Som Mohanlal Patwa

@nus.edu.sg

PhD student, Yong Loo Lin School of Medicine
National University of Singapore

Som Mohanlal Patwa


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https://researchid.co/sompatwa

RESEARCH, TEACHING, or OTHER INTERESTS

Molecular Biology, Virology, Infectious Diseases, Cancer Research
5

Scopus Publications

35

Scholar Citations

5

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • Development of monoclonal antibodies to target the large surface protein of hepatitis B virus and their use in therapeutic and diagnostic applications
    Subha Sankar Paul, Som Mohanlal Patwa, Yee‐Joo Tan
    Journal of Viral Hepatitis, 2023
    Over 250 million people are living with chronic infection caused by the hepatitis B virus (HBV). HBV has three surface proteins, namely small (SHBs), medium (MHBs) and large (LHBs), and they play different roles in the virus life cycle. The approved hepatitis B vaccine only contains the SHBs protein and many studies have focused on characterising the functional domains in SHBs. Although the LHBs protein is less studied, recent studies have shown that it plays important roles in mediating viral entry, replication and assembly. Over the years, there have been major advancements in monoclonal antibody (mAb) discovery tools and multiple mAbs have been developed to specifically target the preS1 domain in LHBs. We summarise the HBV infection systems and antibody discovery strategies that have been utilised by various research groups to assess the potential use of anti‐preS1 mAbs as therapeutic antibodies against HBV or in the development of new diagnostic assays.
  • Improper Proteostasis: Can It Serve as Biomarkers for Neurodegenerative Diseases?
    Ankur Rakesh Dubey, Som Mohanlal Patwa, Sumit Kinger, Yuvraj Anandrao Jagtap, Prashant Kumar, et al.
    Molecular Neurobiology, 2022
  • Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases
    Ankur R. Dubey, Yuvraj A. Jagtap, Prashant Kumar, Som M. Patwa, Sumit Kinger, et al.
    Journal of Cellular Biochemistry, 2022
    Viruses are known to cause various diseases in human and also infect other species such as animal plants, fungi, and bacteria. Replication of viruses depends upon their interaction with hosts. Human cells are prone to such unwanted viral infections. Disintegration and reconstitution require host machinery and various macromolecules like DNA, RNA, and proteins are invaded by viral particles. E3 ubiquitin ligases are known for their specific function, that is, recognition of their respective substrates for intracellular degradation. Still, we do not understand how ubiquitin proteasome system‐based enzymes E3 ubiquitin ligases do their functional interaction with different viruses. Whether E3 ubiquitin ligases help in the elimination of viral components or viruses utilize their molecular capabilities in their intracellular propagation is not clear. The first time our current article comprehends fundamental concepts and new insights on the different viruses and their interaction with various E3 Ubiquitin Ligases. In this review, we highlight the molecular pathomechanism of viruses linked with E3 Ubiquitin Ligases dependent mechanisms. An enhanced understanding of E3 Ubiquitin Ligase‐mediated removal of viral proteins may open new therapeutic strategies against viral infections.
  • Autophagy based cellular physiological strategies target oncogenic progression
    Prashant Kumar, Yuvraj Anandrao Jagtap, Som Mohanlal Patwa, Sumit Kinger, Ankur Rakesh Dubey, et al.
    Journal of Cellular Physiology, 2022
    Evidence accumulated from past findings indicates that defective proteostasis may contribute to risk factors for cancer generation. Irregular assembly of abnormal proteins catalyzes the disturbance of cellular proteostasis and induces the ability of abnormal cellular proliferation. The autophagy mechanism plays a key role in the regular clearance of abnormal/poor lipids, proteins, and various cellular organelles. The results of functional and effective autophagy deliver normal cellular homeostasis, which establishes supportive metabolism and avoids unexpected tumorigenesis events. Still, the precise molecular mechanism of autophagy in tumor suppression has not been clear. How autophagy triggers selective or nonselective bulk degradation to dissipate tumor promotion under stress conditions is not clear. Under proteotoxic insults to knockdown the drive of tumorigenesis, it is critical for us to figure out the detailed molecular functions of autophagy in human cancers. The current article summarizes autophagy‐based theragnostic strategies targeting various phases of tumorigenesis and suggests the preventive roles of autophagy against tumor progression. A better understanding of various molecular partners of autophagic flux will improve and innovate therapeutic approaches based on autophagic‐susceptible effects against cellular oncogenic transformation.
  • Proteasome based molecular strategies against improper cellular proliferation
    Cellular Physiology and Biochemistry, 2021
    Cells contain several proteins that routinely fulfill multiple requirements for normal physiological survival. Proteostasis dysfunction is linked with different complex human disorders, like cancer, neuron degeneration, and imperfect aging. The ubiquitin proteasome system (UPS) forms the primary proteostasis mechanism taking part in cytoprotection. Cancer cells are well known to possess enhanced cytoprotective properties, and different UPS elements are implicated to be dysregulated at several stages of tumor progression. Furthermore, many studies have found tumor cells to exhibit higher levels of various UPS components, possibly contributing to their robust endurance. In this article, we have presented different cellular protein quality control strategies, essential for maintaining healthy proteome. Here, we have also discussed key contributions and functions of UPS involved in molecular pathomechanisms for establishing cancer conditions. Along with this, the emerging different therapeutic strategies against defective proteome linked with improper cellular proliferation and cancer progression are also reviewed. UPS performs critical regulatory functions in modulating the cellular apoptotic pathways. The proteasomal system involvement as probable therapeutic targets influencing cancer cell apoptosis is also discussed. Our article summarizes the recent developments in proteasome-associated pathways regulating tumor cell proteome and survival. Additionally, how the engagement and cross functions of these physiological processes can induce apoptosis and may develop regulation over tumor progression. A better understanding of multifaceted protein quality control pathways may inform therapeutic interventions based on cellular proteostasis response determined against complex diseases.

