Sulaxna

EDUCATION

Ph.D. Biotechnology

RESEARCH, TEACHING, or OTHER INTERESTS

Biotechnology, Multidisciplinary

Scopus Publications

In vivo imaging of prostate tumor-targeted folic acid conjugated quantum dots
Sulaxna Pandey, Prakash Choudhary, Virendra Gajbhiye, Sachin Jadhav, and Dhananjay Bodas
Springer Science and Business Media LLC
AbstractCancer is a major threat to human health; thus, early detection is imperative for successful management. Rapid diagnosis can be achieved by imaging primary (subcutaneous) tumors using fluorophores conjugated with tumor markers. Here, the application of biocompatible, quantum efficient, monodisperse, and photostable polymer-coated quantum dots (PQDs) is demonstrated for targeted prostate tumor imaging in living SCID mice. Briefly, PQDs (blue) are conjugated to folic acid (FA-PQDs) using DCC-NHS chemistry. Initially, in vitro targeted imaging via FA-PQDs is evaluated in LNCaP cells. The confocal microscopic evaluation demonstrates the uptake of FA-PQDs. To understand the dispersion of PQDs in vivo, the biodistribution of PQDs is assessed at different time intervals (1- 180 min) using whole-body fluorescence imaging and computed tomography (CT) scan. PQDs are seen to accumulate in organs like the liver, kidneys, spleen, lungs, and urinary bladder within 60 min, however, PQDs are not observed at 180 min indicating renal clearance. Further, to target the prostate tumor (~ 200 mm3) in mice, FA-PQDs are injected intravenously, and whole-body fluorescence imaging along with a CT scan is recorded. FA-PQDs are seen at the tumor site as compared to PQDs. The results confirm that the FA-PQDs function as excellent nanoprobes for targeted tumor imaging in vivo.


Exploiting the UV excited size-dependent emission of PDMS-coated CdTe quantum dots for in vitro simultaneous multicolor imaging of HepG2 cellular organelles
Sulaxna Pandey and Dhananjay Bodas
Royal Society of Chemistry (RSC)
Multicolor bioimaging can be referred to as the imaging method that non-invasively visualizes biological processes using fluorophores.


Effect of micro-impeller geometries on mixing in a continuous flow active microreactor
Sulaxna Pandey and Dhananjay Bodas
Elsevier BV



Multiplexed bio-imaging using cadmium telluride quantum dots synthesized by mathematically derived process parameters in a continuous flow active microreactor
S. Pandey, D. Mukherjee, P. Kshirsagar, C. Patra, and D. Bodas
Elsevier BV



High-quality quantum dots for multiplexed bioimaging: A critical review
Sulaxna Pandey and Dhananjay Bodas
Elsevier BV



A facile one-step method for cell lysis and DNA extraction of waterborne pathogens using a microchip
Vivek Kamat, Sulaxna Pandey, Kishore Paknikar, and Dhananjay Bodas
Elsevier BV