Sunny Kuriakose
@stcp.ac.in
Associate Professor and Head of the Department
St.Thomas College Palai, Mahatma Gandhi University, Kottayam, Kerala
EDUCATION
BSc from College, Thalassery, Kerala, India (90% marks with 5th rank in the University), 1986
MSc from University of Calicut (73.1% marks with 3rd rank in the University), 1988
Ph.D from Mahatma Gandhi University, 1994
P.D.F from Johannes-Gutenberg University, Mainz, Germany, 2002
RESEARCH INTERESTS
Nanochemistry, Nanobiology, Supramolecular Chemistry and Polymer Chemistry
Scopus Publications
Scopus Publications
Jissy Jacob, Nihita Linson, Sunny Kuriakose, Sabu Thomas, and Sana Kabdrakhmanova
American Chemical Society (ACS)
Sherin Philip and Sunny Kuriakose
Springer Science and Business Media LLC
Bright Brailson Mansingh, Joseph Selvi Binoj, Jissy Jacob, Sabu Thomas, Nihita Linson, and Sunny Kuriakose
Elsevier
Jissy Jacob, Nihita Linson, Joseph Selvi Binoj, Bright Brailson Mansingh, Sunny Kuriakose, and Sabu Thomas
Elsevier
Nihita Linson, Jissy Jacob, and Sunny Kuriakose
Springer Science and Business Media LLC
Sherin Philip and Sunny Kuriakose
Springer Science and Business Media LLC
Nihita Linson, Jissy Jacob, and Sunny Kuriakose
Springer Science and Business Media LLC
Jissy Jacob, Vijay Robert, Ravi Babu Valapa, Sunny Kuriakose, Sabu Thomas, and Sravanthi Loganathan
American Chemical Society (ACS)
Linta Maria Jose, Sunny Kuriakose, and Tessymol Mathew
Elsevier BV
BACKGROUND
By coalescing nanotechnology with photochemistry and microbiology, a new type of photoactive antimicrobial agent based on zinc oxide nanoparticles incorporated into biomacromolecular lignin was formulated, which possesses a wide-spectrum antimicrobial activity, providing dramatic effects in the field of antimicrobial photodynamic therapy.
METHODS
The biomacromolecule lignin was functionally modified with 2-[(E)-(2-hydroxy naphthalen-1-yl) diazenyl] benzoic acid by Steglich esterification, and loaded with zinc oxide nanoparticles. The products were characterized by UV-Visible, FTIR, and NMR spectroscopic techniques, and by SEM, TEM, and X-ray diffraction analysis (XRD). The photoresponsive behavior of the dye, functionally modified lignin-dye ester and its nanoparticle dispersed product was investigated. The photoinduced antibacterial and antifungal effects of zinc oxide nanoparticle encapsulated functionally modified lignin were explicated in detail.
RESULTS
The photostabilization property of the chromophoric system was found to be enhanced when attached to lignin, and was further improved by the encapsulation of photoactive zinc oxide nanoparticles. The detailed studies on the photoinduced antibacterial and antifungal property revealed that upon light irradiation the antibacterial and antifungal efficacies of the test system got magnified.
CONCLUSIONS
Incorporation of photoactive zinc oxide nanoparticles into the functionalized macromolecular system could make drastic changes in their photoresponsive abilities such as enhanced light absorption behavior and excellent photostabilization properties enriched with superior photoinduced antimicrobial efficacy, which rendered the functionally modified system an excellent photoinduced antimicrobial agent, and can be used in various biomedical applications especially in antimicrobial photodynamic therapy.
Sherin Philip, Sunny Kuriakose, and Tessymol Mathew
Wiley
Sherin Philip and Sunny Kuriakose
Springer Science and Business Media LLC
Increased antimicrobial resistance demands the development of new antimicrobial agents with high potency. A wide variety of microbial systems are continuously subjected to mutations which ultimately results in antimicrobial resistance. The present study aimed at the fabrication of a nano drug delivery system which simultaneously is superparamagnetic, fluorescent, non-cytotoxic and antifungal. The developed system is an easily targetable and detectable tool owing to its superparamagnetic and fluorescent characteristics respectively. Superparamagnetic iron oxide nanoparticles stabilized by macromolecular starch have been incorporated into a fluorescently modified carrier system to get the final drug delivery system. The finally developed drug carrier system is found to be non-cytotoxic from the in vitro cytotoxicity studies performed against normal rat spleen cells. The photodynamic antifungal capability of the system was the premier concern of investigation of the present study. The antifungal studies were conducted against Histoplasma capsulatum and Trichophyton rubrum by well diffusion method and the results were compared with the activity of the antibiotic, griseofulvin. The minimum inhibitory concentration against each fungal strain was determined using broth dilution method.
