Comparative study of response surface methodology and artificial neural network for optimization of process parameters for synthesis of gold nanoparticles by Desmostachya bipinnata extract Aditya Lawerence Toppo, Swasti Dhagat, Satya Eswari Jujjavarapu Preparative Biochemistry and Biotechnology, 2023 Green synthesis of nanoparticles has gained attention due to its eco-friendly and sustainable approach to synthesize nanoparticles at a reduced cost. Artificial neural network (ANN) and response surface model (RSM) are important to reduce experimental efforts in nanoparticle synthesis. In this work, optimization of gold nanoparticle synthesis by Desmostachya bipinnata extract was performed using the volume of plant extract, concentration of auric chloride, reaction time, pH, and temperature as process parameters, and the output was absorbance. The experimental design was obtained from RSM and the model was optimized further using ANN. Thirty-two experimental runs generated by RSM were performed and the results obtained experimentally were compared with those generated by RSM and ANN. Different algorithms of ANN were tested to obtain the best one. The optimization studies resulted in a maximum response for 20th run with 15 ml, 2.5 mM, 45 min, 7, and 40 °C as parameters. Optimized input parameters obtained by RSM were 10 ml, 2 mM, 30 min, 6, and 30 °C. The formation of gold nanoparticles was confirmed by UV spectroscopy, XRD, and SEM. Different algorithms of ANN, such as leven marquardt, scaled conjugate gradient, and bayesian network were used. Leven marquardt algorithm was found to be the most suitable algorithm for the current study.
Marine Biosurfactants in Environmental Bioremediation: Scope and Applications Swasti Dhagat, Satya Eswari Jujjavarapu Marine Surfactants Preparations and Applications, 2022 Environmental pollution has become one of the serious problems for the industrialized world, contaminating food, water and soil. These pollutants are highly toxic and are persistent in the ecosystem. Conventionally, pollutants are treated by chemical and physical methods, which do not result in complete removal of pollutants from the environment. Hence, remediation of pollution using biological sources, also known as bioremediation, is a highly promising technique to mitigate environmental pollution. One of the techniques of bioremediation is the use of biosurfactants. Biosurfactants are high molecular weight amphiphilic molecules that consist of both hydrophilic and hydrophobic entities. Marine biosurfactants are highly stable under extreme conditions of temperature, pH and salinity and hence have a wide range of applications in the pharmaceutical, cosmetics and food industries as well as in environmental bioremediation. Biosurfactants improve the efficiency of bioremediation by increasing the bioavailability of pollutants and have been used in bioremediation of oil spills, degradation of polyaromatic hydrocarbons, removal of heavy metals and microbial-enhanced oil recovery. This chapter discusses the role of marine biosurfactants in bioremediation of environmental pollution. The various techniques of bioremediation are also discussed in brief.
Molecular docking and admet analysis of synthetic statins for hmg-coa reductase inhibition activity Indian Journal of Biochemistry and Biophysics, 2021
Screening of Microorganisms from Soils of North Gujarat with Promising Antagonistic Activity against Phytopathogens Causing Damping Off Disease AKGSD Zinkal Rathod, Mayursinh Chavda, Chetan Patel, Mahesh Parmar International Journal of Current Microbiology and Applied Sciences 15 (2 … , 2026 2026
Economics of fermentation processes S Dhagat, SE Jujjavarapu Recent Advances in Bioprocess Engineering and Bioreactor Design, 287-298 , 2024 2024 Citations: 3
Recent Advances in Bioprocess Engineering and Bioreactor Design S Dhagat, SE Jujjavarapu Springer , 2024 2024 Citations: 8
