Dr. Senthilvel Vasudevan
@ksau-hs.edu.sa
Assistant Professor of Statistics (Biostatistics)
king saud bin abdulaziz university for health sciences
I am having interested in teaching, research methodology and research. My Ph.D papers were related to DM and DR and common in the world level. Presented papers in National and International Conferences in India (TN, Kerala, Andhra Pradesh, Pondy, Karnataka, Delhi, Lucknow, and Assam), Sri Lanka, Malaysia (2), Saudi Arabia, USA, & Portugal. Medicine, Nursing and Pharmacy. 56 papers in Journals in that, 18 in SCOPUS. Web of Science Researcher ID: O-3557-2015 ORCID ID: 0000-0001-7175-3534
EDUCATION
M.Sc., M.Phil., DST., PGDBS, Ph.D
RESEARCH INTERESTS
I am having interested in teaching, research methodology and research. My Ph.D papers were related to DM and DR and common in the world level. Presented papers in National and International Conferences in India (TN, Kerala, Andhra Pradesh, Pondy, Karnataka, Delhi, Lucknow, and Assam), Sri Lanka)
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Hisham A. Badreldin, Lamya Alreshoud, Renad Altoukhi, Senthilvel Vasudevan, Wesam Isamil, and Mohamed Salih Aziz Mohamed
Springer Science and Business Media LLC
Objectives The aim of this study was to assess apixaban prescribing practices for stroke prevention in patients with non-valvular atrial fibrillation (NVAF), and to examine the factors contributing to dosing inappropriateness at a large academic medical institution in Saudi Arabia. Methodology A retrospective cohort analysis of all adult patients with NVAF receiving apixaban for stroke prevention was conducted for the period from June 2015 to May 2019. Results Of the 1271 patients included in the analysis, inappropriate apixaban dosing was present in 223 (17.50%) patients and absent in 1048 (82.50%) patients. Among those who received an inappropriate apixaban dosage, 103 (46.19%) and 120 (53.81%) received an over- or under-dosed apixaban regimen, respectively. Increasing age, lower body mass index, a history of minor bleeding, concomitant antiplatelet therapy with either clopidogrel + aspirin or aspirin only, reduced renal function, and elevated CHA 2 DS 2 -VASc score were significantly associated with increasing the risk of receiving an inappropriate apixaban dosage. Conclusion In patients with NVAF receiving apixaban for stroke prevention in this real-world analysis, > 80% were prescribed an appropriate dosage of apixaban. Proactive procedures, such as integrating an electronic dosing algorithm, educating healthcare providers, and involving clinical pharmacists in medication review, may help ensure the use of appropriate apixaban dosages.
Hisham A Badreldin, Jahad Alghamdi, Omar Alshaya, Abdulmajeed Alshehri, Lamya Alreshoud, Renad Altoukhi, Senthilvel Vasudevan, Wesam Ismail, and Mohamed Salih Aziz Mohamed
Informa UK Limited
Purpose We conducted this study to assess the real-world prevalence, nature, predictors, and clinical necessity of apixaban pharmacokinetic (PK) and pharmacodynamic (PD) drug interactions in patients with non-valvular atrial fibrillation (NVAF) at a tertiary medical institution in Saudi Arabia. Patients and Methods An observational retrospective cohort analysis was conducted in adult patients diagnosed with NVAF receiving apixaban for stroke prevention from the period of June 2015 to May 2019. Results Of the 1271 patients included in the analysis, 611 (48.1%) patients had potential PD– or PK–drug interactions with apixaban. Of those, 490 (38.6%) patients had potential PD drug–drug interactions (DDIs) and 121 (9.5%) patients had potential PK-DDIs. PD-DDIs with apixaban were mainly with antiplatelet therapy followed by non-steroidal anti-inflammatory drugs and antidepressants. PK-DDIs with apixaban were mainly with combined P-gp/CYP3A4 inhibitors or inducers. History of minor bleeding was positively correlated with PD-DDIs with apixaban, ß coefficient = 0.455 (OR 1.58; 95% CI 1.01–2.45); p<0.05. History of acute coronary syndrome was positively correlated with PD-DDIs with apixaban, ß coefficient = 0.515 (OR 1.60; 95% CI 1.36–1.99); p<0.05. History of heart failure was positively correlated with PK-DDIs with apixaban, ß coefficient = 0.459 (OR 1.58; 95% CI 1.07–2.35); p<0.05. Almost 15% of the included patients had no clinical indication to receive the potential interacting drug with apixaban and about 20% of them were assuming an inappropriate apixaban dose according to the product package insert. Conclusion Pharmacodynamics and pharmacokinetics interactions are common in more than half of the patients with NVAF receiving apixaban for stroke prevention in this real-world analysis. Some of these interacting medications are not indicated. Drug–drug interactions should always be considered and monitored with apixaban with a regular assessment of the need for any interacting medication.
