Ibrahim Sulyman Olalekan

@unilorin.edu.ng

Lecturer, Faculty of Physical Sciences
Assistant Professor, Faculty of Physical Sciences
University of Ilorin

Ibrahim Sulyman Olalekan


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https://researchid.co/sulalekan9

EDUCATION

(1) University of Ilorin, Ilorin, Nigeria 2017 – 2023
(2) University of Ilorin, Ilorin, Nigeria 2014 – 2017
(3) University of Ilorin, Ilorin, Nigeria 2008 – 2012

RESEARCH, TEACHING, or OTHER INTERESTS

Organic Chemistry, Spectroscopy, Chemistry, Food Science
19

Scopus Publications

341

Scholar Citations

10

Scholar h-index

10

Scholar i10-index

Scopus Publications

  • Mechanistic Insights into Dihydromyricetin: Redox Modulation and Kinase-Mediated Control of Disease Pathogenesis
    Oluwatoyin Adenike Fabiyi, Ayorinde Victor Ogundele, Sulyman Olalekan Ibrahim, Hassan Ibrahim, Héctor Hernán Silva
    International Journal of Molecular Sciences, 2026
    Dihydromyricetin (DHM), a naturally occurring flavanonol predominantly found in medicinal plants like Ampelopsis grossedentata, has emerged as a promising source of natural antioxidants with multi-target pharmacological activities relevant to drug discovery. DHM exhibits a strong redox-modulating capacity, effectively attenuating oxidative stress and inflammation central drivers of chronic disease pathogenesis. Beyond direct radical scavenging, DHM regulates multiple redox-sensitive and kinase-mediated signalling pathways, thereby influencing key cellular processes involved in disease initiation and progression. This review synthesizes current evidence on the therapeutic potential of DHM, critically evaluating its mechanistic basis and translational prospects, with emphasis on its dual redox-driven and kinase-mediated modes of action. We detail its roles in metabolic disorders such as diabetes, obesity, and liver diseases, neuroprotection, cardio protection, and cancer prevention, focusing on the modulation of critical networks such as AMPK, PI3K/Akt, MAPK, NF-κB, and Nrf2. The interplay between these pathways underpins DHM’s efficacy across disease models. Furthermore, we highlight structure–activity relationship (SAR) analyses and molecular modelling studies that elucidate how the flavanonol scaffold, hydroxylation pattern, and stereochemistry of DHM govern its biological activities and target engagement. Key pharmacokinetic limitations, advances in extraction techniques, bioavailability challenges, and emerging formulation strategies including advanced delivery systems are discussed to address translational hurdles. Despite compelling preclinical data, the clinical translation of DHM remains constrained by limited human studies and incomplete mechanistic resolution. This review underscores the need for integrated pharmacological studies and innovative delivery approaches to translate the multifaceted promise of DHM into viable clinical interventions.
  • Progress on anticancer properties of beta-carboline analogues: A review of dynamic synthetic accessibility and bioactivity
    Yusuf Oloruntoyin Ayipo, Abdulfatai Temitope Ajiboye, Sulyman Olalekan Ibrahim, Bolatito Eunice Olanipekun, Wahab Adesina Osunniran, et al.
    Studies in Natural Products Chemistry, 2026
  • Toxicity Assessment of Cyclic Imides and Carbofuran in the Management of Meloidogyne incognita: In Vivo and In Silico Studies
    Oluwatoyin A. Fabiyi, Mariam T. Baker, Ridwan O. Alabi, Oluwakamiye I. Taiwo, Sulyman O. Ibrahim, et al.
    Chemistry and Biodiversity, 2025
