Tao Dong
@ucalgary.ca
Associate Professor, Faculty of Veterinary Medicine
University of Calgary
62
Scopus Publications
4132
Scholar Citations
29
Scholar h-index
39
Scholar i10-index
Scopus Publications
- Root hair developmental regulators orchestrate drought triggered microbiome changes and the interaction with beneficial Rhizobiaceae
Zhenghong Wang, Zewen Li, Yujie Zhang, Jingye Liao, Kaixiang Guan, Jingxuan Zhai, Pengfei Meng, Xianli Tang, Tao Dong, and Yi Song
Springer Science and Business Media LLC - The “Microplastome” - A Holistic Perspective to Capture the Real-World Ecology of Microplastics
Changchao Li, Xinyu Li, Michael S. Bank, Tao Dong, James Kar-Hei Fang, Frederic D. L. Leusch, Matthias C. Rillig, Jie Wang, Lei Wang, Yu Xia,et al.
American Chemical Society (ACS)
Microplastic pollution, an emerging pollution issue, has become a significant environmental concern globally due to its ubiquitous, persistent, complex, toxic, and ever-increasing nature. As a multifaceted and diverse suite of small plastic particles with different physicochemical properties and associated matters such as absorbed chemicals and microbes, future research on microplastics will need to comprehensively consider their multidimensional attributes. Here, we introduce a novel, conceptual framework of the “microplastome”, defined as the entirety of various plastic particles (<5 mm), and their associated matters such as chemicals and microbes, found within a sample and its overall environmental and toxicological impacts. As a novel concept, this paper aims to emphasize and call for a collective quantification and characterization of microplastics and for a more holistic understanding regarding the differences, connections, and effects of microplastics in different biotic and abiotic ecosystem compartments. Deriving from this lens, we present our insights and prospective trajectories for characterization, risk assessment, and source apportionment of microplastics. We hope this new paradigm can guide and propel microplastic research toward a more holistic era and contribute to an informed strategy for combating this globally important environmental pollution issue. - Filamentous prophage Pf4 promotes genetic exchange in Pseudomonas aeruginosa
Tong-Tong Pei, Han Luo, Yuanyuan Wang, Hao Li, Xing-Yu Wang, Yi-Qiu Zhang, Ying An, Li-Li Wu, Junhua Ma, Xiaoye Liang,et al.
Oxford University Press (OUP)
Abstract Filamentous prophages are widespread among bacteria and play crucial functions in virulence, antibiotic resistance, and biofilm structures. The filamentous Pf4 particles, extruded by an important pathogen Pseudomonas aeruginosa, can protect producing cells from adverse conditions. Contrary to the conventional belief that the Pf4-encoding cells resist reinfection, we herein report that the Pf4 prophage is reciprocally and commonly exchanged within P. aeruginosa colonies, which can repair defective Pf4 within the community. By labeling the Pf4 locus with antibiotic resistance and fluorescence markers, we demonstrate that the Pf4 locus is frequently exchanged within colony biofilms, in artificial sputum media, and in infected mouse lungs. We further show that Pf4 trafficking is a rapid process and capable of rescuing Pf4-defective mutants. The Pf4 phage is highly adaptable and can package additional DNA doubling its genome size. We also report that two clinical P. aeruginosa isolates are susceptible to the Pf4-mediated exchange, and the Pf5 prophage can be exchanged between cells as well. These findings suggest that the genetic exchanging interactions by filamentous prophages may facilitate defect rescue and the sharing of prophage-dependent benefits and costs within the P. aeruginosa community. - Thymol-loaded polylactic acid electrospun fibrous membranes with synergistic biocidal and anti-bacterial adhesion properties via morphology control
Xiao-Yan Wang, Md. Mehadi Hassan, Xiao He, Guichun Hu, Yuxuan Ren, Haeun Kim, Seyyed Alireza Mirkhani, Jinguang Hu, Arindom Sen, Jun Wang,et al.
