Sintu Ganai
@wbnsou.ac.in
Assistant Professor, Department of Chemistry
Netaji Subhash Open University
My research focus revolves around pioneering synthetic methods aimed at synthesizing potentially bioactive heterocyclic compounds. Additionally, I have a keen interest in the photophysical analysis of heterocyclic molecules, exploring their biosensing applications, and delving into the realm of solution thermodynamics.
EDUCATION
M.Sc, Ph.D in Chemistry
RESEARCH, TEACHING, or OTHER INTERESTS
Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Spectroscopy
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Avishek Saha, Sourav Ghosh, Sintu Ganai, Puspal Mukherjee, Kalachand Mahali, Bidyut Saha, A.M.A. Henaish, Partha Sarathi Guin, Perwez Alam, and Sanjay Roy
Elsevier BV
Sintu Ganai, Puspal Mukherjee, Kalachand Mahali, Bidyut Saha, A.M.A. Henaish, Simanta Kundu, Jahangeer Ahmed, Afzal Hussain, and Sanjay Roy
Elsevier BV
Sintu Ganai, Shovon Chatterjee, Sanjay Roy, and Puspal Mukherjee
Elsevier BV
Avishek Saha, Kalachand Mahali, Sintu Ganai, Puspal Mukherjee, Nabeen K. Shrestha, A.M.A. Henaish, Jahangeer Ahmed, Simanta Kundu, and Sanjay Roy
Elsevier BV
Avishek Saha, Kalachand Mahali, Puspal Mukherjee, Sintu Ganai, Aslam Hossain, A.M.A. Henaish, Simanta Kundu, Jahangeer Ahmed, and Sanjay Roy
Elsevier BV
Puspal Mukherjee and Sintu Ganai
American Chemical Society (ACS)
Molecular rotor dye thioflavin T (ThT) is almost nonfluorescent in low-viscosity solvents but highly fluorescent when bound to amyloid fibrils. This unique property arises from the rotation of the dimethylaniline moiety relative to the benzothiazole moiety in the excited state, which drives the dye from an emissive locally excited state to a twisted intramolecular charge-transfer state. This process is viscosity-controlled, and therefore, we can use the quantum yield of ThT to assess the viscosity of the environment. In this study, we have investigated the quantum yield of ThT (φThT) in various compositions of six alcoholic solvent mixtures of glycerol with methanol, ethanol, n-propanol, iso-propanol, n-butanol, and tert-butanol. We have proposed an empirical model using φThT as a function of the mole fraction of glycerol to estimate the interaction parameters between the components of the solvent mixtures. This analysis allowed us to predict the extent of nonideality of the solvent mixtures. The Förster–Hoffmann- and Loutfy–Arnold-type power law relationship was established between the quantum yield of ThT and bulk viscosity for solvent mixtures of methanol, ethanol, n-butanol, and tert-butanol with glycerol, and it was found to be similar in nature in all the four mixtures. Applying this knowledge, we proposed a methodology to quantify and predict the bulk viscosity coefficient values of several compositions of n-propanol–glycerol and iso-propanol–glycerol mixtures which have not been previously documented.
Avishek Saha, Kalachand Mahali, Puspal Mukherjee, Sintu Ganai, Aslam Hossain, A.M.A. Henaish, and Sanjay Roy
Elsevier BV
Sanjay Roy, Kalachand Mahali, Sintu Ganai, and Puspal Mukherjee
Pleiades Publishing Ltd
Sintu Ganai, Puspal Mukherjee, Kalachand Mahali, Avishek Saha, Aslam Hossain, A. V. Soldatov, A. M. A. Henaish, Jahangeer Ahmed, and Sanjay Roy
Royal Society of Chemistry (RSC)
This study presents the solubility and solvation thermodynamics of coumarin in a range of aqua-organic solvent mixtures at various temperatures. The solubility order of coumarin was determined as follows: DMF > DMSO > ACN > H2O.
Swarup Roy, Raj Kumar Nandi, Sintu Ganai, K.C. Majumdar, and Tapan K. Das
Elsevier BV
Swarup Roy, Sintu Ganai, Raj Kumar Nandi, K.C. Majundar, and Tapan K. Das
International Association of Advanced Materials
The interaction between pyrimidine-annulated spiro-dihydrofuran (PSDF) with bovine serum albumin (BSA) was investigated following spectroscopic studies. The results indicate that dynamic quenching contributes to the fluorescence quenching of BSA by PSDF. The binding constant (K) and the number of binding sites (n) were calculated from the recorded spectra. Based on the Forster's non-radiative energy transfer theory, the average binding distance between BSA and PSDF was estimated. The synchronous fluorescence spectra and circular dichroism indicate that the conformation of BSA has been subjected to alteration in presence of PSDF. The thermodynamic parameters namely ΔH, ΔG, ΔS were calculated at different temperatures (20 o C, 30 o C, and 40 o C) and the results indicated van der Waals force and hydrogen bonding were predominantly present. The compound PSDF also found to exhibit antifungal activity against Aspergillus sp. In addition, the results obtained from molecular modeling calculation vividly elucidate the binding mode and the binding sites and results were not well in agreement with the experimental observations. Copyright © 2015 VBRI Press.
