Biotechnology, General Biochemistry, Genetics and Molecular Biology
92
Scopus Publications
3988
Scholar Citations
32
Scholar h-index
61
Scholar i10-index
Scopus Publications
Draft genome sequence of Rhodococcus erythropolis DR10, a potential oil degradation actinobacteria Puja Gupta, Jyoti Vakhlu, Pradeep Kumar, Sundeep Jaglan Microbiology Resource Announcements, 2026 We hereby report the draft genome sequence of Rhodococcus erythropolis DR10, an actinobacterium isolated from the soil of Ladakh via minimal media agar. The genome 6,395,202 bp exhibited a 62.5% GC content with 5,883 coding sequences, 1 rRNA, and 53 tRNAs.
Exploring Bioactive Metabolites from Endophytic Fungi of Albizia lebbeck (L.) Benth Nisha Sharma, Manoj Kushwaha, Arem Qayum, Shashank K. Singh, Umesh Goutam, Sundeep Jaglan Journal of Pure and Applied Microbiology, 2026 This manuscript reports a chemical investigation involving reverse-phase semipreparative HPLC-based isolation, followed by mass spectrometric and NMR-based characterization of three endophytic fungi recovered from Albizia lebbeck (L.) Benth. The study yielded two compounds (1-2) from ALE-75 (Sacharicola bicolor), three (3-5) from ALE-85 (Aspergillus pseudoglaucus), and one (6) from ALE-121 (Aspergillus eurotium). The extract from Aspergillus pseudoglaucus exhibited antioxidant potential (IC50 = 11.92 µg/mL in DPPH assay) and moderate cytotoxicity against lung (A549, IC50 = 35 µg/ml), colon (HCT-116, IC50 value of 45.4 µg/ml), and breast (T47D, IC50 value of 2.8 µg/ml) cancer cells, with growth inhibition of 89%, 77%, and 74% at 100 µg/ml. ALE-121 extract showed strong cytotoxicity against lung (A549, IC50 = 11.2 µg/ml), colon (HCT-116, IC50 = 12.5 µg/ml) and breast (T47D, IC50 = 15 µg/ml) cancer cells, with inhibition rates of 85%, 84%, and 75% at 100 µg/ml. Compound 6 (Austrocortinin) showed strong cytotoxicity against these cancer lines, with inhibition rates of 89%, 87%, and 67% at 10 µg/ml. Compound 1 was initially identified through the fermentation process of the endophytic fungus Coriolopsis sp. J5, which was isolated from the mangrove Ceriops tagal and compound 2 in Penicillium chrysogenum LF066 from the marine sponge Tethya aurantium. Compounds 3-5, originally found in Chaetomium globosum and Aspergillus flavus, whereas Compound 6 was initially discovered in the Australian Cortinarius toadstool. Although these compounds have been identified previously, this is the first instance of their reporting in the aforementioned endophytic fungi isolated from Albizia lebbeck.
Investigations on Antioxidant and Antibacterial Potential of 1,2,3-Triazole-Appended Indole-DHA Chalcone Hybrids: In Vitro and In Silico Studies Anshul Grover, Nitika Bhasin, Mohd. Aslam, Sundeep Jaglan, Prashant Singh, Sonika Asija, Kashmiri Lal Chemistryselect, 2025 The present research work involves the synthesis of a small library of newly synthesized 1,2,3‐triazole‐appended indole‐DHA‐chalcone hybrids ( 4a‐4l ) using a molecular hybridization strategy. After thorough characterization via different spectral techniques, these hybrids were assayed for their DPPH (1,1‐diphenyl‐2‐picrylhydrazyl) radical scavenging activity. Hybrids 4h and 4b showed antioxidant activity with IC 50 (half‐maximal inhibitory concentration) of 129.05 and 180.33 µM. These derivatives were further screened for their antibacterial and antibiofilm action against Staphylococcus aureus , Methicillin‐resistant Staphylococcus aureus (MRSA), Escherichia coli , and Pseudomonas aeruginosa . Results revealed that the antibacterial efficacy of the tested compounds was not significant; however, some compounds exhibited good biofilm inhibition. Hybrid 4h displayed the highest biofilm inhibition, that is, 75.67% and 70.34% against S. aureus and MRSA, respectively, at 128 µM concentration. Additionally, docking investigations offered insights on binding interactions between S. aureus 4H8E protein and compound 4h, having a binding energy of −9.6 kcal/mol. Molecular dynamics simulations suggested less deviation of H‐bonds indicating a relatively stable interaction between 4H8E and 4h . SwissADME analysis displayed the majority of compounds complying with Lipinski's rules with either one or no violations. Log of partition coefficient values predicted satisfactory lipophilic character for these compounds. This research work provides much comprehensive view on applications of 1,2,3‐triazoles as antibiofilm and antioxidant agents.