Elsevier BV - Differential plant cell responses to Acidovorax citrulli T3SS and T6SS reveal an effective strategy for controlling plant-associated pathogens
Yumin Kan, Yanjie Zhang, Wenhui Lin, and Tao Dong
American Society for Microbiology
ABSTRACT Acidovorax citrulli is a gram-negative plant pathogen that employs the type Ⅲ secretion system (T3SS) to infect cucurbit crops and cause bacterial fruit blotch. This bacterium also possesses an active type Ⅵ secretion system (T6SS) with strong antibacterial and antifungal activities. However, how plant cells respond to these two secretion systems and whether there is any cross talk between T3SS and T6SS during infection remain unknown. Here, we employ transcriptomic analysis to compare cellular responses to the T3SS and the T6SS during in planta infection and report distinctive effects on multiple pathways. The T3SS-mediated differentially expressed genes were enriched in the pathways of phenylpropanoid biosynthesis, plant-pathogen interaction, MAPK signaling pathway, and glutathione metabolism, while the T6SS uniquely affected genes were related to photosynthesis. The T6SS does not contribute to the in planta virulence of A. citrulli but is critical for the survival of the bacterium when mixed with watermelon phyllosphere bacteria. In addition, T3SS-mediated virulence is independent of the T6SS, and the inactivation of the T3SS does not affect the T6SS-mediated competition against a diverse set of bacterial pathogens that commonly contaminate edible plants or directly infect plants. A T6SS-active T3SS-null mutant (Ac av ) could inhibit the growth of Xanthomonas oryzae pv. oryzae significantly both in vitro and in vivo and also reduce symptoms of rice bacterial blight. In conclusion, our data demonstrate the T6SS in A. citrulli is nonpathogenic to the plant host and can be harnessed as a pathogen killer against plant-associated bacteria. IMPORTANCE Chemical pesticides are widely used to protect crops from various pathogens. Still, their extensive use has led to severe consequences, including drug resistance and environmental contamination. Here, we show that an engineered T6SS-active, but avirulent mutant of Acidovorax citrulli has strong inhibition capabilities against several pathogenic bacteria, demonstrating an effective strategy that is an alternative to chemical pesticides for sustainable agricultural practices. - Wood-inspired polypyrrole/cellulose aerogels with vertically aligned channels prepared by facile freeze-casting for efficient interfacial solar evaporation
Yuxuan Ren, Rufan Zhou, Tao G. Dong, and Qingye Lu
Royal Society of Chemistry (RSC)
A wood-inspired PPy/CA composite with vertically aligned channels was fabricated as a high-performance solar evaporator. The composite could decrease the energy demand for water evaporation and exhibited good stability in saline water. - Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection
Martina Milighetti, Yanchun Peng, Cedric Tan, Michal Mark, Gayathri Nageswaran, Suzanne Byrne, Tahel Ronel, Tom Peacock, Andreas Mayer, Aneesh Chandran,et al.
Elsevier BV - Systematic Review of Material and Structural Design in Interfacial Solar Evaporators for Clean Water Production
Yuxuan Ren, Rufan Zhou, Ruijie Yang, Tao G. Dong, and Qingye Lu
Wiley
Rational and sustainable utilization of resources is critical for the continuous development of this society. Solar energy, as one of the renewables, shows great potential in replacing part of the traditional energy supplies since it is clean, abundant, and easily convertible to thermal, electrical, and biological energies. Using solar energy as the green driving force, interfacial solar evaporation is a promising way for clean water production to alleviate global water shortage, taking advantage of its high evaporation efficiency (more than 80%) and strong adaptability toward various water sources and fields. In recent years, various kinds of materials with diverse designs have been synthesized and applied in interfacial solar evaporation for clean water production. Herein, recent progress in interfacial solar evaporators for clean water production is systematically reviewed, based on the photothermal conversion mechanisms of solar absorbers, including carbonous, semiconductor‐based, and plasmatic ones. Furthermore, key design factors and strategies in interfacial solar evaporators are reviewed and discussed from material and structural design point of view, such as water transport, thermal management, latent heat for water vaporization, and salt accumulation. Finally, some perspectives related to resolving existing problems in the field are given. - A Dueling-Competent Signal-Sensing Module Guides Precise Delivery of Cargo Proteins into Target Cells by Engineered Pseudomonas aeruginosa
Li-Li Wu, Shuangquan Yan, Tong-Tong Pei, Ming-Xuan Tang, Hao Li, Xiaoye Liang, Shuyang Sun, and Tao Dong
