Graduate in Pharmacy, Master's and Doctorate in Pharmaceutical Sciences
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmacology, Multidisciplinary
50
Scopus Publications
1544
Scholar Citations
24
Scholar h-index
35
Scholar i10-index
Scopus Publications
Integrating network pharmacology and in vivo experimentation to investigate the antiulcer mechanism of Coix lacryma-jobi Lincon B. Somensi, Daniela Miorando, Amanda M. Steffler, Cristian A. Dalla Vecchia, Cleidiane V. Ferraz, Ana Laura T. Borba, Khetlyn Freschi, Iuri R. Giacomelli, Maike V. Buzatto, Juliana C. Maccagnan, Adan P. N. Marcelino, Elizama de Gregório, Walter A. Roman Junior Revista Brasileira De Farmacognosia, 2026 Coix lacryma-jobi L., Poaceae, is traditionally used for the treatment of gastrointestinal disorders, yet its gastroprotective and ulcer-healing properties remain poorly explored. This study, integrating network pharmacology, in vivo assays, and molecular docking, demonstrates that the hydroalcoholic extract of C. lacryma jobi exerts its effects through convergent antioxidant, anti-inflammatory, and cytoprotective pathways. In ethanol-induced acute gastric injury, extract of C. lacryma jobi (100 mg/kg) prevented the depletion of reduced glutathione levels and decreased myeloperoxidase activity. Histological and histochemical analyses confirmed preservation of gastric mucosal structure. In addition, the reversal of extract of C. lacryma jobi protective effects by pretreatment with N-ethylmaleimide, indomethacin, and Nω-nitro-l-arginine methyl ester (l-NAME) indicates the involvement of sulfhydryl groups, prostaglandins, and nitric oxide pathways in its gastroprotective mechanism. In chronic acetic acid–induced ulcer, extract of C. lacryma jobi not only reduced the ulcerated area but also produced clear histological improvement, characterized by re‑epithelialization, reorganization of mucosal layers, and partial restoration of glandular architecture. These activities are likely related to decreased levels of reduced glutathione, lipid hydroperoxides, and diminished myeloperoxidase activity. Network pharmacology analyses indicated that the bioactive constituents of extract of C. lacryma jobi primarily exert their effects by modulating inflammatory signaling pathways. Mass spectrometry identified polyphenols, among which quercetin and kaempferol exhibited the highest binding affinity to myeloperoxidase and to IL-1β in docking simulations. Furthermore, no evidence of toxicity was observed in vivo and in silico assays for extract of C. lacryma jobi and its bioactive compounds. Collectively, these findings demonstrate that extract of C. lacryma jobi exerts multi-target gastroprotective and healing effects, supporting its potential as a natural antiulcer agent.
Hidden leprosy in a low-endemic area in southern Brazil: changes in endemicity following an active search Bruno Vitiritti, Filipe Rocha Lima, Nara Tescke de Castilho, Lincon Bordignon Somensi, Rosana Cláudio Silva Ogoshi Brazilian Journal of Infectious Diseases, 2024 BACKGROUND: Leprosy, a neglected tropical disease, is reported in over 120 countries, with upwards of 200,000 new cases annually. This Cross-Sectional Cohort Study aimed to delineate the epidemiological profile of leprosy in a low-endemic area in southern Brazil, both before and after implementing an active search strategy. METHODS: The study examined two surveillance periods in Caçador, Santa Catarina, Brazil. The active search strategy was carried out through the application of the LSQ by the community health workers as a screening and detection tool for new cases of leprosy and this was compared with passive case detection. The first spanned from 2014 to 2020, and the second from January 2021 to August 2023. FINDINGS: 48 leprosy cases were reported throughout the study, 83.3 % of which were diagnosed as multibacillary. The first period had an average detection rate of 0.38 cases per 10,000 inhabitants, increasing to 1.19 cases per 10,000 inhabitants in the second period. Notably, there was a substantial shift in the degree of physical disability (GD), with more Grade 0 and Grade 1 disabilities observed post-active search. MAIN CONCLUSIONS: The study underscores the efficacy of active search strategies in early diagnosis, highlighting a 300 % increase in the annual average of diagnosed cases. This large number of detected cases demonstrates the high sensitivity of the LSQ. This approach significantly aids in uncovering hidden cases of leprosy, enhancing disease management and control in low-endemic areas indicating that the Ministry of Health should intensify leprosy control activities in these regions.
Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds’ medicinal and edible flowers (Tagetes erecta L.) MARIANE MEURER, FABIULA FELISBINO, FABIANA B. MÜLLER, LINCON B. SOMENSI, BENHUR J. CURY, DANIELE T. JERÔNIMO, LARISSA VENZON, TAUANI C.S. FRANÇA, MARIHÁ MARIOTT, ANA C. SANTOS, RUAN KAIO S. NUNES, THAISE BOEING, ALEXANDRE BELLA-CRUZ, PRISCILA DE SOUZA, WALTER A. ROMAN-JUNIOR, KARUPPUSAMY ARUNACHALAM, RUBERLEI G. OLIVEIRA, LUISA M. SILVA Anais Da Academia Brasileira De Ciencias, 2023 The antiulcer mechanisms of the dry extract of T. erecta flowers (DETe) were studied here. The acute ulcers induced by acidified ethanol or indomethacin were reproduced in mice pretreated with DETe (3 - 300 mg/kg). The antiulcer activity of DETe was also verified in mice pretreated with NEM, L-NAME, indomethacin, or yohimbine. The antisecretory effect of DETe was verified in rats, and its anti-Helicobacter pylori activity was determined in vitro. DETe (300 mg/kg, p.o) reduced the ethanol- or indomethacin-induced ulcer by 49 and 93%, respectively. The pre-treatment with L-NAME, NEM or yohimbine abolished the gastroprotective effect of DETe. However, DETe did not change the volume, acidity, or peptic activity in rats and did not affect H. pylori. This study expands knowledge about the antiulcerogenic potential of DETe, evidencing the role of nitric oxide, non-protein sulfhydryl groups, α2 adrenergic receptors, and prostaglandins, but not antisecretory or anti-H. pylori properties.
Dimethyl Cardamonin from Fruits of Campomanesia reitziana D. Legrand Promotes Gastroprotection and Gastric Healing Effects in Rodents Benhur Judah Cury, Thaise Boeing, Lincon Bordignon Somensi, Adriana Campos, Valdir Cechinel‐Filho, Priscila de Souza, Luisa Mota da Silva Chemistry and Biodiversity, 2022 Campomanesia reitziana D. Legrand (Myrtaceae) displays antiulcer properties when given to rodents. The major active chemical components of C. reitziana are chalcones, including 4′,6′‐dihydroxy‐2′‐methoxy‐3′,5′‐dimethylchalcone or dimethyl cardamonin (DMC); therefore, we hypothesized that this compound could have antiulcer effects and the present study aimed to evaluate its gastroprotective and gastric healing properties. DMC was isolated from the fruits of C. reitziana, and its gastroprotective effect was evaluated by ethanol and indomethacin‐induced gastric ulcer models in mice (0.1 mg/kg, i.p. and 1 and 3 mg/kg, p.o.). Oxidative stress and inflammatory parameters were analyzed in the gastric tissue. Moreover, its gastric healing effect was evaluated in rats. In addition, the compound's mode of action was evaluated in vivo and in vitro by measuring H+‐K+‐ATPase activity. Finally, the cytotoxic potential of DMC was tested in fibroblasts and human gastric adenocarcinoma cells. The DMC reduced the ethanol‐induced gastric ulcer in mice by 77 %, increased the adhered mucus, and reduced lipoperoxides levels. The block of nonprotein sulfhydryls (NP‐SH) compounds by pretreatment with N‐ethylmaleimide (NEM), the inhibition of nitric oxide synthase with Nω‐nitro‐L‐arginine methyl ester hydrochloride (L‐NAME), or the antagonism of α2 receptor using yohimbine reversed the gastroprotective effects of DMC. Furthermore, DMC reduced the acidity of gastric content in pylorus‐ligated rats but did not change H+, K+‐ATPase (isolated from rabbit) activity in vitro. DMC reduced the lesion area in acetic acid‐induced ulcers and decreased myeloperoxidase activity. DMC did not change the viability of fibroblast cells (L929) but reduced the viability of human gastric adenocarcinoma cells (AGS). The results confirmed that DMC could significantly enhance the gastric healing process and prevent ulcers due to improving protective factors on the gastric mucosa and reducing gastric acid secretion.