Sherin Philip and Sunny Kuriakose
Springer Science and Business Media LLC
In the present study we have synthesized α-Fe2O3 nanoparticles in a more conventionally established NaBH4 reduction, but using a bio-macromolecule, starch. The synthesized nanoparticles were characterized using UV/visible and FTIR spectroscopic, XRD, SEM, and TEM techniques. The stabilised nanoparticles showed a considerable reduction in size (12–17 nm) compared to the bare nanoparticles (24–52 nm). The magnetic studies were conducted using VSM analysis. The most significant result was observed that the starch stabilised iron oxide nanoparticles showed superparamagnetic behaviour, while the bare nanoparticles remained weakly ferromagnetic. The antimicrobial properties of these superparamagnetic particles were monitored against five bacterial and fungal strains each.
Princy Philip, Tomlal Jose, Sarath KS, and Sunny Kuriakose
SAGE Publications
Silver nanoparticles with 5–10 nm diameters are synthesised using Couroupita guianensis flower extract. The synthesised silver nanoparticles found to show good antimicrobial activity against gram negative and gram positive bacteria. Poly(methyl methacrylate) nanofibers with pristine, surface roughened and coaxial hollow forms are prepared by electrospinning. The structural and morphological properties of these pure and structurally modified poly(methyl methacrylate) nanofibers are evidenced by various analytical techniques. The antimicrobial studies of poly(methyl methacrylate) nanofibers having different architectures incorporated with silver nanoparticles are carried out. It is found that, all the three forms of poly(methyl methacrylate) nanofibers incorporated with silver nanoparticles show antibacterial properties against both gram positive and gram negative bacteria. Among these, surface roughened poly(methyl methacrylate) nanofibers incorporated with silver nanoparticles show highest antibacterial activity than the other two structural forms. The present study offers an alternative to the existing optical lenses. People especially those who suffer from eye problems can protect their eyes in a better way from infectious agents by wearing optical lens made from C. guianensis stabilised silver nanoparticles incorporated poly(methyl methacrylate) nanofibers than that made from pure poly(methyl methacrylate) nanofibers or films.
Linta Maria Jose, Sunny Kuriakose, and Sabu Thomas
Springer Science and Business Media LLC
The present work aims to develop photoresponsive nanoparticle incorporated biomacromolecular aggregates with excellent optical and antimicrobial properties by the apt combination of zinc oxide nanoparticles with lignin, a macromolecular binding system. The biopolymer lignin-stabilized zinc oxide nanoparticles were fabricated by a cost-effective chemical precipitation route. The synthesized ZONPs and lignin-stabilized ZONPs were characterized by UV-visible, FT-IR and fluorescence spectrophotometric techniques, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD) analyses. The antifungal efficacy evaluation of the developed ZONP encapsulated lignin aggregates was done against selected pathogenic fungal strains. The study established the use of ZONPs encapsulated in water-soluble and biocompatible macro matrix lignin as an effective antifungal agent in order to improve the antimicrobial performance in biomedical and environmental applications.
Linta Maria Jose and Sunny Kuriakose
Springer Science and Business Media LLC
The present work describes the synthesis of the polypeptide coated silver nanoparticles by the excellent combination of the macromolecule bovine serum albumin (BSA) and nanosized silver particles (AgNPs). The product was characterised by spectroscopic, microscopic and X-ray diffraction analyses. The thermal characteristics were studied by TG-DTG and DSC measurements. The developed system was evaluated for its antibacterial property by disc diffusion method against the selected pathogenic gram positive and gram negative bacterial strains Streptococcus haemolyticus (+ve), Corynebacterium diphtheriae (+ve), Klebsiella ornithinolytica (-ve) and Salmonella paratyphi (-ve). The study revealed that the AgNP-BSA aggregates displayed appreciable thermal stability and better antimicrobial efficacy and is anticipated to be a promising material for antimicrobial applications.
Sherin Philip and Sunny Kuriakose
Springer Science and Business Media LLC
AbstractPyrene butyric acid (PBA) is a well studied lumophore for its exciting fluorescent properties. The current study focussed on a dendritic modification of PBA with hyperbranched polyglycerols (HPG) by Steglich esterification and further doping with iron oxide nanoparticles (IONP) of α-Fe2O3 phase. The covalent coupling between HPG and PBA was confirmed by FTIR and 1H-NMR spectra. The main objective of the study was to monitor the fluorescent properties of the modified and doped products. Steady state PL emission studies showed a considerable decrease in fluorescence intensity on HPG modification which almost completely disappeared on doping with IONP. This suggests that this fluorosensing property can be explored in identification and estimation of iron oxide nanoparticles which has a great significance in biomedical field both in diagnostics and therapeutics. Lifetime measurements with TCSPC suggested an aggregation enhanced quenching of HPG-PBA conjugates and mixed static and dynamic mechanisms in IONP doped HPG-PBA conjugates.
