Dr. Shivendra Singh
@modyuniversity.ac.in
Assistant Professor
Mody University of Science & Technology
EDUCATION
PhD- IIT Indore
MSc- Jiwaji University Gwalior
BSc- Lucknow University
RESEARCH INTERESTS
Organic synthesis & catalysis
Scopus Publications
Scopus Publications
Yukti Monga, Shivangi Sharma, Shivendra Singh, and Ashu Gupta
Bentham Science Publishers Ltd.
Abstract: The modern world of chemistry needs to find a sustainable solution for the remediation of heavy metals. The method of solving heavy metal problems using abundant and easily available ways is an integral part of green chemistry. This approach stimulates innovation among scientists. These procedures increase performance and decrease the consumption of non-renewable resources, minimizing negative impacts on the environment and less use of harmful chemicals. In this review, we have included some natural ways for the remediation of heavy metals such as Biochar, Clay, Zeolites, and Microorganismbased methods. We have also incorporated the mechanism of action of each of these procedures for the betterment of the reader.
Shivangi Sharma, Yukti Monga, Ashu Gupta, and Shivendra Singh
Royal Society of Chemistry (RSC)
2-Oxindole based natural products and bioactive molecules.
Sunil Dutt, Ashwani Kumar, and Shivendra Singh
MDPI AG
The linkage between metal nodes and organic linkers has led to the development of new porous crystalline materials called metal–organic frameworks (MOFs). These have found significant potential applications in different areas such as gas storage and separation, chemical sensing, heterogeneous catalysis, biomedicine, proton conductivity, and others. Overall, MOFs are outstanding candidates for next-generation energy storage devices, and they have recently attracted the greater devotion of the scientific community worldwide. MOFs can be used to enhance the ability of a device to store energy due to their unique morphology, controllable structures, high surface area, and permanent porosity. MOFs are widely used in super capacitors (SCs), metal (Li, Na, and K) ion batteries, and lithium–sulfur batteries (LSBs) and act as a promising candidate to store energy in an environmentally friendly way. MOFs are also used as efficient materials with better recyclability, efficiency, and capacity retention. In this review, first we summarize the material design, chemical compositions, and physical structure of MOFs and afterward, we highlight the most recent development and understanding in this area, mainly focusing on various practical applications of MOFs in energy storage devices.
Shivangi Sharma, Shivendra Singh, and Dhananjay Yadav
Bentham Science Publishers Ltd.
Abstract: Quinoline and its analogues are found in various natural products, many of which are active pharmacophores with significant bioactivities. This article discussed the plethora of quinoline derivatives and their analogues that have anti-cancer properties. The review will be helpful for the scientific community since several possible anticancer drugs based on quinolines are discussed here. In addition to this, the synthetic aspect of many such quinoline derivatives showing anti-cancer activities is also revealed in this article. These quinoline-based anti-oncogenic molecules can be synthesized using several acids, bases, and azides or with the help of reagents like Jone’s reagent and Lawesson’s reagent.
Shivendra Singh and Shivangi Sharma
Bentham Science Publishers Ltd.
Abstract: An important bioactive heterocycle having several uses in medicinal chemistry, synthetic organic chemistry, material chemistry, and natural product is indole along with its analogues. Many bioactive indole-based heterocycles have important antibacterial, anti-inflammatory, analgesic, antiviral, antimalarial, chemotherapeutic, antifungal, and anti-TB effects, as well as antioxidant capabilities. Several well-known medications, including tadalafil, rizatriptan, sumatriptan, and fluvastatin are indole- based potential bioactive compounds. Based on the existing and latest evidence, researchers have focused on developing indole-based compounds with novel biological and pharmacological properties for decades. Owing to useful bioactivities, we have described many bioactive indoles and their synthetic methods in this review article.
Shivendra Singh, Shivangi Sharma, and Kuldeep Singh
Bentham Science Publishers Ltd.