American Chemical Society (ACS) - VgrG Spike Dictates PAAR Requirement for the Assembly of the Type VI Secretion System
Xiaoye Liang, Hao-Yu Zheng, Ya-Jie Zhao, Yi-Qiu Zhang, Tong-Tong Pei, Yang Cui, Ming-Xuan Tang, Ping Xu, and Tao Dong
American Society for Microbiology
Gram-negative bacteria often encode multiple paralogs of the cone-shaped PAAR that sits atop the VgrG-spike and is thought to sharpen the spear-like T6SS puncturing device. However, it is unclear why PAAR is required for the assembly of some but not all T6SSs and why there are multiple PAARs if they are not required. - Stress responses modulate bacterial competitive fitness in polymicrobial communities
Ming-Xuan Tang, Sherina Dyrma, and Tao Dong
Elsevier - Acquisition of T6SS Effector TseL Contributes to the Emerging of Novel Epidemic Strains of Pseudomonas aeruginosa
Anmin Ren, Minlu Jia, Jihong Liu, Tian Zhou, Liwen Wu, Tao Dong, Zhao Cai, Jiuxin Qu, Yang Liu, Liang Yang,et al.
American Society for Microbiology
Pseudomonas aeruginosa is one predominant pathogen that causes hospital-acquired infections and is one of the commonest coinfecting bacteria in immunocompromised patients and chronic wounds. This bacterium harbors a diverse accessory genome with a high frequency of gene recombination, rendering its population highly heterogeneous. - Pesticin-Like Effector VgrG3<sup>cp</sup> Targeting Peptidoglycan Delivered by the Type VI Secretion System Contributes to Vibrio cholerae Interbacterial Competition
Ming Liu, Meng-Yu Zhao, Heng Wang, Zeng-Hang Wang, Zhao Wang, Ying Liu, Yin-Peng Li, Tao Dong, and Yang Fu
American Society for Microbiology
The type VI secretion system used by a broad range of Gram-negative bacteria delivers toxic proteins to target adjacent eukaryotic and prokaryotic cells. Diversification of effector proteins determines the complex bacterium-bacterium interactions and impacts the health of hosts and environmental ecosystems in which bacteria reside. - Green synthesis of Ag/lignin nanoparticle-loaded cellulose aerogel for catalytic degradation and antimicrobial applications
Xiao He, Haeun Kim, Tao G. Dong, Ian Gates, and Qingye Lu
Springer Science and Business Media LLC - Heterologous Assembly of the Type VI Secretion System Empowers Laboratory Escherichia coli with Antimicrobial and Cell Penetration Capabilities
Yang Cui, Tong-Tong Pei, Xiaoye Liang, Hao Li, Hao-Yu Zheng, and Tao Dong
American Society for Microbiology
The T6SS is a powerful and versatile protein delivery system. However, the complexity of its macromolecular structure and gene regulation makes it not a trivial task to reconstitute the T6SSs of pathogens in a nonpathogenic host. - Essential functions of chaperones and adaptors of protein secretion systems in Gram-negative bacteria
Kevin Manera, Fatima Kamal, Brianne Burkinshaw, and Tao G. Dong
Wiley
Equipped with a plethora of secreted toxic effectors, protein secretion systems are essential for bacteria to interact with and manipulate their neighboring environment to survive in host microbiota and other highly competitive communities. While effectors have received spotlight attention in secretion system studies, many require accessory chaperone and adaptor proteins for proper folding/unfolding and stability throughout the secretion process. Here we review the functions of chaperones and adaptors of three protein secretions systems, T3SS, T4SS, and T6SS, which are employed by many Gram-negative bacterial pathogens to deliver toxins to bacterial, plant, and mammalian host cells through direct contact. Since chaperone and adaptor functions of the T3SS and the T4SS are relatively well studied, we discuss in detail the methods of chaperone-facilitated effector secretion by the T6SS and highlight commonalities between the effector chaperone/adaptor proteins of these diverse secretion systems. While the chaperones and adaptors are generally referred to as accessory proteins as they are not directly involved in toxicities to target cells, they are nonetheless vital for the biological functions of the secretion systems. Future research on biochemical and structural properties of these chaperones will not only elucidate the mechanisms of chaperon-effector binding and release process but also facilitate custom design of cargo effectors to be translocated by these widespread secretion systems for biotechnological applications. - Abiotic factors modulate interspecies competition mediated by the type VI secretion system effectors in Vibrio cholerae
Ming-Xuan Tang, Tong-Tong Pei, Qi Xiang, Zeng-Hang Wang, Han Luo, Xing-Yu Wang, Yang Fu, and Tao Dong
Springer Science and Business Media LLC - Delivery of an Rhs-family nuclease effector reveals direct penetration of the gram-positive cell envelope by a type VI secretion system in Acidovorax citrulli
Tong‐Tong Pei, Yumin Kan, Zeng‐Hang Wang, Ming‐Xuan Tang, Hao Li, Shuangquan Yan, Yang Cui, Hao‐Yu Zheng, Han Luo, Xiaoye Liang,et al.
