Dr. T. Selvankumar
@mahendraarts.org
Professor and Head in Biotechnology
Mahendra Arts & Science College (Autonomous)
Dr. T. Selvankumar is a Professor and Head, the Department of Biotechnology, Mahendra Arts & Science College (Autonomous), Namakkal, Tamil Nadu, India. He obtained his PhD in Environmental Biotechnology, at Bharathidasan University, Tiruchirappalli, Tamil Nadu, India. He has been honored with several awards including the Best Teacher Award 2019, and Best Researcher Award 2022 of Periyar University. He has 24 years of teaching, and research experience in Microbiology, Immunology, Bioprocess Technology and Nanotechnology Biotechnology. His current research is concentrated on identifying peptide drugs, Nanoparticle-based drug delivery and metagenomics. To his credit, he has published 127 research articles in National and International Journals and submitted 48 microbial nucleotide sequence data banks to NCBI. He has carried out research projects from UGC, DST-FIST and DBT.
EDUCATION
M.Sc, M.Phil, Ph.D.
RESEARCH, TEACHING, or OTHER INTERESTS
Biotechnology, Biochemistry, Genetics and Molecular Biology, Microbiology (medical), Health, Toxicology and Mutagenesis
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Tamiliniyaa Manogaran, Jayashree Kanagaraj, Mohammed F. Albeshr, Thangaswamy Selvankumar, Manikandan Palaniappan, Selvi Arumugam, and Rajavel Rangappan
Wiley
AbstractPhotocatalysts that exhibit exceptional performance could be further enhanced for wastewater treatment, particularly in the degradation of organic pollutants and reduction of inorganic heavy metal ions concentrations. This study employed sol–gel techniques was used to create a Type II scheme g‐C3N4/ZnTiO3 (CZT‐2, CZT‐4, and CZT‐6) photocatalyst. FT‐IR, UV‐DRS, XRD, SEM, BET, HR‐TEM, and XPS analysis were conducted to investigate the physical and chemical properties of the g‐C3N4/ZnTiO3 photocatalyst's. An investigation was conducted to evaluate the photocatalytic performance of the synthesized samples. The samples exhibit remarkable efficacy in the degradation of organic contaminants. Among them, CZT‐2 showcased superior photocatalytic performance in the solar light‐induced photodegradation of crystal violet. The photocatalytic activity of g‐C3N4/ZnTiO3 has been significantly enhanced through the establishment of a Type‐II scheme at the interface. This innovative approach efficiently facilitates the separation of photogenerated electron–hole pairs, thereby boosting the photodegradation activity. The discussion also included the chemical process between photocatalysts and crystal violet. The mechanism of the crystal violet‐photocatalyst reaction was also discussed. After undergoing five cycles of reuse, the photocatalyst that was manufactured demonstrated remarkable stability, leading to a reduction in the cost associated with wastewater treatment. The as‐synthesized g‐C3N4/ZnTiO3 composites are very safe for the environment, which suggests that the CZT‐2 composite is very good at getting rid of pollutants.