Abstract: Quinoline derivatives are an important class of heterocyclic compounds and possess various applications in synthetic organic chemistry, medicinal chemistry, material chemistry and natural product chemistry. This review article describes the different quinoline derivatives having antimalarial, analgesic, anti-inflammatory, antineoplastic, antibacterial, antifungal, antiviral, anthelmintic, antiprotozoal, cardiovascular, CNS and other useful bioactivities. We have delineated the general synthetic routes for the synthesis of many bioactive quinoline based heterocycles. In addition to this, we have also discussed the crucial synthetic routes as well as their mechanistic paths for the formation of bioactive quinoline derivatives. The study shows that substitution at the 4 and 8- position of quinoline is more crucial for bioactivity as compared to other positions.
Kuldeep Singh, Shivendra Singh, Rachna Kathal, and Shivangi Sharma
Bentham Science Publishers Ltd.
Abstract: Determination of the exact structure of any compound is extremely critical task. Primarily organic chemistry relies on NMR, IR & Mass spectrometric data. Authors have experienced that introduction of structure elucidation in undergraduate courses and postgraduate courses is helpful for students later in their research career. Based on our experience, this article discusses double bond equivalents, the rule of 13 and the nitrogen rule. We have compared the result of these three rules with real spectroscopic data. This article demonstrates the applicability of double bond equivalents, the rule of 13 and the nitrogen rule in solving compound structures using spectroscopic data. Based on availability of molecular weight or molecular formula, we can predict the possible structure of any organic compound using these concepts. In addition, if we have the spectroscopic data like NMR, IR, Mass spectrometry data and UV spectrophotometry data, we can easily confirm the exact structure. This article will be critical for the all the organic chemist for structure elucidation of organic molecules; however, several spectroscopic data is still required for analyzing the exact structure of any molecule.
Shivangi Sharma and Shivendra Singh
Hindawi Limited
Quinoline-based molecules are major constituents in natural products, active pharmacophores, and have excellent biological activities. Using 2H-thiopyrano[2,3-b]quinoline derivatives and CB1a protein (PDB ID: 2IGR), the molecular docking study has been revealed in this article. The study of in silico molecular docking analysis of such derivatives to determine the binding affinity, residual interaction, and hydrogen bonding of several 2H-thiopyrano[2,3-b]quinolines against CB1a is reported here. The current work demonstrated that 2H-thiopyrano[2,3-b]quinoline derivatives could be effective antitumor agents to produce potent anticancer medicines in the near future.
Shivendra Singh and Shivangi Sharma
Bentham Science Publishers Ltd.
Abstract: Quinoline and its derivatives are part of several natural products. Many of them are active pharmacophores and show enormous biological activities. Owing to their usefulness in drug discovery, we have discussed the plethora of quinoline derivatives showing particularly antibacterial and antifungal activities in this article. Depending upon substitution on the quinoline core, change of functionalities at different positions and change in chain length; unique biological properties are associated with such derivatives of quinolines and in this article, we have delineated the antibacterial and antifungal activities of such activities in detail. In most of the cases, it has been found that substitution at the 5-position leads to enhanced bioactivities. In most cases, 5-halo/5-amino/5-aryl and heteroaryl/5-carbonyl/5-amido show promising antibacterial and antifungal activities. Furthermore, the synthetic aspects of several quinoline derivatives showing antibacterial and antifungal activities are also discussed in this article.
R. Sharma, S. Dutt, and S. Singh
Asian Journal of Chemistry
Using swollen liquid crystals (SLCs) as a soft template, different polyindole nanostructures having different morphology have been synthesized successfully at different temperatures. The SLCs containing indole ring was formed by a quaternary system containing cetyltrimethyl-ammonium bromide (CTAB) or sodium dodecyl sulfate (SDS) as a surfactant, brine, indole:cyclohexane mixture as oil phase and 1-pentanol as co-surfactant. The indole containing mesophases were polymerized using ammonium persulfate as an oxidant and further nanocomposites were extracted from the mesophases. Finally, the extracted and processed samples were characterized using different spectroscopic techniques. The electrochemical properties of polyindole nanostructures were also investigated using cyclic voltammetry.
