Akashdeep Sharma

@drils.org

Post Doc Centre for Process Research and Innovation
Dr Reddy's Institue of Life Sciences

Akashdeep Sharma


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https://researchid.co/skydeep23
As an early-career researcher with a strong foundation in organic
synthesis, I am deeply passionate about exploring the reactivity of complex
organic molecules. My research has primarily focused on the synthesis and
applications of unprotected alkynyl hydrazones, as well as the fascinating
chemistry of diazo compounds and carbenes. I have developed significant
expertise in synthetic methodologies, characterization techniques, and mechanistic
studies of these reactions. I am particularly intrigued by the unique challenges and
opportunities presented by hydrazones, diazo compounds and carbenes, and have
actively followed advancements in this field. I am a dedicated and detail-oriented
researcher, committed to pushing the boundaries of innovation in organic
synthesis.

EDUCATION

Educational Background:
Degree University/Institute Grades/Percentage Year
Ph.D. Indian Institute of
Technology, Jammu, India
9.25 (10 scale) August, 2020-
May, 2025
M.Sc. University of Jammu,
Jammu, J&K, India
8.51 (10 scale) 2017-2019
B.Sc. Hindu College, University
of Delhi, New Delhi, India
74.87 % 2014-2017
12th,
10th
Spring Dales English
School, Kathua - J&K
93.6 %, 92.6% 2014, 2012

