Maria Aparecida Shikanai Yasuda

@usp.br

Infectious and Parasitic Diseases
Faculdade de Medicina, University os São Paulo

Maria Aparecida Shikanai Yasuda


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https://researchid.co/shikanai
Master in Infectious Diseases - Immunology of schistosomiasis, phD in immunology of Chagas disease and Associate Professor Thesis on immunology of parasocccidiodomycosis.
Research on Endemic diseases in immunosupressed host: Immunology and Diagnosis of Chagas disease, Chagas disease in immunosupressed host, Coinfection T. cruzi-HIV, Host-parasite interaction on paracoccidioidomycosis, Endemic diseases in immunosupressed host.

EDUCATION

Graduation in Medicine
Master Degree and pHD on Infectious Diseases
Posgraduation - Iowa University
Visiting Professor _-Medical Mycology Research Center.

RESEARCH INTERESTS

Chagas disease, Paracoccidioidomycosis, Coinfection Trypanasoma cruzi-HIV, Endemic infection sin immunosupressed host
160

Scopus Publications

10606

Scholar Citations

55

Scholar h-index

127

Scholar i10-index

Scopus Publications

  • Telomere-to-telomere assemblies of Paracoccidioides genomes
    Dmitry Grinevich, Oliver Kompathoum, Jingbaoyi Li, David A Turissini, Patrick Kelly, et al.
    Genetics, 2026
    Paracoccidioides is a genus of dimorphic fungal pathogens endemic to Latin America. We generated long-read de novo assemblies for 11 isolates representing 4 species of the brasiliensis complex (Paracoccidioides brasiliensis, Paracoccidioides americana, Paracoccidioides restrepiensis, Paracoccidioides venezuelensis) and Paracoccidioides lutzii. These include the first complete telomere-to-telomere assemblies for P. brasiliensis (Pb18) and P. americana (Pb03), each with 5 chromosomes. Comparative analyses revealed chromosomal fusion and fission events distinguishing P. brasiliensis and P. americana, and a 90 kb tandem duplication in P. americana containing siderophore biosynthesis genes (sid1, sid3, sid4), a cluster of putative virulence factors. Mitochondrial genomes showed conserved gene order but a phylogenetic topology inconsistent with the nuclear tree, suggesting mitochondrial introgression between P. lutzii and P. venezuelensis. RNA transposable elements were enriched near telomeres, correlated with genome size, and most abundant in P. lutzii. These assemblies provide key resources for understanding genome evolution and introgression in Paracoccidioides.
  • Neglected Mycoses in Brazil: A Population-Based Study of Mortality and In-Hospital Mortality Over 25 Years
    Anderson Fuentes Ferreira, Jorg Heukelbach, Eliana Amorim de Souza, Maria Aparecida Shikanai‐Yasuda, Lisandra Serra Damasceno, et al.
    Mycoses, 2026
    Objective To describe the epidemiology, associated factors, spatial distribution, and temporal trends of mortality and in‐hospital mortality related to systemic mycoses in Brazil, 2000–2024. Methods This is a nationwide ecological study combining temporal and spatial analyses using death certificates (DC; underlying and/or associated causes) and hospital admissions (HA; primary and/or secondary diagnoses) with in‐hospital deaths. We estimated rate ratios (RR) with 95% confidence intervals (CI) interpreted as comparative mortality and in‐hospital mortality rates between sociodemographic categories at the aggregate level, stratified by sex and age group; temporal trends were presented with the average annual percent change (AAPC) and 95% CIs; spatial heterogeneity was described across states. Outcomes were expressed as population‐based rates (per 100,000 inhabitants). Results We identified 22,230 mycosis‐related deaths among a total of 30,488,786 deaths (0.07%), corresponding to an overall mortality rate of 0.46 per 100,000 population. Mortality was higher in males (RR 2.91; 95% CI 2.51–3.38) and peaked at ages 60–69 years (RR 3.47; 95% CI 2.67–4.51). Nationwide mortality declined over time (AAPC −1.12; 95% CI −1.41 to −0.83). Deaths were geographically concentrated in the states of Rondônia, Mato Grosso, Goiás and Mato Grosso do Sul. We recorded a total of 4471 in‐hospital deaths among 11,367,369 admissions (0.04%), yielding an in‐hospital mortality rate of 0.09 per 100,000 population. In‐hospital risk of death was higher in males (RR 2.12; 95% CI 1.55–2.89) and in those aged ≥ 70 years (RR 12.50; 95% CI 7.38–21.17). No significant nationwide trend was observed for in‐hospital mortality (AAPC 0.64; 95% CI −1.20 to 2.59). Spatial distribution during the analysis period was heterogeneous, especially in the states of Rondônia, São Paulo, Rio de Janeiro, Paraíba and Paraná. Conclusion Our findings fill an important gap by jointly analysing long‐term mortality and in‐hospital mortality related to systemic mycoses at a nationwide scale, using two complementary information systems. Neglected mycoses remain an important cause of death in Brazil, including deaths during hospitalisation. Distinct individual‐level and spatial patterns support the need for strengthened surveillance, prevention, control, and therapeutic strategies within the Brazilian Unified Health System.
