Suresh Palanivel

@tuni.fi

Post Doctoral Researcher/Faculty of Medicine and Health Technology
Tampere University

Suresh Palanivel


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https://researchid.co/suresh.palanivel

EDUCATION

August 2022 D.Sc (Tech), Biomedical Science and Engineering Tampere University, Tampere, Finland, Finland
June 2012 Master of Science, Biotechnology, Edinburgh Napier University, Edinburgh, United Kingdom
April 2010 B.Tech, Biotechnology, Kamaraj College of Engineering and Technology, Anna University, Virudhunagar, India

RESEARCH, TEACHING, or OTHER INTERESTS

Cancer Research, Cell Biology, Molecular Biology, Drug Discovery
9

Scopus Publications

99

Scholar Citations

5

Scholar h-index

3

Scholar i10-index

Scopus Publications

  • Unlocking the potential of hydroxylated-chalcone-based photosensitive benzoxazines: synthesis, multifunctional properties and theoretical insights from density functional theory
    Subasri Appasamy, Balaji Krishnasamy, Subhapriya Pushparaju, Suresh Palanivel
    Polymer International, 2025
    This work pioneers the synthesis of a new class of benzoxazine monomers incorporating hydroxylated chalcone units (HAN‐HB) using 2′‐hydroxy‐1′‐acetonaphthone (HAN) and p‐hydroxybenzaldehyde (HB) by following the Claisen–Schmidt condensation process. Three types of structurally varied bifunctional benzoxazines (Bz) were prepared using HAN‐HB and paraformaldehyde separately with tyramine (ty), 3‐amino‐1‐propanol (ap) and 2‐(2‐aminoethoxy)ethanol (aee) by adopting Mannich condensation. Both the HAN‐HB and benzoxazine molecular structures were confirmed by different spectroscopic analyses. DSC analysis reveal that HAN‐HB‐ap benzoxazine showed the lowest Tp value of 214 °C. Poly(HAN‐HB‐ty) possesses the highest values of thermal decomposition temperature and percentage char yield. Further, all the polybenzoxazines exhibit self‐extinguishing and good heat‐resistant properties. In addition, the synthesised benzoxazines showed good anti‐microbial behavior. Photosensitive properties of the benzoxazines were studied using UV–visible spectroscopic analysis and the results indicated that the synthesised benzoxazines exhibited both photo‐isomerisation and photocrosslinking due to their inherent molecular rearrangement ability. An aggregation‐caused quenching characteristic was observed for the benzoxazines through a fluorescence study. From the water contact angle study, it was inferred that all the poly(HAN‐HB‐Bz) exhibited a water repellent nature and showed a higher water contact angle of 151°. The corrosion‐resistant behaviour of polybenzoxazines towards a mild steel surface was studied and the results obtained infer that these materials exhibit good protection efficiency. Density functional theory studies were performed for all the chalcone‐based benzoxazines. The incorporation of hydroxyl groups not only improves hydrogen bonding interactions, enhancing thermal stability, but also introduces photo‐reactivity. This dual functionality is not commonly reported in conventional benzoxazines. The results obtained from various studies suggest that the developed chalcone‐based benzoxazines can be suitably exploited for advanced photosensitive coating applications. © 2025 Society of Chemical Industry.
  • Benzenesulfonamide Analogs: Synthesis, Anti-GBM Activity and Pharmacoprofiling
    Akshaya Murugesan, Saravanan Konda Mani, Ramesh Thiyagarajan, Suresh Palanivel, Atash V. Gurbanov, et al.
    International Journal of Molecular Sciences, 2023