Thamaraiselvi Ganesan, Suriyavathana Muthukrishnan, Mohammed F. Albeshr, Thangaswamy Selvankumar, Sobiya Pradeepkumar, K. P. Indumathi, and Braivy Anto
Wiley
AbstractThe production of nanoparticles (NPs) using biological methods may lead to the enhancement of clean, non‐hazardous, and environmentally acceptable procedures. With this context, in the present study silver nanoparticles (AgNPs) were synthesized using the flower extract of Aerva lanata (A. lanata). The following techniques, including UV–visible spectroscopy, XRD, Scanning Electron Microscopy (SEM), and Fourier Transform Infrared Spectroscopy (FTIR), are used to study the crystalline nature, size, shape, and elemental composition of the biosynthesized AgNPs, and antimicrobial applications of the NPs also studied. In UV–visible spectroscopy results a strong absorbance peak at 425 nm confirmed the AgNPs. The SEM results confirmed the spherical shape of the NPs and their average size of 45.05 nm. X‐ray diffractometry XRD spectra confirmed the crystalline nature of the AgNPs. Against the DPPH (2,2‐diphenyl‐1‐picrylhydrazyl), nitric oxide and superoxide radicals, Alf‐AgNPs and ascorbic acid had significant scavenging effects at higher concentration of 250 μg/mL, exhibited 65.76 ± 0.41% and 86.42 ± 0.69%, 78.39 ± 0.49% and 72.72 ± 0.14% and 70.79 ± 0.87% and 72.79 ± 0.33% inhibition, respectively. As produced AgNPs had strong antibacterial and moderate antifungal activities against pathogenic test bacterial strains viz. Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis), Escherichia coli (E. coli), and Klebsiella pneumonia (K. pneumonia) with the maximum zone of inhibition 15 ± 1.07 mm, 12 ± 0.96 mm, 14 ± 1.05 mm, and 15 ± 2.54 mm, respectively at maximum (75 μg/mL) concentration of AgNPs, and the zone of inhibition of fungal strains Aspergillus fumigatus (A. fumigatus) (9 ± 0.67 mm) and Candida albicans (C. albicans) (7 ± 0.75 mm) at 75 μg/mL. It was eventually concluded that the biosynthesized Alf‐AgNPs showed promising antioxidant and antimicrobial agents with very low concentrations.
G. Lavanya, K. Anandaraj, M. Gopu, K. Selvam, T. Selvankumar, M. Govarthanan, and P. Kumar
Springer Science and Business Media LLC
Nagasubramanian Kishore, Srinivasan Balakumar, Chellappan David Raj, Natesan Sivakumar, Ramachandran Thirumalaivasan, Narayanan Mahesh, and Thangaswamy Selvankumar
Elsevier BV
Jeyakumar Saranya Packialakshmi, Mohammed F. Albeshr, Abdulwahed Fahad Alrefaei, Fuchun Zhang, Xinghui Liu, T. Selvankumar, and R. Mythili
Elsevier BV
Mysoon M. Al-Ansari, Latifah Al-Humaid, Majdoleen Aldawsari, Nora Dahmash Al- Dahmash, T. Selvankumar, and R. Mythili
Elsevier BV
Kandasamy Selvam, Chinnappan Sudhakar, Thangaswamy Selvankumar, Balakrishnan Senthilkumar, Woong Kim, Mysoon M. Al-Ansari, and Latifah Al-Humaid
Springer Science and Business Media LLC
Sudha Angamuthu, Selvankumar Thangaswamy, Amutha Raju, Fohad Mabood Husain, Bilal Ahmed, Nasser A. Al-Shabib, Mohammed Jamal Hakeem, Syed Ali Shahzad, Saud A. Abudujayn, and Suliman Y. Alomar
MDPI AG
Shigellosis is a serious foodborne diarrheal disease caused by the Shigella species. It is a critical global health issue. In developing countries, shigellosis causes most of the mortality in children below 5 years of age. Globally, around 165 million cases of diarrhea caused by Shigella are reported, which accounts for almost 1 million deaths, in which the majority are recorded in Third World nations. In this study, silver nanoparticles were synthesized using Mangifera indica kernel (MK-AgNPs) seed extracts. The biosynthesized M. indica silver nanoparticles (MK-AgNPs) were characterized using an array of spectroscopic and microscopic tools, such as UV–Vis, scanning electron microscopy, particle size analyzer, Fourier transform infrared spectroscopy, and X-ray diffractometer. The nanoparticles were spherical in shape and the average size was found to be 42.7 nm. The MK-AgNPs exhibited remarkable antibacterial activity against antibiotic-resistant clinical Shigella sp. The minimum inhibitory concentration (MIC) value of the MK-AgNPs was found to be 20 μg/mL against the multi-drug-resistant strain Shigella flexneri. The results clearly demonstrate that MK-AgNPs prepared using M. indica kernel seed extract exhibited significant bactericidal action against pathogenic Shigella species. The biosynthesized nanoparticles from mango kernel could possibly prove therapeutically useful and effective in combating the threat of shigellosis after careful investigation of its toxicity and in vivo efficacy.
