SHANMUGAPANDIYAN

@sathyabama.ac.in

Professor Pharmacy
sathyabama Institute of Science and Technology

SHANMUGAPANDIYAN


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https://researchid.co/shanmugapandiyan

EDUCATION

M.Pharm, Ph.D

RESEARCH INTERESTS

Pharmacy
23

Scopus Publications

760

Scholar Citations

10

Scholar h-index

12

Scholar i10-index

Scopus Publications

  • In-vivo Wound Healing Activity of Acalypha paniculata
    , A. Elumalai, P. Shanmugapandiyan, , V. Vijay Kumar, , L. Kaviarasan, and
    Natural and Life Sciences Communications, 2025
    The wound healing properties of the ethanol extract of dried aerial parts of Acalypha paniculata (APE) were investigated using excision and incision wound models in Wistar strain albino rats. In this experimental study, second-degree burn wounds were created in twenty prescreened rats, which were divided into four groups of five animals each. Group I served as the control and received normal saline, Group II was treated with povidone-iodine as the standard drug, and Groups III and IV were administered topically APE at doses of 250 and 500 µl/wound respectively. For the excision wound model, wound healing was assessed using parameters such as the percentage of wound contraction and epithelialization duration on days 2, 6, 10, and 14, along with histopathological evaluations. In both models, rats treated with APE demonstrated significantly enhanced wound healing activity (P <0.001) compared to the control group. This was evident from the accelerated wound contraction, shorter epithelialization period, increased skin tensile strength, and complete healing within 18 days for excision and seven days for incision method. Histopathological analysis further confirmed these findings, showing well-developed hair follicles, denser collagen fibers, reduced inflammatory cells, mature fibroblasts, and enlarged capillary-sized blood vessels, comparable to the outcomes observed in the standard treatment group. Our study demonstrates that the positive effects of APE on wound healing can be attributed to its ability to reduce wound size.
  • Stability Indicating Bioanalytical Validation of Elexacaftor, Ivacaftor and Tezacaftor using HPLC in Human Plasma
    S. Marakatham, P. Shanmugapandiyan
    Research Journal of Pharmacy and Technology, 2023
    A simple, precised, accurate method was developed for the estimation of Elexacaftor, Ivacaftor and Tezacaftor in human plasma using the Lumacaftor as internal standard by RP-HPLC (Reverse phase-High performance Liquid Chromatographic) technique. Chromatographic conditions used are stationary phase Azilent (250 x 4.6mm, 5m), Mobile phase 0.01N Potassium di-hydrogen phosphate (pH: 3.5) : Acetonitrile in the ratio of 70:30(v/v) and flow rate was maintained at 1.0ml/min, detection wave length was 250nm, column temperature was set to 30oC and diluent was mobile phase Conditions were finalized as optimized method. Retention time of Ivacaftor, Elexacaftor and Tezacaftor were found to be 2.391min, 3.208min and 3.644min. %CV of the Elexacaftor, Ivacaftor and Tezacaftor was found to be 0.08%, 1.05% and 3.59%. %Recovery was obtained as 96.41%, 95.029% and 98.21%. The linearity concentration is in the range of 435-17400ng/mL of Elexacaftor, 60-2400ng/mL of Ivacaftor and 300-1200ng/mL of Tezacaftor (r2 = 0.999) .The lower limits of quantification were 435ng/mL of Elexacaftor, 600ng/mL of Ivacaftor and 300ng/mL of Tezacaftor which reach the level of both drugs possibly found in human plasma. Further, the reported method was validated as per the ICH guidelines and found to be well within the acceptable range. The proposed method is simple, rapid, accurate, precise, and appropriate for pharmacokinetic and therapeutic drug monitoring in the clinical laboratories.
  • Preliminary Phytochemical Analysis on The Leaves Extracts of Sida acuta Burm.f. and Sida rhombifolia Linn. Family Malvaceae
    Selvadurai S., Shanmugapandiyan P.
    Research Journal of Pharmacy and Technology, 2022
