SONALI LABHADE
@57192
Assistant Professor
Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research,Pimpri, Pune
EDUCATION
PhD Pharmaceutical Sciences, Banasthali Vidyapith, Rajasthan
RESEARCH, TEACHING, or OTHER INTERESTS
Hepatology, Cancer Research, Cell Biology, Chemistry
FUTURE PROJECTS
Molecular glues
Molecular glues represent a promising class of small molecules that facilitate targeted protein degradation, offering novel therapeutic avenues in cancer and tuberculosis (TB) treatment. These compounds work by promoting the interaction between disease-associated proteins and E3 ubiquitin ligases, leading to selective protein degradation. Research has highlighted the potential of molecular glues to address the limitations of traditional therapies, particularly in resistant cancers and persistent TB infections.The exploration of molecular glues is gaining traction, with ongoing studies aiming to further elucidate their mechanisms and optimize their efficacy for clinical applications in oncology and infectious diseases
Applications Invited
Collaborators for research work.
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Sonali D Labhade, Harshad S Kapare, Juilee S Jagtap, Sohan S Chitlange, and Karishma M Rathi
IP Innovative Publication Pvt Ltd
Fungal skin infections are a prevalent health issue that requires investigation into safe and efficient alternative remedies. Herbal components are a good option for cosmetics formulations because they have historically shown antifungal capabilities. Building on this idea, the research seeks to create a novel antifungal herbal bath bomb by utilizing the medicinal properties of plants.The aim of this project is to develop evaluate a herbal bath bomb, with an emphasis on its antifungal qualities. The main goal is to create a bath bomb with carefully chosen herbal elements that have been suggested to have antifungal properties.The study employed a systematic approach to construct the herbal bath bomb, including a variety of herbal ingredients recognized for their antifungal properties. Precise measurement and blending were necessary during the material preparation process to ensure optimal efficacy. The effectiveness of the herbal bath bomb against common fungus strains was evaluated in the lab along with antifungal testing.The results reveal promising antifungal properties of the developed herbal bath bomb, as evidenced by its efficacy against common fungal strains. This study contributes valuable insights into the potential of herbal-based hygiene products for combating fungal skin conditions. The findings support the conclusion that the formulated bath bomb holds promise as a natural and effective solution, paving the way for further exploration and development in the realm of herbal skincare products.
Sonali Labhade, Smita Jain, Sohan Chitlange, Sarvesh Paliwal, and Swapnil Sharma
Elsevier BV
Sonali Dnyaneshwar Labhade, Swapnil Sharma, Sarvesh Paliwal, and Shivani Desai
College of Pharmacy University of Baghdad
In folk medicine there are various medicinal amalgamation possessing hepatoprotective activity. This activity is of significance because several toxins cause liver injury. Hence, many pharmaceutical companies are targeting herbal medicines for the treatment of liver abnormalities and towards evolving a safe and effective formulation with desired route of administration. In current review we have focused on the studies showing hepatoprotective effect using marine compounds and plant derived compounds. Liver disorder, a global health problem, usually include acute or chronic hepatitis, heptoses, and cirrhosis. It may be due to toxic chemicals and certain antibiotics. Uncontrolled consumption of alcohol also affects liver in an unhealthy way. To cure liver disorders several formulations of medicinal plants are being used. It is observed that hepatoprotective effect of plant is mostly due to flavonoids, alkaloids, terpenoids, steroids, and glycoside. A single drug cannot be useful for all the types of liver disorders. Several plant extracts for liver illness results from poisonous chemicals, viruses, extra alcohol consumption, and repeated administration of medication. By using standards of protection and efficacy, manufacture of plant products need to be ruled out. Current review provides an understanding of ethnopharmocology, toxicology of several medicinal plants manifesting hepatoprotective potential. Despite of varied database analysis new discoveries and their probabilities, evidences on viral hepatitis treatment or liver cirrhosis is inadequate. Further information about phytotherapy, toxicology, quality control studies shall be endorsed. Further in depth studies are required to discover quality trait like SAR, MOA, safety and toxicity and therapeutic potential of phytoconstituents in clinical settings.
RECENT SCHOLAR PUBLICATIONS
MOST CITED SCHOLAR PUBLICATIONS
Publications
Research Paper Entitled “Spectrophotmetric Determination and Validation of Glimeperide Concentration in Bulk and Dosage Form” In American Journal of Pharmatech Research, 2015; 5(3):208-13. (Impact Factor: 0.9832).
Research Paper entitled “Formulation and Evaluation of Carvedilol loaded Solid Lipid Nanoparticles” In International Journal of Scientific Progress &Research (IJSPR), 2015; 13(2): 74-78. (Impact factor:1.815)
Research Paper entitled “Development and Validation of RP-HPLC Method for Simultaneous Determination of Diclofenac Sodium and Tizanidine Hydrochloride in bulk and Tablet Formulation” In International Journal of Scientific Research in Science and Technology (IJSRST) 2018; 4(2) Page: 1413-1417.
Review article entitled “Biopolymer Conjugated Protein Based Hydrogel Scaffolds for Tissue Engineering Application” in International Journal of Pharmacy and Pharmaceutical Research, Jan 2020, 17(2) Page: 286-316.
10. N-butanol fraction of Decalepis hamiltonii root shows potential to possess antiproliferative activity and combat oxidative damage in European Chemical Bulletin 2023; 12(5) 3896-3923.
11. Development And Validation of Rp-Hplc Method For Assay of Fluticasone Furoate From Nasal Spray Formulation in European Chemical Bulletin 2023; (Special Issue 1) 2543-2555.
12. S. D. Labhade, S. Jain, S. S. Chitlange, S. Paliwal, S. Sharma, “Decalepis hamiltonii root fraction alleviates CCl4 hepatotoxicity in a rat model via inhibiting oxidative stress, proinflammatory cytokin
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
Patent on Synthesis of PROTAC derivatives as anticancer agents
Publication date: 09/08/2024