  • Paracoccidioidomycosis in Brazil: 25-Year Nationwide Trends in Mortality, Hospitalisations and In-Hospital Deaths of a Neglected Systemic Mycosis
    Anderson Fuentes Ferreira, Jorg Heukelbach, Eliana Amorim de Souza, Maria Aparecida Shikanai‐Yasuda, Lisandra Serra Damasceno, et al.
    Tropical Medicine and International Health, 2026
    Objective To analyse mortality, hospitalisations and in‐hospital mortality related to paracoccidioidomycosis (PCM) in Brazil, 2000–2024, from a spatio‐temporal and social inequalities perspective. Methods We conducted a mixed ecological study using death certificates from the Mortality Information System and hospital admissions from the Hospital Information System of the Brazilian Unified Health System, including admissions that resulted in death. Records with PCM (ICD‐10 B40–B41) as the underlying or associated cause of death, or as the primary or secondary diagnosis, were included. Sex‐ and age‐standardised rates (per 1,000,000 inhabitants) were estimated for Brazil and macro‐regions. Time trends were assessed using Joinpoint regression and spatial distribution was evaluated by health region. Results We identified 4904 deaths mentioning PCM over the 25‐year period (2980 [60.8%] as the underlying cause and 1924 [39.2%] as an associated cause) corresponding to a standardised mortality rate of 1.00/1,000,000 inhabitants. Deaths occurred predominantly among men of working age. Mortality declined nationally (average annual percent change [AAPC] −3.85%). There were 18,239 hospital admissions (standardised hospitalisation rate 3.71/1,000,000), which also decreased over time (AAPC −2.83%). In total, 1136 admissions resulted in death (standardised in‐hospital mortality rate 0.23/1,000,000), with no significant overall trend. The highest mortality, hospitalisation and in‐hospital mortality rates clustered in Rondônia, northern Mato Grosso and health regions in the Southeast and Central‐West. Conclusions Despite declining national rates, PCM remains concentrated in specific endemic territories, disproportionately affecting socially vulnerable populations and reinforcing its status as a neglected systemic mycosis in Brazil. Making PCM a nationally notifiable disease is essential to reduce its burden.
  • Analysis of Aspergillus spp. Isolates According to Temporal–Spatial, Sociodemographic, and Clinical Variables—Microsatellite Typing of Clinical and Environmental Samples of Aspergillus fumigatus in a University Hospital in Sao Paulo, Brazil
    Claudia de Abreu Fonseca, Ricardo Araujo, Vivian Caso Coelho, Carlos Henrique Camargo, Marcello Mihailenko Chaves Magri, et al.
    Mycoses, 2026
    Background Typing Aspergillu s species is crucial for understanding the sources of infection in hospital environments. Objectives This study analysed clinical and air samples as well as their relationship with the clinical forms of aspergillosis. Additionally, we examined the usefulness of the Short Tandem Repeats (STR) technique with two highly discriminatory markers for analysing the Aspergillus fumigatus ( A. fumigatus ) profile. Patients/Methods Seventy‐five air samples (September 2013–July 2014) and 116 clinical samples (2009–2014) were collected in a university hospital. Seventy‐two samples were typed by STR with two markers, MC3 and MC5. Results Of the 75 air samples collected, 10 were positive in the Bone Marrow Transplant unit, a ventilated unit with HEPA filters as were 18 in the Haematology ward, a naturally ventilated unit. Of the 116 clinical samples of Aspergillus spp., 95 were identified as A. fumigatus . High diversity was found, with 42 genotypes in 67 clinical samples and four in five environmental samples. Most isolates were collected during the demolition and renovation of the Emergency unit in the Hospital from 2013 to 2014. Genotype 1 was found in several units during different years. Despite the heterogeneity, identical genotypes were observed three times at short intervals in the same or different wards. Some of these identical genotypes were confirmed as possible clones by genome sequencing while others' genotyping matches failed to be confirmed. Conclusion Despite the diversity of clinical and environmental samples, useful correlations can be established in invasive aspergillosis surveillance programs by using this simple STR method as a preliminary step.