    To investigate the phytochemical screening (group determination) of the plants leaves of Sida acuta Burm.f., and Sida rhombifolia Linn. family Malvaceae. In Ayurvedic system of medicine Sida acuta Burm.f., used as digestive, diuretic, fever, burning of the body and urinary discharge. Sida rhombifolia Linn. used as good in urinary complaints, discharge and strangury, useful in fever, heart diseases, burning sensations, piles, all kinds of inflammations. Present study involved Leaves of Sida acuta Burm.f., and Sida rhombifolia Linn. were studied by preliminary phytochemical screening of leaf powders using different solvent viz; petroleum ether, chloroform, acetone, ethanol and aqueous. Leaf extracts were subjected to preliminary phytochemical analysis of using standard procedures. The phytoconstituents present in it viz. alkaloids, carbhohydrates, glycosides, phytosterols, phenolic compounds, tannins, flavonoids, lignins and saponins are present in leaf extracts of Sida acuta Burm.f., and Sida rhombifolia Linn. The active principles of Sida acuta Burm.f., and Sida rhombifolia Linn. namely Manghaslin, Quercetin 3-(2Gxylosylrutinoside), Myricetin 7-Rhamnoside, Isorhamnetin 3-O-[b-D-glucopyranosyl-(1->2)-a Lrhamnopyranoside], Quercetin 3-(2Gxylosylrutinoside), Peltatoside, Rutin, Quercimeritrin are present. The diversity of phytochemicals study can serve as a valuable source of information and provide suitable standards for identification of this plant material in future investigations.
  • Bioanalytical method development and validation of doravirine, lamavudine and tenofovir disoproxil fumarate using hplc in human plasma
    Marakatham S., Shanmugapandiyan P.
    Research Journal of Pharmacy and Technology, 2021
    A novel, simple and sensitive bioanalytical method was developed for estimation of Doravirine, Lamavudine and tenofovir disoproxil fumarate in human plasma with daclatasvir as internal standard. The method was developed using alliance HPLC using Phenomenex C18 (150mm x 4.6mm, 5m) column with mobile phase of 0.01N Potassium dihydrogen phosphate pH (3.5): Acetonitrile (60:40) at flow rate of 1.0ml/min. Detection wavelength was found to be 277nm. The linearity range for doravirine, lamuvidine and Tenfovir was 50-2000ng/ml, 125-5000ng/ml and 20-800ng/ml. Correlation coefficient was 0.999. The method was validated and stability study was carried out as per FDA guidelines.
  • Combined effect of levothyroxine and oral hypoglycemica agents on blood glucose level in hypothyroidism patients-a prospective observational study
    Anandkumar S., Shanmugapandiyan P.
    International Journal of Research in Pharmaceutical Sciences, 2020
    This study was aimed to evaluate the effect of levothyroxine combination therapy on blood glucose level in hypothyroidism patients. The Study was carried out in a private hospital at Tiruchengode as prospective observationally. Patients who were under the management of thyroid disorder and diabetes mellitus for 1 year period was screened and selected for the study. Effect of levothyroxine on blood glucose level and using a Mini mental state examination questionnaire their cognitive skills were also assessed. Independent sample t' test was used to compare the blood glucose level and complication of the management. There were 42 patients were included in the study and the patients who were on Levothyroxine and Glimepride with Metformin labeled as Group 1 and Glimepride with Metformin alone was labeled as Group 2. Glimepride with metformin therapy shows greater percentage of blood glucose level reduction and significant p<0.05 cognitive impairment was found in the combination therapy. Diabetes mellitus management with levothyroxine and glimepride with metformin has an association on the managing blood glucose level. Efficient management of blood glucose level was obtained with glimepride with metformin alone. Cognition impairment was high in the combination therapy of levothyroxine and glimepride with metformin.
  • Clinical investigation on mini mental score assessment on various stages of hypothyroidism patients
    S. Anandkumar, P. Shanmugapandiyan
    Research Journal of Pharmacy and Technology, 2019