LCMS/MS-Based Mining of the Peptaibiome: A Discovery of New Peptaibols Nisha Sharma, Poonam Choudhary, Priya Kumari, Mohd Murtaza, Vidushi Abrol, Rohit Singh, Sudha Shankar, Andrew J. Wiemer, Manoj Kushwaha, Sundeep Jaglan Journal of the American Society for Mass Spectrometry, 2025 In this study, we employed liquid chromatography–tandem mass spectrometry (LC–MS/MS) to perform chemo-profiling on four fungal species: three Trichoderma species─two strains of Trichoderma asperellum (S3–3 and S3–1) and one Trichoderma longibrachiatum (FS-46)─and one species from the Tolypocladium genus, Tolypocladium inflatum (MTCC-3538). Our analysis identified 78 peptaibols featuring α-aminoisobutyric acid (Aib). Among these, we discovered both cyclic and linear Peptaibols and lipopeptaibols with Aib, ranging in putative molecular weights from 1033.4 to 1953.6 g/mol, corresponding to peptide lengths of 10–20 amino acids. In total, 78 peptaibols, including lipopeptaibols, were identified through LC-MS/MS. Of these, 43 were recognized as new peptaibols based on mass fragmentation patterns and sequence data from the MS/MS analysis. Our findings suggest that LC-MS/MS-based large-scale studies of the peptaibiome will enable the discovery of novel peptaibols and provide a valuable reference for understanding fragmentation patterns of peptaibols, cyclic peptaibols, and lipopeptaibols. Moreover, LC-MS/MS allows rapid identification of peptaibiotics at low concentrations directly in extracts, offering a potential quality control method for selecting beneficial Trichoderma strains for crop protection, while their fragmentation patterns and plausible sequences can guide synthetic design.
Isolation, characterization, and diversity of fungal endophytes from Albizia lebbeck in Jammu & Kashmir, India Nisha Sharma, Mohd Murtaza, Waqas Ahmed, Umesh Goutam, Sundeep Jaglan Journal of Applied Biology and Biotechnology, 2025 Endophytes are microorganisms that reside within various plant parts and cause no damage to the host plant. Fungal endophytes from various medicinal plants have been isolated and characterized due to their beneficial role; however, their diversity in the Albizia lebbeck plant remains unexplored. This study aims to isolate and represent the diversity of endophytic fungi associated with the leaves and stem of A. lebbeck, commonly known as “Siris” or Shirish” in Ayurvedic medicine. This medicinal plant is widely distributed in India, including the Jammu and Kashmir region. Endophytes were isolated and characterized using a combination of morphological and molecular approaches, employing internal transcribed spacer markers. A total of 210 endophytic fungi were successfully isolated (111 from leaves and 99 from stems) from 52 plant samples collected across 13 sites in Jammu and Kashmir. Most of the isolates (99.5%) belonged to the phylum Ascomycota, while only 0.5% were identified as Basidiomycota. Around 82 distinct species were identified, with greater diversity and species richness in leaf samples, highlighting the ecological significance of endophytes in plant systems. These findings inspire us to further investigate the role of fungal endophytes in maintaining plant health and their potential applications in pharmaceuticals.