    The tropomyosin receptor kinase A (TrkA) family of receptor tyrosine kinases (RTKs) emerge as a potential target for glioblastoma (GBM) treatment. Benzenesulfonamide analogs were identified as kinase inhibitors possessing promising anticancer properties. In the present work, four known and two novel benzenesulfonamide derivatives were synthesized, and their inhibitory activities in TrkA overexpressing cells, U87 and MEF cells were investigated. The cytotoxic effect of benzenesulfonamide derivatives and cisplatin was determined using trypan blue exclusion assays. The mode of interaction of benzenesulfonamides with TrkA was predicted by docking and structural analysis. ADMET profiling was also performed for all compounds to calculate the drug likeness property. Appropriate QSAR models were developed for studying structure–activity relationships. Compound 4-[2-(4,4-dimethyl-2,6-dioxocyclohexylidene)hydrazinyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfon-amide (AL106) and 4-[2-(1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)hydrazinyl]-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide (AL107) showed acceptable binding energies with the active sites for human nerve growth factor receptor, TrkA. Here, AL106 was identified as a potential anti-GBM compound, with an IC50 value of 58.6 µM with a less toxic effect in non-cancerous cells than the known chemotherapeutic agent, cisplatin. In silico analysis indicated that AL106 formed prominent stabilizing hydrophobic interactions with Tyr359, Ser371, Ile374 and charged interactions with Gln369 of TrkA. Furthermore, in silico analysis of all benzenesulfonamide derivatives revealed that AL106 has good pharmacokinetics properties, drug likeness and toxicity profiles, suggesting the compound may be suitable for clinical trial. Thus, benzenesulfonamide analog, AL106 could potentially induce GBM cell death through its interaction with TrkA and might be an attractive strategy for developing a drug targeted therapy to treat glioblastoma.
  • Molecular interaction study of novel indoline derivatives with EGFR-kinase domain using multiple computational analysis
    Suresh Palanivel, Olli Yli-Harja, Meenakshisundaram Kandhavelu
    Journal of Biomolecular Structure and Dynamics, 2022
    Epidermal growth factor receptors are constitutively overexpressed in breast cancer cells, which in turn stimulate many downstream signaling pathways that are involved in many carcinogenic processes. This makes EGFR a striking target for cancer therapy. This study focuses on the EGFR kinase domain inactivation by novel synthesized indoline derivatives. The compounds used are N-(2-hydroxy-5-nitrophenyl (4’-methyl phenyl) methyl) indoline (HNPMI), alkylaminophenols − 2-((3,4-Dihydroquinolin-1(2H)-yl) (p-tolyl) methyl) phenol (THTMP) and 2-((1, 2, 3, 4-Tetrahydroquinolin-1-yl) (4 methoxyphenyl) methyl) phenol (THMPP). To get a clear insight into the molecular interaction of EGFR and the three compounds, we have used ADME/Tox prediction, Flexible docking analysis followed by MM/GB-SA, QM/MM analysis, E-pharmacophore mapping of the ligands and Molecular dynamic simulation of protein-ligand complexes. All three compounds showed good ADME/Tox properties obeying the rules of drug-likeliness and showed high human oral absorption. Molecular docking was performed with the compounds and EGFR using Glide Flexible docking mode. This showed that the HNPMI was best among the three compounds and had interactions with key residue Lys 721. The protein-ligand complexes were stable when simulated for 100 ns using Desmond software. The interactions were further substantiated using QM/MM analysis and MM-GB/SA analysis in which HNPMI was scored as the best molecule. All the analyses were carried out with a reference molecule—Gefitinib which is a known standard inhibitor of EGFR. Thus, the study elucidates the potential role of the indoline derivatives as an anti-cancer agent against breast cancer by effectively inhibiting EGFR. Communicated by Ramaswamy H. Sarma
  • Antiproliferative and apoptotic effects of indole derivative, N-(2-hydroxy-5-nitrophenyl (4′-methylphenyl) methyl) indoline in breast cancer cells
    Suresh Palanivel, Akshaya Murugesan, Kumar Subramanian, Olli Yli-Harja, Meenakshisundaram Kandhavelu
    European Journal of Pharmacology, 2020
  • Anticancer activity of THMPP: Downregulation of PI3K/ S6K1 in breast cancer cell line
    Suresh Palanivel, Akshaya Murugesan, Olli Yli-Harja, Meenakshisundaram Kandhavelu
    Saudi Pharmaceutical Journal, 2020