  • Paracoccidioidomycosis in the 21st century: Challenges and milestones
    James Venturini, Norma Beatriz Fernandez, Priscila Marques de Macedo, Ricardo de Souza Cavalcante, Diego H. Caceres, et al.
    Plos Neglected Tropical Diseases, 2026
    Background Paracoccidioidomycosis (PCM) is a neglected tropical fungal disease endemic to Latin America that predominantly affects rural and socioeconomically vulnerable communities. Despite significant morbidity, mortality, and substantial public health implications, PCM remains frequently underdiagnosed and underreported, mainly due to inadequate disease awareness and insufficient surveillance systems. This narrative review highlights recent milestones in the etiology, ecology, epidemiology, clinical manifestations, diagnosis, treatment, antifungal drugs, host–pathogen interactions, genetics, omics approaches, sequelae, and social aspects of PCM. Additionally, it identifies ongoing challenges and critical knowledge gaps for future research. Methods A systematic retrieval of articles published between 2001 and 2025 was conducted from PubMed and the Virtual Health Library (BVS), using descriptors (“Paracoccidioidomycosis” OR “Paracoccidioides”). Duplicate records were removed through the Rayyan QCRI, and two reviewers independently evaluated the articles according to predefined thematic areas. Findings Recent advancements have enhanced our understanding of PCM epidemiology, driven by ecological shifts and socioeconomic transformations that alter disease distribution and clinical presentation. Although substantial progress has been made in identifying and characterizing the causative agent, Paracoccidioides spp., challenges persist in the diagnostic process owing to limited laboratory methodologies and the absence of standardized tests. Current therapeutic options face limitations such as prolonged treatment durations, frequent drug interactions, and complicating disease management. Moreover, PCM significantly affects patients’ quality of life through persistent physical sequelae, psychological impacts, and socioeconomic consequences, including stigmatization and reduced work capacity. Conclusion Addressing these multifaceted challenges requires integrated approaches that combine improved surveillance, enhanced diagnostic tools, novel therapeutic strategies, and targeted social support programs. Sustained collaborative research and international cooperation are essential to fill existing knowledge gaps and achieve better health outcomes for affected populations.
  • Erratum: Correction: Quantitative PCR as a marker for preemptive therapy and its role in therapeutic control in Trypanosoma cruzi/HIV coinfection (PLoS neglected tropical diseases (2024) 18 2 DOI: 10.1371/journal.pntd.0011961.)
    Vera Lúcia Teixeira de Freitas, Christina Terra Gallafrio Novaes, Ana Marli Christovam Sartori, Noemia Barbosa Carvalho, Sheila Cristina Vicente da Silva, et al.
    Plos Neglected Tropical Diseases, 2025
  • Brazilian task force for the management of mucormycosis
    Patrick Leon de Godoy Macedo, Mariane Taborda, Vítor Falcão de Oliveira, Adriana Satie Gonçalves Kono Magri, Lígia Lins Frutuoso, et al.
    Brazilian Journal of Infectious Diseases, 2025
  • "reactivity of cryptococcal lateral flow assay in aspergillosis, histoplasmosis, paracoccidioidomycosis, candidiasis, trichosporonosis, bacterial, and viral infections"
    Edite Hatsumi Yamashiro-Kanashiro, Kelly Aparecida Kanunfre, Evanthia Vetos Mimicos, Vera Lúcia Teixeira de Freitas, Mussya Cisotto Rocha, et al.
    Medical Mycology, 2025