Characterization of secondary metabolites produced during interaction of Pseudomonas fluorescens with Fusarium oxysporum Indian Journal of Agricultural Sciences, 2019
Optimization of DNA extraction for RAPD studies in plantago ovata Annals of Biology, 2012
Optimization of ISSR marker to evaluate genetic diversity in plantago ovata germplasm Annals of Agri Bio Research, 2011
RECENT SCHOLAR PUBLICATIONS
Draft genome sequence of Rhodococcus erythropolis DR10, a potential oil degradation actinobacteria P Gupta, J Vakhlu, P Kumar, S Jaglan Microbiology Resource Announcements 15 (4), e01153-25 , 2026 2026
Exploring Bioactive Metabolites from Endophytic Fungi of Albizia lebbeck (L.) Benth. N Sharma, M Kushwaha, A Qayum, SK Singh, U Goutam, S Jaglan Journal of Pure & Applied Microbiology 20 (1), 612 , 2026 2026
Echinomycin, a peptide antibiotic from a new bacterial source and its potential to tackle drug resistance in methicillin-resistant Staphylococcus aureus M Murtaza, N Bhasin, P Kumari, A Kour, P Choudhary, M Kushwaha, ... Archives of Microbiology 208 (3), 136 , 2026 2026 Citations: 1
Strategies to decipher silent biosynthetic gene clusters in actinomycetes M Murtaza, P Gupta, P Choudhary, M Manzoor, S Sharma, S Jaglan Archives of Microbiology 208 (1), 53 , 2026 2026 Citations: 2
Bioactive potential metabolites from gut associated fungal endofauna of Eisenia fetida M Hassan, S Nisa, M Kushwaha, S Gupta, S Jaglan, SK Shukla, R Singh Biocatalysis and Agricultural Biotechnology, 103898 , 2025 2025
Investigations on Antioxidant and Antibacterial Potential of 1, 2, 3‐Triazole‐Appended Indole‐DHA Chalcone Hybrids: In Vitro and In Silico Studies A Grover, N Bhasin, M Aslam, S Jaglan, P Singh, S Asija, K Lal ChemistrySelect 10 (48), e05287 , 2025 2025
LCMS/MS-based mining of the peptaibiome: A discovery of new peptaibols N Sharma, P Choudhary, P Kumari, M Murtaza, V Abrol, R Singh, ... Journal of the American Society for Mass Spectrometry 36 (11), 2597-2606 , 2025 2025
Smart nano-fertilizers: a path to sustainable agriculture P Gupta, H Dhar, YS Bagal, S Jaglan Environmental Geochemistry and Health 47 (10), 443 , 2025 2025 Citations: 7
LC-MS/MS-based discovery of new cytochalasin from fungus Rosellinia sanctae-cruciana N Sharma, P Choudhary, P Kumari, M Murtaza, V Abrol, C Kumar, ... Natural Product Research, 1-6 , 2025 2025
DHA-indole-triazole hybrids: Click mediated synthesis, antimicrobial, antibiofilm and In Silico studies A Grover, A Kumar, P Kumari, S Jaglan, S Yadav, P Singh, H Om, K Lal Journal of Molecular Structure 1335, 141953 , 2025 2025 Citations: 12
Isolation, characterization, and diversity of fungal endophytes from Albizia lebbeck in Jammu & Kashmir, India N Sharma, M Murtaza, W Ahmed, U Goutam, S Jaglan Journal of Applied Biology & Biotechnology Vol 13 (4), 89-99 , 2025 2025 Citations: 1
Metabolite profiling and bioactivity of fungal endofauna from Xiphinema nuragicum in the rhizosphere of Withania somnifera J Chandan, S Gupta, Z Ahmed, SK Singh, P Kumar, R Choudhary, ... Environmental Science and Pollution Research 32 (13), 8448-8461 , 2025 2025 Citations: 1
