Trends and Gaps in Clinical Research on Tooth Bleaching: A Bibliometric Analysis of Studies Published From 2001 to 2024 Walessa Alana Bragança Aragão, Victória Santos Chemelo, Wallacy Watson Pereira Melo, José Lucas Gomes‐Moura, Sandro Cordeiro Loretto, et al. Journal of Esthetic and Restorative Dentistry, 2025 Introduction The objective of this bibliometric review is to address the main trends and development in dental whitening throughout the 21st century, as well as to identify knowledge gaps on the subject. Method A search was conducted in the Web of Science Core Collection database and information was extracted regarding the journal, authors, keywords, year of publication, number of citations, country, continent of the corresponding author. After reading the articles, data such as study design, type of bleaching technique, types of light sources used with the bleaching, occurrence of tooth sensitivity, and tooth color change analysis method were extracted. Results The journal with the largest number of publications was “Operative dentistry” ( n = 61), and the authors with the most articles were Loguercio AD ( n = 82) and Reis A ( n = 76). The productions are concentrated in Brazil, with emphasis on the State University Ponta Grossa. Most of the articles are randomized clinical studies that used the in‐office bleaching technique with 35% hydrogen peroxide. Conclusion Our results show that the most recent studies used light sources such as a violet LED during whitening; however, more studies are needed to prove the benefits in relation to color change and reduction of tooth sensitivity.
High Concentration Whitening Gel Without Remineralizers: The Importance of Polishing and Fluoridation After Tooth Bleaching Ribeiro MES, Juliana Costa Pereira Baia, Mário Honorato da Silva e Souza Júnior, Sandro Cordeiro Loretto Open Dentistry Journal, 2024 Background This study aimed to evaluate the effects of dental polishing and topical application of neutral fluoride after bleaching with 35% hydrogen peroxide (HP35%) without remineralizing bioactive components in its composition on the surface roughness (SR) of tooth enamel. Material and Methods Fifty healthy bovine incisors were divided into five groups (n=10 each): G1, without treatment (only stored in artificial saliva); G2, dental bleaching with HP35%; G3, dental bleaching with HP35% + tooth polishing with diamond paste; G4, tooth whitening with HP35% + topical application of fluoride; G5, dental bleaching with HP35% + tooth polishing with diamond paste + topical application of fluoride. SR readings were taken at times T0 (before treatment) and T1 (after treatment). Data were analyzed using analysis of variance for samples related to Tukey's post hoc test. Results The lowest mean roughness was observed in G3 at T1 (0.123 Ra) and the highest mean in G1 at T0 (0.198 Ra). However, the values of all groups at T1 were not statistically different (p˃0.05) from the T0 values. Conclusion Coronal polishing and topical application of neutral sodium fluoride did not interfere with the roughness of the enamel bleached with a gel without remineralizing agents in its composition.
Erosive Influence of Amazonian Tucupi on Microshear Bond Strength to Enamel and Dentin Reginna Vyctória Da Trindade Souza De Melo Carneiro, Mara Eliane Soares Ribeiro, Marina Lima Wanderley, Naama Waléria Alves Sousa, Paula Mendes Acatauassú Carneiro, et al. Contemporary Clinical Dentistry, 2024 Background: The scientific literature has studies that assess the influence of erosive challenges with citric acidic drinks and substances on the adhesive bond strength to enamel and dentin, but does not contain information about the influence of regional components of an acidic diet on this process. Thus, this study evaluated the erosive influence of Amazonian tucupi on enamel and dentin microshear bond strength. Materials and Methods: One hundred and sixty-eight healthy bovine incisors teeth were used, divided into 12 groups (n = 14). For erosive cycling, distilled water (negative control), cola-based soft drink (positive control), or tucupi were used, followed by adhesive strategies of (1) etch-and-rinse (conventional) (Adper™ Single Bond 2) and (2) self-etching (Clearfil SE Bond). All specimens were subjected to erosive cycling for 5 days and, after 24 h, composite resin cylinders were built up for the microshear bond strength test. The data showed normal distribution and were analyzed by two-way ANOVA, followed by the Tukey post and test (P ≤ 0.05). Results: There were no significant differences in enamel (P > 0.05). In dentin, only the groups exposed to cola-based soft drink showed significant differences (P < 0.01). The failure mode showed that Type II (mixed) was predominant (95%). Conclusion: The erosive challenge with tucupi did not influence the bond strength to enamel and dentin, regardless of the adhesive strategy used.