Anupama Sharma, Shivendra Singh, and Harlal Singh
Asian Journal of Chemistry
This study presented the bioactive lead(II) compounds of oxazine and thiazine Schiff-bases using NMR (1H, 13C), FT-infrared spectroscopy, UV-visible, molar conductance, elemental analysis and molecular weight. The molecular parameters e.g. bond length, bond angle, HOMO/LUMO energy gap and softness/hardness was calculated by DFT-B3LYP/Lanl2dz basis set. According to the spectral data, the Schiff-base coordinated to the lead atom in bidentate mode. A theoretical DFT computational investigation was conducted to supplement the experimental data. The antibacterial activity of lead complexes against E. coli (–) and S. aureus (+) bacteria was determined by disc-diffusion method. Lead complexes of thiazine derivatives are more active than oxazine derivatives. In order to better understand the molecular interaction and binding mode of the drugs, a molecular docking study has been carried out on the protein 3q8u (NDK) from S. aureus. A docking investigation with the NDK protein (S. aureus) revealed that compound 1h has the highest binding affinity (-8.18 Kcal/mol) among the eight ligands (1a-h).
Nidhi Singh, Krishna Rajotiya, Nikita Lamba, H.L. Singh, K.L. Ameta, and Shivendra Singh
Bentham Science Publishers Ltd.
Abstract: Owing to useful physio-chemical properties of furo-coumarin derivatives, their synthetic and mechanistic investigation has been reported here. We have demonstrated a range of synthetic approaches to access furan-fused coumarin derivatives. Many metalmediated, base, and acid-catalyzed approaches have been revealed for the formation of this coumarin-based fused heterocycles of biological importance. In addition to this, microwaveassisted synthetic routes have also been revealed. The last and most useful approach for the synthesis of these heterocycles includes the use of purely solvent as a reaction media for synthesizing these interesting classes of heterocycles.
Ahanthem Priyanca Devi, Naveen Dhingra, Uma Bhardwaj, R.S. Chundawat, Chetan K. Joshi, Shivendra Singh, and Keshav Lalit Ameta
Elsevier BV
Nidhi Singh, Farha Naaz, Rajesh Verma, Shivendra Singh, and Ramendra K. Singh
Asian Journal of Chemistry
A number of fluorescent conjugates of popular anti-HIV drugs 2′,3′-didehydro-2′,3′-dideoxythymidine (stavudine, d4T) and 3′-azido-3′-deoxythymidine (zidovudine, AZT) with 1,8-naphthalimide were synthesized using the coupling reagent dicyclohexylcarbodiimide (DCC) in the presence of 4-dimethylaminopyridine (DMAP) and N,N-dimethylformamide (DMF) as solvent at room temperature. The steady-state fluorescence measurement studies on these conjugates showed solvatochromic effect. Further, the fluorescence of drug conjugates was recorded in the presence of ions like Na+ and K+ at body level concentration of 135-145 mmol L-1 and 3.6-5.1 mmol L-1, respectively, in phosphate buffer at pH 7.4 in aqueous media. It was observed that the drug conjugates did not show appreciable fluorescence quenching in presence of ions and buffer.
Raj Kumar, Naveen Bunekar, Sunil Dutt, Pulikanti G. Reddy, Abhishek K. Gupta, Keshaw R. Aadil, Vivek K. Mishra, Shivendra Singh, and Chandrani Sarkar
Wiley
Shivendra Singh, Suresh Singh Chauhan, Neeraj Kumar Sharma, Sunil Dutt, and Keshav Lalit Ameta
Bentham Science Publishers Ltd.
: Several easy, efficient and convenient procedures to access indoles fused heterocyclic systems are described in this review. These heterocyclic systems were synthesized from several cyclic or acyclic molecules via a variety of reactions such as Diels-Alder reaction, Michael addition, Morita- Baylis-Hillmann reaction and many other domino/Cascade approaches with high selectivity. Most of the given protocols in this review proceed through organocatalytic pathways; however, some underwent different catalytic and non-catalytic reactions.