  • Alkylamino phenol derivative induces apoptosis by inhibiting EGFR signaling pathway in breast cancer cells
    Suresh Palanivel, Olli Yli-Harja, Meenakshisundaram Kandhavelu
    Anti Cancer Agents in Medicinal Chemistry, 2020
    Background and Objective: The present study was carried out to evaluate the anticancer property of an alkylamino phenol derivative -2-((3,4-Dihydroquinolin-1(2H)-yl)(p-tolyl)methyl)phenol) (THTMP) against human breast cancer cells. The cytotoxicity of the THTMP was assessed to know its specificity towards breast cancer cells without affecting the normal cells. Methods: The THTMP was synthesized and the cytotoxicity was assessed by MTT assay, Caspases enzyme activity, DNA fragmentation and FITC/Annexin V, AO/EtBr staining, RT-PCR and QSAR. In addition, ADME analysis was executed to understand the mode of action of THTMP. Results: THTMP showed potential cytotoxic activity against the growth of MCF7 and SK-BR3 cells with the IC50 values of 87.92μM and 172.51μM, respectively. Interestingly, THTMP found to activate caspase 3 and caspase 9 enzymes in cancer cells, which are the key enzymes implicated in apoptosis. THTMP induced apoptosis in which 33% of the cells entered the late apoptotic stage after 24h of treatment. The results also revealed that the apoptotic response could be influenced by the association of THTMP with the Epidermal Growth Factor Receptor (EGFR) mediated inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/S6K1 signaling pathway. In addition, docking was performed to study the binding mode of the THTMP, which shows better interaction with EGFR. The structural elucidation of THTMP by Quantitative Structure-Activity Relationship model (QSAR) and ADMET screening suggested, THTMP as an effective anticancer compound. Conclusion: This work strengthens the potential of a promising drug-like compound, THTMP, for the discovery of anticancer drug against breast cancer.
  • In vitro characterization of arylhydrazones of active methylene derivatives
    Suresh Palanivel, Anastasia Zhurina, Phuong Doan, Jerome G. Chandraseelan, Vinoth Kumar Megraj Khandelwal, et al.
    Saudi Pharmaceutical Journal, 2018
  • Identification of novel GPR17-agonists by structural bioinformatics and signaling activation
    Konda Mani Saravanan, Suresh Palanivel, Olli Yli-Harja, Meenakshisundaram Kandhavelu
    International Journal of Biological Macromolecules, 2018
  • Aberrantly Binding microRNAs and their Interactions with Nuclear Hormone Receptors
    Jeyalakshmi Kandhavelu, Suresh Palanivel, Meenakshisundaram Kandhavelu
    Microrna Shariqah United Arab Emirates, 2017
    HISTORY Nuclear Hormone Receptors (NHRs) are the most important targets that play vital role in cellular signaling pathways of disease. Regulation of NHRs by using potential non-coding RNAs, miRNA, is clinically important to control a disease. However, the detailed status of miRNA interactions with NHRs remains unclear. Hence, the focus of the present study is to investigate the interface at the genome-wide level in human, mouse and rat using computational biology approach. OBSERVATIONS This big-data analysis explored thousands of available miRNAs interactions with the NHRs and the results showed that 11 miRNAs have conserved targets, where six miRNAs are genetically conserved among different species. This implies that both conserved and non-conserved miRNAs have a potential role in NHRs regulation. We found several "Aberrantly Binding miRNAs" (ABMs) that can bind to the target NHR genes. In this study, for human miR-548, rat miR-Let-7 and miR-30, mouse miR-466 are identified as potential ABMs families. We also found the list of genes targeting ABMs. RESULTS Specifically, these miRNAs majorly targeted bind nuclear subfamily receptor genes in all studied animal species. ABMs family interaction with NHR genes is favored by AT richness and the length of the gene. CONCLUSION Our findings suggest that, specific ABMs family targeting NHRs may act as potential candidates to regulate the downstream signaling pathways.

