Dyadobacter fermentans enzymes uncovers molecular activity determinants in CE15
    M Carbonaro, S Mazurkewich, G Fiorentino, L Lo Leggio, J Larsbrink
    Applied Microbiology and Biotechnology 108 (1), 335 , 2024
    2024
    Citations: 2
  • Boosting enzyme activity in biomass conversion by modulating the hydrolysis process of cellobiohydrolases
    H Liu, Y Ding, S Mazurkewich, W Pei, X Wei, J Larsbrink, C Chipot, ...
    ACS Catalysis 14 (21), 16044-16054 , 2024
    2024
    Citations: 8
  • Genomic mining of Geobacillus stearothermophilus GF16 for xylose production from hemicellulose-rich biomasses using secreted enzymes
    M Carbonaro, M Aulitto, S Mazurkewich, A Di Fraia, P Contursi, D Limauro, ...
    New Biotechnology 82, 14-24 , 2024
    2024
    Citations: 7
  • Streptomyces castrisilvae sp. nov. and Streptomyces glycanivorans sp. nov., novel soil streptomycetes metabolizing mutan and alternan
    T Widén, AT Rangel, V Lombard, E Drula, S Mazurkewich, N Terrapon, ...
    International Journal of Systematic and Evolutionary Microbiology 74 (9), 006514 , 2024
    2024
    Citations: 4
  • Exploring serial crystallography for capturing Michaelis complexes of a glucuronyl esterase involved in lignocellulose degradation
    G Wehlander, S Mazurkewich, LL Leggio, J Larsbrink, G Brändén
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES 80 , 2024
    2024
  • Structural and biochemical analysis of family 92 carbohydrate-binding modules uncovers multivalent binding to β-glucans
    MS Hao, S Mazurkewich, H Li, A Kvammen, S Saha, S Koskela, AR Inman, ...
    Nature communications 15 (1), 3429 , 2024
    2024
    Citations: 18
  • Polysaccharide utilization loci from Bacteroidota encode CE15 enzymes with possible roles in cleaving pectin-lignin bonds
    A Seveso, S Mazurkewich, S Banerjee, JCN Poulsen, L Lo Leggio, ...
    Applied and Environmental Microbiology 90 (1), e01768-23 , 2024
    2024
    Citations: 14
  • A unique AA5 alcohol oxidase fused with a catalytically inactive CE3 domain from the bacterium Burkholderia pseudomallei
    S Mazurkewich, A Seveso, J Larsbrink
    FEBS letters 597 (13), 1779-1791 , 2023
    2023
    Citations: 3
  • Structural and functional investigation of a fungal member of carbohydrate esterase family 15 with potential specificity for rare xylans
    S Mazurkewich, KC Scholzen, RH Brusch, JCN Poulsen, Y Theibich, ...
    Biological Crystallography 79 (6), 545-555 , 2023
    2023
    Citations: 8
  • Structural diversity and substrate preferences of three tannase enzymes encoded by the anaerobic bacterium Clostridium butyricum
    AS Ristinmaa, T Coleman, L Cesar, AL Weinmann, S Mazurkewich, ...
    Journal of Biological Chemistry 298 (4), 101758 , 2022
    2022
    Citations: 25
  • Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion
    Z Zong, S Mazurkewich, CS Pereira, H Fu, W Cai, X Shao, MS Skaf, ...
    Nature Communications 13 (1), 1449 , 2022
    2022
    Citations: 32
  • Enzymes targeting lignin-carbohydrate complexes
    A Seveso, S Mazurkewich, J Larsbrink
    WWSC workshop June 2022, Marstrand, Göteborg , 2022
    2022
  • Characterization of three tannases from Clostridium butyricum active on oak bark extract
    AS Ristinmaa, J Larsbrink, S Mazurkewich, T Coleman, M Hasani
    Symposium on Biomaterials, Fuels and Chemicals (SBFC), New Orleans , 2022
    2022
  • Mechanism of the glucuronoyl esterase OtCE15A: an alpha/beta hydrolase involved with biomass conversion
    S Mazurkewich, Z Zong, H Fu, W Cai, X Shao, C Pereira, M Skaf, ...
    The Microbial Glycobiology Conference, Lisbon , 2022
    2022
  • Characterization of a novel multidomain CE15-GH8 enzyme encoded by a polysaccharide utilization locus in the human gut bacterium Bacteroides eggerthii
    C Kmezik, D Krska, S Mazurkewich, J Larsbrink
    Scientific Reports 11 (1), 17662 , 2021
    2021
    Citations: 29
  • Structure of a C1/C4-oxidizing AA9 lytic polysaccharide monooxygenase from the thermophilic fungus Malbranchea cinnamomea
    S Mazurkewich, A Seveso, S Hüttner, G Brändén, J Larsbrink
    Biological Crystallography 77 (8), 1019-1026 , 2021
    2021
    Citations: 15

MOST CITED SCHOLAR PUBLICATIONS

  • Biochemical and structural features of diverse bacterial glucuronoyl esterases facilitating recalcitrant biomass conversion
    J Arnling Bååth, S Mazurkewich, RM Knudsen, JCN Poulsen, L Olsson, ...
    Biotechnology for biofuels 11 (1), 213 , 2018
    2018
    Citations: 58
  • A polysaccharide utilization locus from the gut bacterium Dysgonomonas mossii encodes functionally distinct carbohydrate esterases
    C Kmezik, S Mazurkewich, T Meents, LS McKee, A Idström, M Armeni, ...
