Sophie Beaubier

Verified @univ-lorraine.fr

University of Lorraine
Laboratoire Réaction et Génie des Procédés - LRGP (UMR CNRS 7274)

https://researchid.co/sophie.beaubier

RESEARCH INTERESTS

Bioprocesses
Plant proteins
Enzymatic transformation
Modelization and optimization of bioprocesses

Scopus Publications

220

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Study of the in vitro digestibility of oilseed protein concentrates compared to isolates for food applications
Sophie Beaubier, Sara Albe-Slabi, Luna Beau, Olivier Galet, and Romain Kapel
Elsevier BV

The role of extraction and purification conditions in flaxseed protein isolate production and its emulsifying properties
Sara Albe-Slabi, Odile Mesieres, Sophie Beaubier, Luna Beau, Arnaud Aymes, Thibault Roques-Carmes, Véronique Sadtler, and Romain Kapel
Elsevier BV

Chelating peptides from rapeseed meal protein hydrolysates: identification and evaluation of their capacity to inhibit lipid oxidation
Sophie Beaubier, Erwann Durand, Charles Lenclume, Frédéric Fine, Arnaud Aymes, Xavier Framboisier, Romain Kapel, and Pierre Villeneuve
Elsevier BV

Improving the in vitro digestibility of rapeseed albumins resistant to gastrointestinal proteolysis while preserving the functional properties using enzymatic hydrolysis
Sophie Beaubier, Carlos Pineda-Vadillo, Odile Mesieres, Xavier Framboisier, Olivier Galet, and Romain Kapel
Elsevier BV

Optimization of Selective Hydrolysis of Cruciferins for Production of Potent Mineral Chelating Peptides and Napins Purification to Valorize Total Rapeseed Meal Proteins
Nastassia Kaugarenia, Sophie Beaubier, Erwann Durand, Arnaud Aymes, Pierre Villeneuve, François Lesage, and Romain Kapel
MDPI AG
Preventing oxidation and microbial spoilage are both major concerns in food industries. In this context, this study aimed to valorize the total rapeseed meal proteins with controlled enzymatic proteolysis to generate potent mineral-chelating peptides from cruciferins while keeping intact the antimicrobial napins. Implementation of proteolysis of total rapeseed protein isolate with the Prolyve® enzyme highlighted an interesting selective hydrolysis of the cruciferins. Hence, the mechanism of this particular hydrolysis was investigated through a Design of Experiments method to obtain a model for the prediction of kinetics (cruciferin degradation and napin purity) according to the operating conditions applied. Then, multicriteria optimization was implemented to maximize the napin purity and yield while minimizing both enzymatic cost and reaction time. Antioxidant assays of the peptide fraction obtained under the optimal conditions proved the high metal-chelating activity preservation (EC50 = 247 ± 27 µg) for more than three times faster production. This fraction might counteract lipid oxidation or serve as preventing agents for micronutrient deficiencies, and the resulting purified napins may have applications in food safety against microbial contamination. These results can greatly help the development of rapeseed meal applications in food industries.

Multiobjective decision making strategy for selective albumin extraction from a rapeseed cold-pressed meal based on Rough Set approach
Sophie Beaubier, Claire Defaix, Sara Albe-Slabi, Arnaud Aymes, Olivier Galet, Frantz Fournier, and Romain Kapel
Elsevier BV

Using the dual isotope method to assess cecal amino acid absorption of goat whey protein in rats, a pilot study
Juliane Calvez, Nadezda Khodorova, Sophie Beaubier, Alexandra Eymard, Daniel Tomé, and Claire Gaudichon
Springer Science and Business Media LLC

Selective extraction of napins: Process optimization and impact on structural and functional properties
Sara Albe-Slabi, Claire Defaix, Sophie Beaubier, Olivier Galet, and Romain Kapel
Elsevier BV

High Metal Chelating Properties from Rapeseed Meal Proteins to Counteract Lipid Oxidation in Foods: Controlled Proteolysis and Characterization
Erwann Durand, Sophie Beaubier, Frederic Fine, Pierre Villeneuve, and Romain Kapel
Wiley