Shivendra Singh and Sampak Samanta
Wiley
A simple, mild and efficient one-pot approach for the construction of 2-aryl-3-nitro-2,9-dihydrothiopyrano[2,3-b]indole derivatives has been realized in CH2Cl2 medium at ambient temperature via three-component tandem reaction of N-protected-2-chloro-3-formylindoles, sodium hydrosulfide and β-substituted nitroolefins/δ-substituted nitrodienes using DABCO (10 mol%) as an organocatalyst, followed by dehydration in the presence of activated molecular sieves (4 A). The significant advantages of this protocol are simple operation, shorter reaction time, high atom economy, good to high yields (73% –89%) and wider substrate scope. In addition, all the synthesized compounds have shown the large positive Stokes shift values (5632–6081 cm−1).
Anvita Srivastava, Soumen Biswas, Shivendra Singh, Shaikh M. Mobin, and Sampak Samanta
Royal Society of Chemistry (RSC)
A diversity-oriented synthesis of 8,9-dihydropyrido[1,2-a]indol-6(7H)-one and salicylate scaffolds was achieved in high yields with excellent diastereoselectivities (≤96 : 4 dr) via an organocatalytic reaction of alkylidene malonates with 4-(2-nitrophenyl) acetoacetate.
Shivendra Singh, Anvita Srivastava, Shaikh M. Mobin, and Sampak Samanta
Royal Society of Chemistry (RSC)
The solvent dependent reaction of 4-hydroxycoumarin with (E)-3-aryl-2-nitroprop-2-enol has been reported for the synthesis functionalized furo/pyrano[3,2-c]chromenes in water and DMSO media.
Pradeep Kumar Jaiswal, Soumen Biswas, Shivendra Singh, and Sampak Samanta
Royal Society of Chemistry (RSC)
A simple, mild, green, catalytic and general procedure for the direct synthesis of highly functionalized 1-methoxycarbonyl-2-aryl/alkyl-3-nitro-9H-carbazoles has been achieved in water medium via a one-pot domino Michael-Henry/aromatization reaction of methyl 2-(3-formyl-1H-indol-2-yl)acetates with aryl/alky-substituted β-nitroolefins under air using DABCO (30 mol%) as an organocatalyst. In addition, the bench scale synthesis can be performed without using toxic organic solvents and a biologically important new fused carbazole has been prepared.
Soumen Biswas, Pradeep Kumar Jaiswal, Shivendra Singh, Shaikh M. Mobin, and Sampak Samanta
Royal Society of Chemistry (RSC)
A simple, mild and robust method for the stereoselective synthesis of (E)-methyl α-(3-formyl-1H-indol-2-yl)-β-aryl/alkyl-substituted acrylates via a condensation reaction of methyl 2-(3-formyl-1H-indol-2-yl)acetate with several alkyl or aryl aldehydes using L-proline (25 mol%) as a catalyst is presented for the first time. In addition, completely metal free based high yielding methods for the syntheses of highly substituted biologically important carbazoles, γ-carbolines and the marine alkaloid prenostodione have been developed through our methodology.
Pradeep Kumar Jaiswal, Soumen Biswas, Shivendra Singh, Biswarup Pathak, Shaikh M. Mobin, and Sampak Samanta
Royal Society of Chemistry (RSC)
For the first time, a very simple, efficient, mild, catalytic and one-step procedure for the synthesis of a series of densely functionalized 1-methoxycarbonyl-2-aryl-3-nitro-4-hydroxy-1,2,3,4-tetrahydro-9H-carbazole derivatives has been achieved via a domino Michael–Henry reaction of methyl 3-formyl-1H-indole-2-acetates with β-nitrostyrenes using DABCO as an organocatalyst. Furthermore, the high enantio-(≤92% ee) and diastereoselective (≤12 : 1 dr) synthesis of the title compounds has been achieved with excellent yields using 9-O-benzylcupreidine (10 mol%) as a catalyst.