Sriwidodo Sriwidodo

Scopus Publications

Strategies to Improve the Oxidative Stability and Shelf Life of Sacha Inchi oil in Pharmaceutical Applications
Nur Aisyah, Feggy Yustika Sitinjak, Sriwidodo, Patihul Husni
Applied Food Research, 2026
Sacha Inchi (Plukenetia volubilis L.) oil, abundant in polyunsaturated fatty acids (PUFAs), presents significant nutritional and therapeutic promise for traditional formulations; yet, it is highly susceptible to oxidation, compromising its stability and reducing shelf life. Diverse modification approaches, including encapsulation, co-microencapsulation (especially with natural antioxidants), and nanoemulsions, have demonstrated substantial improvements in oxidative stability and shelf life relative to conventional systems. Techniques for preparation, including spray drying, freeze-drying, ultrasonic emulsification, and high-pressure homogenization, along with optimization through Response Surface Methodology (RSM), provide stringent control of essential parameters to improve quality, safety, and performance. This study consolidates recent advancements in techniques for Sacha Inchi oil and delineates future potential for safer and more effective solutions.
Chitosan-based microparticulate systems to enhance the bioavailability of natural products: Mechanistic insights and pharmaceutical applications
Patonah Hasimun, Cecep Suhandi, Elis Susilawati, Dolih Gozali, Rahmat Santoso, Taofik Rusdiana, Diki Prayugo Wibowo, Sriwidodo Sriwidodo
Carbohydrate Polymer Technologies and Applications, 2026
Chitosan-based microencapsulation systems are emerging as promising, biocompatible carriers designed to overcome major pharmacokinetic limitations of natural therapeutic agents. Many phytochemicals exhibit poor water solubility, rapid degradation, and low intestinal absorption. As a biodegradable and mucoadhesive biopolymer, chitosan offers distinct advantages by controlling drug release, protecting compounds from enzymatic breakdown, and enhancing passive absorption through the paracellular pathway. These properties make chitosan suitable for delivering diverse bioactive molecules, including alkaloids, phenolics, and botanical extracts. This review examines the fundamental mechanisms and therapeutic significance of chitosan-based microstructures (microspheres and microcapsules) for transporting natural compounds. Key formulation parameters—such as molecular weight, degree of cross-linking, and microparticle size—are evaluated for their impact on drug loading and release behavior. Evidence shows that chitosan microencapsulation enhances therapeutic outcomes in various applications, including cancer therapy, gastrointestinal disorders, orthopedic regeneration, and tissue repair. The review also discusses advanced strategies, including surface functionalization and hybrid composite systems, developed to further improve chitosan’s performance. Despite substantial progress, clinical translation remains hindered by variability in material quality and regulatory constraints. Addressing these challenges through standardized characterization methods and scalable manufacturing approaches is essential for advancing chitosan microcarriers into clinically viable platforms for natural product therapeutics.
Recent advances in lipid nanoparticles for cancer vaccine delivery: Challenges and future perspectives
Nurhasni Hasan, Maryam Aftab, Sania Ikram, Apon Zaenal Mustofa, Sriwidodo Sriwidodo, Huda Shalahudin Darusman, Muhammad Nur Amir, Theofilus A. Tockary, Satoshi Uchida
International Journal of Pharmaceutics X, 2026
Cancer remains a major global health burden, with 19.3 million new cases and 10.3 million deaths reported in 2020. Conventional modalities such as surgery, radiotherapy, and chemotherapy often fail to prevent metastasis or recurrence. Cancer vaccination, which mobilizes durable, tumor-specific immunity, has gained traction, and LNPs have become pivotal to this approach. Originally optimized for siRNA, LNPs' core-shell architecture protects nucleic acids, enhances cellular uptake, and enables efficient cytosolic delivery. Their clinical validation in infectious-disease messenger RNA (mRNA) vaccines has catalyzed rapid progress toward oncology applications. Preclinical and early-phase trials have indicated that mRNA-LNPs encoding tumor-associated antigens or patient-specific neoantigens can expand cytotoxic T cells and elicit preliminary antitumor activity. Key barriers remain. Manufacturing cost and batch consistency challenge scale-up. Physicochemical instability necessitates cold-chain logistics and complicates global deployment. Reactogenicity and anti-PEG antibodies increase safety and dosing concerns. Within tumors, immunosuppressive microenvironments, heterogeneous antigen expression, and suboptimal lymphoid targeting limit the efficacy of vaccines. This review describes the advances in LNP design (ionizable and biodegradable lipids, PEG alternatives, ligand-mediated targeting), formulation strategies (thermostable and lyophilized systems), and delivery routes (intranodal and intratumoral) to overcome these bottlenecks. It also highlights synergistic combinations with checkpoint blockade, radiotherapy, and innate agonists, and examines emerging pipelines leveraging AI-guided neoantigen discovery and quality control. By integrating material engineering, immunology, and translational evidence, we identified failure points and proposed a roadmap for next-generation LNP-based cancer vaccines. The goal is to accelerate progress from bench to clinic, while improving manufacturability, access, and durable patient benefits.