Antimicrobial, antibiofilm, docking, DFT and molecular dynamics studies on click-derived isatin-thiosemicarbazone-1, 2, 3-triazoles A Kumar, K Lal, M Murtaza, S Jaglan, Y Rohila, P Singh, MB Singh, ... Journal of Biomolecular Structure and Dynamics 42 (19), 9919-9938 , 2024 2024 Citations: 13
Valproic Acid Enhances Antioxidant Potential of Setosphaeria rostrata , an Endophytic Fungus of Datura innoxia Mill. V Sharma, V Abrol, Richa, S Jaglan Biology Bulletin 51 (6), 1622-1630 , 2024 2024
Molecular Docking and Molecular Dynamics Simulations of Synthesized Thiazole‐Isatin‐1, 2, 3‐Triazole Hybrids as Promising Inhibitors for DNA Gyrase and Sterol 14α‐Demethylase V Kumar, P Kumari, S Yadav, K Kumari, S Jaglan, K Lal Chemistry & Biodiversity 21 (10), e202400914 , 2024 2024 Citations: 5
Recent insights on the conformational changes, functionality, and physiological properties of plant-based protein–polyphenol conjugates M Manzoor, ZFN Tchameni, ZF Bhat, AK Jaiswal, S Jaglan Food and Bioprocess Technology 17 (8), 2131-2154 , 2024 2024 Citations: 47
Elucidation of Structural, Morphological, Electrical Parameters, and Anti-Bacterial Activity of Polyaniline-Nanocomposite: New Paradigm of Controlling Bacterial Activity S Jacobo, S Sharma, JC Aphesteguy, R Kaur, C Singh, S Jaglan 2024
Epigenetic modifiers as inducer of bioactive secondary metabolites in fungi V Sharma, S Panjgotra, N Sharma, V Abrol, U Goutam, S Jaglan Biotechnology Letters 46 (3), 297-314 , 2024 2024 Citations: 7
Tomato as a Model Plant to Understand Plant–Microbial Interactions P Gupta, H Dhar, YP Sharma, S Jaglan Biotechnological Advances for Disease Tolerance in Plants, 317-335 , 2024 2024 Citations: 1
Biodiversity and bioactive potential of actinomycetes from unexplored high altitude regions of Kargil, India M Murtaza, V Abrol, E Nehra, P Choudhary, SK Singh, S Jaglan Indian Journal of Microbiology 64 (1), 110-124 , 2024 2024 Citations: 8
MOST CITED SCHOLAR PUBLICATIONS
Myco‐biocontrol of insect pests: factors involved, mechanism, and regulation SS Sandhu, AK Sharma, V Beniwal, G Goel, P Batra, A Kumar, S Jaglan, ... Journal of pathogens 2012 (1), 126819 , 2012 2012 Citations: 275
Citrus medica: nutritional, phytochemical composition and health benefits–a review N Chhikara, R Kour, S Jaglan, P Gupta, Y Gat, A Panghal Food & function 9 (4), 1978-1992 , 2018 2018 Citations: 268
Role of Food Safety Management Systems in safe food production: A review A Panghal, N Chhikara, N Sindhu, S Jaglan Journal of food safety 38 (4), e12464 , 2018 2018 Citations: 255
Green synthesis and anticancer potential of chalcone linked-1, 2, 3-triazoles P Yadav, K Lal, A Kumar, SK Guru, S Jaglan, S Bhushan European journal of medicinal chemistry 126, 944-953 , 2017 2017 Citations: 213
Bioactive compounds and pharmacological and food applications of Syzygium cumini–a review N Chhikara, R Kaur, S Jaglan, P Sharma, Y Gat, A Panghal Food & function 9 (12), 6096-6115 , 2018 2018 Citations: 193
Whey valorization: current options and future scenario–a critical review A Panghal, R Patidar, S Jaglan, N Chhikara, SK Khatkar, Y Gat, N Sindhu Nutrition & Food Science 48 (3), 520-535 , 2018 2018 Citations: 164
