Lecture at Department of Maternal-Infant and Public Health Nursing in the University of São Paulo at Ribeirão Preto College of Nursing University of São Paulo
Graduate in Nursing at University of São Paulo at Ribeirão Preto College of Nursing (1997), master's (2005) and PhD in Nursing at Universidade de São Paulo at Ribeirão Preto College of Nursing (2008). Pos-doctoral at University os Surrey-UK (2014-2015).
RESEARCH INTERESTS
Obstetric and Gynaecology, care, women health, Oncology (specilly releted to women)
HIGH-RISK PREGNANCY AND SOCIAL DETERMINANTS OF HEALTH: A DISCURSIVE ANALYSIS Brenda Magalhães Arantes, Flávia Azevedo Gomes-Sponholz, Nayara Gonçalves Barbosa, Lise Maria Carvalho Mendes, Lina Domênica Mapelli, et al. Texto E Contexto Enfermagem, 2025 Objective: To understand the meanings that women who have experienced a high-risk pregnancy attribute to the social determinants of health. Method: This descriptive and qualitative study was conducted at a university hospital, a referral center for high-risk prenatal care, labor, and childbirth in a region of southeastern Brazil. Semi-structured interviews were conducted with 27 postpartum women between April 2023 and February 2024, and analyzed using Michel Pêcheux’s French discourse analysis approach. Results: The results were organized into two discursive chunks: The influence of the female role on the social determinants of health; and Behavioral characteristics during the experience of a high-risk pregnancy: adherence to treatment determined by socio-historical subjectivization. Conclusion: The discursive formations demonstrated how the subject position is rooted in the ideology that is sustained by the place that women historically occupy in society, as it describes how socioeconomic vulnerability, exposure to stressors, the limited capacity of the health system and its public policies interfere with the behaviors and lifestyles of pregnant women classified as high-risk pregnancies.
Type of childbirth, skin-to-skin contact, and breastfeeding in the first hour of life in Manaus, Amazonas Anderson Lima Cordeiro da Silva, Bibiane Dias Miranda Parreira, Nayara Gonçalves Barbosa, Alexandre Faisal Cury, Thais de Oliveira Gozzo, et al. Revista Brasileira De Saude Materno Infantil, 2025 Objectives: to evaluate the influence of type of childbirth, on skin-to-skin contact and breastfeeding in the first hour of life in public maternity hospitals in Manaus, Amazonas, Brazil. Methods: cross-sectional study with 443 puerperal women from eight public maternity hospitals in Manaus (August 2023 to January 2024). Data were collected via a validated questionnaire and analyzed by logistic regression in Stata® 18.0, adjusted for sociodemographic, prenatal, and perinatal variables. Crude and adjusted odds ratios, 95% confidence intervals, and p-values were estimated. Results: vaginal delivery was associated with a higher probability of breastfeeding in the first hour of life (adjusted odds ratio = 2.05; 95%CI= 1.19-3.54; p=0.010) and skin-to-skin contact (adjusted odds ratio = 1.96; 95%CI= 1.15-3.34; p=0.013). Each additional week of gestational age increased the chance of breastfeeding in the first hour of life by 40%. Neonatal complications and the use of analgesia significantly reduced the chances of both outcomes. Conclusions: vaginal delivery favors skin-to-skin contact and breastfeeding in the first hour of life, reinforcing the need for policies that standardize humanized practices, especially after cesarean section, for equity in neonatal care.
Welcoming and bonding in nursing care for homeless women in Primary Care Nayara Gonçalves Barbosa, Amanda Munhoz Garcia, Cinira Magali Fortuna, Tauani Zampieri Fermino, Lise Maria Carvalho Mendes, et al. Revista Brasileira De Enfermagem, 2025 Objectives: to understand primary care nurses’ perceptions regarding the welcoming and building of bonds with homeless women. Methods: a descriptive, qualitative study, conducted with 17 nurses working in primary care in a large city in the countryside of the state of São Paulo. Semi-structured interviews were conducted, and the data were subjected to inductive thematic analysis. Results: three categories emerged: i) “Weaving care: nurses’ support for homeless women”; ii) “Building bonds: support for comprehensive care”; iii) “Repercussions of caring for homeless women for nurses”. Final Considerations: soft technologies provide support, bonding and comprehensive care for homeless women, guaranteeing the universal right to health and human dignity, fundamental elements for achieving the Sustainable Development Goals.