    To assess the cognitive impairment in various conditions of hypothyroidism patients. The study design was a cross sectional observational case control study. The study site was carried out in the department of general medicine at Vivekanandha medical care Hospital, Tiruchengode. Patients of subclinical hypothyroidism without neurological disorder, Patients of overt hypothyroidism without neurological disorder, Normal Euthyroid persons were included in the study, Pediatrics Patients, Comatose patients, Chronic Illness patients, Patients with neurological disorder, pregnant women were excluded from the study. The average MMSE score of hypothyroid patients was 22.56±3.36, average MMSE score of control group is 24.94±2.48. When compared the both group shows (p <0.0001) extremely significant. Hypothyroidism patients have low MMSE score than euthyroid participants which reveals hypothyroidism is significantly associated with cognitive impairment. Present study also reveals patients who have chronic thyroid damage leads to higher risk of cognitive impairment.
  • Stabilitty indicating method development and validation for the quantification of Chlorphenamine Maleate related subtances using HPLC technique
    International Journal of Pharma and Bio Sciences, 2016
  • Synthesis and antitubercular evaluation of 5-chloro-2-(5-(substituted phenyl)-1H-tetrazol-1-yl) pyridine
    International Journal of Chemtech Research, 2013
  • Fabrication and evaluation of extended release matrix tablets of Tramadol Hydrochloride
    International Journal of Pharmacy and Pharmaceutical Sciences, 2013
  • Anti toxic potential of Ecbolium viride (Forsk.) alston in acetaminophen provoked hepatopathy
    Asian Journal of Pharmaceutical and Clinical Research, 2013
  • Development and invitro characterization of Tramadol Hydrochloride sustained release tablets
    International Journal of Pharmtech Research, 2013
  • Synthesis, antimicrobial and anti-inflammatory activities of 3-(1-substituted phenyl-1H-tetrazol-5-yl)pyridine derivatives
    Asian Journal of Pharmaceutical and Clinical Research, 2012
  • Synthesis and antimicrobial evaluation of 2-(5-(substituted phenyl-1H-tetrazol-1-yl) pyridines
    International Journal of Pharmacy and Pharmaceutical Sciences, 2012
  • Antimicrobial activity of chloroform extract of leaves of catharanthus roseus (L) G.DON
    Asian Journal of Chemistry, 2012
  • Preparation and evaluation of paracetamol by solid dispersion technique
    International Journal of Pharmacy and Pharmaceutical Sciences, 2011
  • Antimicrobial activity of ethanolic extract of leaves of tabebuia rosea (Bertol.) DC.
    Asian Journal of Chemistry, 2011
  • Synthesis and pharmacological evaluation of novel schiff base analogues of 3-(4-amino) phenylimino) 5-fluoroindolin-2-one
    R. Nirmal, K. Meenakshi, P. Shanmugapandiyan, C.R. Prakash
    Journal of Young Pharmacists, 2010
  • Synthesis, pharmacological screening, quantum chemical and in vitro permeability studies of N-Mannich bases of benzimidazoles through bovine cornea
    E. Philip Jesudason, S.K. Sridhar, E.J. Padma Malar, P. Shanmugapandiyan, Mohammed Inayathullah, V. Arul, D. Selvaraj, R. Jayakumar
    European Journal of Medicinal Chemistry, 2009
  • Synthesis and antimicrobial activity of 1-(benzothiazol-2′-yl)-5- phenyl-tetrazole
    Asian Journal of Chemistry, 2008
  • Validated high performance thin layer chromatography method for simultaneous estimation of rofecoxib and tizanidine hydrochloride in pure and tablet dosage forms
    Asian Journal of Chemistry, 2007
  • Simultaneous quantification of stavudine, lamivudine and nevirapine by UV spectroscopy, reverse phase HPLC and HPTLC in tablets
    Sockalingam Anbazhagan, Narayanareddy Indumathy, Pitchaimuthu Shanmugapandiyan, Seshaiah Krishnan Sridhar
    Journal of Pharmaceutical and Biomedical Analysis, 2005
  • RP HPLC method for simultaneous estimation of atorvastatin and aspirin from capsule formulation
    Indian Drugs, 2004
  • Synthesis and biological activities of 2,6-diaryl-3-methyl-4-piperidone derivatives
    Natesh Rameshkumar, Anantharaman Veena, Raju Ilavarasan, Mandaleeswaran Adiraj, Pitchaimuthu Shanmugapandiyan, Seshaiah Krishnan Sridhar
    Biological and Pharmaceutical Bulletin, 2003