    Rat model systems were employed to appraise the possible toxicity of cyclic imides in contrast to carbofuran. Hepato‐renal toxicity, hepatotoxicity, electrolytes, haematological indices and distortion to the histological architecture of liver and kidneys were assessed with evaluation of in silico inhibition of acetylcholinesterase (AChE) by the imides. Forty albino rats were divided into eight groups and fed a basal pellet diet for 30 days with 75 mg/mL of imides on a daily basis. This was compared with the carbofuran‐fed and control groups. A significant (p < 0.05) increase was observed in the concentration of bilirubin, urea, uric acid, creatinine, sodium ion, chloride ion, potassium ion, serum alkaline phosphatase (ALP), serum alanine aminotransferase (ALT) and serum aspartate amino transferase (AST) in animals administered with carbofuran, but parameters like albumin, kidney ALP, liver ALP, kidney ALT, liver ALT, kidney AST, liver AST, kidney Gamma (ϒ)‐Glutamyl transferase (GGT) and liver ϒ‐GGT were significantly (p < 0.05) low in carbofuran fed group compared with the control. Likewise, haematological alterations including low % lymphocytes, higher platelet count and high white blood cell count were recorded in contrast to the control group. The histo‐architecture of the liver and kidneys exhibited mild inflammation in some cases. Mild perturbations, though within clinical limits, were observed in some of the animals treated with cyclic imides. The strength of imides as AChE inhibitors was substantiated by an in silico mechanism, depicting the binding affinity of imides. The use of cyclic imides in M. incognita management does not entail any critical concern for toxicity. Cyclic imides could be employed in the control of M. incognita without any major safety compromise.
  • Nickel(II) mixed-ligand complex of 8-hydroxyquinoline and monosodium glutamate: Synthesis, in vitro bioevaluation, and in silico analysis
    Ayuba Mustapha, Mercy Bamigboye, Adefunke Adeniyi, Ayobami Lawal, Sulyman Olalekan Ibrahim, et al.
    Journal of Molecular Structure, 2025
  • Advances in green synthesis and application of nanoparticles from crop residues: A comprehensive review
    Olawale F. Olaniyan, Chinenye Agnes Ariwaodo, Sulyman Olalekan Ibrahim, Olubunmi Atolani, Learnmore Kambizi
    Scientific African, 2025
  • Chemoinformatic-aided Antidiabetic Analysis of the Therapeutic Potential of Phytoconstituents in Eremomastax speciosa Extracts
    Sulyman Olalekan Ibrahim, Halimat Yusuf Lukman, Israel Ehizuelen Ebhohimen, Halimah Funmilayo Babamale, Fatimah Ronke Abdulkadir, et al.
    Borneo Journal of Pharmacy, 2024
    This research attempts to establish the antihyperglycemic potential of Eremomastax speciosa, a medicinal plant utilized in traditional West African diabetes therapy, through virtual simulation. While numerous reports have validated its biological potency, studies on the drug-likeness and antidiabetic properties of its compounds are limited. The in silico pharmacological, and toxicological profile of aqueous, methanolic/methylene phytochemicals from previously reported work was analyzed using Swiss ADME and Protox II online server. The docking process was performed using PyRx-0.8, coupled with AutoDock Vina. Phytochemicals that aligned with Lipinski’s rules for drugs were then subjected to a virtual docking simulation. This simulation replicated the inhibitory effects of E. speciosa phytochemicals on sodium-glucose co-transporters (SGLT2) and α-amylase, similar to metformin, an FDA-approved antidiabetic medicine utilized as a control. Phytochemicals such as 8, 9,10-dimethyltricyclo[4.2.1.1(2,5)]decane-9,10-diol (-6.6 kcal/mol), 11-isopropylidenetricyclo[4.3.1.1(2,5)]undec-3-en-10-one (-7.9 kcal/mol), 4-(1,5-dihydroxy-2,6,6-trimethylcyclohex-2-enyl)but-3-en-2-one (-7.3 kcal/mol), and N-methyl-N-4-[2-acetoxymethyl-1-pyrrolidyl]-2-butynyl]-acetamide (-7.5 kcal/mol) exhibits superior binding affinities to the specific proteins targeted, compared to metformin, implying that E. speciosa is a source of druggable antidiabetic molecules that can be enhanced to achieve better efficacy.