In silico based exploration of natural and synthetic antidiabetic compounds: A comprehensive review of computational approaches
Ahmad Fariz Maulana, Sriwidodo Sriwidodo, Iman Permana Maksum, Yaya Rukayadi
Admet and Dmpk, 2026
Background and purpose: Diabetes mellitus type 2 is a global health issue marked by hyperglycemia and metabolic dysfunction. Despite progress, discovering safe and effective antidiabetic agents remains crucial. This review highlights integrated In Silico, In Vitro, and in vivo methods for identifying novel antidiabetic compounds from natural and synthetic origins. Experimental approach: Computational tools including molecular docking, molecular dynamics, and ADMET prediction identified inhibitors targeting DPP-IV, α-glucosidase, and PPAR. Promising compounds underwent in vitro enzymatic and cellular assays, followed by in vivo efficacy tests in diabetic animal models assessing glucose levels, biochemical markers, and tissue histopathology. Key results: Integrated computational and experimental approaches effectively pinpointed compounds with strong target binding, enzyme inhibition, and positive cellular effects. In vivo data showed significant glucose reduction, enhanced insulin response, and pancreatic protection. ADMET analysis further supported their drug-likeness and safety profiles. Conclusion: Combining computational screening with biological validations forms a cost-effective pipeline for antidiabetic drug discovery. Multi-disciplinary integration increases lead identification success, guiding future refinement of in silico models and expanded in vivo studies to accelerate novel diabetes therapeutic development.
Development of Amorphous Solid Dispersion to Improve the Dissolution and Antiproliferative Activity of Brazilin
Deby Tristiyanti, Sriwidodo Sriwidodo, Syarif Hamdani, Isti Daruwati, Arif Budiman
Drug Design Development and Therapy, 2026
Introduction: Brazilin (BRZ), a major bioactive constituent of Caesalpinia sappan , exhibits promising anticancer activity but suffers from extremely poor aqueous solubility, limiting its oral bioavailability and therapeutic efficacy. Drug solubility is a critical determinant of absorption and therapeutic efficacy, so strategies to enhance the solubility of BRZ are essential. Amorphous solid dispersions (ASDs) have been widely employed to enhance the solubility and dissolution behavior of poorly soluble compounds. This study aimed to develop and characterize ASDs of BRZ using polyvinylpyrrolidone (PVP) as a polymer carrier, to investigate molecular interactions through in silico docking, and to evaluate their physicochemical properties, dissolution behavior, physical stability, and antiproliferative activity. Methods: ASDs of BRZ with PVP were prepared using the solvent evaporation method with drug-to-polymer weight ratios of 1:1, 1:3, and 1:5. The formulations were characterized using powder X-ray diffraction (PXRD), differential scanning calorimetry (DSC), and Fourier-transform infrared (FT-IR) spectroscopy. Solubility, in vitro dissolution, and antiproliferative activity against DU145 prostate cancer cells were evaluated. Physical stability was evaluated over 30 days under dry (25 °C/0% RH) and humid (25 °C/90% RH) storage conditions using PXRD to detect any possible recrystallization. Results: PXRD and DSC analyses confirmed the complete amorphization of BRZ within the ASD matrix, as evidenced by the disappearance of crystalline diffraction peaks and characteristic melting endotherms. FT-IR spectroscopy, supported by in silico studies, revealed hydrogen bond formation between the hydroxyl group of BRZ and the carbonyl group of PVP. The BRZ:PVP (1:5) formulation achieved a 5.7-fold increase in solubility compared to crystalline BRZ. Dissolution testing showed a characteristic spring-and-parachute profile, with ASDs maintaining supersaturation for a prolonged period. Moreover, enhanced antiproliferative activity against DU145 cells was observed for BRZ ASDs, with the lowest IC 5 0 value of 14.02 μg/mL at a 1:5 ratio, compared to 20.12 μg/mL for crystalline BRZ. Stability testing showed that all ASDs maintained their amorphous form under dry storage conditions for 30 days, whereas samples stored at 90% relative humidity exhibited recrystallization. Conclusion: BRZ ASDs using PVP effectively improved solubility, dissolution profile, and antiproliferative activity. The formulations demonstrated good stability under dry storage conditions but were sensitive to high humidity. These findings suggest that ASDs represent a promising strategy for enhancing the therapeutic potential of poorly soluble natural anticancer compounds. Keywords: brazilin, amorphous solid dispersion, polyvinylpyrrolidone, dissolution, antiproliferative effects
Natural Bioactive-Based Advanced Wound Dressings for Diabetic Wound Healing: A Systematic Review of Emerging Biomaterial Platforms