Neuroprotective effects of strength training in a neuroinflammatory animal model Elizama de Gregório, Gabriela Cristiane Mendes, Lincon Bordignon Somensi, Cassio Geremia Freire, Luiza Freitas Lopes, Karine Ramires Lima, Guilherme Salgado Carrazoni, Ben-Hur Souto Neves, Steffanie Severo Picua, Luisa Mota da Silva, Pamela Billig Mello-Carpes, Juliana Sartori Bonini, Weber Claudio da Silva BMC Neuroscience, 2022 Background The preventive role of muscular strength on diminishing neuroinflammation is yet unknown. In this study, the role of the prophylactic muscular strength exercise was investigated in order to verify whether it would diminish cognitive alterations and modify the antioxidant intracellular scenery in an animal neuroinflammatory model in of the CA1 region of the hippocampus. Methods The animals received muscular strength training (SE) three times a week for eight weeks. Subsequently, the stereotaxic surgery was performed with an intra-hippocampal infusion of either saline solution (SAL) or lipopolysaccharide (LPS). Next, we performed the behavioral tests: object recognition and social recognition. Then, the animals were euthanized, and their hippocampus and prefrontal cortex were collected. In another moment, we performed the dosage of the antioxidant activity and histological analysis. Results The results showed that the muscular strength exercises could show a beneficial prophylactic effect in the cognitive deficiencies caused by acute neuroinflammation. Regarding oxidative stress, there was an increase in catalase enzyme activity (CAT) in the group (SE + LPS) compared to the control groups (p < 0.05). As for the cognitive alterations, there were found in the (SE + LPS) group, diminishing the mnemonic hazard of the discriminative and social memories compared to the control groups (p < 0.05). Conclusion We concluded, therefore, that the exercise performed prophylactically presents a protective effect capable of minimizing such mnemonic deficits and increasing catalase enzyme activity in rats that suffered a local neuroinflammatory process in the hippocampus.
Lupeol Stearate Accelerates Healing and Prevents Recurrence of Gastric Ulcer in Rodents Lincon Bordignon Somensi, Philipe Costa, Thaise Boeing, Luísa Nathália Bolda Mariano, Elizama de Gregório, Aline Teixeira Maciel E Silva, Bruna Longo, Claudriana Locatelli, Priscila de Souza, Cássia Gonçalves Magalhães, Lucienir Pains Duarte, Luisa Mota da Silva Evidence Based Complementary and Alternative Medicine, 2022
Gastroprotective activity of hydroalcoholic extract of the leaves of Urera baccifera in rodents Régis Carlos Benvenutti, Cristian Alex Dalla Vecchia, Gelvani Locateli, Patrícia Zanotelli Serpa, Junir Antonio Lutinski, Sinval Adalberto Rodrigues Junior, Vanessa Corralo, Max Vidal Gutiérrez, Wagner Vilegas, Lincon Bordignon Somensi, Bruna Longo, Jessica Ferreira Knihs, Luisa Mota da Silva, Sérgio Faloni de Andrade, Walter Antônio Roman Junior Journal of Ethnopharmacology, 2020
Effect of magnetic plate in memory of rats Neuza Maria Ferraz De Melo Gonçalvex, Adriane Granato Gonçalves, Lincon Bordignon Somensi, Neliza . Ferraz Archives of Veterinary Science, 2015
RECENT SCHOLAR PUBLICATIONS
Uma breve história da educação dos cegos no Brasil e a constante luta contra a “invisibilização” social: A brief history of the education of the blind in Brazil and the … JC de Mello, LB Somensi, JC Bonin Ponto de Vista Jurídico 14 (2), e3953-e3953 , 2025 2025