Mohammed Abujamal, Mariam Abdalla, Hind Almodaimegh, and Senthilvel Vasudevan
Diva Enterprises Private Limited
Objectives: Our review is focused on aspirin efficacy as a chemo-preventive agent in colorectal cancer (CRC). Method: We have searched related articles in the following data base through Pub Med, Science Direct, Cochrane Library, Scopus and Google Scholar, restricted to the studies from the year 2000 to 2015. This review focuses on the therapeutic efficacy of aspirin in CRC chemo-prevention. We provide an overview of the association of aspirin treatment with reduction of CRC incidence, recurrence, and CRC-related mortality. Results: Regular use of aspirin was associated with significant reduction in the incidence and recurrence of colorectal cancer (p = 0.004), lower number of adenomas (p = 0.003), prolonged time of the first adenoma detection (p = 0.02) and lower risk of mortality (p > 0.001). Conclusion: Regular use of aspirin effectively reduces the incidence of colorectal cancer, its recurrence rate, and its specific mortality.
Senthilvel Vasudevan, Sumathi Senthilvel, and Jayanthi Sureshbabu
Elsevier BV
Abstract Background An Iodine deficiency disorder causes a major problem of brain damage in human beings and it is a major public health problem in India and worldwide. Objective To assess the knowledge, attitude and practice regarding use of iodized salt among households and to find the iodine content level at the traders and retail vendors in the rural study areas of the Marakkanam block. Methods A community based descriptive study on IDD was conducted in Marakkanam block population, Tamil Nadu with a sample size of 1233 individuals. Results The goiter prevalence was high in female gender when compared with male and higher goiter prevalence rate was found in the lower economic group. Among 1233 individuals, 796 (64.6%) were heard about iodized salt, whereas 437 (35.4%) were not heard about it. Only 294 (23.8%) of the respondents were aware that iodine deficiency caused some disease or health problem. Total of 525 salt sample packets was collected at the traders' level and it that 99% of the salt samples were iodized but most of them weren't adequately iodized. Conclusion From our present study, we have concluded that nearly one fourth of the study population didn't have enough knowledge about IDD and its consequences. To eliminate the lack of their knowledge on IDD by conducting an effective awareness programs. Try to eradicate IDD related diseases in the study areas by encouraging the community people to use iodized salt, encourage the retail shop owners, vendors to sell an adequate iodized salt packets and by reducing the cost of the iodized salt packets through Government of Tamilnadu or private Non – Governmental Organizations.
Sumathi Senthilvel, Senthilvel Vasudevan, PS Anju, Anjana Sukumaran, and Jayanthi Sureshbabu
Medknow
Background: Menopause is a physiological event in the women's life that can strongly affect the quality of life (QOL). More than 80% of women state that physical and physiological symptoms commonly accompany menopause and affect women's health and well-being. Objective: The aim of the study was to assess the menopause-related symptoms and their impact on the women's life. Materials and Methods: We have done a hospital-based descriptive study at the Outpatient and Inpatient Department of Obstetrics and Gynecology, Amrita Institute of Medical Sciences and Research Centre, Kochi, Kerala, with 150 postmenopausal women. The data were collected using the structured Menopause-specific QOL (MENQOL) questionnaire. The data were collected for 4 weeks from the Outpatient and Inpatient of Department of OBG with inclusion criteria of women who were coming as bystanders' age in between 50 and 65 years. Statistical Analysis: Mean, standard deviation, frequency, and proportions were calculated. The association between the MENQOL scores and selected demographic variables was found using one-way ANOVA test. Results: Among 150 postmenopausal women, 51 (34%) were in the age group of 55–59 years and more than half of the study population (n = 116, 77.3%) were married. The management of menopausal symptoms was followed by 28 (18.7%) women. The prevalence levels of the classical menopausal symptoms such as hot flushes, night sweats, and vaginal dryness in women aged 50–65 years were 75.3%, 58%, and 30.7%, respectively. The overall MENQOL mean total score was found as 112.47 ± 28.80. The majority of them experienced the mean physical symptom, which was found to be 62.05 ± 17.82. The associations between QOL scores with educational status and socioeconomic status were statistically highly significant with P < 0.01 and with marital status statistically significant with P < 0.05. Conclusion: From the present study, we have concluded that the postmenopause-related physical symptoms are frequently reported by the middle age group classifications. The association between QOL scores with educational status, socioeconomic status, and marital status was statistically highly significant. By nursing education, creating appropriate awareness and health education on the management of postmenopausal symptoms to that age group and it could be reducing the burden of the women population.