Wiley - A -lightweight, mechanically strong, and shapeable copper-benzenedicarboxylate/cellulose aerogel for dye degradation and antibacterial applications
Yuxuan Ren, Steven J. Hersch, Xiao He, Rufan Zhou, Tao G. Dong, and Qingye Lu
Elsevier BV - Identification of Small Molecule Inhibitors of the Pathogen Box against Vibrio cholerae
Haeun Kim, Brianne J. Burkinshaw, Linh G. Lam, Kevin Manera, and Tao G. Dong
American Society for Microbiology
Cholera is a serious infectious disease in tropical regions causing millions of infections annually. Vibrio cholerae , the causative agent of cholera, has gained multi-antibiotic resistance over the years, posing greater threat to public health and current treatment strategies. Here we report two compounds that effectively target the growth of V. cholerae and have the potential to control cholera infection. - More Than Just a Spearhead: Diverse Functions of PAAR for Assembly and Delivery of Toxins of the Contractile Injection Systems
Hao-Yu Zheng, Liang Yang, and Tao Dong
American Society for Microbiology
The type VI secretion system (T6SS) belongs to the evolutionarily related group of contractile injection systems that employ a contractile outer sheath to inject a rigid spear-like inner tube into target bacterial and eukaryotic cells. The tip of the rigid tube is often decorated by a PAAR-repeat protein as a key structural component. - VgrG-dependent effectors and chaperones modulate the assembly of the type VI secretion system
Xiaoye Liang, Tong-Tong Pei, Hao Li, Hao-Yu Zheng, Han Luo, Yang Cui, Ming-Xuan Tang, Ya-Jie Zhao, Ping Xu, and Tao Dong
Public Library of Science (PLoS)
The type VI secretion system (T6SS) is a spear-like nanomachine found in gram-negative pathogens for delivery of toxic effectors to neighboring bacterial and host cells. Its assembly requires a tip spike complex consisting of a VgrG-trimer, a PAAR protein, and the interacting effectors. However, how the spike controls T6SS assembly remains elusive. Here we investigated the role of three VgrG-effector pairs in Aeromonas dhakensis strain SSU, a clinical isolate with a constitutively active T6SS. By swapping VgrG tail sequences, we demonstrate that the C-terminal ~30 amino-acid tail dictates effector specificity. Double deletion of vgrG1&2 genes (VgrG3+) abolished T6SS secretion, which can be rescued by ectopically expressing chimeric VgrG3 with a VgrG1/2-tail but not the wild type VgrG3. In addition, deletion of effector-specific chaperones also severely impaired T6SS secretion, despite the presence of intact VgrG and effector proteins, in both SSU and Vibrio cholerae V52. We further show that SSU could deliver a V. cholerae effector VasX when expressing a plasmid-borne chimeric VgrG with VasX-specific VgrG tail and chaperone sequences. Pull-down analyses show that two SSU effectors, TseP and TseC, could interact with their cognate VgrGs, the baseplate protein TssK, and the key assembly chaperone TssA. Effectors TseL and VasX could interact with TssF, TssK and TssA in V. cholerae. Collectively, we demonstrate that chimeric VgrG-effector pairs could bypass the requirement of heterologous VgrG complex and propose that effector-stuffing inside the baseplate complex, facilitated by chaperones and the interaction with structural proteins, serves as a crucial structural determinant for T6SS assembly. - Contact-independent killing mediated by a T6SS effector with intrinsic cell-entry properties
Li Song, Junfeng Pan, Yantao Yang, Zhenxing Zhang, Rui Cui, Shuangkai Jia, Zhuo Wang, Changxing Yang, Lei Xu, Tao G. Dong,et al.