In vivo and in silico assays demonstrate that the hydroalcoholic extract of Aloysia polystachya and carvone promote anti-ulcer effects AM Steffler, D Miorando, JC Maccagnan, K Freschi, ALT Borba, ... Journal of Ethnopharmacology, 120896 , 2025 2025
Integration of In Vivo and In Silico Studies Reveals that the Hydroalcoholic Extract of Fridericia chica Improves Gastric Healing and Reduces Recurrence in Rodents D Miorando, AM Steffler, VL Simomura, CAD Vecchia, CV Ferraz, ... Revista Brasileira de Farmacognosia, 1-15 , 2025 2025
Gastroprotective role of a flavonoid-rich subfraction from Fridericia chica (Bonpl.) L. G. Lohmann: a medicinal plant used in the Amazon region: Gastroprotective … D Miorando, AM Steffler, CAD Vecchia, VL Simomura, JJ Veloso, ... Inflammopharmacology 32 (5), 3499-3519 , 2024 2024 Citations: 5
Socioeconomic profile pregnant women with Gestational and Congenital Syphilis in SC-Brazil MAM Habermann, MH Testoni, V Dorgievicz, GM Habermann, ... OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 22 (7), e5705-e5705 , 2024 2024
Hidden leprosy in a low-endemic area in southern Brazil: changes in endemicity following an active search B Vitiritti, FR Lima, NT de Castilho, LB Somensi, RCS Ogoshi The Brazilian Journal of Infectious Diseases 28 (4), 103853 , 2024 2024 Citations: 4
Desafios de saúde de pessoas privadas de liberdade no Brasil–revisão sistemática LC Lopes, CCC Lopes, JC Bonin, LB Somensi Cuadernos de Educación y Desarrollo-QUALIS A4 16 (6), e4438-e4438 , 2024 2024
A jornada da transição hormonal na disforia de gênero: relato e análise de caso CLG dos Santos, ML Beck, LB Somensi, FH Pitanga OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 22 (6), e5064-e5064 , 2024 2024
Evolução da fístula colecistoentérica decorrente de síndrome de Mirrizi L Serraglio, MS Cruz, EB Lopes, LB Somensi Cuadernos de Educación y Desarrollo-QUALIS A4 16 (6), e4172-e4172 , 2024 2024
Hanseníase: um levantamento de casos no Meio Oeste de Santa Catarina BB Agnoleto, GO Souza, ALS da Silva, BVF Zanardo, E de Gregório, ... Cuadernos de Educación y Desarrollo-QUALIS A4 16 (5), e4220-e4220 , 2024 2024
Aqueous extract of the bark of Uncaria tomentosa, an amazonian medicinal plant, promotes gastroprotection and accelerates gastric healing in rats VL Simomura, D Miorando, BMM de Oliveira, A Mânica, LC Bohnen, ... Journal of Ethnopharmacology 321, 117542 , 2024 2024 Citations: 13
Obesidade infantil: uma análise sobre o perfil nutricional de crianças escolares frequentadoras da unidade básica de saúde do bairro martello no município de Caçador, nos anos … JA de Albuquerque Neto, NMM Moraes, LB Somensi, AP de Souza, ... OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 22 (1), 2228-2250 , 2024 2024
Efeito do consumo de erva-mate no sistema musculoesquelético de jogadores de futebol amador GM Camargo, R Sens, AC Lorenzzon, Y Borges, LD Streck, I Wellwock, ... OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 21 (11), 19533-19551 , 2023 2023
A retinopatia diabética e a nefropatia diabética como evolução clínica da Diabetes Mellitus: revisão sistemática ACP Roncaglio, GS Matos, VL Maeta, JC Bonin, LB Somensi Cuadernos de Educación y Desarrollo-QUALIS A4 15 (9), 9262-9280 , 2023 2023