RECENT SCHOLAR PUBLICATIONS

  • Pharmacognostical Standardization of Sida acuta Leaves (Malvaceae Family)
    S Selvadurai, K Thirumalai, S Anbazhagan, P Shanmugapandiyan
    Research Journal of Pharmacognosy and Phytochemistry 16 (1), 1-4 , 2024
    2024
    Citations: 1
  • Fluctuations due to Altitude, Season and Time on Potency of Stigmasterol content of Jamun
    G Palshikar, G Soni, K Otari, P Shanmugapandiyan
    Research Journal of Pharmacy and Technology, 1320-1323 , 2024
    2024
    Citations: 2
  • Stability indicating bioanalytical validation of elexacaftor, ivacaftor and tezacaftor using HPLC in human plasma
    S Marakatham, P Shanmugapandiyan
    Research Journal OF Pharmacy and Technology 16 (8), 3780-3786 , 2023
    2023
    Citations: 6
  • FORMULATION AND EVALUATION OF FLOATING DRUG DELIVERY OF FEXOFENADINE HCL
    VV Kumar, Y Ismail, M Nandhini, P Shanmugapandiyan, K Pradeep
    2023
  • Preliminary phytochemical analysis on the leaves extracts of Sida acuta Burm. f. and Sida rhombifolia Linn. family Malvaceae
    S Selvadurai, P Shanmugapandiyan
    Research Journal of Pharmacy and Technology 15 (4), 1512-1516 , 2022
    2022
    Citations: 8
  • Bioanalytical Method Development and Validation of Doravirine, Lamavudine and Tenofovir Disoproxil Fumarate using HPLC in Human Plasma
    S Marakatham, P Shanmugapandiyan
    Research Journal of Pharmacy and Technology 14 (8), 4087-4091 , 2021
    2021
    Citations: 5
  • Comparative Pharmacognostical Studies Of Leaves Of Sida Acuta Burm. F., Sida Cordifolia Linn. And Sida Rhombifolia Linn.(Malvaceae Family).
    S SELVADURAI, P SHANMUGAPANDIYAN
    International Journal of Pharmaceutical Research (09752366) 13 (2) , 2021
    2021
  • Hepatoprotective effect on methanolic extracts of Tagetes erecta leaves and Tridax procumbens against drug induced hepatic injury
    AS Chandra, P Shanmugapandiyan
    International Journal of Research in Pharmaceutical Sciences 12 (2), 1415-1421 , 2021
    2021
    Citations: 3
  • Analgesic nephropathy due to diclofenac in a 24-year-old Indian male patient: A case report
    S Pandit, V Mishra, C Desai
    Journal of Young Pharmacists 12 (3), 291 , 2020
    2020
  • EFFECT OF THYROID REPLACEMENT THERAPY ON COGNITION IN HYPOTHYROIDISM PATIENTS
    P SHANMUGAPANDIYAN, S ANANDKUMAR, SHA BANU, SH KRISHNA, ...
    INTERNATIONAL RESEARCH JOURNAL OF PHARMACY Учредители: Pan Health Care … , 2020
    2020
  • COMBINED EFFECT OF LEVOTHYROXINE AND ORAL HYPOGLYCEMICA AGENTS ON BLOOD GLUCOSE LEVEL IN HYPOTHYROIDISM PATIENTS-A PROSPECTIVE OBSERVATIONAL STUDY
    S ANANDKUMAR, P SHANMUGAPANDIYAN
    INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACEUTICAL SCIENCES 11 (2), 1870-1873 , 2020
    2020
  • Cardioprotective efficacy of Tridax procumbens methanolic extract in Doxorubicin induced Oxidative Cardiac Damage
    AS Chandra, P Shanmugapandiyan
    Research Journal of Pharmacy and Technology 13 (1), 110-113 , 2020
    2020
    Citations: 7
  • A Review on Effect of Seasonal Variation on Phytochemicals of Medicinal Plants
    GS Palshikar, S Ambavade, P Shanmugapandiyan
    LAP LAMBERT Academic Publishing , 2020
    2020
    Citations: 2
  • Hepatoprotective of eclipta alba methanolic extract in isoniazid and rifampicin proved oxidative hepatic injury
    AS Chandra, P Shanmugapandiyan
    International Journal of Pharmacy Research & Technology (IJPRT) 10 (2), 74-79 , 2020
    2020
    Citations: 4
  • Effect of Thyroid Replacement with Statin Therapy on Cognitive Functions and Lipid Profile in Hypothyroidism Patients
    S Anandkumar, P Shanmugapandiyan
    Journal of Pharmaceutical Sciences and Research 11 (9), 3233-3236 , 2019
    2019
  • Clinical Investigation on Mini Mental Score Assessment on various stages of Hypothyroidism patients
    S Anandkumar, P Shanmugapandiyan
    Research Journal of Pharmacy and Technology 12 (10), 4763-4766 , 2019
    2019
    Citations: 1
  • Bioanalytical Method Development and Validation of Nitrofurantoin in Human Plasma By LC-MS/MS
    MS Kumar, P Shanmugapandiyan
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH 8 (10), 4186-4194 , 2017
    2017
    Citations: 1
  • RP-HPLC-PDA method for the simultaneous determination of phenylepherine, chlorpheneramine, paracetamol and dextromethorphan in bulk and marketed formulation
    MS Kumar, P Shanmugapandiyan
    J. Pharm. Res 11 (2), 306-12 , 2017
    2017
    Citations: 6
  • New validated stability indicating gradient RP-HPLC method for the assay & related substances of miconazole nitrate and assay of benzoic acid in miconazole nitrate 2.0% w/w gel
    S Kumaravel, P Shanmugapandiyan
    International Journal of Pharma and Bio Sciences 8 (2), 308-312 , 2017
    2017
    Citations: 3
  • Validated stability indicating gradient RP-HPLC method for the estimation of antihypertensive drugs in bulk and pharmaceutical dosage forms
    S Kumaravel, DN Raj, S Anbazhagan, P Shanmugapandiyan
    Indian Journal of Research in Pharmacy and Biotechnology 4 (3), 142 , 2016
    2016