Springer Science and Business Media LLC
AbstractBacterial type VI secretion systems (T6SSs) inject toxic effectors into adjacent eukaryotic and prokaryotic cells. It is generally thought that this process requires physical contact between the two cells. Here, we provide evidence of contact-independent killing by a T6SS-secreted effector. We show that the pathogen Yersinia pseudotuberculosis uses a T6SS (T6SS-3) to secrete a nuclease effector that kills other bacteria in vitro and facilitates gut colonization in mice. The effector (Tce1) is a small protein that acts as a Ca2+- and Mg2+-dependent DNase, and its toxicity is inhibited by a cognate immunity protein, Tci1. As expected, T6SS-3 mediates canonical, contact-dependent killing by directly injecting Tce1 into adjacent cells. In addition, T6SS-3 also mediates killing of neighboring cells in the absence of cell-to-cell contact, by secreting Tce1 into the extracellular milieu. Efficient contact-independent entry of Tce1 into target cells requires proteins OmpF and BtuB in the outer membrane of target cells. The discovery of a contact-independent, long-range T6SS toxin delivery provides a new perspective for understanding the physiological roles of T6SS in competition. However, the mechanisms mediating contact-independent uptake of Tce1 by target cells remain unclear. - Engineered Type Six Secretion Systems Deliver Active Exogenous Effectors and Cre Recombinase
Steven J. Hersch, Linh Lam, and Tao G. Dong
American Society for Microbiology
Delivery of protein-based drugs, antigens, and gene-editing agents has broad applications. The type VI protein secretion system (T6SS) can target both bacteria and eukaryotic cells and deliver proteins of diverse size and function.
RECENT SCHOLAR PUBLICATIONS
- Amidase and lysozyme dual functions in TseP reveal a new family of chimeric effectors in the type VI secretion system
ZH Wang, Y An, T Zhao, TT Pei, DY Wang, X Liang, W Qin, T Dong
eLife 13, RP101125 2025 - Not just passengers: effectors contribute to the assembly of the type VI secretion system as structural building blocks
S Dyrma, TT Pei, X Liang, T Dong
Journal of Bacteriology, e00455-24 2025 - Non-adapted bacterial infection suppresses plant reproduction
JT Yang, ZM Tan, YT Jiang, YX Bai, YJ Zhang, HW Xue, TD Xu, T Dong, ...
Science Advances 11 (2), eads7738 2025 - Filamentous prophage Pf4 promotes genetic exchange in Pseudomonas aeruginosa
TT Pei, H Luo, Y Wang, H Li, XY Wang, YQ Zhang, Y An, LL Wu, J Ma, ...
The ISME Journal 18 (1), wrad025 2024 - Stress responses modulate bacterial competitive fitness in polymicrobial communities
MX Tang, S Dyrma, T Dong
Stress: Immunology and Inflammation, 161-171 2024 - LLPS condensates of Fha initiate the inside-out assembly of the type VI secretion system
TT Pei, Y An, XY Wang, H Luo, Y Kan, H Li, MX Tang, ZY Ye, JX Liang, ...
bioRxiv, 2023.12. 21.572528 2023 - Differential plant cell responses to Acidovorax citrulli T3SS and T6SS reveal an effective strategy for controlling plant-associated pathogens
Y Kan, Y Zhang, W Lin, T Dong
MBio 14 (4), e00459-23 2023 - VgrG Spike Dictates PAAR Requirement for the assembly of the type VI secretion system
X Liang, HY Zheng, YJ Zhao, YQ Zhang, TT Pei, Y Cui, MX Tang, P Xu, ...
