• Ph.D in Organic Chemistry awarded in July,2014, from Sri Venkateswara University, Tirupathi, India
• M.Phil in Organic Chemistry with Ist Class from Annamalai University, Guntur, India, March, 2009.
• M.Sc in Organic Chemistry with Ist Class from Acharya Nagarjuna University, Guntur, India, From 2002-2004.
• B.Sc in M.P.C with Ist Class from Acharya Nagarjuna University, Guntur, India, From 1998-2001.
RESEARCH, TEACHING, or OTHER INTERESTS
Chemistry, Multidisciplinary, Organic Chemistry, Drug Discovery
Ultrasound mediated nano ZnO catalyzed synthesis of new α-aminophosphonates as potential anti-diabetic agents; an in silico ADMET, molecular docking study, α-amylase and α-glucosidase inhibitory activity CH. Subramanyam, K. Kiran Kumar, K. Venkata Ramana, C. Gladis Raja Malar, S. Mohan, et al. Synthetic Communications, 2023 A more efficient and ecologically friendly method has been devised for the preparation of α-amino phosphonates by Kabachnik-Fields (K-F) reaction in a solvent-free environment using an ultrasonication technique catalyzed by nano ZnO. Primarily, an in silico ADMET and molecular docking analysis was carried out on each molecule prior to synthesis to get insight into drug-likeliness behavior and their capacity to inhibit α-amylase and α-glucosidase. The structure of the newly synthesized compounds was confirmed using spectroscopic analysis, and each one’s in vitro inhibitory action against α-amylase and α-glucosidase was evaluated. The compounds diethyl (4-(4-oxo-4H-chromen-2-yl)phenylamino)(4-hydroxy-3-nitrophenyl)methylphosphonate (7e) and diethyl (4-(4-oxo-4H-chromen-2-yl)phenylamino)(benzo[d][1,3]dioxol-6-yl)methylphosphonate (7h) exhibited the highest inhibitory activity against α-amylase in comparison to the reference substance acarbose. The compounds diethyl (4-(4-oxo-4H-chromen-2-yl)phenylamino)(4-fluorophenyl)methylphosphonate (7d), diethyl (4-(4-oxo-4H-chromen-2-yl)phenylamino)(3-(trifluoromethyl)phenyl)methylphosphonate (7 g) and diethyl (4-(4-oxo-4H-chromen-2-yl)phenylamino)(benzo[d][1,3]dioxol-6-yl)methylphosphonate (7h) have shown the highest inhibitory activity against α-glucosidase than the reference drug, Acarbose. The remaining compounds have shown equipotent to good inhibitory activity against both the tested enzymes. Graphical Abstract
Synthesis and anti-microbial activity evaluation of phosphorylated urea/thio-urea derivatives Der Pharmacia Lettre, 2012
RECENT SCHOLAR PUBLICATIONS
Green synthesis, ADME and docking studies, and in vitro assessment of chromone-based α-aminophosphonates as dual inhibitors of α-amylase and α-glucosidase SNMBAJC Bhuvaneswari Chalapaka, Subramanyam Chennamsetty, Gladis Raja Malar ... Synthetic Communications, https://doi.org/10.1080/00397911.2 , 2026 2026 Citations: 1
Design and synthesis of new bis(α-aminophosphonates) via ultrasound-driven nano-BF 3 ·SiO 2 catalysis targeting α-amylase inhibition: In silico ADME and … M Haji Basha, K Prasada Rao, C Subramanyam, GR Satyanarayana, ... Phosphorus, Sulfur, and Silicon and the Related Elements, 1-15 , 2026 2026
Methane Sulphonic Anhydride Enabled an Efficient and Straightforward Protocol for the Synthesis of Hydroxamic Acid Derivatives and Evaluation of their In-silico ADME Properties K Cheruvupalli, VR Kesamsetty, N Kerru, C Subramanyam International Journal of Peptide Research and Therapeutics 32 (2), 23 , 2026 2026