RESEARCH, TEACHING, or OTHER INTERESTS

Organic Chemistry, Chemistry
11

Scopus Publications

63

Scholar Citations

5

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Stereoselective Synthesis of Indoline-Fused Cyclobutanes via Dual Functionalization of Alkynyl Diazo Carboxylates
    Priya Sharma, Akashdeep Sharma, Nishant Joon, Ramani Gurubrahamam
    Organic Letters, 2026
    We report stereoselective synthesis of indoline-fused cyclobutanes through dual functionalization of alkynyl diazoacetates. The development proceeds through Rh-catalyzed insertion of alkynyl carbenes into 2-alkenyl anilines, followed by a base-promoted alkynoate-allenoate isomerization and cycloaddition cascade. The protocol expands the synthetic utility of alkynyl diazoacetates and provides a broad range of indoline-fused cyclobutanes with excellent yields and stereoselectivity (up to 97% yield and >20:1 dr). The synthetic applications of densely functionalized indoline scaffolds are shown toward obtaining useful motifs.
  • Synergistic surface-functionalized metal-organic polyhedra for solketal synthesis from glycerol and acetone
    Akashdeep Sharma, Řeha David, Shruti Srivastava, Venkatesha R. Hathwar, Soumik Siddhanta, Michal Otyepka, Kolleboyina Jayaramulu
    Applied Materials Today, 2025
  • Tailoring Conductive MXene@MOF Interfaces: New Generation of Synapse Devices for Neuromorphic Computing
    Akashdeep Sharma, Hyeon-Seung Lee, Chae-Min Yeom, Harikrishnan K. Surendran, Chandrabhas Narayana, Sunil Babu Eadi, Radek Zboril, Hi-Deok Lee, Kolleboyina Jayaramulu
    Chemistry of Materials, 2024
    Synapse devices, pivotal components in neuromorphic computing, demonstrate unique properties that are essential for advanced computing systems. These devices, characterized by their metal/resistive layer/metal structure, rely heavily on active layer material. One important challenge in developing synapse devices for artificial neural networks lies in constructing these networks at a hardware level to achieve in-memory computing, enabling the efficient processing of information while minimizing power consumption. Herein, we present a rational design and in situ synthesis of two-dimensional (2D/2D) heteronanostructures intricately integrating Ti-based metal carbide as Ti-MXene (Ti3C2) with copper-based metal–organic framework as Cu-tetrakis (4-carboxyphenyl) porphyrin (Cu-TCPP) through van der Waals interactions to form a hybrid as [Ti3C2@Cu-TCPP] (1). The hybrid exhibits synergistic properties of both counterparts with an intricate hierarchical structure, ensuring exceptional stability and remarkable conductivity, fundamental for the progression of advanced neuromorphic devices. The resultant hybrids show an advanced neuromorphic device with comprehensive comparative analysis using DC I–V sweeps was conducted to evaluate different device types, focusing on parameters such as the high-resistance state, low-resistance state, and on/off ratio. Results demonstrated that Ti3C2@Cu-TCPP@PVA-based devices exhibited an impressive on/off ratio of approximately 102, outperforming Cu-TCPP@PVA and Ti3C2@PVA-based devices. This highlights the superior performance of Ti3C2@Cu-TCPP@PVA and its potential for advanced applications in neural network systems. Furthermore, the conduction mechanism was elucidated, revealing the dominance of the space-charge limited conduction mechanism during the SET process and the Schottky emission mechanism during the RESET process.
  • Rhodium(II)-Catalyzed Alkynyl Carbene Insertion into N-H Bonds
    Akashdeep Sharma, Himani Vaid, Riya Kotwal, Zuhaib N. Mughal, Ramani Gurubrahamam
    Organic Letters, 2024
    The first insertion of an alkynyl carbene into N-H bonds under Rh-catalysis is developed. Alkynyl hydrazone carboxylates are used as donor-acceptor carbene precursors and are exquisitely inserted into the N-H bonds of various amines, amides, and 1,2-diamines. A wide variety of 3-alkynyl 3,4-dihydroquinoxalin-2(1H)-ones and densely functionalized α-alkynyl α-amino esters are obtained in good to excellent yields. Further, chemoselective N-H insertion reactions, mechanistic studies, and various synthetic transformations for obtaining valuable heterocycles are demonstrated.
  • Doyle-Kirmse Reaction on Alkynyl Hydrazone Carboxylates: Synthesis of 1,4-Allenyne and 1,5-Enyne Thioaryl Carboxylates
    Himani Vaid, Akashdeep Sharma, Paru Jamwal, Pryanka Sharma, Ramani Gurubrahamam
    Organic Letters, 2024
    The first Doyle-Kirmse reaction on alkynyl diazoacetates using allyl/propargyl sulfides is reported. The development provides diversified 1,5-enyne and 1,4-allenyne thioaryl carboxylates in good yields under ligand-/additive-free AuCl and Rh2(OAc)4 catalysis, respectively (48 examples, up to 96% yield). The study demonstrated the dual role of allyl sulfide as a ligand and substrate. Also, we have exemplified various synthetic modifications of the products to showcase the utility of different functional groups.
  • Porous materials as effective chemiresistive gas sensors
    Akashdeep Sharma, Sunil Babu Eadi, Hemanth Noothalapati, Michal Otyepka, Hi-Deok Lee, Kolleboyina Jayaramulu
    Chemical Society Reviews, 2024
    This review emphasizes the crucial role of chemiresistive gas sensors (CGS) in gas detection. It underscores porous materials as alternatives, showcasing their exceptional attributes. The review explores CGS-based porous materials in real-life applications.
  • Acidic graphene organocatalyst for the superior transformation of wastes into high-added-value chemicals
    Aby Cheruvathoor Poulose, Miroslav Medveď, Vasudeva Rao Bakuru, Akashdeep Sharma, Deepika Singh, Suresh Babu Kalidindi, Hugo Bares, Michal Otyepka, Kolleboyina Jayaramulu, Aristides Bakandritsos, Radek Zbořil
    Nature Communications, 2023
    Our dependence on finite fossil fuels and the insecure energy supply chains have stimulated intensive research for sustainable technologies. Upcycling glycerol, produced from biomass fermentation and as a biodiesel formation byproduct, can substantially contribute in circular carbon economy. Here, we report glycerol’s solvent-free and room-temperature conversion to high-added-value chemicals via a reusable graphene catalyst (G-ASA), functionalized with a natural amino acid (taurine). Theoretical studies unveil that the superior performance of the catalyst (surpassing even homogeneous, industrial catalysts) is associated with the dual role of the covalently linked taurine, boosting the catalyst’s acidity and affinity for the reactants. Unlike previous catalysts, G-ASA exhibits excellent activity (7508 mmol g−1 h−1) and selectivity (99.9%) for glycerol conversion to solketal, an additive for improving fuels’ quality and a precursor of commodity and fine chemicals. Notably, the catalyst is also particularly active in converting oils to biodiesel, demonstrating its general applicability.
  • Synthesis of Tetrasubstituted 1,4-Dicarbonyl (Z)-2,3-Dihaloalkenes via Electrophilic Halogenation of Alkynyl Hydrazones
    Akashdeep Sharma, Paru Jamwal, Ramani Gurubrahamam
    Organic Letters, 2023
    A highly practical and stereoselective route to 1,4-dicarbonyl 2,3-dihaloalkenes is presented. The strategy involves bench-stable unprotected alkynyl hydrazones and commercially available N-halosuccinimides that provide γ-oxo-α,β-(Z)-dihaloenoates in excellent yields with complete Z-selectivity. The protocol also furnishes vicinal dihaloalkenes with two different halogen atoms. Also, a straightforward one-pot synthesis of dihaloenoates from readily accessible 2-oxo-3-butynoate is demonstrated. In addition, potential synthetic transformations of 4-oxo-2,3-dibromoenoates are explored, which include the synthesis of valuable five- and six-membered heterocycles.
  • Decomposition of Alkynyl Hydrazones: Synthesis of Allenoates, Dihaloallenoates, and Angularly Fused Tricyclic Azepines
    Paru Jamwal, Akashdeep Sharma, Ramani Gurubrahamam
    Organic Letters, 2023
    An unprecedented decomposition of unprotected alkynyl hydrazones is attempted that has provided allenoates, tetrasubstituted α,γ-dihaloallenoates, and functionalized tricyclic azepines. A reaction of alkynyl hydrazones with N-halosuccinimides captures the electrophile in 2-fold that delivers fully substituted dibromo- and diiodoallenoates in good yields. In addition, a DABCO-promoted Wolff-Kishner reduction of hydrazones, followed by isomerization, provides versatile allenoates under mild conditions. In contrast, a similar decomposition with ambiphilic DBU furnishes a completely different tricyclic azepine scaffold in excellent yield and diastereoselectivity.
  • Synthesis of Alkynyl Hydrazones from Unprotected Hydrazine and Their Reactivity as Diazo Precursors
    Akashdeep Sharma, Paru Jamwal, Himani Vaid, Ramani Gurubrahamam
    Organic Letters, 2023
    Alkynyl hydrazones are synthesized conveniently from 2-oxo-3-butynoates and hydrazine by suppressing the susceptible formation of pyrazoles. The resultant hydrazones are transformed into alkynyl diazoacetates under metal-free and mild oxidative conditions in excellent yields. Further, the alkynyl cyclopropane and propargyl silane carboxylates are synthesized in good yields by developing an unprecedented copper-catalyzed alkynyl carbene transfer reaction.
  • Asymmetric Organocatalysis of Activated Alkynes and Enynes
    Akashdeep Sharma, Koppanathi Nagaraju, Gunda Ananda Rao, Ramani Gurubrahamam, Kwunmin Chen
    Asian Journal of Organic Chemistry, 2021