Journal of Bacteriology 205 (2), e00356-22 2023 - Pesticin-Like Effector VgrG3cp Targeting Peptidoglycan Delivered by the Type VI Secretion System Contributes to Vibrio cholerae Interbacterial Competition
M Liu, MY Zhao, H Wang, ZH Wang, Z Wang, Y Liu, YP Li, T Dong, Y Fu
Microbiology Spectrum 11 (1), e04267-22 2023 - Acquisition of T6SS effector TseL contributes to the emerging of novel epidemic strains of Pseudomonas aeruginosa
A Ren, M Jia, J Liu, T Zhou, L Wu, T Dong, Z Cai, J Qu, Y Liu, L Yang, ...
Microbiology Spectrum 11 (1), e03308-22 2023 - A Dueling-Competent Signal-Sensing Module Guides Precise Delivery of Cargo Proteins into Target Cells by Engineered Pseudomonas aeruginosa
LL Wu, S Yan, TT Pei, MX Tang, H Li, X Liang, S Sun, T Dong
ACS Synthetic Biology 12 (2), 360-368 2023 - Heterologous assembly of the type VI secretion system empowers laboratory Escherichia coli with antimicrobial and cell penetration capabilities
Y Cui, TT Pei, X Liang, H Li, HY Zheng, T Dong
Applied and Environmental Microbiology 88 (19), e01305-22 2022 - Systematic mutagenesis reveals critical effector functions in the assembly and dueling of the H1-T6SS in Pseudomonas aeruginosa
LL Wu, TT Pei, S Yan, MX Tang, LW Wu, H Li, X Liang, S Sun, T Dong
bioRxiv, 2022.09. 14.507963 2022 - Essential functions of chaperones and adaptors of protein secretion systems in gram‐negative bacteria
K Manera, F Kamal, B Burkinshaw, TG Dong
The FEBS Journal 289 (16), 4704-4717 2022 - Abiotic factors modulate interspecies competition mediated by the type VI secretion system effectors in Vibrio cholerae
MX Tang, TT Pei, Q Xiang, ZH Wang, H Luo, XY Wang, Y Fu, T Dong
The ISME Journal 16 (7), 1765-1775 2022 - Delivery of an Rhs‐family nuclease effector reveals direct penetration of the gram‐positive cell envelope by a type VI secretion system in Acidovorax citrulli
TT Pei, Y Kan, ZH Wang, MX Tang, H Li, S Yan, Y Cui, HY Zheng, H Luo, ...
mLife 1 (1), 66-78 2022 - A lightweight, mechanically strong, and shapeable copper-benzenedicarboxylate/cellulose aerogel for dye degradation and antibacterial applications
Y Ren, SJ Hersch, X He, R Zhou, TG Dong, Q Lu
Separation and Purification Technology 283, 120229 2022 - Identification of small molecule inhibitors of the pathogen box against Vibrio cholerae
H Kim, BJ Burkinshaw, LG Lam, K Manera, TG Dong
Microbiology Spectrum 9 (3), e00739-21 2021 - More than just a spearhead: diverse functions of PAAR for assembly and delivery of toxins of the contractile injection systems
HY Zheng, L Yang, T Dong
msystems 6 (6), e01386-21 2021 - VgrG-dependent effectors and chaperones modulate the assembly of the type VI secretion system
X Liang, TT Pei, H Li, HY Zheng, H Luo, Y Cui, MX Tang, YJ Zhao, P Xu, ...