Antiulcer mechanisms of the hydroalcoholic extract from Aztec marigolds’ medicinal and edible flowers ( Tagetes erecta L. ) M Meurer, F Felisbino, FB Mueller, LB Somensi, BJ Cury, DT Jeronimo, ... Anais da Academia Brasileira de Ciências 95 (suppl 1), e20220427 , 2023 2023 Citations: 5
Perfil de sobrepeso e obesidade em crianças atendidas pelo Serviço de Atenção Primária de uma cidade no meio-oeste catarinense BPD Caramori, EH Bellaver, MH Testoni, G de Oliveira Souza, ... Cuadernos de Educación y Desarrollo-QUALIS A4 15 (3), 2847-2869 , 2023 2023
A IMPOSSIBILIDADE DO TRATAMENTO FARMACOLÓGICO PARA HEPATITE C CRÔNICA DEVIDO À INTERAÇÕES MEDICAMENTOSAS É da Silva Anselmo, AP Schermack, LB Somensi, AC Bahr, E de Gregório Revista Contemporânea 3 (6), 5665-5684 , 2023 2023
Fechamento do forame oval patente: uma revisão de literatura AE da Silva, LB Volpato, WCFN da Silva, JS Bonini, A Bahr, LB Somensi, ... Revista contemporânea 3 (6), 5244-5260 , 2023 2023 Citations: 1
Aleitamento materno: fatores de desmame em crianças menores de 1 ano IF Malheiros, I da Silva, MAMH Silva, LB Somensi, R Cervini, ET da Silva, ... Revista Eletrônica Acervo Saúde| ISSN 2178, 2091 , 2023 2023 Citations: 1
Geraniol accelerates the gastric healing, minimizes ulcers recurrence, and reduces anxiolytic-like behavior in ulcerated rodents by oral or inhaled route L Venzon, MC Meurer, TC dos Santos Franca, B Longo, M Mariott, ... Inflammopharmacology 30 (6), 2331-2344 , 2022 2022 Citations: 8
MOST CITED SCHOLAR PUBLICATIONS
Luteolin prevents irinotecan‐induced intestinal mucositis in mice through antioxidant and anti‐inflammatory properties T Boeing, P De Souza, S Speca, LB Somensi, LNB Mariano, BJ Cury, ... British journal of pharmacology 177 (10), 2393-2408 , 2020 2020 Citations: 161
Hydroalcoholic extract of Tagetes erecta L. flowers, rich in the carotenoid lutein, attenuates inflammatory cytokine secretion and improves the oxidative stress in an animal … MC Meurer, M Mees, LNB Mariano, T Boeing, LB Somensi, M Mariott, ... Nutrition research 66, 95-106 , 2019 2019 Citations: 103
Evidence of gastric ulcer healing activity of Maytenus robusta Reissek: in vitro and in vivo studies LM Da Silva, T Boeing, LB Somensi, BJ Cury, VMB Steimbach, ... Journal of Ethnopharmacology 175, 75-85 , 2015 2015 Citations: 83
Antiulcer mechanisms of Vernonia condensata Baker: A medicinal plant used in the treatment of gastritis and gastric ulcer T Boeing, LM Da Silva, LB Somensi, BJ Cury, APM Costa, M Petreanu, ... Journal of ethnopharmacology 184, 196-207 , 2016 2016 Citations: 81
Artepillin C, drupanin, aromadendrin-4′-O-methyl-ether and kaempferide from Brazilian green propolis promote gastroprotective action by diversified mode of action P Costa, MO Almeida, M Lemos, C Arruda, R Casoti, LB Somensi, ... Journal of ethnopharmacology 226, 82-89 , 2018 2018 Citations: 79
Essential oil of Cymbopogon citratus (lemongrass) and geraniol, but not citral, promote gastric healing activity in mice L Venzon, LNB Mariano, LB Somensi, T Boeing, P de Souza, TM Wagner, ... Biomedicine & Pharmacotherapy 98, 118-124 , 2018 2018 Citations: 71
Pharmacological reports about gastroprotective effects of methanolic extract from leaves of Solidago chilensis (Brazilian arnica) and its components quercitrin and … M De Barros, L Mota da Silva, T Boeing, LB Somensi, BJ Cury, ... Naunyn-Schmiedeberg's archives of pharmacology 389 (4), 403-417 , 2016 2016 Citations: 67
