Surfacehcm

Surfacehcm - Địa điểm uy tín mua bán các sản phẩm công nghệ: Máy tính Microsoft Surface, phụ kiện công nghệ chính hãng, uy tín, giá tốt nhất thị trường, cam kết hàng luôn có sẵn.

Surfacehcm
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RECENT SCHOLAR PUBLICATIONS

BPS2025-Functional assessment of recombinant human alpha-cardiac myosin and the effect of atrial arrhythmia mutations
AD Pawar, SC Yokota, JA Spudich, K Ruppel, M Kawana
Biophysical Journal 124 (3), 615a 2025



BPS2025-Multiscale approach and atomic resolution insights for the dysregulation leading to cardiomyopathies
AM Houdusse, L Lannes, D Auguin, CM Kikuti, M Juille, N Nandwani, ...
Biophysical Journal 124 (3), 298a 2025



A FRET assay to quantitate levels of the human β-cardiac myosin interacting heads motif based on its near-atomic resolution structure
RR Goluguri, P Guhathakurta, N Nandwani, A Dawood, S Yakota, ...
bioRxiv 2024



From amoeboid myosin to unique targeted medicines for a genetic cardiac disease
JA Spudich
Frontiers in Physiology 15, 1496569 2024



Reassessing the unifying hypothesis for hypercontractility caused by myosin mutations in hypertrophic cardiomyopathy
JA Spudich, N Nandwani, J Robert-Paganin, A Houdusse, KM Ruppel
The EMBO Journal 43 (19), 4139-4155 2024



One must reconstitute the functions of interest from purified proteins
JA Spudich
Frontiers in Physiology 15, 1390186 2024



Incomplete-penetrant hypertrophic cardiomyopathy MYH7 G256E mutation causes hypercontractility and elevated mitochondrial respiration
S Lee, AS Vander Roest, CA Blair, K Kao, SB Bremner, MC Childers, ...
Proceedings of the National Academy of Sciences 121 (19), e2318413121 2024



Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy
L Sen-Martn, Fernndez-Trasancos, M Lpez-Unzu, D Pathak, ...
bioRxiv, 2024.03. 22.584986 2024



Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human β-cardiac myosin allosterically
N Nandwani, D Bhowmik, MC Childers, RR Goluguri, A Dawood, ...
bioRxiv, 2024.02. 29.582851 2024



Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation
C Liu, A Karabina, A Meller, A Bhattacharjee, CJ Agostino, GR Bowman, ...
Proceedings of the National Academy of Sciences 121 (9), e2315472121 2024



Motility Assay to Probe the Calcium Sensitivity of Myosin and Regulated Thin Filaments
C Liu, KM Ruppel, JA Spudich
Familial Cardiomyopathies: Methods and Protocols, 169-189 2023



Cryo-electron tomography reveals the structural diversity of cardiac proteins in their cellular context
RA Woldeyes, M Nishiga, AS Vander Roest, L Engel, P Giri, ...
bioRxiv 2023



Abstract EC. 03: Distinct Molecular Signatures Of HCM-And DCM-causing Mutations At The Same Residue In The Transducer Of Cardiac Myosin
M Kawana, RR Goluguri, A Dawood, JA Spudich, K Ruppel
Circulation Research 133 (Suppl_1), AEC. 03-AEC. 03 2023



Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients
S Nag, SK Gollapudi, CL Del Rio, JA Spudich, R McDowell
Science Advances 9 (30), eabo7622 2023



Homologous mutations in [Formula: see text], embryonic, and perinatal muscle myosins have divergent effects on molecular power generation
C Liu, A Karabina, A Meller, A Bhattacharjee, CJ Agostino, GR Bowman, ...
bioRxiv: the preprint server for biology 2023



Homologous mutations in β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generation
C Liu, A Karabina, A Meller, A Bhattacharjee, CJ Agostino, GR Bowman, ...
bioRxiv 2023



Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration
S Lee, ASV Roest, CA Blair, K Kao, SB Bremner, MC Childers, D Pathak, ...
bioRxiv, 2023.06. 08.544276 2023



Structural changes in myosin affect chemo-mechanical properties of the myosin-actin interaction
D Pathak, N Nandwani, JA Spudich, K Ruppel
Biophysical Journal 122 (3), 147a 2023