Andhi Fahrurroji, Cecep Suhandi, Anis Chaerunisaa, Liza Pratiwi, Sriwidodo Sriwidodo
International Journal of Nanomedicine, 2026
Background: Diabetic ulcers are complex wounds that are difficult to treat due to persistent inflammation, excessive oxidative stress, impaired angiogenesis, and microbial infections that disrupt normal healing. Advanced wound dressings such as hydrogels, nanofibre matrices, hydrocolloids, and 3D bioprinted constructs are increasingly developed to incorporate natural bioactive compounds with multifunctional therapeutic properties. However, systematic understanding of their mechanisms and translational relevance remains limited. Objective: This study aims to systematically review natural-based hydrogel, hydrocolloid, and hydrofiber formulations in diabetic wound healing. Methods: A Systematic Literature Review following PRISMA guidelines was conducted using ScienceDirect, SpringerLink, PubMed, and Scopus (2020-2025). Risk of bias was assessed using SYRCLE's tool. Results: From 5256 initial records, 4412 articles were screened, and 14 studies were included after applying eligibility criteria. These studies examined advanced dressings such as hydrogels, hydrocolloids, nanofibers, 3D bioprinted constructs, and hybrid nanocomposites incorporating natural bioactive compounds. The formulations demonstrated antimicrobial, anti-inflammatory, antioxidant, pro-angiogenic, and re-epithelialization effects. Common compounds included curcumin, berberine, propolis, bee venom, and plant extracts combined with polymers such as chitosan, alginate, hyaluronic acid, collagen, and GelMA. Advanced fabrication improved drug delivery, physicochemical properties, and healing outcomes. At the molecular level, these systems modulated pathways such as NF-κB, PI3K/Akt, MAPK, VEGF, and TGF-β/Smad, contributing to reduced inflammation, oxidative stress suppression, enhanced angiogenesis, and extracellular matrix remodeling. Risk of bias assessment indicated unclear risks in randomization and blinding, although internal validity was generally acceptable Translational readiness remained limited (TRL 2-6), with hydrogels and nanosystems showing the highest potential, while 3D bioprinting faces scalability and regulatory challenges. Conclusion: Natural-based advanced dressings offer a promising strategy for diabetic wound management. Successful clinical translation requires alignment with scalability, stability, cost-effectiveness, and regulatory compliance. Future research should prioritize standardized preclinical models, controlled release systems, and scalable, regulation-compliant biomaterial designs to accelerate clinical application.
Design Evolution of Curcumin-Loaded Nanostructured Lipid Carriers: Formulation Strategies, Functional Modifications, and Mechanistic–Translational Perspectives
Ikra Nurohman, Cecep Suhandi, Anis Chaerunisaa, Gofarana Wilar, Garnadi Jafar, Sriwidodo Sriwidodo
International Journal of Nanomedicine, 2026
Curcumin possesses broad therapeutic potential but remains severely limited by poor solubility, instability, and low systemic bioavailability. Nanostructured lipid carriers (NLCs) have emerged as an advanced lipid-based delivery platform capable of overcoming these constraints through optimized lipid organization, high drug-loading capacity, and tunable surface functionality. This review provides a comprehensive examination of the design evolution of curcumin-loaded NLCs (Cur-NLCs), encompassing core components, formulation strategies, preparation techniques, and quality determinants that govern physicochemical and biological performance. Evidence-based classification of formulation approaches is presented, highlighting single-drug, co-loaded, and surface-modified or functionally engineered NLC systems and their respective therapeutic advantages. Mechanistic insights are discussed to elucidate how NLCs enhance curcumin's stability, absorption, intracellular trafficking, and controlled release. Current challenges, including formulation heterogeneity, scalability, long-term stability, and translational readiness, are critically evaluated, alongside emerging clinical observations from engineered NLCs that further underscore their translational relevance. From a translational standpoint, the review identifies NLC designs based on pharmaceutically accepted lipids, scalable preparation methods, and minimal surface complexity as the most feasible candidates for near-term clinical development, while more elaborate multifunctional or ligand-modified systems are discussed as promising but longer-term strategies. However, the progress outlined in this review highlights NLCs as a highly adaptable platform capable of unlocking curcumin's full pharmacological potential and accelerating its pathway toward therapeutic applicability.