K.C. Majumdar, Raj Kumar Nandi, and Sintu Ganai
Elsevier BV
K. Majumdar, Biswajit Sinha, Inul Ansary, Sintu Ganai, Debankan Ghosh, B. Roy, and B. Sridhar
Georg Thieme Verlag KG
Abstract A simple and straightforward approach for the regioselective synthesis of pyranocoumarin and bis-fused benzo-2H-pyran derivatives using mild, easy to handle, and cheaper molecular iodine mediated heterocyclization is described.
K.C. Majumdar and Sintu Ganai
Elsevier BV
K. Majumdar and Sintu Ganai
Georg Thieme Verlag KG
A catalyst-free, one-pot strategy for the synthesis of 1,2,3-triazole-fused 1,4-benzodiazepinone derivatives from N-substituted 2-azidobenzamides and propargyl bromide, in the presence of a base, is reported. The products are formed in good to excellent yields via N-alkylation followed by a 1,3-dipolar cycloaddition.
Krishna C Majumdar and Sintu Ganai
Beilstein Institut
Reaction of o-azidobenzenesulfonamides with ethyl carbonochloridate afforded the corresponding amide derivatives, which gave 3-ethoxy-1,2,4-benzothiadiazine 1,1-dioxides through an intramolecular aza-Wittig reaction. The reaction was found to be general through the synthesis of a number of benzothiadiazine 1,1-dioxides. Acid-catalyzed hydrolysis of 3-ethoxy-1,2,4-benzothiadiazine 1,1-dioxides furnished the 2-substituted benzothiadiazine-3-one 1,1-dioxides in good yields and high purity, which is the core moiety of RSV inhibitors.
K.C. Majumdar, Sintu Ganai, and Biswajit Sinha
Elsevier BV
K.C. Majumdar, Sintu Ganai, Raj Kumar Nandi, and Krishanu Ray
Elsevier BV
K. Majumdar, Sintu Ganai, Buddhadeb Chattopadhyay, and Krishanu Ray
Georg Thieme Verlag KG
An efficient one-pot approach for the synthesis of highly substituted pyrrolocoumarin, quinolone, and pyrrolopyridine deriv- atives has been achieved by palladium acetate catalyzed reaction in DMF through initially formed enamine from cyclic and acyclic ke- tones and 6-amino-5-bromocoumarin, 6-amino-5-bromo-1-methyl quinolone, and 2-amino-3,5-dibromopyridine, respectively.
K. Majumdar and Sintu Ganai
Georg Thieme Verlag KG
An effective protocol for the synthesis of potentially bio- active benzo(e)chromeno(6,5-b)(1,4)diazepine-3,8(7H,13H)-dione and dibenzo(b,e)(1,4)diazepin-11(10H)-one derivatives in good to excellent yields has been achieved by CuI/L-Proline catalyzed cou- pling reaction as the key step. The methodology offers clean reac- tion conditions and easy isolation of the products in 61-92% yields.
K. C. Majumdar, Sintu Ganai, and Raj Kumar Nandi
Royal Society of Chemistry (RSC)
A simple and efficient method for the synthesis of some hitherto unreported pyrimidine-annulated spiro-dihydrofurans has been described. In the presence of AgSbF6 spiro- and furo-pyrimidine (10-hydroxy-4,7,9-substituted-1-oxa-7,9-diazaspiro[4.5]dec-3-ene-6,8-dione) heterocycles are obtained in good yields. The nature of the alkyne moiety present in substrates dictates the mode of cyclization to form the furopyrimidine derivatives.
K. Majumdar, Raj Nandi, Sintu Ganai, and Abu Taher
Georg Thieme Verlag KG
3 H-pyrano[3,2- F]quinoline-3-one, 4-methyl-4,7-phen-anthrolin-3(4 H)-one, and 1,3-dimethylpyrido[3,2- D]pyrimidine-2,4(1 H,3 H)-dionederivatives have been synthesized by hitherto unreported silver-catalyzed6- ENDO-dig mode of cycloisomerization fromvarious N-propargylated heterocyclic compounds. The silver-catalyzedreaction provides the synthesis of potential bioactive compoundsin excellent yields.
K. Majumdar, Sudipta Ponra, and Sintu Ganai
Georg Thieme Verlag KG
Pyrido[3,2-d]pyrimidine derivatives have been synthesized by the hetero-Diels―Alder reaction of 5-amino-1,3-dimethyl uracil and O-propargylated salicylaldehyde. The reaction requires only a single-step operation and provides potentially bioactive polycyclic heterocycles in high yields (71―82%) from easily available starting materials.
K. Majumdar, Krishanu Ray, and Sintu Ganai
Georg Thieme Verlag KG
A new efficient approach for the synthesis of unsymmetricaly substituted piperazine 2,5-dione derivatives is described by using intramolecular aza-Wittig reaction as the key step. The reaction conditions are very simple, offer easy isolation, and excellent yields of the products.
K. Majumdar, Krishanu Ray, Sintu Ganai, and Tapas Ghosh
Georg Thieme Verlag KG
A catalyst-free, effective method for the synthesis of the hitherto unreported 1,2,3-triazole-fused diazepinone framework in good to excellent yield through 1,3-dipolar cycloaddition is reported. The generality of the reaction is demonstrated by the synthesis of an array of [1,2,3]triazolodiazepinones. The methodology offers a clean reaction and easy isolation of the products in good to excellent yield.