A rational approach for the production of highly soluble and functional sunflower protein hydrolysates
Sophie Beaubier, Sara Albe-Slabi, Arnaud Aymes, Marine Bianeis, Olivier Galet, and Romain Kapel
MDPI AG
Exploitation of plant proteins as an alternative to animal proteins currently presents an important challenge for food industries. In this contribution, total sunflower protein isolate from cold press meal was used as a starting material for the generation of highly soluble and functional hydrolysates that could be used in various food formulations. To do this, a rational and complete approach of controlled hydrolysis was implemented using the individual Alcalase and Prolyve enzymes. The method of stopping the hydrolysis reaction was also evaluated. The influence of operating conditions on hydrolysis kinetics and enzymatic mechanism was studied to identify the appropriate hydrolysis conditions. The gain of the solubility was then analyzed and compared to that of the initial proteins. Finally, the emulsifying and foaming properties (capacities and stabilities) of the resulting hydrolysates were also assessed. As a result, controlled enzymatic proteolysis significantly improved the sunflower protein solubility at neutral pH (twofold increase) and generated highly soluble hydrolysates. The limited proteolysis also maintained the good foam capacities and allowed an improvement in the initial foam stabilities and emulsifying capacities and stabilities of sunflower proteins. This contribution can greatly increase the value of sunflower meal and help in the development of sunflower protein products in the future.

Ultrafiltration fractionation of bovine hemoglobin hydrolysates: Prediction of separation performances for optimal enrichment in antimicrobial peptide
Sophie Beaubier, Rémi Przybylski, Alice Bodin, Naïma Nedjar, Pascal Dhulster, and Romain Kapel
MDPI AG
Hydrolysis of bovine hemoglobin (bHb), the main constituent of bovine cruor by-product, releases a natural antimicrobial peptide (NKT) which could present a major interest for food safety. To enrich this, tangential ultrafiltration can be implemented, but ultrafiltration conditions are mainly empirically established. In this context, the application of a simulation method for predicting the NKT yield and enrichment was investigated. Ultrafiltration performances were studied for decolored bHb hydrolysates at different degrees of hydrolysis (DH; 3%, 5%, 10% and 18%) and colored hydrolysates (3% and 5% DH) with 1 and 3 kg·mol−1 regenerated cellulose membranes. The simulation method helped to identify the most promising hydrolysate (in terms of NKT enrichment, yield and productivity) as the 3% DH colored hydrolysate, and UF conditions (volumetric reduction factor of 5 and 3 with 1 and 3 kg·mol−1 membrane, respectively) for higher antimicrobial recovery. A maximal enrichment factor of about 29 and NKT purity of 70% in permeate were observed. The results showed that the antimicrobial activity was in relation with the process selectivity and NKT purity. Finally, this reliable method, applied for predicting the ultrafiltration performances to enrich peptides of interest, is part of a global approach to rationally valorize protein resources from various by-products.

A new approach for modelling and optimizing batch enzymatic proteolysis
Sophie Beaubier, Xavier Framboisier, Frantz Fournier, Olivier Galet, and Romain Kapel
Elsevier BV

Production and antioxidant capacity of bioactive peptides from plant biomass to counteract lipid oxidation
Erwann Durand, Sophie Beaubier, Isidora Ilic, Frederic fine, Romain Kapel, and Pierre Villeneuve
Elsevier BV

Simultaneous quantification of the degree of hydrolysis, protein conversion rate and mean molar weight of peptides released in the course of enzymatic proteolysis
Sophie Beaubier, Xavier Framboisier, Irina Ioannou, Olivier Galet, and Romain Kapel
Elsevier BV

RECENT SCHOLAR PUBLICATIONS

Study of the in vitro digestibility of oilseed protein concentrates compared to isolates for food applications
S Beaubier, S Albe-Slabi, L Beau, O Galet, R Kapel
Food Chemistry 464, 141737 2025

The role of extraction and purification conditions in flaxseed protein isolate production and its emulsifying properties
S Albe-Slabi, O Mesieres, S Beaubier, L Beau, A Aymes, ...
LWT 215, 117170 2025

Chelating peptides from rapeseed meal protein hydrolysates: identification and evaluation of their capacity to inhibit lipid oxidation
S Beaubier, E Durand, C Lenclume, F Fine, A Aymes, X Framboisier, ...
Food Chemistry 422, 136187 2023

Improving the in vitro digestibility of rapeseed albumins resistant to gastrointestinal proteolysis while preserving the functional properties using enzymatic hydrolysis
S Beaubier, C Pineda-Vadillo, O Mesieres, X Framboisier, O Galet, ...
Food Chemistry 407, 135132 2023

Optimization of selective hydrolysis of cruciferins for production of potent mineral chelating peptides and napins purification to valorize total rapeseed meal proteins
N Kaugarenia, S Beaubier, E Durand, A Aymes, P Villeneuve, F Lesage, ...
Foods 11 (17), 2618 2022

