@tanuvas.ac.in
University Deputy Librarian
Tamil Nadu Veterinary and Animal Sciences University
Bioinformatics, Information Technology, Information Science
Scopus Publications
Scholar Citations
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N. Gokul Kannaa, P.L. Sujatha, V. Appa Rao, I. Manikkavasagan, K. Vijayarani, and T. Arvind Prabhu
Agricultural Research Communication Center
Background: The development of obesity involves hormones and neurotransmitters. The prevalence of obesity is measured by body mass index (BMI) raised to unacceptable levels in both men and women worldwide. Thyroid hormones are involved in multiple physiological processes, regulate basal metabolic rate, promote the adrenergic nervous system to generate heat in response to cold exposure and stimulate gluconeogenesis and lipolysis and lipogenesis. The increase in the production of thyroid hormone will increase the basal metabolic rate in the body. Thus, the increase in BMR reduces the breakdown of LDL-cholesterol, total cholesterol, and triglycer ides, which causes fat storage. The reduction in the fat level will eventually lead to a lower risk of obesity. Methods: Cissus quadrangularis has been reported to reduce obesity in humans, but no scientific evidence is available to support its use. The computational approach is used to study its biological properties such as molecular docking and functional analysis was performed using BIOVIA Discovery Studio software. Result: The molecular docking, pharmacodynamic and pharmacokinetic studies conducted on the active principles of Cissus quadrangularis showed good interaction with selected target proteins involved in obesity. Almost all the active principles possess anti-obesity properties. Amoyrone and ascorbic acid of Cissus quadrangularis has shown excellent interaction, drug likeliness, pharmacokinetic properties. This finding might help in developing an alternate, cost-effective, safe, eco-friendly anti-obese drug. However the results could be validated with in vivo and in vitro studies.
Sowmya. M, Ramesh. S, Ganne Venkata Sudhakar Rao, Ramesh. S, Jalantha. P, Sujatha. P. L, and Indumathi. R
Indian Veterinary Association
Urolithiasis is the third most common urinary tract disorder affecting both men and women with an estimated global frequency of approximately 14%. Ethylene glycol is a lithiatic agent which is a potent component for experimental induction of urolithiasis. The enzymes like glycolate oxidase, oxalate oxidase are employed in oxalate metabolism which involve in caliculi formation. CD44 is a receptor of the stone modulating protein, Osteopontin (OPN). Tinospora cordifo-lia is a medicinal plant distributed throughout the Indian subcontinent, and contains many phytochemicals used for various ailments. GC-MS and ADME analysis were done and active principles (
S. Pavithra, S.P. Preetha, P.L. Sujatha, M.R Srinivasan, A. Karthikeyan, C. Balachandran, K.V. Venkateswaran, and P. Kumarasamy
IEEE
Rhipicephalus sanguineus is a brown dog tick that transmits rickettsial infection between dogs and man. It can be prevented by using ectoparasiticides generally acting through acetylcholinesterase inhibiting mechanism which is responsible for the catalysis of acetylcholine neurotransmitter. To overcome the toxic effects produced by synthetic ectoparasticides, new in silico approaches were carried out using the active principles from the custard apple. Custard apple is a small tree cultivated throughout India with various medicinal properties. A novel docking study was performed using the active ingredients present in the leaves of the custard apple. The dock scores were analysed and the best active ingredient-target interactions were identified. The active principle Norcorydine gives good docking scores with Acetylcholinesterase. Hence the present study projects the positive role of custard apple in the synthesis of bio-insecticides for the control of ectoparasites.
E. Felix Anto Ophelia, P.L. Sujatha, and P. Kumarasamy
IEEE
Although skin aging due to UV exposure (photoaging) and chronological skin aging have been thought to be distinct, photoaging has a considerable effect on chronological aging. UV irradiation of skin leads to oxidative stress and increases reactive oxygen species (ROS) and also reduces antioxidant enzyme. As a consequence, several cell surface cytokines and growth factor receptors are activated which results in recruitment of several adaptor proteins to regulate downstream signaling. AP-1 is a transcription factor which up-regulates matrix-metalloproteinases and down-regulates type 1 procollagen. Thus AP-1 can be an effective target for photoaging. In this study, the effect of 56 active ingredients from several natural and easily available traditional remedies for skin aging has been studied by means of in silico approach and the potential active ingredients have been identified.
P L. Sujatha, Ravi Reddy, Jaideep Mahendra, K. Kumanan, P. Kumarasamy, S P. Preetha, and S. Pavithra
IEEE
Oral cancer is a type of cancer which targets mouth and surrounding tissues. It includes, lips, cheeks, tongue, sinuses, throat. Oral cancer could be life threatening, if not diagnosed in early stages. American Cancer Society says that men are at more risk than women. Oral cancer can be treated like any other cancers. But still the efficacy of the drugs is questionable. Hence, an attempt was tried to find the suitable inhibitors for the treatment of oral cancer using bioactive principles of Cissus quadrangularis, targeting SIRT3, P21 and P53. The Resveratol in Cissus quadrangularis has showed very good interaction with two target proteins involved in oral cancer viz., SIRT3 and P21. Resveratol also has very good pharmacodynamic and pharmacokinetic properties. This study concludes that Resveratol in Cissus quadrangularis has the potential to serve as an anticancerous drug. However, the results might be validated through in-vivo and in-vitro studies to prove the efficacy of the active compounds and to protect the mankind from oral cancer.