Senthilvel Vasudevan, CK Priyankaraj, Sumathi Senthilvel, and Jayanthi Sureshbabu
Diva Enterprises Private Limited
background and Objectives: Iodine is an essential micronutrient needed for normal human growth and brain development. Methods and Study design: A community based observational study was done in Anichakuppam, Villupuram district, Tamil Nadu, South India in the year of 2012 with a sample of 2830 individuals from 1233 households. Eight villages were randomly selected and data were collected by house-to-house survey. All age groups were included with an exclusion of <2 years in this present study. Results: In the present study, overall goiter prevalence was 8% of which the visible goiter rate was 2.6%. The prevalence of goiter is more in the lower socio-economic group, higher prevalence was found in females as compared to males’ population. Conclusion: We have concluded that the prevalence of goiter would be reduced by consuming mineral water for drinking purpose and by a program of distribution of iodized salt has been initiated to eliminate goiter problem.
Abdulmalik A. Alkatheri, Abdulkareem M. Albekairy, Anan Jarab, Rami Bustami, Nabil Khalidi, Abdulrahman Alshaya, Khalid Bin Saleh, Sultan Alraddadi, Shmeylan Alharbi, Senthilvel Vasudevan,et al.
International Scientific Information, Inc.
BACKGROUND Evidence suggests that patients who are more satisfied with their treatment show better adherence with the prescribed therapy. Although there is valuable data about medication adherence among renal transplant recipients (RTRs), there is a limited literature about their treatment satisfaction and its relation to adherence. The aim of the present study was to investigate factors that can predict medication adherence and to explore the relationship between treatment satisfaction and medication adherence in renal transplant recipients. MATERIAL AND METHODS Adult RTRs were included in the study using convenient sampling. The participants were asked to complete the 8-item Morisky Medication Adherence Scale (MMAS-8) and Treatment Satisfaction Scale TSQM 1.4 in addition to several socio-demographic and treatment-related data. The results were statistically analyzed using univariate and multivariate logistic regression modelling in a stepwise procedure. RESULTS A total of 151 RTRs were included in the study, of which 52 were classified as adherent (34%). Univariate analysis showed that, in comparison with non-adherent RTRs, the adherent group demonstrated significantly higher satisfaction scores in the domains of convenience (96.6±8.7 vs. 85.3±19.3), side effects (95.9±14.1 vs. 82.6±24.1), and global satisfaction (93.4±9.8 vs. 86.7±16.7), while they had marginally higher satisfaction scores in the effectiveness domain (90.4±11.6 vs. 86.5±14.5). Results from multiple logistic regression showed that higher likelihood of adherence was significantly associated with increased satisfaction score in the convenience domain [AOR=1.76, 95% CI=(1.21, 2.55); p=0.003] and marginally related to increased satisfaction scores in the side effects domain [AOR=1.31, 95% CI=(0.99, 1.74); p=0.061]. Male RTRs were significantly more likely to be adherent than female RTRs [AOR=2.23, 95% CI=(1.02, 4.84); p=0.043]. CONCLUSIONS Although the adherence rate among RTRs is relatively low, males and RTRs who reported higher treatment satisfaction (convenience and side effects domains) showed better medication adherence. It is recommended that interventional programs for the improvement of dialysis patient adherence should be developed, in addition to designing strategies to improve treatment convenience and knowledge of medication side effects.
