RECENT SCHOLAR PUBLICATIONS
- Homologous mutations in human β, embryonic, and perinatal muscle myosins have divergent effects on molecular power generationC Liu, A Karabina, A Meller, A Bhattacharjee, CJ Agostino, GR Bowman, ...Proceedings of the National Academy of Sciences 121 (9), e2315472121 2024
- One must reconstitute the functions of interest from purified proteinsJA SpudichFrontiers in Physiology 15, 1390186 2024
- Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathyL Sen Martin, A Fernandez Trasancos, MA Lopez Unzu, D Pathak, ...bioRxiv, 2024.03. 22.584986 2024
- Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allostericallyN Nandwani, D Bhowmik, MC Childers, RR Goluguri, A Dawood, ...bioRxiv, 2024.02. 29.582851 2024
- Motility Assay to Probe the Calcium Sensitivity of Myosin and Regulated Thin FilamentsC Liu, KM Ruppel, JA SpudichFamilial Cardiomyopathies: Methods and Protocols, 169-189 2023
- Cryo-electron tomography reveals the structural diversity of cardiac proteins in their cellular contextRA Woldeyes, M Nishiga, AS Vander Roest, L Engel, P Giri, ...bioRxiv 2023
- Abstract EC. 03: Distinct Molecular Signatures Of HCM-And DCM-causing Mutations At The Same Residue In The Transducer Of Cardiac MyosinM Kawana, RR Goluguri, A Dawood, JA Spudich, K RuppelCirculation Research 133 (Suppl_1), AEC. 03-AEC. 03 2023
- Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patientsS Nag, SK Gollapudi, CL Del Rio, JA Spudich, R McDowellScience Advances 9 (30), eabo7622 2023
- Homologous mutations in [... formula...], embryonic, and perinatal muscle myosins have divergent effects on molecular power generationC Liu, A Karabina, A Meller, A Bhattacharjee, CJ Agostino, GR Bowman, ...bioRxiv 2023
- Structural changes in myosin affect chemo-mechanical properties of the myosin-actin interactionD Pathak, N Nandwani, JA Spudich, K RuppelBiophysical Journal 122 (3), 147a 2023
- Changes in myosin biomechanics influence growth and maturation of iPSC-cardiomyocytesD Bernstein, AS Vander Roest, S Wu, B Pruitt, M Zhao, G Fajardo, ...Biophysical Journal 122 (3), 148a 2023
- Sarcomere dynamics simulations to uncover mechanisms in hypertrophic cardiomyopathyAS Vander Roest, JA Spudich, K Ruppel, M Regnier, D BernsteinBiophysical Journal 122 (3), 148a-149a 2023
- Molecular characterization of a novel MYH7 mutation Q222H in a patient with severe dilated cardiomyopathyM Kawana, RR Goluguri, A Dawood, JA Spudich, K RuppelBiophysical Journal 122 (3), 258a 2023
- Cryo-EM structure of the folded-back state of human β-cardiac myosinA Grinzato, D Auguin, C Kikuti, N Nandwani, D Moussaoui, D Pathak, ...Biophysical Journal 122 (3), 258a-259a 2023
- Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respirationS Lee, AS Vander Roest, C Blair, K Kao, SB Bremner, MC Childers, ...bioRxiv, 2023.06. 08.544276 2023
- Hypertrophic cardiomyopathy: mutations to mechanisms to therapiesM Kawana, JA Spudich, KM RuppelFrontiers in Physiology 13, 975076 2022
- A small-molecule myosin inhibitor as a targeted multi-stage antimalarialDV Trivedi, A Karabina, G Bergnes, A Racca, H Wander, S Jung, N Mittal, ...bioRxiv, 2022.09. 09.507317 2022
- Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin functionMM Morck, D Bhowmik, D Pathak, A Dawood, J Spudich, KM RuppelElife 11, e76805 2022
- Allosteric destabilization of the super-relaxed state of cardiac myosin by hypertrophic cardiomyopathy-causing mutationsN Nandwani, D Bhowmik, A Dawood, K Ruppel, JA SpudichBiophysical Journal 121 (3), 292a 2022
- First-in-class drug candidate (MPH-220) efficiently improves spastic gait disorders by selective inhibition of fast skeletal muscle myosin-2M Gyimesi, AI Horvath, D Turos, SK Suthar, M Penzes, L Canon, C Kikuti, ...Biophysical Journal 121 (3), 291a 2022