Graphical Abstractᅟ
Sherin Philip and Sunny Kuriakose
Elsevier BV
Abstract Superparamagnetic iron oxide nanoparticles have always been a topic of significance in biomedical research due to their tremendous range of applications. The present study reports the synthesis of superparamagnetic Fe2O3 nanoparticles by a simple NaBH4-reduction, stabilised by supramolecular inclusion host β-cyclodextrin. The crystallite size was calculated from X-ray diffraction studies using Debye Scherrer equation and found to be in the range 14-23 nm. The antibacterial activity of the sample was studied against Vibrio cholerae and Clostridium botulinum using disc diffusion method. Antifungal activity was monitored against three fungal strains Candida auris, Trichophyton rubrum and Cryptococcus gatti using well diffusion method.
Linta Maria Jose and Sunny Kuriakose
Springer Science and Business Media LLC
This study establishes the synthesis of silver nanoparticles (AgNPs), synthesis of a photoresponsive system 2-[(E)-(3-hydroxynaphthalen-2-yl) diazenyl] benzoic acid, and encapsulation of AgNPs into the biomacromolecular system, bovine serum albumin (BSA) functionally modified with the photoactive system by means of DCC coupling. The optical properties, structural properties, morphology, and size distribution were confirmed by various characterisation techniques such as ultraviolet (UV)/visible, Fourier transform infrared (FTIR), nuclear magnetic resonance (NMR), photoluminescence (PL) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction analysis (XRD). The photo responsive behaviour of the functionally modified BSA and nanoparticle dispersed system were investigated. The antibacterial effects of AgNPs and photo induced antimicrobial properties of the functionally modified BSA-AgNP conjugates were evaluated against some selected bacterial strains such as Corynebacterium diphtheriae (gram +ve), Bacillus cereus (gram +ve), Raoultella ornithinolytica (gram -ve), and Salmonella typhimurium (gram -ve) using disc diffusion. We found that silver nanoparticles encapsulating functionally modified BSA seem to be an effective photoactive antimicrobial agent against the multidrug resistant strains of bacteria with better photo responsive properties and with wide applications in antimicrobial photodynamic therapy (APDT).
Sherin Philip and Sunny Kuriakose
Elsevier BV
Abstract Increased microbial resistance being a serious issue, we synthesized iron oxide nanoparticle-encapsulated β -cyclodextrin with potential antibacterial properties. Since iron is already a biologically significant trace metal, iron and its oxides are always significant in the field of medicine. In the present study, we have successfully synthesized α -Fe2O3 nanoparticles encapsulated into a supramolecular host system, β -cyclodextrin. The products were characterized using UV/visible, photoluminescence and FTIR spectroscopic techniques. The particle size and crystalline nature were investigated using XRD measurements. The surface morphology and topography of the aggregates were studied using scanning and high-resolution transmission electron microscopies. The human pathogenic bacterial strains S.aureus, K.Pneumoniae and S.typhi were randomly selected for the study based on their pathogenic effect on humans. MIC values were also determined for each species.
Soumya Jose and Sunny Kuriakose
Springer Science and Business Media LLC
A photoactive system, (2E)-3-{3-[(Z)-naphthalen-1-yldiazenyl] phenyl} prop-2-enoic acid, was synthesized and incorporated on to beta-cyclodextrin (β-CD) core through esterification of the hydroxyl groups of β-CD with the free carboxyl moiety of the chromophoric system by DCC coupling. The silver nanoparticle was synthesized by the reduction reaction executed on silver acetate in presence of dodecyl amine. The silver nano particles were dispersed in β-CD aggregates modified with photoactive system by phase transfer mechanism. The products were characterized by elemental analysis, melting point determination, UV–visible, FT-IR and NMR (1H and 13C) spectral methods and SEM and TGA-DTG thermal studies. The thermal studies shows that the silver nanoparticle dispersed functionally modified beta cyclodextrin exhibited enhanced thermal stability compared to the functionalised β-CD.