Biorefinery system for production of thermostable exopolysaccharide by a novel thermophile Brevibacillus borstelensis MK878423 and its study on impact of … S Dhagat, SE Jujjavarapu Biomass Conversion and Biorefinery 13 (9), 7521-7531 , 2023 2023 Citations: 12
Comparative study of response surface methodology and artificial neural network for optimization of process parameters for synthesis of gold nanoparticles by Desmostachya … AL Toppo, S Dhagat, S Eswari Jujjavarapu Preparative Biochemistry & Biotechnology 53 (2), 195-206 , 2023 2023 Citations: 9
Utility of lignin‐modifying enzymes: a green technology for organic compound mycodegradation S Dhagat, SE Jujjavarapu Journal of Chemical Technology & Biotechnology 97 (2), 343-358 , 2022 2022 Citations: 37
Microbial pathogenesis: mechanism and recent updates on microbial diversity of pathogens S Dhagat, SE Jujjavarapu Antimicrobial Resistance: Underlying Mechanisms and Therapeutic Approaches … , 2022 2022 Citations: 9
Marine Biosurfactants in Environmental Bioremediation: Scope and Applications S Dhagat, SE Jujjavarapu Marine Surfactants, 309-326 , 2022 2022
Insights into Production and Applications of Microbial Lipopeptides S Dhagat, SE Jujjavarapu Microbial Surfactants, 222-242 , 2021 2021
Green synthesis of bioemulsifier and exopolysaccharides by Brevibacillus borstelensis and process parameters optimization using response surface model, genetic algorithm and NSGA S Dhagat, SE Jujjavarapu Journal of environmental management 291, 112667 , 2021 2021 Citations: 17
Simulated annealing and artificial neural network as optimization tools to enhance yields of bioemulsifier and exopolysaccharides by thermophilic Brevibacillus borstelensis S Dhagat, SE Jujjavarapu Journal of Environmental Chemical Engineering 9 (4), 105499 , 2021 2021 Citations: 34
Molecular docking and ADMET analysis of synthetic statins for HMG-CoA reductase inhibition activity AL Toppo, M Yadav, S Dhagat, S Ayothiraman, JS Eswari Indian Journal of Biochemistry and Biophysics (IJBB) 58 (2), 127-134 , 2021 2021 Citations: 37
Simultaneous production of bioemulsifier and exopolysaccharides by thermophilic Brevibacillus borstelensis using response surface model, Genetic Algorithm and NSGA S Dhagat, SE Jujjavarapu Res. Sq , 2020 2020 Citations: 1
Emerging strategies on in silico drug development against COVID-19: challenges and opportunities M Yadav, S Dhagat, JS Eswari European Journal of Pharmaceutical Sciences 155, 105522 , 2020 2020 Citations: 40
Lipopeptides as Therapeutics: Molecular Docking and Drug Design SE Jujjavarapu, S Dhagat Biotechnological Applications in Human Health, 61-67 , 2020 2020 Citations: 1
Structure based drug design and molecular docking studies of anticancer molecules paclitaxel, etoposide and topotecan using novel ligands M Yadav, S Dhagat, JS Eswari Current Drug Discovery Technologies 17 (2), 183-190 , 2020 2020 Citations: 28
Isolation of a novel thermophilic bacterium capable of producing high-yield bioemulsifier and its kinetic modelling aspects along with proposed metabolic pathway S Dhagat, SE Jujjavarapu Brazilian Journal of Microbiology 51 (1), 135-143 , 2020 2020 Citations: 18
Proteins and amino acids from thermophilic microorganisms: current research trends and applications JS Eswari, S Dhagat, R Sen Thermophiles for Biotech Industry: A Bioprocess Technology Perspective, 53-67 , 2019 2019 Citations: 3
Heat-Stable Enzymes from Thermophilic Microorganisms: Biochemical Properties and Commercial Application Potential JS Eswari, S Dhagat, R Sen Thermophiles for biotech industry: A bioprocess technology perspective, 31-51 , 2019 2019 Citations: 1
Platform Chemicals by Thermophiles JS Eswari, S Dhagat, R Sen Thermophiles for Biotech Industry: A Bioprocess Technology Perspective, 69-85 , 2019 2019
MOST CITED SCHOLAR PUBLICATIONS
Evolutionary trends in industrial production of α-amylase SE Jujjavarapu, S Dhagat Recent patents on biotechnology 13 (1), 4-18 , 2019 2019 Citations: 85
Emerging strategies on in silico drug development against COVID-19: challenges and opportunities M Yadav, S Dhagat, JS Eswari European Journal of Pharmaceutical Sciences 155, 105522 , 2020 2020 Citations: 40