RECENT SCHOLAR PUBLICATIONS

  • Unlocking the potential of hydroxylated‐chalcone‐based photosensitive benzoxazines: synthesis, multifunctional properties and theoretical insights from density functional theory
    S Appasamy, B Krishnasamy, S Pushparaju, S Palanivel
    Polymer International 74 (10), 914-926 , 2025
    2025
    Citations: 1
  • Benzenesulfonamide analogs: Synthesis, anti-GBM activity and pharmacoprofiling
    A Murugesan, S Konda Mani, R Thiyagarajan, S Palanivel, AV Gurbanov, ...
    International Journal of Molecular Sciences 24 (15), 12276 , 2023
    2023
    Citations: 4
  • Molecular interaction study of novel indoline derivatives with EGFR-kinase domain using multiple computational analysis
    S Palanivel, O Yli-Harja, M Kandhavelu
    Journal of Biomolecular Structure and Dynamics 40 (16), 7545-7554 , 2022
    2022
    Citations: 17
  • Evaluation of Cytotoxic Effects and Underlying Mechanism of Phenolic Compounds on Breast Cancer Cell Lines
    S Palanivel
    Tampere University , 2022
    2022
    Citations: 1
  • Antiproliferative and apoptotic effects of indole derivative, N-(2-hydroxy-5-nitrophenyl (4′-methylphenyl) methyl) indoline in breast cancer cells
    S Palanivel, A Murugesan, K Subramanian, O Yli-Harja, M Kandhavelu
    European journal of pharmacology 881, 173195 , 2020
    2020
    Citations: 24
  • Alkylamino phenol derivative induces apoptosis by inhibiting egfr signaling pathway in breast cancer cells
    S Palanivel, O Yli-Harja, M Kandhavelu
    Anti-Cancer Agents in Medicinal Chemistry-Anti-Cancer Agents) 20 (7), 809-819 , 2020
    2020
    Citations: 7
  • Anticancer activity of THMPP: Downregulation of PI3K/S6K1 in breast cancer cell line
    S Palanivel, A Murugesan, O Yli-Harja, M Kandhavelu
    Saudi Pharmaceutical Journal 28 (4), 495-503 , 2020
    2020
    Citations: 6
  • In vitro characterization of arylhydrazones of active methylene derivatives
    S Palanivel, A Zhurina, P Doan, JG Chandraseelan, VKM Khandelwal, ...
    Saudi pharmaceutical journal 26 (3), 430-436 , 2018
    2018
    Citations: 5
  • Identification of novel GPR17-agonists by structural bioinformatics and signaling activation
    KM Saravanan, S Palanivel, O Yli-Harja, M Kandhavelu
    International journal of biological macromolecules 106, 901-907 , 2018
    2018
    Citations: 31
  • Aberrantly binding microRNAs and their interactions with nuclear hormone receptors
    J Kandhavelu, S Palanivel, M Kandhavelu
    Microrna 6 (3), 200-207 , 2017
    2017
    Citations: 3
  • Investigation of small molecule interaction with receptors in cancer therapy
    S Palanivel
    Cell Signaling, Cell Therapy & Cancer Therapeutics , 2017
    2017
  • Cell Signaling, Cell Therapy and Cancer Therapeutics
    S Palanivel
    2017
  • QSAR and Molecular Docking Analysis of synthetic compounds against Breast Cancer Targets
    S Palanivel, O Yli-Harja, M Kandhavelu
    Indo-German workshop on computing in chemistry, biology and medicine , 2017
    2017
  • Toxicity assessment of arylhydrazones of active methylene compounds
    S Palanivel, JG Chandraseelan, O Yli-Harja, M Kandhavelu, FI Guseinov, ...
    Journal of Hazardous Materials , 2016
    2016
  • Investigation of small molecule effects in human embryonic kidney cell lines
    S Palanivel, O Yli-Harja, M Kandhavelu
    Biomeditech Research Day 2015 , 2015
    2015
  • Development of efficient cell segmentation tool for microscope image
    O Sandberg, S Palanivel, P Doan, O Yli-Harja, M Kandhavelu
    2015 Tampere Meeting on Single Cell Measurements and Analysis , 2015
    2015
  • Analysis of Ca2+ and cAMP signaling regulated by GPR17 at single cell level.
    S Palanivel, O Yli-Harja, M Kandhavelu
    BioMediTech Research Day 2014, Tampere, Finland. 5.12. 2014 , 2014
    2014