    Considering the need for a rapid, sensitive, and specific test for the early diagnosis of cryptococcal meningitis in critical regions where lumbar puncture and culture are inaccessible, we analyzed the specificity of the Lateral Flow Assay for cryptococcal antigen (LFA) in 217 serum specimens. Group 1: 68 HIV-uninfected patients with paracoccidioidomycosis, histoplasmosis, aspergillosis, trichosporonosis and 21 with tuberculosis; Group 2: 149 patients with HIV infection, including seven with histoplasmosis, and one with aspergillosis, and Group 3 with 24 proven cryptococcosis patients. Cross-reactivity of cryptococcal mannans and polysaccharides secreted by Paracoccidioides brasiliensis, Histoplasma capsulatum, and Trichosporon spp has been described in vitro. However, only a few cases of positive LFA tests in aspergillosis, trichosporonosis, candidemia, and bacterial infections sera have been reported. We observed false-positive LFA in 2/29 aspergillosis specimens but not in other mycoses or tuberculosis. Among 149 HIV-infected patients, three specimens tested positive, two had cytomegalovirus infections, one of whom also had toxoplasmosis and the other, Kaposi's sarcoma; one patient had no opportunistic infections. We observed sensitivities of 0.933 (serum), 0.95 (CSF), and 1.0 (serum or CSF) for LFA, and for all negative controls (N = 217, serum), a specificity of 0.977 and a negative predictive value (NPV) of 0 938. The specificity and NPV were 0.964 and 0 791, respectively, for 55 patients with mycoses; and 0.98 and 0.912 for 149 HIV-infected patients. We confirmed LFA's high specificity and accuracy for the control groups. There were 6.89% of false-positive results for aspergillosis, and no false-positive results for paracoccidioidomycosis, histoplasmosis, tuberculosis, or other bacterial diseases.
  • Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case series
    Noemia Barbosa Carvalho, Vera Lucia Teixeira de Freitas, Nadia Emi Aikawa, Lucas Teixeira Vieira, Rita Cristina Bezerra, et al.
    Revista Da Sociedade Brasileira De Medicina Tropical, 2025
    Patients with chronic Chagas disease (CD) and autoimmune rheumatic disorders (ARD) receiving immunosuppressive therapy are at risk for CD reactivation (CDR). This study monitored parasitemia over 9-121 months in six patients with CD and ARD using conventional and quantitative PCR and parasitology. Five patients showed parasitemia; two had elevated levels of parEq/mL (49-458.7). One patient received benznidazole with a marked decrease in parasitemia; in the other, treatment was discontinued after 12 days due to toxicity. No CDR occurred. These findings support the need for qPCR standardization for preemptive therapy and suggest that benznidazole may prevent CDR in patients with high parasitemia.
  • Quantitative PCR as a marker for preemptive therapy and its role in therapeutic control in Trypanosoma cruzi/HIV coinfection
    Vera Lúcia Teixeira de Freitas, Christina Terra Gallafrio Novaes, Ana Marli Christovam Sartori, Noemia Barbosa Carvalho, Sheila Cristina Vicente da Silva, et al.
    Plos Neglected Tropical Diseases, 2024
    Background Trypanosoma cruzi and HIV coinfection can evolve with depression of cellular immunity and increased parasitemia. We applied quantitative PCR (qPCR) as a marker for preemptive antiparasitic treatment to avoid fatal Chagas disease reactivation and analyzed the outcome of treated cases. Methodology This mixed cross-sectional and longitudinal study included 171 Chagas disease patients, 60 coinfected with HIV. Of these 60 patients, ten showed Chagas disease reactivation, confirmed by parasites identified in the blood, cerebrospinal fluid, or tissues, 12 exhibited high parasitemia without reactivation, and 38 had low parasitemia and no reactivation. Results We showed, for the first time, the success of the timely introduction of benznidazole in the non-reactivated group with high levels of parasitemia detected by qPCR and the absence of parasites in reactivated cases with at least 58 days of benznidazole. All HIV+ patients with or without reactivation had a 4.0–5.1 higher chance of having parasitemia than HIV seronegative cases. A positive correlation was found between parasites and viral loads. Remarkably, treated T. cruzi/HIV-coinfected patients had 77.3% conversion from positive to negative parasitemia compared to 19.1% of untreated patients. Additionally, untreated patients showed ~13.6 times higher Odds Ratio of having positive parasitemia in the follow-up period compared with treated patients. Treated and untreated patients showed no differences regarding the evolution of Chagas disease. The main factors associated with all-cause mortality were higher parasitemia, lower CD4 counts/μL, higher viral load, and absence of antiretroviral therapy. Conclusion We recommend qPCR prospective monitoring of T. cruzi parasitemia in HIV+ coinfected patients and point out the value of pre-emptive therapy for those with high parasitemia. In parallel, early antiretroviral therapy introduction is advisable, aiming at viral load control, immune response restoration, and increasing survival. We also suggest an early antiparasitic treatment for all coinfected patients, followed by effectiveness analysis alongside antiretroviral therapy.