An efficient protocol for synthesis of hydroxamic acids via methane sulphonic anhydrides: An in-silico ADME properties of the synthesised amino acid derivative of hydroxamic acids K Cheruvupalli, VR Kesamsetty, N Kerru, C Subramanyam 2025
Sulfonamide derivatives of substituted (piperidin-4-yl)-1 H -benzo[ d ]imidazoles: design, synthesis, antimicrobial and anti-inflammatory activities, and docking … RR Ummadi, VN Ratnakaram, SR Devineni, C Subramanyam, H Singh Chemical Papers, 1-24 , 2025 2025
Microwave-driven synthesis of α-aminophosphonates targeting diabetes: in silico and in vitro assessment of α-amylase and α-glucosidase inhibition RRTSC Manjula K. Synthetic Communications, https://doi.org/10.1080/00397911.2025.25 , 2025 2025
Eco-friendly TiO 2 –ZnO nano-catalysts: synthesis, catalytic performance in synthesis of α-amino/hydroxyphosphonates and their ADME, docking and antimicrobial … RR Ummadi, VN Ratnakaram, SR Devineni, C Subramanyam, ... Research on Chemical Intermediates 51 (7), 3767-3795 , 2025 2025 Citations: 9
Nano-ZnO catalyzed microwave synthesis of novel α-aminophosphonates: anti-diabetic potential via molecular docking, ADMET analysis, and α-amylase and α-glucosidase inhibition … HR Addanki, C Subramanyam, KV Ramana, CGR Malar, ... Organic Communications 18 (2), 82 , 2025 2025 Citations: 2
ZnO catalyzed microwave synthesis of novel α-Nano diabetic potential via molecular docking,-aminophosphonates: anti amylase inhibition studies C Gladis, KV Ramana, C Subramanyam, H Rao, VM Rao, ... Organic Communications , 2025 2025 Citations: 2
Ultrasound-assisted synthesis of α-aminophosphonates using nano ZnO catalyst: evaluation of their anti-diabetic activity MH Basha, C Subramanyam, CGR Malar, KK Kumar, M Seelam, ... Organic Communications 17 (4), 264 , 2024 2024
Synthesis of novel chromenyl phosphonates via nano-ZnO-catalyzed microwave method: Exploring potential anti-diabetic agents through molecular docking, ADMET analysis … M Kavala, RR Tiruveedula, S Chennamsetty Synthetic Communications 54 (17), 1433-1449 , 2024 2024 Citations: 2
Ultrasound mediated nano ZnO catalyzed synthesis of new α -aminophosphonates as potential anti-diabetic agents; an in silico ADMET, molecular docking study, α -amylase … CH Subramanyam, K Kiran Kumar, K Venkata Ramana, ... Synthetic Communications 53 (23), 2041-2060 , 2023 2023 Citations: 8
In silico molecular docking study and nano TiO2-SiO2 catalyzed microwave facilitated synthesis of new bis (a-aminophosphonates) as potential anti-diabetic agents MPP Kumar, A Vejendla, C Malar, G Raja, S Chennamsetty, S Talari, ... PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS , 2023 2023 Citations: 7
In silico ADMET, molecular docking study, and nano Sb 2 O 3 -catalyzed microwave-mediated synthesis of new α-aminophosphonates as potential anti-diabetic … SM Altaff, TR Rajeswari, C Subramanyam Main Group Metal Chemistry 45 (1), 225-241 , 2022 2022 Citations: 2
Nano TiO2. SiO2 catalyzed, microwave assisted synthesis of new α-aminophosphonates as potential anti-diabetic agents: In silico ADMET and molecular docking study MH Basha, C Subramanyam, CGR Malar, SS Rao, KP Rao Organic Communications 15 (2), 183 , 2022 2022 Citations: 8