Sacha Inchi Oil–Based Nanostructured Lipid Carriers for Curcumin Delivery: Development and Physicochemical Characterization
Ikra Nurohman, Anis Chaerunisaa, Gofarana Wilar, Garnadi Jafar, Cecep Suhandi, Sriwidodo Sriwidodo
Nanotechnology Science and Applications, 2026
Background and Objective: Curcumin exhibits potent antioxidant activity beneficial for the prevention of various degenerative diseases; however, its highly lipophilic nature and susceptibility to degradation limit its solubility and physicochemical stability. To address these limitations, curcumin was formulated into nanostructured lipid carriers (NLCs), a lipid-based colloidal delivery system composed of solid and liquid lipids stabilized by surfactants. In this study, sacha inchi oil, a natural oil rich in omega-3 and other unsaturated fatty acids, was investigated as a novel liquid lipid component to improve lipid matrix structure and drug accommodation. Methods: Curcumin-loaded NLCs were prepared using the hot homogenization method followed by probe sonication. Curcumin served as the active compound, while solid lipids (oleum cacao, glyceryl behenate (Compritol ® 888 ATO), or glyceryl palmitostearate (Precirol ® ATO 5)), sacha inchi oil as the liquid lipid, and surfactants (Tween 80, Poloxamer, or a Tween 80–Span 80 combination) were used. The resulting NLCs were characterized in terms of particle size, polydispersity index (PDI), zeta potential (ZP), entrapment efficiency (EE), physicochemical properties (FTIR, DSC, XRD), morphology, and in vitro release behavior. Results: Physicochemical analyses confirmed successful incorporation of curcumin into the lipid matrix without undesirable interactions. Among the tested formulations, CaTS2 (oleum cacao 4.5%, sacha inchi oil 1%, Tween 80 12.5%, Span 80 1%, and curcumin 0.1%) demonstrated the most favorable characteristics, with a particle size of 95.50 ± 0.87 nm, PDI of 0.119 ± 0.157, and ZP of − 22.30 ± 0.98 mV. Entrapment efficiency reached 97.24% and morphological analysis showed predominantly spherical particles. In vitro release exhibited a biphasic pattern, consisting of an initial burst followed by sustained release up to 480 min. Kinetic modeling revealed that CaTS2 followed the Korsmeyer–Peppas model ( R2 = 0.793; n = 0.301), consistent with Fickian diffusion, whereas pure curcumin followed the Higuchi model ( R2 = 0.819). The similarity factor (f 2 = 29.04) indicated a distinctly different release profile between the two systems. Conclusion: Sacha inchi oil–based nanostructured lipid carriers were successfully developed and demonstrated favorable physicochemical characteristics, supporting their potential as a stable delivery system for curcumin. Keywords: curcumin, nanostructured lipid carriers, sacha inchi oil, drug delivery, lipid-based nanoparticle
Study of various forms of propolis nanoparticles and their antibacterial effectiveness
Ammar Fadhil, Sriwidodo, Khaled M. Elamin, Ahmed Fouad Abdelwahab Mohammed, Safwat A Mahmoud, Nasrul Wathoni
Opennano, 2026
Most bacteria are beneficial to human health, but some have pathogenic properties. Pathogenic bacteria cause diseases in the host by directly damaging tissues or cells during replication via toxin production. Propolis nanoparticles is a method that has the potential to be an effective antibacterial. Advantages of using nanotechnology include boosting the drug delivery system and absorption of active herbal medicine substances, which have poor bioavailability owing to their high molecular weight, improved solubility, rapid penetration with low cytotoxicity, reduced drug dosage, and fewer side effects. This study reviews the literature on the effectiveness of propolis in various forms of nanoparticle technology as an antibacterial agent, which may help researchers to develop nanoparticle technology in the pharmaceutical industry. We conducted this research using search engines, including Scopus, PubMed, and ScienceDirect, with the keywords " Nanoparticles,”" Propolis,”and "Antibacterial,” without limiting the year of publication. We conducted a search between April and June 2025. They related the reviewed articles to knowledge of nanoparticle use. Propolis is a natural resinous substance produced by honeybees in various forms. These parameters were used to extract 1699 articles, which were reviewed and examined. The study identified eight types of propolis nanoparticles with antibacterial properties: nanoemulsions, nanostructured lipid carriers (NLC), nanosheets, metal nanoparticles, chitosan nanoparticles, nanoencapsulation, solid lipid nanoparticles (SLN), and polymer nanoparticles. The effectiveness of antibacterial propolis nanoparticles varies agents. The metallic form of propolis nanoparticles is the most effective nanoparticles. Metallic propolis nanoparticles can inhibit 19 types of bacteria and can be applied in eight different forms.
Antistunting potential of deepsea water concentrate as multivitamin granules: stability and in vivo activity study
Barmi Hartesi, Bambang Retnoaji, Sriwidodo Sriwidodo, Yoga Windhu Wardhana, Muhaimin Muhaimin, Mayang Kusuma Dewi, Sjaikhurrizal El Muttaqien, Anis Yohana Chaerunisaa
Scientific Reports, 2025
Stunting in children is caused by severely inadequate nutrients; therefore, balanced nutritious foods such as multivitamins is the most promising alternative interventions. Concentrated deep seawater is rich in minerals, thus provide potent multivitamin sources. The hygroscopic nature of minerals makes them prone to moisture. Consequently, the fabrication of a non-hygroscopic dosage form and the study on its potential for stunting conditions are highly needed. The concentrate was encapsulated into granules by using different fillers with Florite as desiccant. Physicochemical evaluations were conducted using Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Scanning Electron Microscopy (SEM). An in vivo anti-stunting study was performed using zebrafish as an animal model. The results indicated that encapsulation using Avicel PH 102 as filler, either with or without addition of Florite 10%, provided good stability after 5 months of storage. Antistunting activity test showed that, after induction by rotenone, treatments with deep seawater either in form of concentrate water or granule improved the stunted condition of the zebra fish embryos shown as the improvement in the hatching rate, brain length, and body length. Deep seawater concentrate was successfully formulated into granules which provided moisture protection of its highly hygroscopic nature as well as antistunting activity.