MOST CITED SCHOLAR PUBLICATIONS

  • Simultaneous quantification of stavudine, lamivudine and nevirapine by UV spectroscopy, reverse phase HPLC and HPTLC in tablets
    S Anbazhagan, N Indumathy, P Shanmugapandiyan, SK Sridhar
    Journal of pharmaceutical and biomedical analysis 39 (3-4), 801-804 , 2005
    2005
    Citations: 108
  • Synthesis, pharmacological screening, quantum chemical and in vitro permeability studies of N-Mannich bases of benzimidazoles through bovine cornea
    EP Jesudason, SK Sridhar, EJP Malar, P Shanmugapandiyan, ...
    European journal of medicinal chemistry 44 (5), 2307-2312 , 2009
    2009
    Citations: 103
  • Synthesis and biological activities of 2, 6-diaryl-3-methyl-4-piperidone derivatives
    N Rameshkumar, A Veena, R Ilavarasan, M Adiraj, P Shanmugapandiyan, ...
    Biological and Pharmaceutical Bulletin 26 (2), 188-193 , 2003
    2003
    Citations: 99
  • Synthesis, X-ray crystal structure, DNA binding, antioxidant and cytotoxicity studies of Ni( ii ) and Pd( ii ) thiosemicarbazone complexes
    E Ramachandran, P Kalaivani, R Prabhakaran, NP Rath, S Brinda, ...
    Metallomics 4 (2), 218-227 , 2012
    2012
    Citations: 81
  • Synthesis pharmacological evaluation of novel Schiff base analogues of 3-(4-amino) phenylimino) 5-fluoroindolin-2-one
    R Nirmal, K Meenakshi, P Shanmugapandiyan, CR Prakash
    Journal of Young Pharmacists 2 (2), 162-168 , 2010
    2010
    Citations: 75
  • Preparation and evaluation of paracetamol by solid dispersion technique
    D Akiladevi, P Shanmugapandiyan, D Jebasingh, S Basak
    Int J Pharm Pharm Sci 3 (1), 188-191 , 2011
    2011
    Citations: 56
  • RP HPLC method for simultaneous estimation of Atorvastatin and Aspirin from capsule formulation
    K Manoj, P Shanmugapandiyan, S Anbazhagan
    INDIAN DRUGS-BOMBAY- 41, 284-289 , 2004
    2004
    Citations: 52
  • Synthesis and biological activity of 2-(thiazolidin-4-one) phenyl]-1H-phenylbenzimidazoles and 2-[4-(azetidin-2-one)-3-chloro-4-phenyl]-1H-phenyl benzimidazoles
    P Shanmugapandiyan, KS Denshing, R Ilavarasan, N Anbalagan, ...
    IJPSDR 2 (2), 115-119 , 2010
    2010
    Citations: 44
  • The effect of tempidon on the EEG of cats in acute and chronic experiments
    M Nikolova, D Stéphanova, D Tchavdarov
    Activitas nervosa superior 16 (4), 264-268 , 1974
    1974
    Citations: 16
  • Synthesis and antitubercular evaluation of 5-chloro-2-(5 (substituted phenyl)-1H-tetrazol-1-yl) pyridine
    S George, P Shanmugapandiyan