Sheena Varghese and Sunny Kuriakose
Informa UK Limited
Abstract This paper describes the synthesis of carbon nanoparticle (CNP) from natural sources such as kitchen soot, synthesis of a chromophoric system {5-[4-(dimethylamino) benzylidene]-4-oxo-2-thioxo1, 3-thiazolidin-3-yl} acetic acid and its incorporation into β-cyclodextrin (β-CD) through the esterification of the hydroxyl group with the free carboxyl function of the chromophoric system by DCC coupling. Encapsulation of CNP into functionally modified β-CD system was achieved. Characterisation of the products was undertaken by UV–visible, FT-IR, NMR, fluorescence spectroscopic methods, SEM, TEM and X-ray diffraction methods. Their antibacterial activities were addressed. The antibacterial activity of CNP and functionally modified β-CD-CNP products were tested against various pathogenic bacterial strains such as Streptcoccus haemoliticus (+ve), Staphylococcus aureus (+ve), Klebsiella pneumonia (−ve) and E. coli (MTCC1687) (−ve) by disc diffusion method. The results showed that the CNPs and functionally modified products have good antibacterial activity against selected pathogenic bacterial strains.
Rekha Sree and Sunny Kuriakose
Elsevier BV
Abstract Alkali salts of tungsten based heteropoly acids with different central atom such as P, Si and Co were prepared and evaluated for transesterification of both edible and non-edible oils to their corresponding fatty acid methyl esters. The catalyst of sodium salt of tungstic acid with Co as central atom (Na5CoW12O40) showed optimum activity towards transesterification compared with other heteropoly tungstates. The catalysts activities were correlated with the observed physico-chemical characteristics derived from FT-infrared (FT-IR), X-ray diffraction (XRD), temperature-programmed desorption of ammonia (NH3-TPD) and carbon dioxide (CO2-TPD). The Na5CoW12O40 catalyst exhibiting high activity even at 65 °C is due to the presence of strong acidic as well as basic sites. The disclosed catalyst is tolerable towards water and free fatty acids present in the oils. The influence of catalyst loading, reaction time and reaction temperature is studied to optimize the reaction parameters.
Ambily Chandran, Sunny Kuriakose, and Tessymol Mathew
Wiley
In the present work, chromophoric system (E)-4-(naphthalen-1-yl diazenyl)benzoic acid was synthesized and incorporated into lignin core. The end hydroxyl group of lignin was modified with the free carboxyl group of the chromophoric systems by dicyclohexylcarbodiimide coupling. The products were characterized by means of UV–visible, fluorescence, FT-IR, and NMR spectroscopic methods and subjected to photoresponsive studies. The results show that modification enhances the light absorption and light fastening properties of the chromophoric system. The photoinduced trans–cis isomerization on the newly developed photosensitive biopolymeric system and the chromophoric system were investigated. Results also show that the trans–cis photoisomerization and the reverse cis–trans thermal conversions of the photoactive groups were also assisted by the incorporation onto biopolymeric core. Copyright © 2014 John Wiley & Sons, Ltd.
Ambily Chandran, Sunny Kuriakose, and Tessymol Mathew
Wiley
The chemical modification of starch is of interest because the modification would not change the fundamental skeleton of starch, would keep the original physicochemical and biochemical properties and finally would bring new or improved properties. A chromophoric system 4-[(E)-2-(3-hydroxynaphthalen-2-yl)diazen-1-yl]benzoic acid was synthesized and incorporated into the biopolymeric core of starch by DCC coupling. The products were characterized by UV–visible, fluorescence, FT-IR, and NMR spectroscopic methods and subjected to thermal and photoresponsive studies. The results show that modification enhances the light absorption and light fastening properties of the chromophoric system. Thermal stability of the polymeric system greatly enhances on attaching to chromophoric system. In this research article an attempt has been done to explore present and future industrial prospects of functionally modified starches.
Thomas V. Mathew and Sunny Kuriakose
Springer Science and Business Media LLC
We developed a new 4-(1-pyrenyl)butyric acid functionalised chitosan matrix for the stabilisation of silver nanoparticles (AgNP). The functional modification of chitosan was achieved by the esterification of the hydroxylic groups of chitosan with the carboxylic acid group of the 4-(1-pyrenyl)butyric acid. Silver nanoparticles were synthesised using the reduction method and these nanoparticles were stabilised into the biopolymeric scaffolds of functionalised chitosan. The morphology and the structure have been determined using FT IR, NMR, DSC, TG, SEM and TEM analysis. The thermal stability and photoresponsive properties of the products were analysed and the resulting product possessed intense photosensitive flourescence and thermal properties. The product was biocompatible and can find applications in biomedical, agricultural fields and environmental protection.