An in silico ADMET, molecular docking study and microwave-assisted synthesis of new phosphorylated derivatives of thiazolidinedione as potential anti-diabetic … HR Addanki, MR Vallabhaneni, S Chennamsetty, P Pullagura, ... Synthetic Communications 52 (2), 300-315 , 2022 2022 Citations: 14
Synthesis, spectral characterization and anti-diabetic activity evaluation of phosphoramidate derivatives D Ravikumar, C Subramanyam, C Venkataramaiah, W Rajendra, KP Rao Indian Journal of Chemistry (IJC) 61 (1), 60-68 , 2022 2022
In silico molecular docking study, synthesis and α -amylase inhibitory activity evaluation of phosphorylated derivatives of purine M Pavan Phani Kumar, V Anuradha, C Subramanyam, VV Hari Babu Phosphorus, Sulfur, and Silicon and the Related Elements 196 (11), 1010-1017 , 2021 2021 Citations: 15
A simple, efficient synthesis and molecular docking studies of 2-styrylchromones. P Pullagura, MR Vallabhaneni, HR Addanki, S Chennamsetty, ... Organic Communications 14 (2) , 2021 2021 Citations: 10
Synthesis, α -amylase inhibitory activity evaluation and in silico molecular docking study of some new phosphoramidates containing heterocyclic ring SKM Altaff, T Raja Rajeswari, C Subramanyam Phosphorus, Sulfur, and Silicon and the Related Elements 196 (4), 389-397 , 2020 2020 Citations: 20
MOST CITED SCHOLAR PUBLICATIONS
Microwave-assisted synthesis and anti-inflammatory activity evaluation of some novel α-aminophosphonates B Sujatha, S Mohan, C Subramanyam, KP Rao Phosphorus, Sulfur, and Silicon and the Related Elements 192 (10), 1110-1113 , 2017 2017 Citations: 39
Synthesis and anti-diabetic activity evaluation of phosphonates containing thiazolidinedione moiety B Sujatha, S Chennamsetty, V Chintha, R Wudayagiri, K Prasada Rao Phosphorus, Sulfur, and Silicon and the Related Elements 195 (7), 586-591 , 2020 2020 Citations: 26
Synthesis, spectral characterization and bioactivity evaluation of novel α-aminophosphonates C Subramanyam, S Thaslim Basha, G Madhava, S Nayab Rasool, ... Phosphorus, Sulfur, and Silicon and the Related Elements 192 (3), 267-270 , 2017 2017 Citations: 26
Synthesis, α -amylase inhibitory activity evaluation and in silico molecular docking study of some new phosphoramidates containing heterocyclic ring SKM Altaff, T Raja Rajeswari, C Subramanyam Phosphorus, Sulfur, and Silicon and the Related Elements 196 (4), 389-397 , 2020 2020 Citations: 20
Solvent-free sonochemical kabachnic-fields reaction to synthesize some new α-aminophosphonates catalyzed by nano-BF 3 •SiO 2 D Ravikumar, S Mohan, C Subramanyam, KP Rao Phosphorus, Sulfur, and Silicon and the Related Elements 193 (6), 400-407 , 2018 2018 Citations: 19
Convenient one-pot synthesis and biological evaluation of phosphoramidates and phosphonates containing heterocycles SK Nayab Rasool, C Subramanyam, DB Janakiramudu, P Supraja, ... Phosphorus, Sulfur, and Silicon and the Related Elements 193 (7), 470-474 , 2018 2018 Citations: 18
Analysis of single channel seismic data along the continental margin of India for gas hydrates HK Gupta, C Subramanyam, HY Rao, NK Thakur, TG Rao, B Ashalatha, ... National Geophysical Research Institute (NGRI) Tech Rep. No.-98-Lithos 221 , 1998 1998 Citations: 17
In silico molecular docking study, synthesis and α -amylase inhibitory activity evaluation of phosphorylated derivatives of purine M Pavan Phani Kumar, V Anuradha, C Subramanyam, VV Hari Babu Phosphorus, Sulfur, and Silicon and the Related Elements 196 (11), 1010-1017 , 2021 2021 Citations: 15