RECENT SCHOLAR PUBLICATIONS

  • Development of monoclonal antibodies to target the large surface protein of hepatitis B virus and their use in therapeutic and diagnostic applications
    SS Paul, SM Patwa, YJ Tan
    Journal of Viral Hepatitis 30 (11), 870-878 , 2023
    2023.0
    Citations: 8
  • Improper proteostasis: can it serve as biomarkers for neurodegenerative diseases?
    AR Dubey, SM Patwa, S Kinger, YA Jagtap, P Kumar, S Singh, R Dhiman, ...
    Molecular Neurobiology 59 (6), 3382-3401 , 2022
    2022.0
    Citations: 5
  • Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases
    AR Dubey, YA Jagtap, P Kumar, SM Patwa, S Kinger, A Kumar, S Singh, ...
    Journal of Cellular Biochemistry 123 (2), 161-182 , 2022
    2022.0
    Citations: 6
  • Autophagy based cellular physiological strategies target oncogenic progression
    P Kumar, YA Jagtap, SM Patwa, S Kinger, AR Dubey, VK Prajapati, ...
    Journal of Cellular Physiology 237 (1), 258-277 , 2022
    2022.0
    Citations: 11
  • Proteasome Based Molecular Strategies Against Improper Cellular Proliferation.
    AR Dubey, S Kinger, YA Jagtap, SM Patwa, P Kumar, S Singh, A Kumar, ...
    Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG) 55 , 2021
    2021.0
    Citations: 5
  • HBx interacts with the host YBX3 protein and up-regulates its expression to mediate efficient Hepatitis B viral replication
    MV Boo, J Chu, ZJ Lim, SM Patwa, WJ Hong, SG Lim, J Gunaratne, ...
    Frontiers in Cellular and Infection Microbiology 16, 1732356 , 0

MOST CITED SCHOLAR PUBLICATIONS

  • Autophagy based cellular physiological strategies target oncogenic progression
    P Kumar, YA Jagtap, SM Patwa, S Kinger, AR Dubey, VK Prajapati, ...
    Journal of Cellular Physiology 237 (1), 258-277 , 2022
    2022.0
    Citations: 11
  • Development of monoclonal antibodies to target the large surface protein of hepatitis B virus and their use in therapeutic and diagnostic applications
    SS Paul, SM Patwa, YJ Tan
    Journal of Viral Hepatitis 30 (11), 870-878 , 2023
    2023.0
    Citations: 8
  • Biochemical strategies of E3 ubiquitin ligases target viruses in critical diseases
    AR Dubey, YA Jagtap, P Kumar, SM Patwa, S Kinger, A Kumar, S Singh, ...
    Journal of Cellular Biochemistry 123 (2), 161-182 , 2022
    2022.0
    Citations: 6
  • Improper proteostasis: can it serve as biomarkers for neurodegenerative diseases?
    AR Dubey, SM Patwa, S Kinger, YA Jagtap, P Kumar, S Singh, R Dhiman, ...
    Molecular Neurobiology 59 (6), 3382-3401 , 2022
    2022.0
    Citations: 5
  • Proteasome Based Molecular Strategies Against Improper Cellular Proliferation.
    AR Dubey, S Kinger, YA Jagtap, SM Patwa, P Kumar, S Singh, A Kumar, ...
    Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG) 55 , 2021
    2021.0
    Citations: 5
  • HBx interacts with the host YBX3 protein and up-regulates its expression to mediate efficient Hepatitis B viral replication
    MV Boo, J Chu, ZJ Lim, SM Patwa, WJ Hong, SG Lim, J Gunaratne, ...
    Frontiers in Cellular and Infection Microbiology 16, 1732356 , 0