P. Stalin, V. Senthilvel, K. Kanimozhy, Zile Singh, R. Rajkamal, and Anil J. Purty
Informa UK Limited
The objectives of this study are to determine the prevalence of domestic accidents, describe the factors associated with domestic accidents and assess the medical and economical consequences of domestic accidents. Community-based cross-sectional study was conducted in a semi-urban area of Tamil Nadu during February 2013. A total of 3947 study participants were interviewed using a structured questionnaire. Study variables included were socio-demography, housing conditions, epidemiological factors, medical and economical consequences of domestic accidents. Means and proportions were calculated. The prevalence of domestic accidents was 12.7%. Out of 500 domestic accidents, falls (54.4%) was the most common type of domestic accident. Females and the respondents in age group of 21–40 years were more commonly affected. About 60% of victims received treatment. Mean duration of hospital stay, mean amount of money spent for treatment and mean number of days away from routine work for falls category were 16 days, US$25 and 8 days, respectively, which are higher than other types of accidents. The burden and impact of domestic accidents was high. Therefore, in order to prevent and control domestic accidents, promotion of house safety measures and creation of awareness among the community using IEC programmes have to be undertaken.
Anil Jacob Purty, Preetam Mahajan, Zile Singh, A Meenakshi, N Murugan, Johnson Cherian, Senthilvel, Joy Bazroy, and Sandeep Arepally
Diva Enterprises Private Limited
Sajeev Slater, V Senthilvel, and J Joshima
Diva Enterprises Private Limited
Purulent pericarditis is a rare but life-threatening bacterial infection. Most patients have preceding or concurrent infection that is the source of pericarditis. These infections include pneumonia, meningitis, acute osteomyelitis, and acute soft tissue infections. In the present case bacterial cellulitis was the source of infection. Both the doctors and the patient contributed in act of negligence, which lead to the death the patient
Dinesh Dimri, J Venkatachalam, Senthilvel, Zile Singh, Joy Bazroy, Anil J Purty, Natesan Boomika, and Jayanthi
Diva Enterprises Private Limited
Ratendar Kumar Singh, Parnadi Bhaskar Rao, Arvind Kunar Baronia, Banani Poddar, Afzal Azim, Mohan Gurjar, Neha Singh, Vasudevan Senthilvel, and Kamlesh Singh
South African Medical Association NPC
Results. Biliary stones (38%) were the most common cause of acute pancreatitis. Survivors differed from non-survivors with respect to organ failure, APACHE II and SOFA scores and IAP on admission. There was a significant correlation between IAP on ICU admission and admission SOFA (r=0.56, p<0.001) and APACHE II (r=0.54, p<0.001) in predicting mortality. Patients with elective admission had a mortality rate of 53% (20/38) compared to 83% (10/12) for those admitted as emergencies. Analysis of receiver operating characteristic curves for detecting mortality revealed an area under the curve of 0.915 (95% confidence interval (CI) 0.83 - 0.99) for IAP, 0.826 (95% CI 0.71 - 0.93) for SOFA, and 0.831 (95% CI 0.71 - 0.94) for APACHE II.
PreetamB Mahajan, AnilJ Purty, Zile Singh, Johnson Cherian, Murugan Natesan, Sandeep Arepally, and V Senthilvel
Medknow
Objective: To study the prevalence of obesity and overweight among school children in Puducherry. To identify any variation as per age, gender, place of residence and type of school. Setting and design: Secondary data analysis of a school-based cross sectional study in all the four regions of Puducherry. Materials and Methods: Children between 6 and 12 yrs were sampled using multistage random sampling with population proportionate to size from 30 clusters. Anthropometric data (BMI) was analyzed using CDC growth charts. Data was analyzed using SPSS, BMI (CDC) calculator, CI calculator and OR calculator. Results: The prevalence of overweight (≥85th percentile) among children was 4.41% and prevalence of obesity (>95th percentile) was 2.12%. Mahe region had the highest prevalence of overweight (8.66%) and obesity (4.69%). Female children from private schools and urban areas were at greater risk of being overweight and obese. Conclusions: Childhood obesity is a problem in Puducherry and requires timely intervention for its control.
RECENT SCHOLAR PUBLICATIONS
MOST CITED SCHOLAR PUBLICATIONS
Publications
Vasudevan S, Natesan M. Availability, Utilization of Iodized Salt, Status of Iodine Deficiency Disorder and Level
of Iodine Content at Households’ Salt among Coastal Areas of Population in Villupuram District, Tamil Nadu, India. Int J Sci and Med Res
2021;1(1):12–20.