Bee venom in pharmacology: Mechanistic insights from pro-inflammatory trigger to anti-inflammatory therapeutic agent
Sriwidodo Sriwidodo, Cecep Suhandi, Gofarana Wilar, Nasrul Wathoni
Biomedicine and Pharmacotherapy, 2025
Downregulation of Cyclin-D, Wnt3a, and C-Myc in prostate cancer by dose-dependent combination of concentrated marine minerals and curcumin
Syafika Alaydrus, Sriwidodo Sriwidodo, Ajeng Diantini, Riezki Amalia, Wahyuni Wahyuni, Ayu Wulandari
Journal of Applied Pharmaceutical Science, 2025
Standardisation of Fermented Uncaria nervosa Bark Extract as an Anti-Acne Gel Preparation
Maria Almeida, Angga C Narsa, Kusuma, Sriwidodo
Tropical Journal of Natural Product Research, 2025
Antioxidant and Photoprotective Activity of Bromelain Cream: An In Vitro and In Vivo Study
Zahra Marissa, Soraya Ratnawulan Mita, Cahya Khairani Kusumawulan, Sriwidodo Sriwidodo
Cosmetics, 2025
Catechins as Antimicrobial Agents and Their Contribution to Cosmetics
Soraya Ratnawulan Mita, Nurul Inaya Muhtar, Sri Agung Fitri Kusuma, Sriwidodo Sriwidodo, Ryan Proxy Hendrawan
Cosmetics, 2025
Potential of Natural-Based Sun Protection Factor (SPF): A Systematic Review of Curcumin as Sunscreen
Ayunda Myela Shabrina, Raden Siti Salma Azzahra, Ivana Nathania Permata, Humaira Praswatika Dewi, Ratnadani Amalia Safitri, Ira Maya, Rizqa Nurul Aulia, Sriwidodo Sriwidodo, Soraya Ratnawulan Mita, Eri Amalia, Norisca Aliza Putriana
Cosmetics, 2025
Complexed hyaluronic acid-based nanoparticles in cancer therapy and diagnosis: Research trends by natural language processing
Abd Kakhar Umar, Patanachai K. Limpikirati, Bachtiar Rivai, Ilham Ardiansah, Sriwidodo Sriwidodo, Jittima Amie Luckanagul
Heliyon, 2025
Pharmacokinetics and Toxicity Overview of Active Compounds Berberine, Palmatine, and Jatrorrhizine From Fibraurea tinctoria Lour: Drug-Likeness, ADMET Prediction, and In Vivo Extract Toxicity Assessment
Indah Purwaningsih, Iman Permana Maksum, Dadan Sumiarsa, Sriwidodo Sriwidodo
Journal of Toxicology, 2025
Sacha Inchi (Plukenetia volubilis): Potential Bioactivity, Extraction Methods, and Microencapsulation Techniques
Sarah Gustia Redjeki, Alfa Fildzah Hulwana, Rizqa Nurul Aulia, Ira Maya, Anis Yohana Chaerunisaa, Sriwidodo Sriwidodo
Molecules, 2025
Characteristics of soybean (Glycine max) protein hydrolysate by bromelain and its effect on inflammation and kidney disorders in gentamicin-induced male Wistar rats
Meilinah Hidayat, Amirah Barnas, Virginia Nussy, Timothy Wantania, Sijani Prahastuti, et al.
Iranian Journal of Basic Medical Sciences, 2025
Formulation and Evaluation of Facial Serum Containing Sacha Inchi Oil (Plukenetia volubilis L.) from Indonesia as an Anti-Aging: Stability, In Vitro, and Skin Irritation Assessments
Ira Maya, Sriwidodo Sriwidodo, Soraya Ratnawulan Mita, Cahya Khairani Kusumawulan, Norisca Aliza Putriana, Eri Amalia, Rizqa Nurul Aulia, Hadiyan Nur Sofyan, Fauzan Dzulfannazhir, Moh Hamdan Nugraha
Cosmetics, 2024
The effects of combined co-expression of groel/es and trigger factor chaperone towards Thermus thermophilus DNA polymerase enzyme expression on Escherichia coli BL21(DE3)
Iman Permana Maksum, Diandra Firdiani Utami, Sriwidodo Sriwidodo, Ryan Adibagus Haryanto, Riyona Desvy Pratiwi
Journal of Applied Pharmaceutical Science, 2024
Proposed molecular mechanism of non-competitive inhibition using molecular dynamics simulations between α-glucosidase enzyme and mangostin compound as antidiabetic
Ahmad Fariz Maulana, Iman Permana Maksum, Sriwidodo Sriwidodo, Yaya Rukayadi
Journal of Molecular Modeling, 2024
DEVELOPMENT OF MYCROCRYSTALLINE CELLULOSE ORIGINATE FROM SAGO (METROXYLON SAGU) STEM BARK BY HYDROLISIS METHODE USING NITRIC ACID
NUR ILLIYYIN AKIB, SRIWIDODO, ADRYAN FRISTIOHADY LUBIS, MERY DINA SYNTIA SAMANI, AHMAD FAHMI NUR, RINA ANDRIANI, ANIS YOHANA CHAERUNISAA
International Journal of Applied Pharmaceutics, 2024
Isolation and Quantification of Palmatine from Fibraurea tinctoria Lour: In Vitro Antioxidant Activity and In Silico Antidiabetic Activity Evaluation