Synthesis and Biological Activity of Novel Diphenyl N - Substituted Carbamimidoylphosphoramidate Derivatives C Subramanyam, KV Ramana, S Rasheed, S Adam, CN Raju Phosphorus, Sulfur, and Silicon and the Related Elements 188 (9), 1228-1235 , 2013 2013 Citations: 15
An in silico ADMET, molecular docking study and microwave-assisted synthesis of new phosphorylated derivatives of thiazolidinedione as potential anti-diabetic … HR Addanki, MR Vallabhaneni, S Chennamsetty, P Pullagura, ... Synthetic Communications 52 (2), 300-315 , 2022 2022 Citations: 14
Expeditious, Nano-BF 3 · SiO 2 -Catalyzed Michaelis–Arbuzov Reaction in an Ionic Liquid: Synthesis of Privileged Aryl/Heterocyclic Phosphonates S Rasheed, DS Rao, C Subramanyam, ST Basha, CN Raju Synthetic Communications 44 (20), 2988-2998 , 2014 2014 Citations: 13
Bismuth (III) chloride mediated Michaelis–Arbuzov reaction: A facile synthesis of substituted arylphosphonates/phosphinates and bioactivity evaluation C Subramanyam, G Madhava, SK Thaslim Basha, S Rasheed, AU Sankar, ... Phosphorus, Sulfur, and Silicon and the Related Elements 190 (11), 1948-1957 , 2015 2015 Citations: 12
New N -Linked Phosphonamidate Derivatives of 6-Chloropurine: Synthesis and Evaluation of Antimicrobial and Antioxidant Activities C Subramanyam, DS Rao, CN Raju, S Adam, SDS Murthy Phosphorus, Sulfur, and Silicon and the Related Elements 189 (10), 1572-1585 , 2014 2014 Citations: 11
A simple, efficient synthesis and molecular docking studies of 2-styrylchromones. P Pullagura, MR Vallabhaneni, HR Addanki, S Chennamsetty, ... Organic Communications 14 (2) , 2021 2021 Citations: 10
Eco-friendly TiO 2 –ZnO nano-catalysts: synthesis, catalytic performance in synthesis of α-amino/hydroxyphosphonates and their ADME, docking and antimicrobial … RR Ummadi, VN Ratnakaram, SR Devineni, C Subramanyam, ... Research on Chemical Intermediates 51 (7), 3767-3795 , 2025 2025 Citations: 9
Ultrasound mediated nano ZnO catalyzed synthesis of new α -aminophosphonates as potential anti-diabetic agents; an in silico ADMET, molecular docking study, α -amylase … CH Subramanyam, K Kiran Kumar, K Venkata Ramana, ... Synthetic Communications 53 (23), 2041-2060 , 2023 2023 Citations: 8
Nano TiO2. SiO2 catalyzed, microwave assisted synthesis of new α-aminophosphonates as potential anti-diabetic agents: In silico ADMET and molecular docking study MH Basha, C Subramanyam, CGR Malar, SS Rao, KP Rao Organic Communications 15 (2), 183 , 2022 2022 Citations: 8
Synthesis and bioactivity evaluation of some novel sulfonamide derivatives C Subramanyam, S Nayab Rasool, DB Janakiramudu, S Rasheed, ... Phosphorus, Sulfur, and Silicon and the Related Elements 192 (7), 845-849 , 2017 2017 Citations: 8
In silico molecular docking study and nano TiO2-SiO2 catalyzed microwave facilitated synthesis of new bis (a-aminophosphonates) as potential anti-diabetic agents MPP Kumar, A Vejendla, C Malar, G Raja, S Chennamsetty, S Talari, ... PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS , 2023 2023 Citations: 7
2-(Benzo [d] thiazol-2-yl) phenyl-4-nitrophenyl alkyl/aryl substituted phosphoramidates: Synthesis, characterization and antimicrobial activity evaluation SM Reddy, DS Rao, K Madhu, C Subramanyam, PG Kumari, CN Raju Phosphorus, Sulfur, and Silicon and the Related Elements 193 (3), 136-140 , 2018 2018 Citations: 6