    International Journal of ChemTech Research 5 (5), 2603 , 2013
    2013
    Citations: 13
  • Synthesis, antimicrobial and anti-inflammatory activities of 3-(1-substituted phenyl-1H-tetrazol-5-yl) pyridine derivatives
    S George, PS Varma, I Suresh, P Shanmugapandiyan
    Asian J. Pharm. Clin. Res 5 (4), 81-84 , 2012
    2012
    Citations: 10
  • Synthesis and antimicrobial evaluation of 2-(5-(substituted phenyl-1H-tetrazol-1-yl) pyridines
    S George, P Shanmugapandiyan
    Int J Pharm Pharm Sci 4, 104-106 , 2011
    2011
    Citations: 10
  • Synthesis & Anti-Microbial Evaluation Of N-(2-(4-Substituted Phenyl)-4-Oxothiazolidin-3-Yl) Isonicotinamide Derivatives
    S Ramachandran, P Shanmugapandiyan, CN Nalini
    International Journal of Pharmaceutical Sciences and Research 2 (6), 1564 , 2011
    2011
    Citations: 9
  • Preliminary phytochemical analysis on the leaves extracts of Sida acuta Burm. f. and Sida rhombifolia Linn. family Malvaceae
    S Selvadurai, P Shanmugapandiyan
    Research Journal of Pharmacy and Technology 15 (4), 1512-1516 , 2022
    2022
    Citations: 8
  • Antimicrobial activity of ethanolic extract of leaves of Tabebuia rosea (Bertol.) DC.
    VS Saravanan, P Shanmugapandiyan, GM Ali, RM Kumar, T Manikandan, ...
    2011
    Citations: 8
  • Cardioprotective efficacy of Tridax procumbens methanolic extract in Doxorubicin induced Oxidative Cardiac Damage
    AS Chandra, P Shanmugapandiyan
    Research Journal of Pharmacy and Technology 13 (1), 110-113 , 2020
    2020
    Citations: 7
  • Stability indicating bioanalytical validation of elexacaftor, ivacaftor and tezacaftor using HPLC in human plasma
    S Marakatham, P Shanmugapandiyan
    Research Journal OF Pharmacy and Technology 16 (8), 3780-3786 , 2023
    2023
    Citations: 6
  • RP-HPLC-PDA method for the simultaneous determination of phenylepherine, chlorpheneramine, paracetamol and dextromethorphan in bulk and marketed formulation
    MS Kumar, P Shanmugapandiyan
    J. Pharm. Res 11 (2), 306-12 , 2017
    2017
    Citations: 6
  • Synthesis and antimicrobial activity of 1-(benzothiazol-2′-yl)-5-phenyl-tetrazole
    P Shanmugapandiyan, R Atmakuru
    Asian J. Chem 20, 992-998 , 2008
    2008
    Citations: 6
  • Synthesis and biological applications of certain 1-acetamido-(benzothiazol-2’-yl)-5-aryltetrazole and benzothiazol-2’-yl-1-ethylamine-5-aryltetrazoles
    P Shanmugapandiyan, A Ramesh
    J Pharm Chem 2, 169-173 , 2008
    2008
    Citations: 6