Hesperidin, a citrus flavanone glycoside, accelerates the gastric healing process of acetic acid-induced ulcer in rats LM da Silva, BC Pezzini, LB Somensi, LNB Mariano, M Mariott, T Boeing, ... Chemico-biological interactions 308, 45-50 , 2019 2019 Citations: 65
Role of the antioxidant properties in the gastroprotective and gastric healing activity promoted by Brazilian green propolis and the healing efficacy of Artepillin C: P. Costa … P Costa, LB Somensi, RCMVAF da Silva, LNB Mariano, T Boeing, ... Inflammopharmacology 28 (4), 1009-1025 , 2020 2020 Citations: 58
Irinotecan-induced intestinal mucositis in mice: a histopathological study T Boeing, MB Gois, P de Souza, LB Somensi, DMG Sant´ Ana, ... Cancer chemotherapy and pharmacology 87 (3), 327-336 , 2021 2021 Citations: 42
Constituents of leaves from Bauhinia curvula Benth. exert gastroprotective activity in rodents: role of quercitrin and kaempferol AP Beber, P de Souza, T Boeing, LB Somensi, LNB Mariano, BJ Cury, ... Inflammopharmacology 26 (2), 539-550 , 2018 2018 Citations: 37
Diuretic effect of extracts, fractions and two compounds 2α, 3β, 19α-trihydroxy-urs-12-en-28-oic acid and 5-hydroxy-3, 6, 7, 8, 4′-pentamethoxyflavone from Rubus rosaefolius … P de Souza, T Boeing, LB Somensi, CC Cechinel-Zanchett, JK Bastos, ... Naunyn-Schmiedeberg's archives of pharmacology 390 (4), 351-360 , 2017 2017 Citations: 36
Gastroprotective activity of hydroalcoholic extract of the leaves of Urera baccifera in rodents RC Benvenutti, CA Dalla Vecchia, G Locateli, PZ Serpa, JA Lutinski, ... Journal of Ethnopharmacology 250, 112473 , 2020 2020 Citations: 35
Influence of Prostanoids in the Diuretic and Natriuretic Effects of Extracts and Kaempferitrin from Bauhinia forficata Link Leaves in Rats P de Souza, LM da Silva, T Boeing, LB Somensi, CC Cechinel‐Zanchett, ... Phytotherapy Research 31 (10), 1521-1528 , 2017 2017 Citations: 33
Gastroprotective and anti-secretory mechanisms of 2-phenylquinoline, an alkaloid isolated from Galipea longiflora E Breviglieri, LM da Silva, T Boeing, LB Somensi, BJ Cury, A Gimenez, ... Phytomedicine 25, 61-70 , 2017 2017 Citations: 33
Hydroalcoholic extract from Baccharis dracunculifolia recovers the gastric ulcerated tissue, and p ‐coumaric acid is a pivotal bioactive compound to this action P Costa, T Boeing, LB Somensi, BJ Cury, VL Espíndola, TCS França, ... Biofactors 45 (3), 479-489 , 2019 2019 Citations: 32
Gastroprotective xanthones isolated from Garcinia achachairu: Study on mucosal defensive factors and H+, K+-ATPase activity LNB Mariano, LM da Silva, P de Souza, T Boeing, LB Somensi, ... Chemico-Biological Interactions 258, 30-39 , 2016 2016 Citations: 32
Hydroalcoholic extract from bark of Persea major (Meisn.) LE Kopp (Lauraceae) exerts antiulcer effects in rodents by the strengthening of the gastric protective factors LB Somensi, T Boeing, BJ Cury, VMB Steimbach, R Niero, LM de Souza, ... Journal of ethnopharmacology 209, 294-304 , 2017 2017 Citations: 30
Diuretic, natriuretic and potassium-sparing effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats CLB de Almeida, T Boeing, LB Somensi, VMB Steimbach, LM da Silva, ... Chemico-Biological Interactions 268, 103-110 , 2017 2017 Citations: 30
Flavonoid‐rich fraction of Bauhinia forficata Link leaves prevents the intestinal toxic effects of irinotecan chemotherapy in IEC‐6 cells and in mice CC Cechinel‐Zanchett, T Boeing, LB Somensi, VMB Steimbach, ... Phytotherapy Research 33 (1), 90-106 , 2019 2019 Citations: 28