Indah Purwaningsih, Iman Maksum, Dadan Sumiarsa, Sriwidodo Sriwidodo
Drug Design Development and Therapy, 2024
Characterisation of Physical Properties of Curcumin Isolated from Curcuma domestica Val
Deby Tristiyanti, Sriwidodo, Ari Budiman, Diki P. Wibowo
Tropical Journal of Natural Product Research, 2023
Physicochemical Characteristics, Fatty Acid Profile, and In Vitro Antioxidant Activity Evaluation of Sacha Inchi Seed Oil from Indonesia
Ira Maya, Devani Olivia Winardi, Eri Amalia, Soraya Ratnawulan Mita, Cahya Khairani Kusumawulan, Norisca Aliza Putriana, Sriwidodo Sriwidodo
Cosmetics, 2023
IMPROVEMENT OF SIMVASTATIN SOLUBILITY USING HPMCAS, LOCUST BEAN GUM, SODIUM ALGINATE AND TPGS AS A POLYMER WITH SOLID DISPERSION METHOD
IYAN SOPYAN, ZIRLY YUSRIANI KAMILAH, SANDRA MEGANTARA, SRIWIDODO
International Journal of Applied Pharmaceutics, 2023
Nanoparticle-Based Antioxidants in Stress Signaling and Programmed Cell Death in Breast Cancer Treatment
Yedi Herdiana, Sriwidodo Sriwidodo, Ferry Ferdiansyah Sofian, Gofarana Wilar, Ajeng Diantini
Molecules, 2023
Effect of Drug–Polymer Interaction in Amorphous Solid Dispersion on the Physical Stability and Dissolution of Drugs: The Case of Alpha-Mangostin
Arif Budiman, Neng Vera Nurani, Eli Laelasari, Muchtaridi Muchtaridi, Sriwidodo Sriwidodo, Diah Lia Aulifa
Polymers, 2023
Preparation and molecular interaction of organic solvent-free piperine pro-liposome from soy lecithin
Eri Amalia, Iyan Sopyan, Norisca Aliza Putriana, Sriwidodo Sriwidodo
Heliyon, 2023
Nano Delivery Chitosan-Protein/Hydrolysate of Green Peas Bromelain (PHGPB) Synthesized by Colloidal-Spray Drying Method
Meilinah Hidayat, Khomaini Hasan, Muhamad Yusuf, Sriwidodo Sriwidodo, Camellia Panatarani, I Made Joni
Polymers, 2023
Overview of refolding methods on misfolded recombinant proteins from Escherichia coli inclusion bodies
Ahmad Nabiel, Yosua Yosua, Sriwidodo Sriwidodo, Iman Permana Maksum
Journal of Applied Biology and Biotechnology, 2023
An Overview of Culture Conditions for Recombinant Protein Expression in Escherichia coli
Journal of Applied Biotechnology Reports, 2023
A Review of Fibraurea tinctoria and Its Component, Berberine, as an Antidiabetic and Antioxidant
Indah Purwaningsih, Iman Permana Maksum, Dadan Sumiarsa, Sriwidodo Sriwidodo
Molecules, 2023
OPTIMIZATION OF LACTOBACILLUS PLANTARUM FERMENTATION FOR ENHANCED PHENOLIC PRODUCTION FROM EXTRACT OF BAJAKAH BARK (UNCARIA NERVOSA) BY RESPONSE SURFACE METHODOLOGY
MARIA ALMEIDA, ANGGA CIPTA NARSA, SRI AGUNG FITRI KUSUMA, SRIWIDODO SRIWIDODO
International Journal of Applied Pharmaceutics, 2023
Structure-based computational screening of 470 natural quercetin derivatives for identification of SARS-CoV-2 Mpro inhibitor
Abd. Kakhar Umar, James H. Zothantluanga, Jittima Amie Luckanagul, Patanachai Limpikirati, Sriwidodo Sriwidodo
Peerj, 2023
In Silico Study of Mangostin Compounds and Its Derivatives as Inhibitors of α-Glucosidase Enzymes for Anti-Diabetic Studies
Ahmad Fariz Maulana, Sriwidodo Sriwidodo, Yaya Rukayadi, Iman Permana Maksum
Biology, 2022
STUDY ON INCREASING SOLUBILITY OF ISOLATES: METHODS AND ENHANCEMENT POLYMERS
FERIS DZAKY RIDWAN NAFIS, SRIWIDODO, ANIS YOHANA CHAERUNISAA
International Journal of Applied Pharmaceutics, 2022
Inhibition of Crystal Nucleation and Growth in Aqueous Drug Solutions: Impact of Different Polymers on the Supersaturation Profiles of Amorphous Drugs—The Case of Alpha-Mangostin
Arif Budiman, Zahra Ganesya Citraloka, Muchtaridi Muchtaridi, Sriwidodo Sriwidodo, Diah Lia Aulifa, Agus Rusdin
Pharmaceutics, 2022
The Impact of Water-Soluble Chitosan on the Inhibition of Crystal Nucleation of Alpha-Mangostin from Supersaturated Solutions
Arif Budiman, Nisrina Nurfadilah, Muchtaridi Muchtaridi, Sriwidodo Sriwidodo, Diah Lia Aulifa, Agus Rusdin
Polymers, 2022
A REVIEW ON HOW TO CHARACTERIZE AND EVALUATE THE OPHTHALMIC IN SITU GEL PREPARATIONS
INSAN SUNAN KURNIAWANSYAH, TAOFIK RUSDIANA, SRIWIDODO, IYAN SOPYAN