Expanding the chemical diversity through microorganisms co-culture: Current status and outlook D Arora, P Gupta, S Jaglan, C Roullier, O Grovel, S Bertrand Biotechnology advances 40, 107521 , 2020 2020 Citations: 147
Capsaicin production by Alternaria alternata, an endophytic fungus from Capsicum annum; LC–ESI–MS/MS analysis S Devari, S Jaglan, M Kumar, R Deshidi, S Guru, S Bhushan, ... Phytochemistry 98, 183-189 , 2014 2014 Citations: 128
Bioactive compounds, food applications and health benefits of Parkia speciosa (stinky beans): a review N Chhikara, HR Devi, S Jaglan, P Sharma, P Gupta, A Panghal Agriculture & food security 7 (1), 46 , 2018 2018 Citations: 126
Polysaccharides based nanomaterials for targeted anti-cancer drug delivery D Dheer, D Arora, S Jaglan, RK Rawal, R Shankar Journal of drug targeting 25 (1), 1-16 , 2017 2017 Citations: 124
Recent advances in near-infrared light-responsive nanocarriers for cancer therapy A Saneja, R Kumar, D Arora, S Kumar, AK Panda, S Jaglan Drug Discovery Today 23 (5), 1115-1125 , 2018 2018 Citations: 122
Evaluation of novel indigenous fungal consortium for enhanced bioremediation of heavy metals from contaminated sites D Talukdar, T Jasrotia, R Sharma, S Jaglan, R Kumar, R Vats, R Kumar, ... Environmental Technology & Innovation 20, 101050 , 2020 2020 Citations: 117
Nanocarriers based delivery of nutraceuticals for cancer prevention and treatment: A review of recent research developments D Arora, S Jaglan Trends in Food Science & Technology 54, 114-126 , 2016 2016 Citations: 110
Nutritional, Physicochemical and Functional Quality of Beetroot (Beta vulgaris L.) Incorporated Asian Noodles N Chhikara, K Kushwaha, S Jaglan, P Sharma, A Panghal Cereal Chemistry , 2019 2019 Citations: 95
Isolation and characterization of bioactive metabolites from Xylaria psidii, an endophytic fungus of the medicinal plant Aegle marmelos and their role in mitochondrial … D Arora, N Sharma, V Singamaneni, V Sharma, M Kushwaha, V Abrol, ... Phytomedicine 23 (12), 1312-1320 , 2016 2016 Citations: 92
Secalonic acid-D represses HIF1α/VEGF-mediated angiogenesis by regulating the Akt/mTOR/p70S6K signaling cascade SK Guru, AS Pathania, S Kumar, D Ramesh, M Kumar, S Rana, A Kumar, ... Cancer research 75 (14), 2886-2896 , 2015 2015 Citations: 92
An update on polysaccharide-based nanomaterials for antimicrobial applications D Arora, N Sharma, V Sharma, V Abrol, R Shankar, S Jaglan Applied Microbiology and Biotechnology 100 (6), 2603-2615 , 2016 2016 Citations: 84
Bioremediation potential of novel fungal species isolated from wastewater for the removal of lead from liquid medium R Sharma, D Talukdar, S Bhardwaj, S Jaglan, R Kumar, R Kumar, ... Environmental technology & innovation 18, 100757 , 2020 2020 Citations: 78
Therapeutic applications of resveratrol nanoformulations D Arora, S Jaglan Environmental chemistry letters 16 (1), 35-41 , 2018 2018 Citations: 67
Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill. V Sharma, V Singamaneni, N Sharma, A Kumar, D Arora, M Kushwaha, ... Bioorganic & Medicinal Chemistry Letters 28 (12), 2217-2221 , 2018 2018 Citations: 59