  • Characterization, Chemical Composition and Cream Formulation from the Seed Butter of Mangifera indica L.
    Chemist, 2024
  • Nanoparticles as Antioxidant Agents: A Comprehensive Review
    Sulyman Olalekan Ibrahim, Halimat Yusuf Lukman, Fatimat Ronke Abdulkadir, Monsurat Yemisi Bello, Yusuf Oloruntoyin Ayipo, et al.
    Al Bahir Journal for Engineering and Pure Sciences, 2024
  • An Insight into the Physicochemical, Drug-likeness, Pharmacokinetics and Toxicity Profile of Kigelia Africana (Lam) Bioactive Compounds
    Sulyman Olalekan Ibrahim, Halimat Yusuf Lukman, Marili Funmilayo Zubair, Oluwagbemiga Tayo Amusan, Fatimah Ronke Abdulkadri, et al.
    Al Bahir Journal for Engineering and Pure Sciences, 2024
  • Chemical Characterization, Cytotoxicity, Anti-inflammatory, Antioxidant, Antimicrobial and Anti-toxoplasmosis of Chrysophyllum albidum Seed Oil
    Chemist, 2024
  • Synthesis and Chemical Characterization of Alkyd Resins Using Maleic and Phthalic Anhydrides and Seed Oil of Luffa aegyptiaca
    Marili Funmilayo ZUBAİR, Sulyman Olalekan IBRAHİM, Kenneth STEPHEN, Abdulmumeen Amao HAMİD, Olamilekan IBUKUN, et al.
    Journal of the Turkish Chemical Society Section A Chemistry, 2023
  • Gas Chromatography-Mass Spectrometric analysis and antioxidant property of leaf extracts of Chamaecrista rotundifolia
    A. A. Hamid, A. Shehu, M. I. Bale, Umar. Idris, S. B. Issa, et al.
    Journal of Phytomedicine and Therapeutics, 2023
  • Influence of dietary Plukenetia conophora seed on growth performance, hepatic antioxidant status, blood chemistry, fillet quality, fatty acid, and oxidative stability of Clarias gariepinus
    Kazeem D. Adeyemi, Oluwaseun O. Oludemokun, Marili F. Zubair, Olubunmi Atolani, Sulyman O. Ibrahim
    Animal Feed Science and Technology, 2022
  • Chemical Characterization, Preparation of Biosurfactant and Biochemical Evaluation of Seed Oil of Luffa aegyptiaca
    Chemist, 2022
  • Influence of dietary supplementation of kigelia pinnata and plukenetia conophora leaves on cytokine expression, immunoglobulins, blood chemistry, caecal microbiota and meat quality in broiler chickens
    K. Adeyemi, M. Adegoke, MO Mudashir, FM Owoyomi, T. Hamzat, et al.
    Poultry Science Journal, 2021
  • Dietary Supplementation of Tetracarpidium conophorum (African Walnut) Seed Enhances Muscle n-3 Fatty Acids in Broiler Chickens
    Kazeem D. Adeyemi, Abdulraheem Abdulrahman, Sulyman O. Ibrahim, Marili F. Zubair, Olubunmi Atolani, et al.
    European Journal of Lipid Science and Technology, 2020
  • Chemical and biological evaluations of potent antiseptic cosmetic products obtained from Momordica charantia seed oil
    Marili Funmilayo Zubair, Olubunmi Atolani, Sulyman Olalekan Ibrahim, Olubunmi Stephen Oguntoye, Halimat Amin Abdulrahim, et al.
    Sustainable Chemistry and Pharmacy, 2018
  • Fatty acids composition, antimicrobial potential and cosmeceutical utilization of prosopis africana seed oil
    Marili Funmilayo Zubair, Olubunmi Atolani, Sulyman Olalekan Ibrahim, Olubunmi Stephen Oguntoye, Rukayat Abiodun Oyegoke, et al.
    Journal of the Mexican Chemical Society, 2018
  • Green synthesis and characterisation of natural antiseptic soaps from the oils of underutilised tropical seed
    Olubunmi Atolani, Elizabeth Temitope Olabiyi, Abdullateef Abiodun Issa, Hidiat Taiwo Azeez, Ehi Gift Onoja, et al.
    Sustainable Chemistry and Pharmacy, 2016

