Potential of OCT angiography in evaluating the effectiveness of treatment for choroidal melanoma (preliminary results) A.S. Stoyukhina, S.A. Smolin Vestnik Oftalmologii, 2026 Optical coherence tomography angiography (OCT-A) is an informative method for identifying and evaluating the vascular network of small choroidal melanomas (CM). It is also valuable for monitoring tumor regression and vascular changes after radiation therapy. However, there is only a limited number of studies specifically focused on treated CM. Purpose. This study aimed to determine OCT-A signs associated with different outcomes of eye-preserving treatment. Material and methods. OCT-A was performed in 12 patients (12 eyes) after eye-preserving treatment for CM. At the time of examination, the mean follow-up period after treatment was 66 months (ranging from 4 to 374 months). Six patients were examined after brachytherapy, three — after transpupillary thermotherapy, two — after destructive laser photocoagulation, and one — after stereotactic radiosurgery. Image analysis was performed using customized segmentation to improve the accuracy of data interpretation. Results. Large straight vessels were identified in the areas of chorioretinal scars, and at the border between scars and preserved retina there were looped vessels (loss of terminal capillaries with formation of loops). No vascular signal was detected in areas of pigment hyperplasia. Numerous thin vessels forming anastomoses with retinal vessels were observed in regions of residual tumor. Vascular network including arches and arcs appeared in cases of continued tumor growth. Dense vascular networks without a distinct pattern or anastomoses with retinal vessels were detected in areas of reaction to radiation. Conclusion. OCT-A is a valuable method for monitoring tumor regression and vascular changes after radiation therapy, but accurate interpretation of its data requires careful customized segmentation. Large-caliber linear vessels should be differentiated from projection artifacts. Moderate tortuosity and large atypical choroidal vessels may represent compensatory remodeling of the vascular bed.
Choroidal neovascularization associated with choroidal nevi S.A. Smolin, A.S. Stoyukhina Vestnik Oftalmologii, 2025 Choroidal neovascularization (CNV) is a pathological angiogenic process observed in various fundus diseases, including choroidal nevi. This article reviews key information on the pathogenesis of CNV associated with choroidal nevi, examines diagnostic methods using optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A), including modern classifications and criteria for assessing disease activity. The article also discusses approaches to the differential diagnosis of nevi combined with neovascular age-related macular degeneration, progressive nevi, and melanomas, and analyzes the features of treatment with antiangiogenic agents and their effects on pigmented choroidal lesions.
Cytomegalovirus chorioretinitis in human immunodeficiency virus (case study) I.Yu. Razumova, I.V. Andreeva, A.S. Stoyukhina, S.A. Smolin Vestnik Oftalmologii, 2025 Cytomegalovirus retinitis affecting the posterior pole of the eye is the most common opportunistic infection in acquired immunodeficiency syndrome (AIDS). It typically develops at CD4 lymphocyte levels below 50—100 cells/μL and, if untreated, leads to blindness. Much less frequently, cytomegalovirus infection results in choroiditis, followed by secondary retinal changes. This article presents a clinical case of cytomegalovirus chorioretinitis in a human immunodeficiency virus-infected patient.
Analysis of Optical Coherence Tomography Data: Problems and Solutions Ю.Н. Юсеф, А.А. Плюхова, А.И. Бурсов, К.В. Барышев, С.A. Смолин, А.Л. Сидамонидзе Oftalmologija Vostochnaja Evropa, 2025 В данной обзорной статье рассматривается оптическая когерентная томография (ОКТ) как важный метод диагностики в офтальмологии, позволяющий визуализировать структуры глазного яблока с высокой точностью. Обсуждаются преимущества ОКТ и возможности для выявления и мониторинга офтальмологических заболеваний. Статья предназначена для офтальмологов и студентов технических вузов, интересующихся анализом медицинских данных. Особое внимание уделяется тенденциям в анализе данных ОКТ, включая применение методов глубокого обучения для автоматического анализа изображений и важность формирования высококачественных датасетов. Подчеркивается значимость разработки баз данных для разных возрастных групп и улучшения доступности и стандартизации данных ОКТ. Также обсуждаются проблемы валидации алгоритмов анализа изображений ОКТ, необходимость в искусственных наборах данных с аномалиями и трехмерной структурой, а также в разработке автоматических методов сегментации слоев и измерения их толщины. This review article discusses optical coherence tomography (OCT) as an important diagnostic method in ophthalmology, which allows visualising the structures of the eyeball with high accuracy. The advantages of OCT and its potential for detecting and monitoring ophthalmological diseases are discussed. The article is intended for ophthalmologists and students of technical universities interested in data analysis. Special attention is given to trends in OCT data analysis, Including the application of deep learning techniques to automatic image analysis and the importance of the deep learning techniques for automatic image analysis and the importance of generating high quality datasets. The importance of developing databases for different age groups and improving the accessibility and availability of OCT data is emphasised. for different age groups and improving the accessibility and standardisation of OCT data. Also discussed are the problems of validation of OCT image analysis algorithms, the need for artificial datasets with anomalies and three-dimensional structure, as well as the need for the development of automatic methods of layer segmentation. development of automatic methods for layer segmentation and thickness measurement.
Isolated primary vitreoretinal lymphoma (case report) A.S. Stoyukhina, E.N. Korobov, S.A. Smolin Vestnik Oftalmologii, 2024 This case report presents the diagnostic features of isolated primary intraocular lymphoma, which was initially misdiagnosed as neovascular age-related macular degeneration. A comprehensive examination using ultrasound, optical coherence tomography, and fundus autofluorescence revealed changes characteristic of vitreoretinal lymphoma. Molecular genetic analysis of the vitreous body showed the presence of a MYD88 gene mutation and B-cell clonality by immunoglobulin heavy chain (IGH) gene rearrangement tests, which confirmed the diagnosis.
Experience in using metroplasty using distal compression hemostasis for organ-preserving surgery at placenta accreta I.E. Talanova, S.A. Smolin, A.I. Umarova, K.A. Belova, E.V. Balagurova Russian Journal of Human Reproduction, 2021 <h3></h3> В статье представлен клинический случай, описывающий успешный исход органосохраняющей операции при полном предлежании и истинном врастании плаценты у пациентки 35 лет с рубцом на матке после предыдущего кесарева сечения. В процессе скринингового ультразвукового исследования настоящей беременности в сроке 20 нед выявлено предлежание плаценты, при проведении третьего ультразвукового скринингового исследования подтверждено полное предлежание плаценты, заподозрено врастание плаценты. Пациентка с беременностью сроком 35 нед госпитализирована в акушерскую клинику ФГБУ «Ивановский научно-исследовательский институт материнства и детства им. В.Н. Городкова» Минздрава России. Результаты инструментальных методов исследования подтвердили полное предлежание, заподозрено истинное врастание плаценты в области рубца на матке. В связи с полученными данными обследования выполнена метропластика с использованием дистального компрессионного гемостаза и с последующей аппаратной реинфузией аутоэритровзвеси для уменьшения объема кровопотери.