PLoS pathogens 17 (12), e1010116 2021
MOST CITED SCHOLAR PUBLICATIONS
- A view to a kill: the bacterial type VI secretion system
BT Ho, TG Dong, JJ Mekalanos
Cell host & microbe 15 (1), 9-21 2014
Citations: 679 - Identification of T6SS-dependent effector and immunity proteins by Tn-seq in Vibrio cholerae
TG Dong, BT Ho, DR Yoder-Himes, JJ Mekalanos
Proceedings of the National Academy of Sciences 110 (7), 2623-2628 2013
Citations: 361 - Role of RpoS in virulence of pathogens
T Dong, HE Schellhorn
Infection and immunity 78 (3), 887-897 2010
Citations: 233 - Manganese scavenging and oxidative stress response mediated by type VI secretion system in Burkholderia thailandensis
M Si, C Zhao, B Burkinshaw, B Zhang, D Wei, Y Wang, TG Dong, X Shen
Proceedings of the National Academy of Sciences 114 (11), E2233-E2242 2017
Citations: 226 - Identification of divergent type VI secretion effectors using a conserved chaperone domain
X Liang, R Moore, M Wilton, MJQ Wong, L Lam, TG Dong
Proceedings of the National Academy of Sciences 112 (29), 9106-9111 2015
Citations: 178 - Global effect of RpoS on gene expression in pathogenic Escherichia coli O157:H7 strain EDL933
T Dong, HE Schellhorn
BMC genomics 10, 1-17 2009
Citations: 175 - Generation of reactive oxygen species by lethal attacks from competing microbes
TG Dong, S Dong, C Catalano, R Moore, X Liang, JJ Mekalanos
Proceedings of the National Academy of Sciences 112 (7), 2181-2186 2015
Citations: 168 - RpoS regulation of gene expression during exponential growth of Escherichia coli K12
T Dong, MG Kirchhof, HE Schellhorn
Molecular Genetics and Genomics 279, 267-277 2008
Citations: 162 - Control of RpoS in global gene expression of Escherichia coli in minimal media
T Dong, HE Schellhorn
Molecular Genetics and Genomics 281, 19-33 2009
Citations: 155 - Characterization of the RpoN regulon reveals differential regulation of T6SS and new flagellar operons in Vibrio cholerae O37 strain V52
TG Dong, JJ Mekalanos
Nucleic acids research 40 (16), 7766-7775 2012
Citations: 132 - A type VI secretion system effector delivery mechanism dependent on PAAR and a chaperone–co-chaperone complex
BJ Burkinshaw, X Liang, M Wong, ANH Le, L Lam, TG Dong
Nature microbiology 3 (5), 632-640 2018
Citations: 128 - The type VI secretion system engages a redox-regulated dual-functional heme transporter for zinc acquisition
M Si, Y Wang, B Zhang, C Zhao, Y Kang, H Bai, D Wei, L Zhu, L Zhang, ...
Cell reports 20 (4), 949-959 2017
Citations: 125 - Antagonistic regulation of motility and transcriptome expression by RpoN and RpoS in Escherichia coli
T Dong, R Yu, H Schellhorn
Molecular microbiology 79 (2), 375-386 2011
Citations: 121 - Envelope stress responses defend against type six secretion system attacks independently of immunity proteins
SJ Hersch, N Watanabe, MS Stietz, K Manera, F Kamal, B Burkinshaw, ...
Nature microbiology 5 (5), 706-714 2020
Citations: 115 - Secretome analysis of Vibrio cholerae type VI secretion system reveals a new effector-immunity pair
E Altindis, T Dong, C Catalano, J Mekalanos
MBio 6 (2), 10.1128/mbio. 00075-15 2015
Citations: 114 - Intramolecular chaperone-mediated secretion of an Rhs effector toxin by a type VI secretion system
TT Pei, H Li, X Liang, ZH Wang, G Liu, LL Wu, H Kim, Z Xie, M Yu, S Lin, ...
Nature Communications 11 (1), 1865 2020
Citations: 72 - Vibrio cholerae type 6 secretion system effector trafficking in target bacterial cells
BT Ho, Y Fu, TG Dong, JJ Mekalanos
Proceedings of the National Academy of Sciences 114 (35), 9427-9432 2017
Citations: 72 - Contact-independent killing mediated by a T6SS effector with intrinsic cell-entry properties
L Song, J Pan, Y Yang, Z Zhang, R Cui, S Jia, Z Wang, C Yang, L Xu, ...
Nature Communications 12 (1), 423 2021
Citations: 70 - Phenotypic diversity caused by differential RpoS activity among environmental Escherichia coli isolates
SM Chiang, T Dong, TA Edge, HE Schellhorn
Applied and Environmental Microbiology 77 (22), 7915-7923 2011
Citations: 70 - Microbial herd protection mediated by antagonistic interaction in polymicrobial communities.
DTG Wong M, Liang X, Smart M, Tang L, Moore R, Ingalls B
Appl Environ Microbiol 2016
Citations: 66