Does the Elapsed Time from Bleaching and the Use of Sodium Ascorbate Influence the Bond Strength of Resin Cement to Bleached Enamel? Ana Lílian Correia Lopes, Mara Eliane Soares Ribeiro, Jorge Henrique Pinheiro Barbosa, Max Pinto da Costa da Rocha, Mário Honorato da Silva e Souza Júnior, et al. Materials, 2023 The objective of this study was to evaluate different delaying times after bleaching and the use of different sodium ascorbate (SA) concentrations (10% and 35%) in the bond strength of adhesive cementation to enamel. This study used 54 sound bovine incisors, which were randomly assigned to the following groups: G1 (unbleached/control+ adhesive cementation (AC)); G2 (bleached + AC after 7 days); G3 (bleached + 10% SA + AC after 24 h); G4 (bleached + 10% SA + AC after 7 days); G5 (bleached + 35% SA + AC after 24 h); and G6 (bleached + 35% SA + AC after 7 days). After bleaching, G3, G4, G5, and G6 received an application of SA before the cylinders build up with RelyX Veneer cement. The samples were subjected to microshear test, and the results were analyzed by two-way ANOVA with Tukey’s post hoc test. Group one presented the highest mean bond strength (19.1 MPa) and G3 the lowest (16.96 MPa). There was no statistical difference between the groups tested (p ˃ 0.05). The fracture pattern observed was predominantly mixed. The adhesive cementation may be performed 24 h after bleaching when SA (10% or 35%) is used or after 7 days, without compromising bond strength.
Excessive Dental Bleaching with 22% Carbamide Peroxide Combined with Erosive and Abrasive Challenges: New Insights into the Morphology and Surface Properties of Enamel Edson de Sousa Barros Júnior, Mara Eliane Soares Ribeiro, Rafael Rodrigues Lima, Mário Honorato da Silva e Souza Júnior, Sandro Cordeiro Loretto Materials, 2022 This study aimed to evaluate the effects of 22% carbamide peroxide combined with an erosive challenge and simulated brushing on enamel. Bovine incisor teeth were divided into G1, tooth bleaching; G2, tooth bleaching + erosive challenge; and G3, tooth bleaching + erosive challenge + simulated brushing, and evaluated at T0, before any intervention; T1, 14 days after the proposed treatments; and T2, 28 days after the proposed treatments. Tooth bleaching was performed daily for 1 h for 28 days. The microhardness, surface roughness, mass variation, and ultrastructure were analyzed at T0, T1, and T2. Two-way analysis of variance for repeated measures was performed and Tukey’s post hoc test (α = 5%) was used. The surface roughness increased in groups G2 and G3 as a function of time, whereas microhardness and mass measurements demonstrated a significant reduction for groups associated with challenges. Ultrastructural evaluation indicated a loss of the aprismatic layer and exposure of the enamel prisms in all groups after 14 days of bleaching, with more pronounced results in G2 and G3 after 28 days. In conclusion, abrasive and erosive challenges potentiated the deleterious effects of tooth whitening on microhardness, ultramorphology, and mass, without affecting the roughness of dental enamel.
Does Addition of 10-MDP Monomer in Self-etch Adhesive Systems Improve the Clinical Performance of Noncarious Cervical Lesion Restorations? A Systematic Review and Meta-analysis RP de Oliveira, JCP Baia, TSP da Silva, MB Magno, LC Maia, et al. Operative Dentistry, 2021 SUMMARY Background Functional acidic monomers are able to chemically interact with hydroxyapatite, and this bond appears to be very stable. Therefore, this aspect of the 10-MDP molecule made it attractive and added to self-etch adhesives. Objectives The objective of this Systematic Review (SR) and Meta-analysis (MA) was to determine whether systems with the 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP) functional monomer in their formula showed better clinical performance in restorations placed in noncarious cervical lesions (NCCL) when compared to systems without it. The PROSPERO registration number of the MA is CRD42016050538. Data and sources An e-search was conducted through MEDLINE via PubMed, Cochrane Library, Scopus, Web of Science, OpenGrey, Clinical Trials, Current Controlled Trials, and EU Clinical Trials Register, and a search through the references of included studies was also performed. Randomized Controlled Clinical Trials, in which the effectiveness of self-etch adhesive systems, with or without the 10-MDP functional monomer for NCCL, was discussed, were included. Risk of bias was performed according to the Cochrane Collaboration tool, and the certainty of evidence was evaluated through GRADE. Study selection The data were grouped, heterogeneity (I2) was tested, and after duplicate removal, 4208 manuscripts were retrieved. From these, 11 studies were included in the qualitative analysis (risk of bias), with nine classified as low risk and two unclear. GRADE analysis detected moderate-to-high certainty of evidence, so the quantitative synthesis [Meta-analysis (MA)] was performed including the 11 studies. Results and Conclusion There were no statistical differences in the clinical performance of restorations conducted using “with or without 10-MDP” adhesive types, for all evaluated criteria (p=0.05), with heterogeneity ranging from 0% to 53%. Thus, the presence of 10-MDP functional monomer did not influence the clinical performance of restorations placed in NCCL.
Is buffalo enamel a suitable substrate for bond strength tests? Juliana Costa Pereira Baia, Mara Eliane Soares Ribeiro, Bárbara Catarina Lima Nogueira, Rafael Rodrigues Lima, Mário Honorato Silva e Souza Júnior, et al. Clinical Cosmetic and Investigational Dentistry, 2019
Difference in effectiveness between strontium acetate and arginine-based toothpastes to relieve dentin hypersensitivity. A systematic review American Journal of Dentistry, 2015