Utility of lignin‐modifying enzymes: a green technology for organic compound mycodegradation S Dhagat, SE Jujjavarapu Journal of Chemical Technology & Biotechnology 97 (2), 343-358 , 2022 2022 Citations: 37
Molecular docking and ADMET analysis of synthetic statins for HMG-CoA reductase inhibition activity AL Toppo, M Yadav, S Dhagat, S Ayothiraman, JS Eswari Indian Journal of Biochemistry and Biophysics (IJBB) 58 (2), 127-134 , 2021 2021 Citations: 37
Simulated annealing and artificial neural network as optimization tools to enhance yields of bioemulsifier and exopolysaccharides by thermophilic Brevibacillus borstelensis S Dhagat, SE Jujjavarapu Journal of Environmental Chemical Engineering 9 (4), 105499 , 2021 2021 Citations: 34
Biosurfactant assisted silver nanoparticle synthesis: a critical analysis of its drug design aspects SDPM J Satya Eswari Advances in Natural Sciences: Nanoscience and Nanotechnology 9, 045007 , 2018 2018 Citations: 33
Structure based drug design and molecular docking studies of anticancer molecules paclitaxel, etoposide and topotecan using novel ligands M Yadav, S Dhagat, JS Eswari Current Drug Discovery Technologies 17 (2), 183-190 , 2020 2020 Citations: 28
In silico discovery of novel ligands for antimicrobial lipopeptides for computer-aided drug design SE Jujjavarapu, S Dhagat Probiotics and antimicrobial proteins 10 (2), 129-141 , 2018 2018 Citations: 24
Isolation of a novel thermophilic bacterium capable of producing high-yield bioemulsifier and its kinetic modelling aspects along with proposed metabolic pathway S Dhagat, SE Jujjavarapu Brazilian Journal of Microbiology 51 (1), 135-143 , 2020 2020 Citations: 18
Green synthesis of bioemulsifier and exopolysaccharides by Brevibacillus borstelensis and process parameters optimization using response surface model, genetic algorithm and NSGA S Dhagat, SE Jujjavarapu Journal of environmental management 291, 112667 , 2021 2021 Citations: 17
Computer-Aided Design of Antimicrobial Lipopeptides as Prospective Drug Candidates JS Eswari, S Dhagat, M Yadav CRC Press , 2019 2019 Citations: 16
Homology modeling and molecular docking studies of Bacillomycin and Iturin synthetases with novel ligands for the production of therapeutic lipopeptides JS Eswari, S Dhagat, S Kaser, A Tiwari Current Drug Discovery Technologies 15 (2), 132-141 , 2018 2018 Citations: 15
Biosurfactants, bioemulsifiers, and biopolymers from thermophilic microorganisms JS Eswari, S Dhagat, R Sen Thermophiles for Biotech Industry: A Bioprocess Technology Perspective, 87-97 , 2019 2019 Citations: 14
Oroxylum indicum leaf extracts for screening of antimicrobial properties and phytochemicals J Satya Eswari, S Dhagat, S Naik, S and Dibya Pharmaceutical Bioprocessing 6 (1), 7-14 , 2018 2018 Citations: 13
Biorefinery system for production of thermostable exopolysaccharide by a novel thermophile Brevibacillus borstelensis MK878423 and its study on impact of … S Dhagat, SE Jujjavarapu Biomass Conversion and Biorefinery 13 (9), 7521-7531 , 2023 2023 Citations: 12
Identification of novel ligands for therapeutic lipopeptides: daptomycin, surfactin and polymyxin SE Jujjavarapu, S Dhagat, V Kurrey Current Drug Targets 19 (13), 1589-1598 , 2018 2018 Citations: 12
Comparative study of response surface methodology and artificial neural network for optimization of process parameters for synthesis of gold nanoparticles by Desmostachya … AL Toppo, S Dhagat, S Eswari Jujjavarapu Preparative Biochemistry & Biotechnology 53 (2), 195-206 , 2023 2023 Citations: 9
Microbial pathogenesis: mechanism and recent updates on microbial diversity of pathogens S Dhagat, SE Jujjavarapu Antimicrobial Resistance: Underlying Mechanisms and Therapeutic Approaches … , 2022 2022 Citations: 9
Recent Advances in Bioprocess Engineering and Bioreactor Design S Dhagat, SE Jujjavarapu Springer , 2024 2024 Citations: 8
Thermophiles for Biotech Industry JS Eswari, S Dhagat, R Sen Springer Singapore , 2019 2019 Citations: 7