RECENT SCHOLAR PUBLICATIONS

  • Mechanistic Insights into Dihydromyricetin: Redox Modulation and Kinase-Mediated Control of Disease Pathogenesis
    OA Fabiyi, AV Ogundele, SO Ibrahim, H Ibrahim, HH Silva
    International Journal of Molecular Sciences 27 (10), 4626 , 2026
    2026
  • Computational Bioprospecting for Novel Plasmodium falciparum lactate Dehydrogenase Inhibitors Toward Malaria Treatment
    SO Ibrahim, YO Ayipo, MN Mordi, HY Lukman, FA Abubakar, SO Usman, ...
    In Silico Research in Biomedicine, 100335 , 2026
    2026
  • Fatty Acids and Its Derivatives from the Extracts of Ficus mucoso Leaves
    AA Hamid, GO Egharevba, SB Issa, OM Olalere, BT Akinloye, YT Yakub, ...
    Biology, Medicine, & Natural Product Chemistry 15 (1), 151-157 , 2026
    2026
  • Multiscale computational profiling of a promising carbapenemase inhibitor: from binding dynamics to quantum reactivity
    AO Mustapha, AJ Adeniyi, ME Alaka, SO Ibrahim, YO Ayipo
    Exploration of Drug Science 4, 1008140 , 2026
    2026
  • Progress on anticancer properties of beta-carboline analogues: A review of dynamic synthetic accessibility and bioactivity
    YO Ayipo, AT Ajiboye, SO Ibrahim, BE Olanipekun, WA Osunniran, ...
    Studies in Natural Products Chemistry 88, 131-166 , 2026
    2026
  • In Vitro and In Silico Evaluation of ADME/Drug-Likeness and Docking Studies of Bioactive Carotenoids from Capsicum chinense with Antioxidant Potential
    BM Amos-Tautua, IT Ajoko, SO Ibrahim
    Chemical Research and Technology 3 (1), 1-22 , 2026
    2026
    Citations: 1
  • Toxicity Assessment of Cyclic Imides and Carbofuran in the Management of Meloidogyne incognita : In Vivo and In Silico Studies
    OA Fabiyi, MT Baker, RO Alabi, OI Taiwo, SO Ibrahim, OA David, ...
    Chemistry & Biodiversity 22 (11), e00501 , 2025
    2025
  • Nickel (II) mixed-ligand complex of 8-hydroxyquinoline and monosodium glutamate: Synthesis, in vitro bioevaluation, and in silico analysis
    A Mustapha, M Bamigboye, A Adeniyi, A Lawal, SO Ibrahim, M Subair, ...
    Journal of Molecular Structure 1343, 142667 , 2025
    2025
    Citations: 1
  • Advances in green synthesis and application of nanoparticles from crop residues: A comprehensive review
    OF Olaniyan, CA Ariwaodo, SO Ibrahim, O Atolani, L Kambizi
    Scientific African 28, e02654 , 2025
    2025
    Citations: 27
  • De novo in silico screening of natural products for antidiabetic drug discovery: ADMET profiling, molecular docking, and molecular dynamics simulations
    SO Ibrahim, YO Ayipo, HY Lukman, FA Abubakar, A Na’Allah, ...
    In Silico Pharmacology 13 (1), 29 , 2025
    2025
    Citations: 13
  • Investigation of Aframomum melegueta compounds as ERK5 inhibitor related to breast cancer via molecular docking and dynamic simulation
    PO Ottu, OO Babalola, C Oluwamodupe, AF Oluwatobiloba, IO Kehinde, ...
    In Silico Pharmacology 13 (1), 18 , 2025
    2025
    Citations: 7
  • Virtual Screening of Chitosan Derivatives as Potential Inhibitors against Cassava Linamarase
    WO Adetoun Akitoye, Oluwafemi Aina, Akinkunmi Bamigboye, Sulyman Ibrahim ...
    10th Annual Symposium of the American Chemical Society (ACS) Nigeria … , 2025
    2025
  • Chemical Characterization and Comparative Analysis of Alkyd resins from Gossypium Hirsutum Seed Oil Using Maleic and Phthalic Anhydrides
    SO Ibrahim, S Kenneth, FR Abdulkadir, AA Hamid, OJ Ibukun, MF Zubair, ...
    Sultan Qaboos University Journal For Science 30 (1), 1-10 , 2025
    2025
  • In Silico Medicinal and Pharmacological Evaluation of Phytochemical Constituents from the Root Bark Extract of Enantia Chlorantha as Potential Antimalarial Drugs
    S Ibrahim, H Lukman, Y Ayipo, H Babamale, F Abdulkadir, A Hamid, ...
    Journal of Pure & Applied Sciences 23 (2), 178-188 , 2024
    2024
    Citations: 1
  • Preparation and Characterization of Biodegradable Diethanolamide Surfactant from Cotton Seed Oil
    FR Abdulkadir, OO Oluwaniyi, SO Ibrahim, MO Ameen, KS Jubril
    Ilorin Journal of Science 11 (3 (Special)), 397-402 , 2024
    2024
  • Chemical Characterization, Cytotoxicity, Anti-inflammatory, Antioxidant, Antimicrobial and Anti-toxoplasmosis of Chrysophyllum albidum Seed Oil.
    O Atolani, ET Areh, OS Oguntoye, MF Zubair, OS Adeyemi, OA Owolodun, ...
    Chemist 95 (1) , 2024
    2024
    Citations: 1
  • Characterization, Chemical Composition and Cream Formulation from the Seed Butter of Mangifera indica L.
    AJ Aliyua, SO Ibrahimb, K Abdulmumeena, O Atolania
    The Chemist, 70 , 2024
    2024
  • Chemoinformatic-aided antidiabetic analysis of the therapeutic potential of phytoconstituents in Eremomastax speciosa extracts
    SO Ibrahim, HY Lukman, IE Ebhohimen, HF Babamale, FR Abdulkadir, ...
    Borneo Journal of Pharmacy 7 (2), 172-186 , 2024
    2024
    Citations: 5
  • Nanoparticles as Antioxidant Agents: A Comprehensive Review
    SO Ibrahim, HY Lukman, FR Abdulkadir, MY Bello, YO Ayipo, ...
    Al-Bahir 5 (1), 3 , 2024
    2024
    Citations: 2
  • An insight into the physicochemical, drug-likeness, pharmacokinetics and toxicity profile of Kigelia africana (Lam) bioactive compounds
    SO Ibrahim, HY Lukman, MF Zubair, OT Amusan, FR Abdulkadri, B Lawal, ...
    Al-Bahir 4 (1), 4 , 2024
    2024
    Citations: 12