Changes in myosin biomechanics influence growth and maturation of iPSC-cardiomyocytes
D Bernstein, AS Vander Roest, S Wu, B Pruitt, M Zhao, G Fajardo, ...
Biophysical Journal 122 (3), 148a 2023



Sarcomere dynamics simulations to uncover mechanisms in hypertrophic cardiomyopathy
AS Vander Roest, JA Spudich, K Ruppel, M Regnier, D Bernstein
Biophysical Journal 122 (3), 148a-149a 2023

MOST CITED SCHOLAR PUBLICATIONS

The regulation of rabbit skeletal muscle contraction: I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of
JA Spudich, S Watt
Journal of biological chemistry 246 (15), 4866-4871 1971
Citations: 5567



Single myosin molecule mechanics: piconewton forces and nanometre steps
JT Finer, RM Simmons, JA Spudich
nature 368 (6467), 113-119 1994
Citations: 2501



Disruption of the Dictyostelium Myosin Heavy Chain Gene by Homologous Recombination
A De Lozanne, JA Spudich
Science 236 (4805), 1086-1091 1987
Citations: 1196



Fluorescent actin filaments move on myosin fixed to a glass surface.
SJ Kron, JA Spudich
Proceedings of the National Academy of Sciences 83 (17), 6272-6276 1986
Citations: 1130



Optimized localization analysis for single-molecule tracking and super-resolution microscopy
KI Mortensen, LS Churchman, JA Spudich, H Flyvbjerg
Nature methods 7 (5), 377-381 2010
Citations: 1078



Myosin-V is a processive actin-based motor
AD Mehta, RS Rock, M Rief, JA Spudich, MS Mooseker, RE Cheney
Nature 400 (6744), 590-593 1999
Citations: 1002



Single-molecule biomechanics with optical methods
AD Mehta, M Rief, JA Spudich, DA Smith, RM Simmons
Science 283 (5408), 1689-1695 1999
Citations: 941



Quantitative measurements of force and displacement using an optical trap
RM Simmons, JT Finer, S Chu, JA Spudich
Biophysical journal 70 (4), 1813-1822 1996
Citations: 739



A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
EM Green, H Wakimoto, RL Anderson, MJ Evanchik, JM Gorham, ...
Science 351 (6273), 617-621 2016
Citations: 724



Myosin subfragment-1 is sufficient to move actin filaments in vitro
YY Toyoshima, SJ Kron, EM McNally, KR Niebling, C Toyoshima, ...
Nature 328 (6130), 536-539 1987
Citations: 663



Myosin structure and function in cell motility
HM Warrick, JA Spudich
Annual review of cell biology 3 (1), 379-421 1987
Citations: 661



Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination
M Clarke, JA Spudich
Annual review of biochemistry 46 (1), 797-822 1977
Citations: 659



Movement of myosin-coated fluorescent beads on actin cables in vitro
MP Sheetz, JA Spudich
Nature 303 (5912), 31-35 1983
Citations: 615



How molecular motors work
JA Spudich
Nature 372 (6506), 515-518 1994
Citations: 599



The neck region of the myosin motor domain acts as a lever arm to generate movement.
TQ Uyeda, PD Abramson, JA Spudich
Proceedings of the National Academy of Sciences 93 (9), 4459-4464 1996
Citations: 592



Myosin step size: estimation from slow sliding movement of actin over low densities of heavy meromyosin
TQP Uyeda, SJ Kron, JA Spudich
Journal of molecular biology 214 (3), 699-710 1990
Citations: 572



Myosin-V stepping kinetics: a molecular model for processivity
M Rief, RS Rock, AD Mehta, MS Mooseker, RE Cheney, JA Spudich
Proceedings of the National Academy of Sciences 97 (17), 9482-9486 2000
Citations: 510



[33] Assays for actin sliding movement over myosin-coated surfaces
SJ Kron, YY Toyoshima, TQP Uyeda, JA Spudich
Methods in enzymology 196, 399-416 1991
Citations: 504



Cytoskeletal elements of chick embryo fibroblasts revealed by detergent extraction
S Brown, W Levinson, JA Spudich
Journal of supramolecular structure 5 (2), 119-130 1976
Citations: 479



Myosin VI is a processive motor with a large step size
RS Rock, SE Rice, AL Wells, TJ Purcell, JA Spudich, HL Sweeney
Proceedings of the National Academy of Sciences 98 (24), 13655-13659 2001
Citations: 473