Microbiology, Multidisciplinary, Animal Science and Zoology, Biochemistry, Genetics and Molecular Biology
13
Scopus Publications
Scopus Publications
Advances in Antiviral Strategies for Oral Herpes Infections in Immunocompromised Patients Nishant Burnase, Bikash Kumar, Pachaiyappan Saravana Kumar, Rajathirajan Siva Dharshini, Reena Das, Anand Barapatre Oral Diseases, 2026 Objective This review explores conventional antiviral therapies and innovative treatment strategies for managing oral herpes simplex virus (HSV) or human herpesvirus (HHV) infections, particularly in immunocompromised patients. It aims to evaluate clinical outcomes, address challenges such as drug resistance, and assess the sustainability of current and emerging therapeutic approaches. Subject A descriptive review of current treatment strategies for oral HSV infections in immunosuppressed individuals is presented. Relevant studies are analyzed for their contributions, highlighting therapeutic advancements, limitations of existing drugs, and novel approaches in development. Results Oral herpesvirus infections can lead to considerable morbidity and mortality in immunocompromised patients. Resistance to standard antivirals often develops due to prolonged or inconsistent use and impaired cell‐mediated immunity. To overcome these issues, innovative strategies like gene therapy, RNA interference (RNAi), and CRISPR‐Cas9 have emerged. These approaches aim to suppress viral gene expression, strengthen innate immunity, and genetically modify host cells to resist viral entry and replication. Conclusion Emerging antiviral therapies show promise in addressing the limitations of conventional treatments, particularly drug resistance and non‐specific targeting. These novel approaches offer more effective, precise, and safer options for treating oral viral infections in immunosuppressed populations at heightened risk for severe outcomes.
Design Of Robust Controller for Ball and Beam P. Jekan, Dharshini R, Mohith R, Swathi A 2025 IEEE International Students Conference on Electrical Electronics and Computer Science Sceecs 2025, 2025 In this study, fuzzy logic controllers, PID, PD, and fractional-order PID are used to build a dependable control system for a ball and beam setup. Due to its extreme nonlinearity and instability, the ball and beam system presents considerable difficulties in preserving stability and accurate control in the face of uncertainties and shocks. Four control strategies—fuzzy logic controllers, fractional-order PID, proportional-derivative (PD), and proportional-integral-derivative (PID)—are created and put into practice to handle these problems. The PID controller balances fast reaction times with little overshoot by reducing steady-state error and offering comprehensive control. With an emphasis on improving stability and transient responsiveness while lowering the risk of overshoot, the PD controller streamlines the control architecture. By using fractional calculus, the fractional-order PID controller improves performance when managing nonlinearities and gives the user more control over the dynamics of the system. Linguistic variables are also used by the fuzzy logic controller to address system uncertainties and enhance flexibility. During the design stage, develops a mathematical model for the ball and beam system.
Metabolic Engineering Approaches for Bioenergy Production Reghunathan Sarath, Rajathirajan Siva Dharshini, Ramachandran Srinivasan, Mohandass Ramya Applied Biotechnology for Emerging Pollutants Remediation and Energy Conversion, 2023
Production of Biofuels and Value-Added Products Using Anaerobic Digestion of Wastewater Rajathirajan Siva Dharshini, Shivakumar Renuka Dharani, K. N. Arul Jothi, Ramachandran Srinivasan, Mohandass Ramya Biotechnology for Toxicity Remediation and Environmental Sustainability, 2023 Water resources are significantly polluted by industrial, agricultural, and residential wastes. With the growth of industries and the economy, the rate of water contamination has increased. Water treatment requires removing harmful pollutants and proceeds with recycling or discharge into water bodies. Regular water treatments are cost- and energy-consuming. Anaerobic digestion includes specialized bioreactors, a microbial inoculum of restricted or facultative anaerobes. It has a significant advantage for producing value-added products, such as biofuels and petrochemicals, by metabolizing wastewater with the help of microbes. It is a beneficial two-in-one process and is highly economical in energy production and wastewater treatment. Instead of using cost-consuming different generation feedstocks for energy production, we can use the polluted wastewater released from various industries to increase the yield of energy and other value-added derivatives. The ultimate aim of this review is to visualize the recent advances in anaerobic digestion of different wastewaters from industries to produce biofuels and other value-added products. Accomplishing sustainable energy and simultaneous water treatment requires wide-ranging improvements in all economic, social, and technical aspects. Anaerobic digestion will be a future investment for a sustainable environment.