Rajathirajan Siva Dharshini, Mani Poonkothai, Palanisamy Srinivasan, Raja Mythili, Asad Syed, Abdallah M. Elgorban, Thangasamy Selvankumar, and Woong Kim
Springer Science and Business Media LLC
S. Akash, Baskaran Sivaprakash, Natarajan Rajamohan, and Thangaswamy Selvankumar
Elsevier BV
R. Mythili, P. Srinivasan, L. Praburaman, Mysoon M. Al-Ansari, Latifah Al-Humaid, S. Vijayalakshmi, and T. Selvankumar
Springer Science and Business Media LLC
Sukumar Kayalvizhi, Kandasamy Selvam, Chinnappan Sudhakar, Thangaswamy Selvankumar, Mysoon M. Al-Ansari, Latifah Al-Humaid, and S. Vijayalakshmi
Springer Science and Business Media LLC
S. Ponmani, K. Saranya, Shanmugavel Uma Maheswari, Muhammad Nasir Iqbal, Srikala Ganapathy, and T. Selvankumar
Informa UK Limited
Ramakrishnan Rajarajeshwari, Thangaswamy Selvankumar, Gnanamangai Balasubramanian Mythili, Rajamanickam Mohanraj, and Sekaran Ganesan Dhana
World Researchers Associations
Receptor tyrosine kinase is a large transmembrane protein family that is often deregulated to cause lung cancer. EGFR is a cell membrane receptor that is over-expressed in lung cancer with numerous active mutated genes. Pharmacologically active compounds were purified from methanolic leaf extract of Schefflera stellata (Geartn.) Baill. which shows the potent inhibitory effect on over-expressed EGFRs. FTIR analysis D4 and D5 shows the presence of different functional groups such as carboxylic acids, phenol, amines, alcohols, alkanes, alkenes, aromatics, alkyl halides, esters, aromatic amines, ethers, aliphatic amines, saturated aliphatic compounds with 14 major characteristics peaks of bioactive components. Docking studies were carried out between the EGFR tyrosine kinase and purified bioactive compounds (D4 and D5). Totally 5 bioactive molecules were docked with both wild and mutated EGFR. The 3 ligand molecules were picked out based on their binding energy. Among 3 bioactive molecules 1, 2-benzene dicarboxylic acid, mono (2-Ethylhexyl) ester (CID 20393) was found to be most effective that inhibiting over-expressed EGFR tyrosine kinase. The results confirmed that the purified bioactive compounds of Schefflera stellata (Geartn.) Baill. methanolic leaf extract possessed different bioactive functional constituents and its inhibitory role in binding with the D5 compound in over-expressed EGFR in lung cancer cells using docking studies.
Nivedhitha Kabeerdass, Selvankumar Thangaswamy, Vaithilingam Mohanasrinivasan, Chandrasekaran Rajasekaran, Selvakumar Sundaram, Thajuddin Nooruddin, and Maghimaa Mathanmohun
Springer Science and Business Media LLC
Kandasamy Selvam, Fuad Ameen, Mohammad Amirul Islam, Chinnappan Sudhakar, and Thangaswamy Selvankumar
Oxford University Press (OUP)
Abstract Aims The lignocellulosic waste, Borassus flabellifer empty fruit bunch waste (BFEFBW), was employed to produce laccase using Bacillus aestuarii KSK under solid-state fermentation (SSF) conditions and to assess the efficiency of malachite green (MG) dye decolourization. Methods and Results Abiotic factors such as pH (5.0–9.0), temperature (25–45°C) and incubation time (24–96 h) were optimized using Response surface methodology-Box-Behenan Design (RSM-BBD) to exploit the laccase production. The anticipated model revealed that the highest laccase activity of 437 U/ml shows after 60 h of incubation at 35°C at pH 7.0. The bacterial laccase was used to remove 89% of the MG dye in less time. Conclusion The laccase from B. aestuarii KSK decolorizes the MG and thereby making it a suitable choice for wastewater treatment from industrial effluents. Significance and Impact of the Study This study is the first report on the production of laccase from B. flabellifer empty fruit bunch waste as a substrate. Bacillus aestuarii KSK was isolated from the soil sample and used to produce laccase under SSF conditions. The bacterial laccase has the potential for industrial application in textile waste dye treatment.