    Journal of Biological Chemistry 296 , 2021
    2021
    Citations: 49
  • Structural and kinetic characterization of 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolase, a protocatechuate degradation enzyme evolutionarily …
    W Wang, S Mazurkewich, MS Kimber, SYK Seah
    Journal of Biological Chemistry 285 (47), 36608-36615 , 2010
    2010
    Citations: 44
  • Multimodular fused acetyl–feruloyl esterases from soil and gut Bacteroidetes improve xylanase depolymerization of recalcitrant biomass
    C Kmezik, C Bonzom, L Olsson, S Mazurkewich, J Larsbrink
    Biotechnology for biofuels 13 (1), 60 , 2020
    2020
    Citations: 43
  • Genomic and transcriptomic analysis of Candida intermedia reveals the genetic determinants for its xylose-converting capacity
    C Geijer, F Faria-Oliveira, AD Moreno, S Stenberg, S Mazurkewich, ...
    Biotechnology for biofuels 13 (1), 48 , 2020
    2020
    Citations: 36
  • Structural and biochemical studies of the glucuronoyl esterase OtCE15A illuminate its interaction with lignocellulosic components
    S Mazurkewich, JCN Poulsen, LL Leggio, J Larsbrink
    Journal of Biological Chemistry 294 (52), 19978-19987 , 2019
    2019
    Citations: 35
  • Structure–function analyses reveal that a glucuronoyl esterase from Teredinibacter turnerae interacts with carbohydrates and aromatic compounds
    JA Bååth, S Mazurkewich, JCN Poulsen, L Olsson, LL Leggio, J Larsbrink
    Journal of Biological Chemistry 294 (16), 6635-6644 , 2019
    2019
    Citations: 34
  • Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion
    Z Zong, S Mazurkewich, CS Pereira, H Fu, W Cai, X Shao, MS Skaf, ...
    Nature Communications 13 (1), 1449 , 2022
    2022
    Citations: 32
  • Characterization of a novel multidomain CE15-GH8 enzyme encoded by a polysaccharide utilization locus in the human gut bacterium Bacteroides eggerthii
    C Kmezik, D Krska, S Mazurkewich, J Larsbrink
    Scientific Reports 11 (1), 17662 , 2021
    2021
    Citations: 29
  • Structural diversity and substrate preferences of three tannase enzymes encoded by the anaerobic bacterium Clostridium butyricum
    AS Ristinmaa, T Coleman, L Cesar, AL Weinmann, S Mazurkewich, ...
    Journal of Biological Chemistry 298 (4), 101758 , 2022
    2022
    Citations: 25
  • Structural and kinetic characterization of the 4-carboxy-2-hydroxymuconate hydratase from the gallate and protocatechuate 4, 5-cleavage pathways of Pseudomonas putida KT2440
    S Mazurkewich, AS Brott, MS Kimber, SYK Seah
    Journal of Biological Chemistry 291 (14), 7669-7686 , 2016
    2016
    Citations: 25
  • Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii
    D Krska, S Mazurkewich, HA Brown, Y Theibich, JCN Poulsen, AL Morris, ...
    Biochemistry 60 (27), 2206-2220 , 2021
    2021
    Citations: 21
  • Structural and biochemical analysis of family 92 carbohydrate-binding modules uncovers multivalent binding to β-glucans
    MS Hao, S Mazurkewich, H Li, A Kvammen, S Saha, S Koskela, AR Inman, ...
    Nature communications 15 (1), 3429 , 2024
    2024
    Citations: 18
  • Structural insights of the enzymes from the chitin utilization locus of Flavobacterium johnsoniae
    S Mazurkewich, R Helland, A Mackenzie, VGH Eijsink, PB Pope, ...
    Scientific Reports 10 (1), 13775 , 2020
    2020
    Citations: 17
  • Structure of a C1/C4-oxidizing AA9 lytic polysaccharide monooxygenase from the thermophilic fungus Malbranchea cinnamomea
    S Mazurkewich, A Seveso, S Hüttner, G Brändén, J Larsbrink
    Biological Crystallography 77 (8), 1019-1026 , 2021
    2021
    Citations: 15
  • Polysaccharide utilization loci from Bacteroidota encode CE15 enzymes with possible roles in cleaving pectin-lignin bonds
    A Seveso, S Mazurkewich, S Banerjee, JCN Poulsen, L Lo Leggio, ...
    Applied and Environmental Microbiology 90 (1), e01768-23 , 2024
    2024
    Citations: 14
  • Biochemical and structural analysis of RraA proteins to decipher their relationships with 4-hydroxy-4-methyl-2-oxoglutarate/4-carboxy-4-hydroxy-2-oxoadipate aldolases
    S Mazurkewich, W Wang, SYK Seah
    Biochemistry 53 (3), 542-553 , 2014
    2014
    Citations: 10
  • Boosting enzyme activity in biomass conversion by modulating the hydrolysis process of cellobiohydrolases
    H Liu, Y Ding, S Mazurkewich, W Pei, X Wei, J Larsbrink, C Chipot, ...
    ACS Catalysis 14 (21), 16044-16054 , 2024
    2024
    Citations: 8
  • Structural and functional investigation of a fungal member of carbohydrate esterase family 15 with potential specificity for rare xylans
    S Mazurkewich, KC Scholzen, RH Brusch, JCN Poulsen, Y Theibich, ...
    Biological Crystallography 79 (6), 545-555 , 2023
    2023
    Citations: 8
  • Genomic mining of Geobacillus stearothermophilus GF16 for xylose production from hemicellulose-rich biomasses using secreted enzymes
    M Carbonaro, M Aulitto, S Mazurkewich, A Di Fraia, P Contursi, D Limauro, ...
    New Biotechnology 82, 14-24 , 2024
    2024
    Citations: 7