  • Representations of Chagas disease among Bolivian immigrants in the city of São Paulo
    Cássio Silveira, Colin Forsyth, Nivaldo Carneiro Junior, Alejandro Goldberg, Lia Maria Britto da Silva, et al.
    Frontiers in Tropical Diseases, 2024
  • Multiple myeloma and Chagas disease: qPCR as a marker for preemptive antiparasitic therapy: a case reports series and review
    Noemia Barbosa Carvalho, Vera Lúcia Teixeira de Freitas, Fernanda Salles Seguro, Rita Cristina Bezerra, Giancarlo Fatobene, et al.
    Revista do Instituto De Medicina Tropical De Sao Paulo, 2024
  • Correction: Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the “Network for healthcare and study of Trypanosoma cruzi/ HIV co-infection and other immunosuppression conditions” (PLOS Neglected Tropical Diseases)
    Maria Aparecida Shikanai-Yasuda, Mauro Felippe Felix Mediano, Christina Terra Gallafrio Novaes, Andréa Silvestre de Sousa, Ana Marli Christovam Sartori, et al.
    Plos Neglected Tropical Diseases, 2023
  • Prevalence and Associated Factors of Cryptococcal Antigenemia in HIV-Infected Patients with CD4 < 200 Cells/µL in São Paulo, Brazil: A Bayesian Analysis
    Evanthia Vetos Mimicos, Victor Fossaluza, Camila de Melo Picone, Camila Caroline de Sena, Hélio Rodrigues Gomes, et al.
    Journal of Fungi, 2022
  • Aplastic Anemia and Chagas Disease: T. cruzi Parasitemia Monitoring by Quantitative PCR and Preemptive Antiparasitic Therapy
    Noêmia Barbosa Carvalho, Vera Teixeira de Freitas, Rita Cristina Bezerra, Erika Shimoda Nakanishi, Elvira Pereira Velloso, et al.
    Tropical Medicine and Infectious Disease, 2022
  • Evaluation of the Sensititre YeastOne and Etest in Comparison with CLSI M38-A2 for Antifungal Susceptibility Testing of Three Azoles, Amphotericin B, Caspofungin, and Anidulafungin, against Aspergillus fumigatus and Other Species, Using New Clinical Breakpoints and Epidemiological Cutoff Values
    Marcia S. C. Melhem, Vivian C. Coelho, Claudia A. Fonseca, Lidiane de Oliveira, Lucas X. Bonfietti, et al.
    Pharmaceutics, 2022
  • Access and right to health for Bolivian migrants in a Brazilian metropolis
    Nivaldo Carneiro Junior, Fernando Aith, Rubens Antonio da Silva, Dalva Marli Valério Wanderley, Expedito José Luna, et al.
    Saude E Sociedade, 2022
  • Genetic diversity of Trypanosoma cruzi strains isolated from chronic chagasic patients and non-human hosts in the state of São Paulo, Brazil
    Thiago Kury Moreno de Souza, Elizabeth Visone Nunes Westphalen, Sansão da Rocha Westphalen, Helena Hilomi Taniguchi, Carlos Roberto Elias, et al.
    Memorias do Instituto Oswaldo Cruz, 2022
  • Clinical profile and mortality in patients with T. Cruzi/HIV co-infection from the multicenter data base of the "network for healthcare and study of trypanosoma cruzi/HIV co-infection and other immunosuppression conditions"
    Maria Aparecida Shikanai-Yasuda, Mauro Felippe Felix Mediano, Christina Terra Gallafrio Novaes, Andréa Silvestre de Sousa, Ana Marli Christovam Sartori, et al.
    Plos Neglected Tropical Diseases, 2021
  • Monocyte-derived dendritic cells can revert in vitro antigen-specific cellular anergy in active human paracoccidioidomycosis
    Paula Keiko Sato, Telma Miyuki Oshiro, Érika Cano Passos, Tatiana Giselle Rodrigues Miranda, Constância Lima Diogo, et al.
    Journal of Fungi, 2021
  • Emerging and reemerging forms of trypanosoma cruzi transmission
    Memorias do Instituto Oswaldo Cruz, 2021
  • A Specific IL6 Polymorphic Genotype Modulates the Risk of Trypanosoma cruzi Parasitemia While IL18, IL17A, and IL1B Variant Profiles and HIV Infection Protect Against Cardiomyopathy in Chagas Disease
    Alexandra Gomes dos Santos, Elieser Hitoshi Watanabe, Daiane Tomomi Ferreira, Jamille Oliveira, Érika Shimoda Nakanishi, et al.
    Frontiers in Immunology, 2020
  • COVID-19: Implications for People with Chagas Disease
    Ezequiel José Zaidel, Colin J. Forsyth, Gabriel Novick, Rachel Marcus, Antonio Luiz P. Ribeiro, et al.
    Global Heart, 2020
  • Polymorphism in the Promoter Region of the IL18 Gene and the Association With Severity on Paracoccidioidomycosis
    Paula Keiko Sato, Felipe Delatorre Busser, Flávia Mendes da Cunha Carvalho, Alexandra Gomes dos Santos, Aya Sadahiro, et al.
    Frontiers in Immunology, 2020
  • Genomic diversity of the human pathogen Paracoccidioides across the South American continent
    Marcus de Melo Teixeira, Maria Emilia Cattana, Daniel R. Matute, José F. Muñoz, Alicia Arechavala, et al.
    Fungal Genetics and Biology, 2020