RECENT SCHOLAR PUBLICATIONS

  • Stereoselective Synthesis of Indoline-Fused Cyclobutanes via Dual Functionalization of Alkynyl Diazo Carboxylates
    P Sharma, A Sharma, N Joon, R Gurubrahamam
    Organic Letters 28 (11), 3577-3582 , 2026
    2026
  • Rhodium (II)-Catalyzed Alkynyl Carbene Insertion into N–H Bonds
    A Sharma, H Vaid, R Kotwal, ZN Mughal, R Gurubrahamam
    Organic Letters 26 (23), 4887-4892 , 2024
    2024
    Citations: 5
  • Doyle–Kirmse reaction on alkynyl hydrazone carboxylates: synthesis of 1, 4-allenyne and 1, 5-enyne thioaryl carboxylates
    H Vaid, A Sharma, P Jamwal, P Sharma, R Gurubrahamam
    Organic Letters 26 (10), 2135-2140 , 2024
    2024
    Citations: 11
  • Synthesis of Tetrasubstituted 1,4-Dicarbonyl ( Z )-2,3-Dihaloalkenes via Electrophilic Halogenation of Alkynyl Hydrazones
    A Sharma, P Jamwal, R Gurubrahamam
    Organic Letters 25 (39), 7236-7241 , 2023
    2023
    Citations: 4
  • Decomposition of Alkynyl Hydrazones: Synthesis of Allenoates, Dihaloallenoates, and Angularly Fused Tricyclic Azepines
    P Jamwal, A Sharma, R Gurubrahamam
    Organic Letters 25 (36), 6607-6612 , 2023
    2023
    Citations: 8
  • Synthesis of alkynyl hydrazones from unprotected hydrazine and their reactivity as diazo precursors
    A Sharma, P Jamwal, H Vaid, R Gurubrahamam
    Organic Letters 25 (11), 1889-1894 , 2023
    2023
    Citations: 18
  • Asymmetric organocatalysis of activated alkynes and enynes
    A Sharma, K Nagaraju, GA Rao, R Gurubrahamam, K Chen
    Asian Journal of Organic Chemistry 10 (7), 1567-1579 , 2021
    2021
    Citations: 17