MOST CITED SCHOLAR PUBLICATIONS

  • Green synthesis and characterisation of natural antiseptic soaps from the oils of underutilised tropical seed
    O Atolani, ET Olabiyi, AA Issa, HT Azeez, EG Onoja, SO Ibrahim, ...
    Sustainable Chemistry and Pharmacy 4, 32-39 , 2016
    2016
    Citations: 92
  • Chemical and biological evaluations of potent antiseptic cosmetic products obtained from Momordica charantia seed oil
    MF Zubair, O Atolani, SO Ibrahim, OS Oguntoye, HA Abdulrahim, ...
    Sustainable Chemistry and Pharmacy 9, 35-41 , 2018
    2018
    Citations: 39
  • Chemical constituents and antimicrobial properties of Phyllanthus amarus (Schum & Thonn).
    MF Zubair, O Atolani, SO Ibrahim, OO Adebisi, AA Hamid, RA Sowunmi
    Bayero Journal of Pure & Applied Sciences 10 (1) , 2017
    2017
    Citations: 37
  • Dietary Supplementation of Tetracarpidium conophorum (African Walnut) Seed Enhances Muscle n‐3 Fatty Acids in Broiler Chickens
    KD Adeyemi, A Abdulrahman, SO Ibrahim, MF Zubair, O Atolani, ...
    European Journal of Lipid Science and Technology 122 (6), 1900418 , 2020
    2020
    Citations: 32
  • Advances in green synthesis and application of nanoparticles from crop residues: A comprehensive review
    OF Olaniyan, CA Ariwaodo, SO Ibrahim, O Atolani, L Kambizi
    Scientific African 28, e02654 , 2025
    2025
    Citations: 27
  • Papaya (Carica papaya L., pawpaw)(ed) nonvitamin and nonmineral nutritional supplements
    AB Nafiu, A Alli-Oluwafuyi, A Haleemat, IS Olalekan, MT Rahman
    Elsevier , 2019
    2019
    Citations: 21
  • Chemical composition and nutritional characterization of cotton seed as potential feed supplement
    MF Zubair, OS Ibrahim, O Atolani, AA Hamıd
    Journal of the Turkish Chemical Society Section A: Chemistry 8 (4), 977-982 , 2021
    2021
    Citations: 14
  • De novo in silico screening of natural products for antidiabetic drug discovery: ADMET profiling, molecular docking, and molecular dynamics simulations
    SO Ibrahim, YO Ayipo, HY Lukman, FA Abubakar, A Na’Allah, ...
    In Silico Pharmacology 13 (1), 29 , 2025
    2025
    Citations: 13
  • Fatty acids composition, antimicrobial potential and cosmeceutical utilization of Prosopis africana seed oil
    MF Zubair, O Atolani, SO Ibrahim, OS Oguntoye, RA Oyegoke, GA Olatunji
    Journal of the Mexican Chemical Society 62 (3), 39-50 , 2018
    2018
    Citations: 13
  • An insight into the physicochemical, drug-likeness, pharmacokinetics and toxicity profile of Kigelia africana (Lam) bioactive compounds
    SO Ibrahim, HY Lukman, MF Zubair, OT Amusan, FR Abdulkadri, B Lawal, ...
    Al-Bahir 4 (1), 4 , 2024
    2024
    Citations: 12
  • Investigation of Aframomum melegueta compounds as ERK5 inhibitor related to breast cancer via molecular docking and dynamic simulation