International Journal of Applied Pharmaceutics, 2022
Overexpression of soluble recombinant Thermus thermophilus (Tth) DNA polymerase in Escherichia coli BL21(DE3) using an MBP fusion tag as a solubility enhancer
I. Maksum, Dian Utami, Eva Annisa Nurhakim, Yosua, Sriwidodo, Muhammad Yusuf, M. Fadhlillah, Ryan Adibagus Haryanto
Journal of Applied Pharmaceutical Science, 2022
DESIGN-EXPERT SOFTWARE (DOE): AN APPLICATION TOOL FOR OPTIMIZATION IN PHARMACEUTICAL PREPARATIONS FORMULATION
IYAN SOPYAN, DOLIH GOZALI, SRIWIDODO, RIZKA KHOIRUNNISA GUNTINA
International Journal of Applied Pharmaceutics, 2022
Complexed Polymer Film-Forming Spray: An Optimal Delivery System for Secretome of Mesenchymal Stem Cell as Diabetic Wound Dressing?
Abd. Kakhar Umar, Jittima Amie Luckanagul, James H. Zothantluanga, Sriwidodo Sriwidodo
Pharmaceuticals, 2022
DEVELOPMENT OF CATHELICIDIN IN LIPOSOME CARRIER USING THIN LAYER HYDRATION METHOD
ANIS YOHANA CHAERUNISAA, MAYANG KUSUMA DEWI, SRIWIDODO, I. MADE JONI, REIVA FARAH DWIYANA
International Journal of Applied Pharmaceutics, 2022
Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability
Sriwidodo Sriwidodo, Reza Pratama, Abd. Kakhar Umar, Anis Yohana Chaerunisa, Afifah Tri Ambarwati, Nasrul Wathoni
Antioxidants, 2022
Refolding of bioactive human epidermal growth factor from E. coli BL21(DE3) inclusion bodies & evaluations on its in vitro & in vivo bioactivity
Iman Permana Maksum, Yosua Yosua, Ahmad Nabiel, Riyona Desvy Pratiwi, Sriwidodo Sriwidodo, Ukun M.S. Soedjanaatmadja
Heliyon, 2022
Liposome-polymer complex for drug delivery system and vaccine stabilization
Sriwidodo, Abd. Kakhar Umar, Nasrul Wathoni, James H. Zothantluanga, Sanjoy Das, Jittima Amie Luckanagul
Heliyon, 2022
The Future Prospective: Potential Magnesium and Calcium for Detracting Side Effect Cisplatin
Syafika Alaydrus, Ajeng Diantini, Riezki Amalia, Sriwidodo Sriwidodo, Anis Yohana Chaerunisa, Nasrul Wathoni
Research Journal of Pharmacy and Technology, 2022
Film-forming spray of water-soluble chitosan containing liposome-coated human epidermal growth factor for wound healing
Abd. Kakhar Umar, Sriwidodo Sriwidodo, Iman Permana Maksum, Nasrul Wathoni
Molecules, 2021
Characterization and acute oral toxicity of concentrated minerals of Pamekasan Madura seawater
S. Alaydrus, A. Umar, Sriwidodo Sriwidodo, A. Diantini, Nasrul Wathoni, Riezki Amalia
Journal of Advanced Pharmaceutical Technology and Research, 2021
Lyophilized autologous serum stabilized with sucrose promotes the proliferation and migration of keratinocyte
Maksum Iman Permana, Jubaedah Siti, Yosua Yosua, Melpin Rostina, Rondonowu Mervina, Enus Sutarya, Rachman Saadah Diana, Sriwidodo Sriwidodo, Subroto Toto
Journal of Applied Pharmaceutical Science, 2021
Active and non-active stations as an adaptive method for Objective Structured and Clinical Examination during the COVID-19 pandemic
Ida Musfiroh, Holis Abdul Holik, Raden Bayu Indradi, Sriwidodo Sriwidodo
Pharmacy Education, 2021
Potential Combination of Bittern Water with Vitamin B Complex for Mineral Deficiency Therapy in Cattle: A Literature Study
Ega Megawati, Sriwidodo Bardi, Iwan Setyabudi
Jurnal Medik Veteriner, 2021
Expression of human epidermal growth factor using Ssp DnaB mini-intein as fusion partner in Escherichia coli BL21(DE3)
Yosua Yosua, Melati Rima, Sriwidodo Sriwidodo, Maksum Iman Permana
Journal of Applied Pharmaceutical Science, 2021
Pro-environmental behaviour of healthcare professionals: A study applying theory of planned behaviour
International Journal of Business and Globalisation, 2021
Stabilization of eye drops containing autologous serum and recombinant human epidermal growth factor for dry eye syndrome
Sriwidodo Sriwidodo, InsanSunan Kurniawan Syah, ImanPermana Maksum, Toto Subroto, Ulvi Zasvia, AbdKakhar Umar
Journal of Advanced Pharmaceutical Technology and Research, 2020
A review: Floating drug delivery system as a tool to improve dissolution rate in gastric
IYAN SOPYAN, SRIWIDODO, RETNO WAHYUNINGRUM, NORISCA ALIZA P.