RECENT SCHOLAR PUBLICATIONS

  • Telomere-to-telomere assemblies of Paracoccidioides genomes
    D Grinevich, O Kompathoum, J Li, DA Turissini, P Kelly, MK Sutherland, ...
    Genetics, iyag082 , 2026
    2026
  • Paracoccidioidomycosis in Brazil: 25‐Year Nationwide Trends in Mortality, Hospitalisations and In‐Hospital Deaths of a Neglected Systemic Mycosis
    AF Ferreira, J Heukelbach, EA de Souza, MA Shikanai‐Yasuda, ...
    Tropical Medicine & International Health , 2026
    2026
  • Neglected Mycoses in Brazil: A Population‐Based Study of Mortality and In‐Hospital Mortality Over 25 Years
    AF Ferreira, J Heukelbach, EA De Souza, MA Shikanai‐Yasuda, ...
    Mycoses 69 (2), e70144 , 2026
    2026
  • Paracoccidioidomycosis in the 21st century: Challenges and milestones
    J Venturini, NB Fernandez, PM De Macedo, RS Cavalcante, DH Caceres, ...
    PLOS Neglected Tropical Diseases 20 (1), e0013819 , 2026
    2026
    Citations: 3
  • Analysis of Aspergillus spp. Isolates According to Temporal–Spatial, Sociodemographic, and Clinical Variables—Microsatellite Typing of Clinical and Environmental Samples …
    CA Fonseca, R Araujo, VC Coelho, CH Camargo, MMC Magri, AL Motta, ...
    Mycoses 69 (1), e70126 , 2026
    2026
  • Brazilian task force for the management of mucormycosis
    PL de Godoy Macedo, M Taborda, VF de Oliveira, ASGK Magri, ...
    The Brazilian Journal of Infectious Diseases 29 (6), 104579 , 2025
    2025
    Citations: 7
  • Telomeric assemblies of Paracoccidioides genomes
    D Grinevich, O Kompathoum, J Li, DA Turissini, P Kelly, MK Sutherland, ...
    bioRxiv , 2025
    2025
    Citations: 1
  • Reactivity of cryptococcal lateral flow assay in aspergillosis, histoplasmosis, paracoccidioidomycosis, candidiasis, trichosporonosis, bacterial, and viral infections
    EH Yamashiro-Kanashiro, KA Kanunfre, EV Mimicos, VLT de Freitas, ...
    Medical Mycology 63 (8), myaf068 , 2025
    2025
    Citations: 6
  • Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case series
    NB Carvalho, VLT Freitas, NE Aikawa, LT Vieira, RC Bezerra, ...
    Revista da Sociedade Brasileira de Medicina Tropical 58, e00802-2025 , 2025
    2025
  • Quantitative PCR as a marker for preemptive therapy and its role in therapeutic control in Trypanosoma cruzi/HIV coinfection (vol 18, e0011961, 2024)
    VLT FREITAS, CTG Novaes, AMC Sartori, NB Carvalho, SCV SILVA, ...
    PUBLIC LIBRARY SCIENCE , 2025
    2025
  • Representations of Chagas disease among Bolivian immigrants in the city of São Paulo
    C Silveira, C Forsyth, NC Junior, A Goldberg, LMB da Silva, RA da Silva, ...
    Frontiers in Tropical Diseases 5, 1331026 , 2024
    2024
  • Quantitative PCR as a marker for preemptive therapy and its role in therapeutic control in Trypanosoma cruzi /HIV coinfection
    VLT Freitas, CTG Novaes, AMC Sartori, NB Carvalho, SCV Silva, ...
    PLoS Neglected Tropical Diseases 18 (2), e0011961 , 2024
    2024
    Citations: 9
  • Multiple myeloma and Chagas disease: qPCR as a marker for preemptive antiparasitic therapy: a case reports series and review
    NB Carvalho, VLT Freitas, FS Seguro, RC Bezerra, G Fatobene, ...
    Revista do Instituto de Medicina Tropical de São Paulo 66, e10 , 2024
    2024
    Citations: 5
  • Assessment of biomarkers and clinical parameters as predictors of survival in patients with chagasic heart failure
    EA Bocchi, G Veiga Guimarães, C Espinoza Romero, PK Sato, ...
    PLOS Neglected Tropical Diseases 17 (12), e0011847 , 2023
    2023
    Citations: 8
  • Guidelines for Trypanosoma cruzi -HIV Co-infection and other Immunosuppressive Conditions: Diagnosis, Treatment, Monitoring, and Implementation from the …
    EA Almeida, FSNS Mendes, AN Ramos, AS Sousa, TBS Pavan, ...
    Revista da Sociedade Brasileira de Medicina Tropical 56, e0549-2023 , 2023
    2023
    Citations: 13
  • Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com Cardiomiopatia da Doença de Chagas–2023
    JA Marin-Neto, A Rassi Jr, GMM Oliveira, LCL Correia, AN Ramos, ...
    Arquivos Brasileiros de Cardiologia 120 (6), e20230269 , 2023
    2023
    Citations: 46
  • Correction: Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the “Network for healthcare and study of Trypanosoma …
    MA Shikanai-Yasuda, MFF Mediano, CTG Novaes, AS Sousa, ...
    PLOS Neglected Tropical Diseases 17 (1), e0011036 , 2023
    2023
    Citations: 1
  • Infectologia bases clínicas e tratamento
    MAS Yasuda
    Infectologia bases clínicas e tratamento, 767; ilus , 2023
    2023
  • SBC guideline on the diagnosis and treatment of patients with cardiomyopathy of Chagas disease–2023
    JA Marin-Neto, A Rassi Jr, GMM Oliveira, LCL Correia, AN Ramos Junior, ...
    Arquivos brasileiros de cardiologia 120, e20230269 , 2023
    2023
    Citations: 110
  • Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the"" Network for healthcare and study of Trypanosoma cruzi/HIV co …
    MA Shikanai-Yasuda, MFF Mediano, CTG Novaes, AS SOUSA, ...
    PUBLIC LIBRARY SCIENCE , 2023
    2023