MOST CITED SCHOLAR PUBLICATIONS

  • Identification of novel GPR17-agonists by structural bioinformatics and signaling activation
    KM Saravanan, S Palanivel, O Yli-Harja, M Kandhavelu
    International journal of biological macromolecules 106, 901-907 , 2018
    2018
    Citations: 31
  • Antiproliferative and apoptotic effects of indole derivative, N-(2-hydroxy-5-nitrophenyl (4′-methylphenyl) methyl) indoline in breast cancer cells
    S Palanivel, A Murugesan, K Subramanian, O Yli-Harja, M Kandhavelu
    European journal of pharmacology 881, 173195 , 2020
    2020
    Citations: 24
  • Molecular interaction study of novel indoline derivatives with EGFR-kinase domain using multiple computational analysis
    S Palanivel, O Yli-Harja, M Kandhavelu
    Journal of Biomolecular Structure and Dynamics 40 (16), 7545-7554 , 2022
    2022
    Citations: 17
  • Alkylamino phenol derivative induces apoptosis by inhibiting egfr signaling pathway in breast cancer cells
    S Palanivel, O Yli-Harja, M Kandhavelu
    Anti-Cancer Agents in Medicinal Chemistry-Anti-Cancer Agents) 20 (7), 809-819 , 2020
    2020
    Citations: 7
  • Anticancer activity of THMPP: Downregulation of PI3K/S6K1 in breast cancer cell line
    S Palanivel, A Murugesan, O Yli-Harja, M Kandhavelu
    Saudi Pharmaceutical Journal 28 (4), 495-503 , 2020
    2020
    Citations: 6
  • In vitro characterization of arylhydrazones of active methylene derivatives
    S Palanivel, A Zhurina, P Doan, JG Chandraseelan, VKM Khandelwal, ...
    Saudi pharmaceutical journal 26 (3), 430-436 , 2018
    2018
    Citations: 5
  • Benzenesulfonamide analogs: Synthesis, anti-GBM activity and pharmacoprofiling
    A Murugesan, S Konda Mani, R Thiyagarajan, S Palanivel, AV Gurbanov, ...
    International Journal of Molecular Sciences 24 (15), 12276 , 2023
    2023
    Citations: 4
  • Aberrantly binding microRNAs and their interactions with nuclear hormone receptors
    J Kandhavelu, S Palanivel, M Kandhavelu
    Microrna 6 (3), 200-207 , 2017
    2017
    Citations: 3
  • Unlocking the potential of hydroxylated‐chalcone‐based photosensitive benzoxazines: synthesis, multifunctional properties and theoretical insights from density functional theory
    S Appasamy, B Krishnasamy, S Pushparaju, S Palanivel
    Polymer International 74 (10), 914-926 , 2025
    2025
    Citations: 1
  • Evaluation of Cytotoxic Effects and Underlying Mechanism of Phenolic Compounds on Breast Cancer Cell Lines
    S Palanivel
    Tampere University , 2022
    2022
    Citations: 1
  • Investigation of small molecule interaction with receptors in cancer therapy
    S Palanivel
    Cell Signaling, Cell Therapy & Cancer Therapeutics , 2017
    2017
  • Cell Signaling, Cell Therapy and Cancer Therapeutics
    S Palanivel
    2017
  • QSAR and Molecular Docking Analysis of synthetic compounds against Breast Cancer Targets
    S Palanivel, O Yli-Harja, M Kandhavelu
    Indo-German workshop on computing in chemistry, biology and medicine , 2017
    2017
  • Toxicity assessment of arylhydrazones of active methylene compounds
    S Palanivel, JG Chandraseelan, O Yli-Harja, M Kandhavelu, FI Guseinov, ...
    Journal of Hazardous Materials , 2016
    2016
  • Investigation of small molecule effects in human embryonic kidney cell lines
    S Palanivel, O Yli-Harja, M Kandhavelu
    Biomeditech Research Day 2015 , 2015
    2015
  • Development of efficient cell segmentation tool for microscope image
    O Sandberg, S Palanivel, P Doan, O Yli-Harja, M Kandhavelu
    2015 Tampere Meeting on Single Cell Measurements and Analysis , 2015
    2015
  • Analysis of Ca2+ and cAMP signaling regulated by GPR17 at single cell level.
    S Palanivel, O Yli-Harja, M Kandhavelu
    BioMediTech Research Day 2014, Tampere, Finland. 5.12. 2014 , 2014
    2014