    PO Ottu, OO Babalola, C Oluwamodupe, AF Oluwatobiloba, IO Kehinde, ...
    In Silico Pharmacology 13 (1), 18 , 2025
    2025
    Citations: 7
  • Influence of dietary Plukenetia conophora seed on growth performance, hepatic antioxidant status, blood chemistry, fillet quality, fatty acid, and oxidative stability of …
    KD Adeyemi, OO Oludemokun, MF Zubair, O Atolani, SO Ibrahim
    Animal Feed Science and Technology 288, 115298 , 2022
    2022
    Citations: 7
  • Synthesis and chemical characterization of alkyd resins using maleic and phthalic anhydrides and seed oil of Luffa aegyptiaca
    MF Zubair, SO Ibrahim, K Stephen, AA Hamid, O Ibukun, O Atolani
    Journal of the Turkish Chemical Society Section A: Chemistry 10 (3), 689-702 , 2023
    2023
    Citations: 6
  • Chemoinformatic-aided antidiabetic analysis of the therapeutic potential of phytoconstituents in Eremomastax speciosa extracts
    SO Ibrahim, HY Lukman, IE Ebhohimen, HF Babamale, FR Abdulkadir, ...
    Borneo Journal of Pharmacy 7 (2), 172-186 , 2024
    2024
    Citations: 5
  • Chemical compositions from the leaf extracts ofFuntumiaafricana (Benth.) stapf with its antioxidant and anti-inflammatory activity.
    AA Hamid, MF Zubair, FO Olajide, SO Ibrahim, A Shehu, MI Bale, ...
    Nigerian Journal of Chemical Research 23 (2), 83-96 , 2018
    2018
    Citations: 5
  • Chemical Characterization, Preparation of Biosurfactant and Biochemical Evaluation of Seed Oil of Luffa aegyptiaca.
    MF Zubair, SO Ibrahim, O Atolani, AA Hamid, OJ Ibukun, HA Abdulrahim
    Chemist 93 (1) , 2022
    2022
    Citations: 3
  • Nanoparticles as Antioxidant Agents: A Comprehensive Review
    SO Ibrahim, HY Lukman, FR Abdulkadir, MY Bello, YO Ayipo, ...
    Al-Bahir 5 (1), 3 , 2024
    2024
    Citations: 2
  • In Vitro and In Silico Evaluation of ADME/Drug-Likeness and Docking Studies of Bioactive Carotenoids from Capsicum chinense with Antioxidant Potential
    BM Amos-Tautua, IT Ajoko, SO Ibrahim
    Chemical Research and Technology 3 (1), 1-22 , 2026
    2026
    Citations: 1
  • Nickel (II) mixed-ligand complex of 8-hydroxyquinoline and monosodium glutamate: Synthesis, in vitro bioevaluation, and in silico analysis
    A Mustapha, M Bamigboye, A Adeniyi, A Lawal, SO Ibrahim, M Subair, ...
    Journal of Molecular Structure 1343, 142667 , 2025
    2025
    Citations: 1
  • In Silico Medicinal and Pharmacological Evaluation of Phytochemical Constituents from the Root Bark Extract of Enantia Chlorantha as Potential Antimalarial Drugs
    S Ibrahim, H Lukman, Y Ayipo, H Babamale, F Abdulkadir, A Hamid, ...
    Journal of Pure & Applied Sciences 23 (2), 178-188 , 2024
    2024
    Citations: 1