Fungal Endophytes: A Storehouse of Bioactive Compounds Arindam Maity, Suraj Kumar Shah, Yadu Nandan Dey, Yasasve Madhavan Mini Reviews in Medicinal Chemistry, 2023 Fungal endophytes are the microbial adaptations that usually enter the plant tissues during their life cycle without harming the host plants. They are found everywhere on earth and generally depend on the hosts by developing various symbiotic relationships, like mutualism, hostility, and parasitism on rare occasions, leading to the growth and rise in the nutrient content of the hosts. Endophytes can develop tolerance in host organisms against the stresses induced by either living or non-living agents. They may protect them from insects or pests by building resistance. Interestingly, endophytes can synthesize many phytohormones, natural medicinal compounds and several essential enzymes beneficial for biotechnological perspectives that can be obtained by culturing plant tissue in a suitable medium. These endophytes are a reservoir of many new active phytoconstituents, like alkaloids, phenolics, steroids, quinones, tannins, saponins, etc., which exhibit anticancer, antiinsecticidal, antioxidant, antibacterial, antiviral, antifungal, and many more properties. Exploring the new bioactive chemical entities from the endophytes may supply potent lead compounds for drug discovery to combat numerous disease conditions. Hence, the present review was carried out to explore the significance of the fungal endophytes and their medicinal, food, and cosmetic use.
Pyridine: the scaffolds with significant clinical diversity Sourav De, Ashok Kumar S K, Suraj Kumar Shah, Sabnaz Kazi, Nandan Sarkar, et al. Rsc Advances, 2022 The nitrogen-bearing heterocycle pyridine in its several analogous forms occupies an important position as a precious source of clinically useful agents in the field of medicinal chemistry research.
Aqueous NH3-mediated syntheses of 2-styrylquinoline-4-carboxamides by domino ring opening cyclization strategy Chandran R., Ashwini Pise, Suraj Kumar Shah, Rahul D., Anirudh Baluni, et al. Synthetic Communications, 2021 A straightforward and efficient protocol for the synthesis of medicinally relevant 2-styrylquinoline-4-carboxamide has been developed by aqueous ammonia-mediated domino ring-opening and cyclization strategy of 3-hydroxyoxindole. The starting precursors 3-hydroxyoxindoles were easily prepared through organocatalytic “on water” reaction of isatin and benzalacetone in high yields. The wide substrate scope with operationally simple experimental procedures provides an opportunity to create library of 2-styrylquinoline-4-carboxamide derivatives. Graphical abstract
Copper-Catalyzed Thiolation of Terminal Alkynes Employing Thiocyanate as the Sulfur Source Leading to Enaminone-Based Alkynyl Sulfides under Ambient Conditions Chandran R., Ashwini Pise, Suraj Kumar Shah, Rahul D., Suman V., et al. Organic Letters, 2020 A highly efficient protocol for copper-catalyzed thio-alkynylation of enaminone-based thiocyanates with terminal alkynes under mild conditions has been developed. This scalable amino group-directed thio-alkynylation proceeds in the open air with a broad substrate scope and an excellent yield. The demonstrated synthetic transformation creates the opportunity for a wide variety of sulfur-containing useful materials. Gram-scale synthesis and further synthetic transformations of alkynyl sulfides highlight the potential utility of the method.