MOST CITED SCHOLAR PUBLICATIONS

  • Guideliness in paracoccidioidomycosis
    MA Shikanai-Yasuda, FF de Queiroz Telles, RP Mendes, AL Colombo, ...
    Revista da Sociedade Brasileira de Medicina Tropical 39 (3) , 2006
    2006
    Citations: 653
  • Oral transmission of Chagas disease
    MA Shikanai-Yasuda, NB Carvalho
    Clinical Infectious Diseases 54 (6), 845-852 , 2012
    2012
    Citations: 588
  • Brazilian guidelines for the clinical management of paracoccidioidomycosis
    MA Shikanai-Yasuda, RP Mendes, AL Colombo, F Queiroz-Telles, ...
    Revista da Sociedade Brasileira de Medicina Tropical 50 (5), 715-740 , 2017
    2017
    Citations: 545
  • II Consenso Brasileiro em doença de Chagas, 2015
    JCP Dias, AN Ramos Jr, ED Gontijo, A Luquetti, MA Shikanai-Yasuda, ...
    Epidemiologia e Serviços de Saúde 25, 7-86 , 2016
    2016
    Citations: 497
  • Cytomegalovirus infection in transplant recipients
    LS Azevedo, LC Pierrotti, E Abdala, SF Costa, TMV Strabelli, SV Campos, ...
    Clinics 70 (7), 515-523 , 2015
    2015
    Citations: 434
  • 2 nd Brazilian Consensus on Chagas Disease, 2015
    JCP Dias, AN Ramos Jr, ED Gontijo, A Luquetti, MA Shikanai-Yasuda, ...
    Revista da Sociedade Brasileira de Medicina Tropical 49, 03-60 , 2016
    2016
    Citations: 403
  • Manifestations of Chagas disease (American trypanosomiasis) in patients with HIV/AIDS
    AMC Sartori, KY Ibrahim, EV Nunes Westphalen, LMA Braz, OC Oliveira, ...
    Annals of Tropical Medicine & Parasitology 101 (1), 31-50 , 2007
    2007
    Citations: 248
  • Paracoccidioidomycosis: eco-epidemiology, taxonomy and clinical and therapeutic issues
    AL Bocca, AC Amaral, MM Teixeira, PK Sato, MA Shikanai-Yasuda, ...
    Future microbiology 8 (9), 1177-1191 , 2013
    2013
    Citations: 247
  • Brazilian guidelines for the management of candidiasis–a joint meeting report of three medical societies: Sociedade Brasileira de Infectologia, Sociedade Paulista de …
    AL Colombo, T Guimarães, LFA Camargo, R Richtmann, ...
    The Brazilian Journal of Infectious Diseases 17 (3), 283-312 , 2013
    2013
    Citations: 234
  • Possible oral transmission of acute Chagas' disease in Brazil
    MA Shikanai-Yasuda, C Brisola Marcondes, LA Guedes, GS Siqueira, ...
    Revista do Instituto de Medicina Tropical de São Paulo 33 (5), 351-357 , 1991
    1991
    Citations: 225
  • Posaconazole treatment of refractory eumycetoma and chromoblastomycosis
    R Negroni, A Tobón, B Bustamante, MA Shikanai-Yasuda, H Patino, ...
    Revista do Instituto de Medicina Tropical de São Paulo 47, 339-346 , 2005