Using the dual isotope method to assess cecal amino acid absorption of goat whey protein in rats, a pilot study
J Calvez, N Khodorova, S Beaubier, A Eymard, D Tom, C Gaudichon
Amino Acids 54 (5), 811-821 2022

Multiobjective decision making strategy for selective albumin extraction from a rapeseed cold-pressed meal based on Rough Set approach
S Beaubier, C Defaix, S Albe-Slabi, A Aymes, O Galet, F Fournier, ...
Food and Bioproducts Processing 133, 34-44 2022

Antioxidant chelating peptides production from Rapeseed meal proteins proteolysis
E Durand, P Villeneuve, N Kaugarenia, N Barouh, R Kapel
2022

Optimization of potent mineral chelating peptides production from rapeseed meal proteins proteolysis and peptide characterizations
N Kaugarenia, S Beaubier, E Durand, F Lesage, X Framboisier, A Aymes, ...
2022

Selective extraction of napins: Process optimization and impact on structural and functional properties
S Albe-Slabi, C Defaix, S Beaubier, O Galet, R Kapel
Food Hydrocolloids 122, 107105 2022

Study of Linseed Protein Extraction and Purification: Impact of Process Conditions on Protein Functional and Structural Properties.
SA Slabi, S Beaubier, M Ndiaye, O Galet, R Kapel
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY 98, 100-100 2021

High metal chelating properties from rapeseed meal proteins to counteract lipid oxidation in foods: controlled proteolysis and characterization
E Durand, S Beaubier, F Fine, P Villeneuve, R Kapel
European Journal of Lipid Science and Technology 123 (6), 2000380 2021

A rational approach for the production of highly soluble and functional sunflower protein hydrolysates
S Beaubier, S Albe-Slabi, A Aymes, M Bianeis, O Galet, R Kapel
Foods 10 (3), 664 2021

A new approach for modelling and optimizing batch enzymatic proteolysis
S Beaubier, X Framboisier, F Fournier, O Galet, R Kapel
Chemical Engineering Journal 405, 126871 2021

Ultrafiltration fractionation of bovine hemoglobin hydrolysates: prediction of separation performances for optimal enrichment in antimicrobial peptide
S Beaubier, R Przybylski, A Bodin, N Nedjar, P Dhulster, R Kapel
Membranes 11 (2), 73 2021

Production and antioxidant capacity of bioactive peptides from plant biomass to counteract lipid oxidation
E Durand, S Beaubier, I Ilic, R Kapel, P Villeneuve
Current Research in Food Science 4, 365-397 2021

A Rational Approach for the Production of Highly Soluble and Functional Sunflower Protein Hydrolysates. Foods 2021, 10, 664
S Beaubier, S Albe-Slabi, A Aymes, M Biaines, O Galet, R Kapel
s Note: MDPI stays neutral with regard to jurisdictional claims in published 2021

Simultaneous quantification of the degree of hydrolysis, protein conversion rate and mean molar weight of peptides released in the course of enzymatic proteolysis
S Beaubier, X Framboisier, I Ioannou, O Galet, R Kapel
Journal of Chromatography B 1105, 1-9 2019

fine, F., Kapel, R., & Villeneuve, P.(2021). Production and antioxidant capacity of bioactive peptides from plant biomass to counteract lipid oxidation
E Durand, S Beaubier, I Ilic
Current Research in Food Science 4, 365-397

Exploring the in Vitro Digestibility of Oilseed Protein Concentrates Compared to Isolates for Food Applications
S Beaubier, S Albe-Slabi, L Beau, O Galet, R Kapel
Available at SSRN 4937624

MOST CITED SCHOLAR PUBLICATIONS

Improving the in vitro digestibility of rapeseed albumins resistant to gastrointestinal proteolysis while preserving the functional properties using enzymatic hydrolysis
S Beaubier, C Pineda-Vadillo, O Mesieres, X Framboisier, O Galet, ...
Food Chemistry 407, 135132 2023
Citations: 22

A new approach for modelling and optimizing batch enzymatic proteolysis
S Beaubier, X Framboisier, F Fournier, O Galet, R Kapel
Chemical Engineering Journal 405, 126871 2021
Citations: 17

A rational approach for the production of highly soluble and functional sunflower protein hydrolysates
S Beaubier, S Albe-Slabi, A Aymes, M Bianeis, O Galet, R Kapel
Foods 10 (3), 664 2021
Citations: 16

Selective extraction of napins: Process optimization and impact on structural and functional properties
S Albe-Slabi, C Defaix, S Beaubier, O Galet, R Kapel
Food Hydrocolloids 122, 107105 2022
Citations: 15