MOST CITED SCHOLAR PUBLICATIONS

  • Synthesis of alkynyl hydrazones from unprotected hydrazine and their reactivity as diazo precursors
    A Sharma, P Jamwal, H Vaid, R Gurubrahamam
    Organic Letters 25 (11), 1889-1894 , 2023
    2023
    Citations: 18
  • Asymmetric organocatalysis of activated alkynes and enynes
    A Sharma, K Nagaraju, GA Rao, R Gurubrahamam, K Chen
    Asian Journal of Organic Chemistry 10 (7), 1567-1579 , 2021
    2021
    Citations: 17
  • Doyle–Kirmse reaction on alkynyl hydrazone carboxylates: synthesis of 1, 4-allenyne and 1, 5-enyne thioaryl carboxylates
    H Vaid, A Sharma, P Jamwal, P Sharma, R Gurubrahamam
    Organic Letters 26 (10), 2135-2140 , 2024
    2024
    Citations: 11
  • Decomposition of Alkynyl Hydrazones: Synthesis of Allenoates, Dihaloallenoates, and Angularly Fused Tricyclic Azepines
    P Jamwal, A Sharma, R Gurubrahamam
    Organic Letters 25 (36), 6607-6612 , 2023
    2023
    Citations: 8
  • Rhodium (II)-Catalyzed Alkynyl Carbene Insertion into N–H Bonds
    A Sharma, H Vaid, R Kotwal, ZN Mughal, R Gurubrahamam
    Organic Letters 26 (23), 4887-4892 , 2024
    2024
    Citations: 5
  • Synthesis of Tetrasubstituted 1,4-Dicarbonyl ( Z )-2,3-Dihaloalkenes via Electrophilic Halogenation of Alkynyl Hydrazones
    A Sharma, P Jamwal, R Gurubrahamam
    Organic Letters 25 (39), 7236-7241 , 2023
    2023
    Citations: 4
  • Stereoselective Synthesis of Indoline-Fused Cyclobutanes via Dual Functionalization of Alkynyl Diazo Carboxylates
    P Sharma, A Sharma, N Joon, R Gurubrahamam
    Organic Letters 28 (11), 3577-3582 , 2026
    2026

Publications

Publications:
1. Sharma, A.; Nagaraju, K.; Rao, G. A.; Gurubrahamam, R.; Chen, K. Asymmetric organocatalysis of activated
alkynes and enynes. Asian J. Org. Chem. 2021, 10, 1567–1579.
2. Sharma, A.; Jamwal, P.; Vaid, H.; Gurubrahamam, R. Synthesis of Alkynyl Hydrazones from Unprotected
Hydrazine and Their Reactivity as Diazo Precursors. Org. Lett. 2023, 25, 1889–1894.
3. Jamwal, P.;† Sharma, A.;
† Gurubrahamam, R. Decomposition of Alkynyl Hydrazones: Synthesis of Allenoates,
Dihaloallenoates, and Angularly Fused Tricyclic Azepines. Org. Lett. 2023, 25, 6607–6612.
4. Sharma, A.;
† Jamwal, P.;† Gurubrahamam, R. Synthesis of Tetrasubstituted 1,4-Dicarbonyl (Z)-2,3-Dihaloalkenes
via Electrophilic Halogenation of Alkynyl Hydrazones. Org. Lett. 2023, 25, 7236–7241.
5. Sharma, A.; Vaid, H.; Kotwal, R.; N. M. Zuhaib; Gurubrahamam, R.; Rhodium(II)-Catalyzed Alkynyl Carbene
Insertion into N–H Bonds. Org. Lett. 2024, 26, 4887–4892.
6. Vaid, H.; Sharma, A.; Jamwal, P.; Sharma, P.; Gurubrahamam, R. Doyle–Kirmse Reaction on Alkynyl Hydrazone
Carboxylates: Synthesis of 1,4-Allenyne and 1,5-Enyne Thioaryl Carboxylates. Org. Lett. 2024, 26, 2315–2140.
7. Sharma, A.; Shukla, R.; Gurubrahamam, R. Synthesis of Benzo[b]azepines via [4+2] Cycloaddition of Propargyl
Amines, Manuscript under revision..

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

Conferences and Workshops:
1. Presented Poster in Indo-French conference on “Fostering Catalysis for Societal Benefit (FCSB-2024)” held at School
of Chemistry, University of Hyderabad, India during 15-17 January 2024.
2. Best Post Presentation award in International Conference on “Frontiers in Catalysis (FIC-24)” held at Central
University of Rajasthan, Rajasthan, India during January 04-05, 2024.
3. 4. 5. 6. 7. 8. Presented Poster in 31st CRSI-NSC & CRSI-ACS SYMPOSIUM SERIES National Institute of Technology Rourkela,
Odisha, India, 6-8 July, 2023.
Presented Poster in “International Conference on Frontiers at the Chemistry-Allied Sciences Interface (FCASI-
2023)” organized by the Department of Chemistry, University of Rajasthan, Jaipur, India during April 20-21, 2023.
Best Post Presentation award in “CSIR-One Week One Lab Campaign” at CSIR-IIIM Jammu on 7th June 2023.
Attended a workshop on “Application Training Course on Bruker Single Crystal XRD” held at Indian institute of
Technology Jammu from 3-5 August 2021.
Attended a seminar by Prof. V.S. Parmar, Head of Chemistry Department, University of Delhi on the topic “Current
Challenges in Science, Environment and Society” in 2017.
Attended workshop “ChemCareers” of Royal Society of Chemistry (RSC) held at Hindu College, University of Delhi
in 2015 & 2016.