C. Sudhakar, C. Shobana, T. Selvankumar, and K. Selvam
Wiley
The present study emphasizes the production and optimization of prodigiosin (PG) pigment from Serratia marcescens strain CSK, which was isolated from Shevaroy Hills, Salem district, Tamil Nadu, India. The response surface methodology analysis was applied for the optimization process of PG production. The maximum production of PG (2950 mg/L) was obtained at pH 7.0 with the addition of tryptophan (4.0 g/L) and sucrose (3.0 g/L) with 60 h of incubation. Further, the PG was characterized using high‐performance liquid chromatography, Fourier‐transform infrared spectroscopy, and gas chromatography‐mass spectrometry. The purified PG exhibited strong antioxidant and antibacterial activities. Also, PG's cytotoxic effects against human breast cancer (MCF‐7) cells were observed through acridine orange‐ethidium bromide (AO‐EB) and Hoechst staining. Molecular dockingstudies revealed that PG could bind positively to the caspase‐3 (breast cancer protein 1RE1) binding site with a binding energy score of 17.37 kcal/mol. Overall, the novel PG was found to be an anticancer drug for potential applications in the pharmaceutical industry.
T. Kiruthika, M. Poonkothai, K. Kalaiarasi, Jamaan S. Ajarem, Ahmed A. Allam, Jong Seong Khim, C. Sudhakar, T. Selvankumar, and M. Alaguprathana
Elsevier BV
Kandasamy Selvam, Gadah Albasher, Ohoud Alamri, Chinnappan Sudhakar, Thangaswamy Selvankumar, Selvakumar Vijayalakshmi, and Lakshmanan Vennila
Elsevier BV
Rajarajeshwari Ramakrishnan, Selvankumar Thangaswamy, Mythili Gnanamangai Balasubramaian, Mohanraj Rajamanickam, Naresh Srinivasan, and Dhana Sekaran Ganesan
EManuscript Technologies
Objectives: The present study was focused on the fractionation and isolation of biologically active plant secondary metabolites from methanol leaf extract of Schefflera stellata (Geartn.) Baill. and their cytotoxic effect were evaluated by performing an MTT assay over the Lung cancer cell line (A549). Materials and Methods: Bioactive molecules were fractioned and purified using Column and TLC. Purified constituents exhibit its antioxidant property by dot plot assay using DPPH method. The cytotoxic activity of the purified compound was evaluated by MTT assay. Results: Extraction, isolation, seperation of bioactive molecules from methanol leaf extract of Schefflera stellata (Geartn.) Baill. Using silica column chromatography. 32 fractions were obtained in column and subjected to TLC and dot plot assay by DPPH method. Out of 32 fractions, 2 fractions (D4 and D5) revealed the presence of antioxidant property and were characterized by GC-MS. D5 exhibit bioactive compound, which were taken for cytotoxic studies against lung cancer cell line by MTT assay, the cell viability was found to decrease with increasing concentration (50, 100, 150, 200, 250 µg/ml) with an IC 50 concentration of 150 µg/ml. Conclusion: The present study proves that the purified D5 compound of S. stellata (Geartn.) Baill. has the natural source of antioxidant, which possess the strong cytotoxic activity against lung cancer line (A549).
C. Sudhakar, M. Poonkothai, T. Selvankumar, and K. Selvam
Springer Science and Business Media LLC
Nivedhitha Kabeerdass, Selvam Kandasamy, Gadah Albasher, Ohoud Alamri, Nouf Alsultan, Selvankumar Thangaswamy, and Maghimaa Mathanmohun
Elsevier BV
K. Selvam, Ahmed A. Allam, Jamaan S. Ajarem, C. Sudhakar, T. Selvankumar, B. Senthilkumar, and Woong Kim
Elsevier BV
R. Karthika, B. Jayanthi, A. Aruna, and T. Selvankumar
Springer International Publishing
R. Thirumalaisamy, B. Jayanthi, R. Rathika, and T. Selvankumar
Elsevier