International Journal of Applied Pharmaceutics, 2020
Effects of Growth Medium on Extracellular Secretion of Human Epidermal Growth Factor in Escherichia coli by Co-expression with Bacillus cereus Phospholipase C
F P U Latifah, A Indriyani, R D Pratiwi, Sriwidodo, IP Maksum
Iop Conference Series Materials Science and Engineering, 2020
Preparation and optimization of chitosan-hegf nanoparticle using ionic gelation method stabilized by polyethylene glycol (PEG) for wound healing therapy
Sriwidodo, Toto Subroto, Iman Permana Maksum, Anas Subarnas, Bethary Kesumawardhany, Desak Made Diah Dwi Lestari, Abd. Kakhar Umar
International Journal of Research in Pharmaceutical Sciences, 2020
Film-forming sprays for topical drug delivery
Abd. Kakhar Umar, Maria Elvina Tresia Butarbutar, Sriwidodo Sriwidodo, Nasrul Wathoni
Drug Design Development and Therapy, 2020
Activity and effectiveness of recombinant hEGF excreted by escherichia coli BL21 on wound healing in induced diabetic mice
Sriwidodo Sriwidodo, Iman Permana Maksum, Toto Subroto, Nasrul Wathoni, Anas Subarnas, Abd. Kakhar Umar
Journal of Experimental Pharmacology, 2020
Optimization of secreted recombinant human epidermal growth factor production using pectate lyase B from Escherichia coli BL21(DE3) by central composite design and its production in high cell density culture
Sriwidodo Sriwidodo, Toto Subroto, ImanP Maksum, Nasrul Wathoni, Tina Rostinawati, Himmatul Ulya, IndahU Putri
Journal of Pharmacy and Bioallied Sciences, 2019
Optimization extracellular secretion of recombinant human epidermal growth factor (hEGF) in Escherichia coli BL21 (DE3) pd881-ompa-hegf by using Response Surface Method (RSM)
Annisa Indriyani, Nenden Indriyani Anggraeni, Sriwidodo, Iman Permana Maksum
International Journal of Research in Pharmaceutical Sciences, 2019
Repellent activity of essential oils from cananga odorata lamk. and cymbopogon nardus L. on corn starch-based thixogel
Nasrul Wathoni, Sriwidodo Sriwidodo S, Ferry Ferdiansyah Sofian, Angga Cipta Narsa, Ajeng Ninda Mutiara
Journal of Young Pharmacists, 2018
Evaluation of setting time and flow properties of self-synthesize alginate impressions
Calista Halim, Arief Cahyanto, Sriwidodo, Zulia Harsatiningsih
Aip Conference Proceedings, 2018
Drug delivery system by hydrogel soft contact lens materials: A review
Journal of Pharmaceutical Sciences and Research, 2018
Synthesis of sodium carboxymethyl cellulose (Na-CMC) from water hyacinth with mixed solvent using succinic acid and epichlorohydrin as crosslinker
Research Journal of Chemistry and Environment, 2018
Extracellular secretion of recombinant human epidermal growth factor by using trimethylamine N-Oxide reductase a (TORA) signal peptide in escherichia coli BL21 (DE3)
Journal of Pharmaceutical Sciences and Research, 2017
The sterility of reusable instruments at Central Surgery installation’s room storage of one of the hospital in Bandung
Journal of Pharmaceutical Sciences and Research, 2017
The antibacterial activity of contact lens solutions against microbial keratitis
Arif Budiman, Haniq Fauzi, Rr Sulistiyaningsih, Sriwidodo Sriwidodo
National Journal of Physiology Pharmacy and Pharmacology, 2017
Extracellular secretion recombinant of human epidermal growth factor (hEGF) using pectate lyase B (PelB) signal peptide in escherichia coli BL21(DE3)
International Journal of Research in Pharmaceutical Sciences, 2017
Starch as pharmaceutical excipient
International Journal of Pharmaceutical Sciences Review and Research, 2016
Epichlorohydrin as crosslinking agent for synthesis of carboxymethyl cellulose sodium (Na-CMC) as pharmaceutical excipient from water hyacinth (Eichorrnia Crassipes L.)
International Journal of Chemical Sciences, 2015
Characterization and optimization of natural maltodextrin-based niosome
Journal of Applied Pharmaceutical Science, 2013

Sriwidodo Sriwidodo

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