    2005
    Citations: 193
  • Acute Chagas disease outbreak associated with oral transmission
    JP Dias, C Bastos, E Araújo, AV Mascarenhas, E Martins Netto, F Grassi, ...
    Revista da Sociedade Brasileira de Medicina Tropical 41, 296-300 , 2008
    2008
    Citations: 186
  • An open-label comparative pilot study of oral voriconazole and itraconazole for long-term treatment of paracoccidioidomycosis
    FQ Telles, LZ Goldani, HT Schlamm, JM Goodrich, AE Ingroff, ...
    Clinical infectious diseases 45 (11), 1462 , 2007
    2007
    Citations: 150
  • Recommendations for management of Chagas disease in organ and hematopoietic tissue transplantation programs in nonendemic areas
    MJ Pinazo, B Miranda, C Rodríguez-Villar, J Altclas, MB Serra, ...
    Transplantation Reviews 25 (3), 91-101 , 2011
    2011
    Citations: 140
  • Real-Time PCR in HIV/ Trypanosoma cruzi Coinfection with and without Chagas Disease Reactivation: Association with HIV Viral Load and CD4 + Level
    VLT de Freitas, SCV da Silva, AM Sartori, RC Bezerra, EVN Westphalen, ...
    PLoS Neglected Tropical Diseases 5 (8), e1277 , 2011
    2011
    Citations: 139
  • Brazilian consensus on Chagas disease, 2015
    JCP Dias, AN Ramos Jr, ED Gontijo, A Luquetti, MA Shikanai-Yasuda, ...
    Epidemiologia e Serviços de Saúde 25, 7-86 , 2016
    2016
    Citations: 137
  • Detection of the 43,000-molecular-weight glycoprotein in sera of patients with paracoccidioidomycosis
    MJ Mendes-Giannini, JP Bueno, MA Shikanai-Yasuda, AW Ferreira, ...
    Journal of Clinical Microbiology 27 (12), 2842-2845 , 1989
    1989
    Citations: 131
  • Co-infection Trypanosoma cruzi/HIV: systematic review (1980-2010)
    EA Almeida, AN Ramos Júnior, D Correia, MA Shikanai-Yasuda
    Revista da Sociedade Brasileira de Medicina Tropical 44, 762-770 , 2011
    2011
    Citations: 129
  • Trypanosoma cruzi Parasitemia in Chronic Chagas Disease: Comparison between Human Immunodeficiency Virus (HIV)–Positive and HIV-Negative Patients
    AMC Sartori, JE Neto, EV Nunes, LMA Braz, HH Caiaffa-Filho, ...
    The Journal of infectious diseases 186 (6), 872-875 , 2002
    2002
    Citations: 118
  • Randomized trial with itraconazole, ketoconazole and sulfadiazine in paracoccidioidomycosis
    MA Shikanai-Yasuda, G Benard, Y Higaki, GMB Del Negro, SUN Hoo, ...
    Medical mycology 40 (4), 411-417 , 2002
    2002
    Citations: 111

GRANT DETAILS

15 grants of public financial agencies (Fundação de Amparo a Pesquisa do Estado de São Paulo , São Paulo, Brazil and CNPq - Conselho de Desenvolvimento CIentífico e Tecnológico, Brazil.