Fertility preservation counseling for women of reproductive age diagnosed with cancer: an integrative review Júlia Casemiro Barioni, Thais de Oliveira Gozzo Jornal Brasileiro De Reproducao Assistida, 2024 This integrative review synthesizes the scientific evidence on fertility preservation counseling prior to oncological treatment for women of reproductive age diagnosed with cancer. Bibliographic research was conducted on databases PubMed, CINAHL, LILACS, EMBASE, Scopus, and Web of Science. The structured search strategy for the review question was “counseling AND antineoplastic agents AND fertility preservation”. The use of controlled descriptors and keywords was adapted for each database. Study selection through the Rayyan platform was independent and blinded. The final sample comprised seven studies emphasizing the importance of clarifying factors related to the risk of infertility due to oncological treatment and fertility preservation techniques, such as success rate, pregnancy rate, cost, available options, and side-effects, as well as discussing the possibilities of adoption and surrogacy. This review provided evidence reinforcing the importance of counseling for fertility preservation, promoting motherhood for women who face oncological treatment. Organized networks linking oncology and reproductive medicine units are crucial to facilitate patient referral between these services and interprofessional communication.
Accessibility to prenatal care at the Street Outreach Office: nurse perceptions in northern Brazil Nayara Gonçalves Barbosa, Karoline Cardoso Netto, Lise Maria Carvalho Mendes, Thaís de Oliveira Gozzo, Herla Maria Furtado Jorge, et al. Revista Brasileira De Enfermagem, 2024 Objectives: to understand nurse perspectives regarding homeless pregnant women’s accessibility to prenatal care. Methods: a qualitative study, with analysis based on the concept of accessibility. Semi-structured interviews were carried out with 11 nurses who work at the Street Outreach Office in northern Brazil. Results: nurses are faced with geographic barriers and dangerous situations in border regions, recognizing that there is a context of physical, sexual and psychological violence that involves homeless pregnant women who seek care at the Street Outreach Office. Street Outreach Office nurses’ work occurs in conjunction with other services in the Health Care Network. The implementation of educational measures is a powerful strategy, as is establishing links with women. Final Considerations: the Street Outreach Office’s work provides meetings with pregnant women on site in the territory, which can provide geographic and socio-organizational accessibility to prenatal care.
Phase angle is related to oxidative stress and antioxidant biomarkers in breast cancer patients undergoing chemotherapy Bruna R. da Silva, Sarah Rufato, Mirele S. Mialich, Loris P. Cruz, Thais Gozzo, et al. Plos One, 2023 Purpose The study aimed to analyze the influence of chemotherapy on health biomarkers and examine the relationship between phase angle (PhA) and oxidative stress. Methods A prospective study was performed. Women who were starting chemotherapy were recruited. Also, this study included a control group of women without cancer. Bioelectrical impedance multiple-frequency (BIS) analysis, 24h food recall, and blood samples were collected at 2-time points: diagnosis (T0) and after one month of completion of therapy (T1) for the main study group and one-time point for the control group. T-tests or Mann-Whitney Wilcoxon Test was used to compare variables. Linear regression analysis was conducted to test if PhA is related to the dependent variables after adjusting for age and body mass index. Results 119 women were included (61 with breast cancer and 58 healthy). There was no difference between the groups concerning anthropometrics, fat mass, and fat-free mass. Breast cancer patients had a worsening in PhA (p<0.001) after chemotherapy completion. PhA was positive statistically correlated with extracellular water, albumin, and the antioxidant markers at both times. The linear model showed that PhA was significantly predicted by C reactive protein, 2,2-Diphenyl-1-picrylhydrazyl (DPPH), Malondialdehyde (MDA), total body water/extracellular water, and body mass index fat mass. This model explained 58% of PhA variability (p<0.001). Conclusion Our findings show that PhA is an easy and affordable tool that correlates oxidative stress markers in breast cancer patients, regardless of age or body mass index.
An Evaluation of Metabolic, Dietetic, and Nutritional Status Reveals Impaired Nutritional Outcomes in Breast Cancer Patients Bruna Ramos da Silva, Sarah Rufato, Mirele S. Mialich, Loris P. Cruz, Thais Gozzo, et al. Nutrition and Cancer, 2022 Nutritional status can change in breast cancer patients after treatment. However, the metabolic implications of those alterations are poorly understood. We used a cross-sectional study design to compare body composition, lipids, glucose levels, and adiposity indices in breast cancer patients with a matched control and a healthy group. We recruited women who completed their chemotherapy (BC group) and compared them with a group of women without cancer age and body mass index-paired (MC group) and a group of healthy women (HC group). We estimated body composition by bioelectrical impedance analysis, physical function by handgrip strength, and food consumption by 24-hour food record. A blood sample was collected. We calculated visceral obesity indices (VAI and LAP) and insulin resistance-triglyceride glucose (TyG). Eighty-eight women were included (BC = 36, MC = 36, HC = 16). BC patients demonstrated worse phase angle values, nutritional risk index and lower handgrip strength. Additionally, according to the indices, BC had impairments in lipids, worse glucose levels, and elevated visceral fat adiposity and presented important unhealthy dietary patterns characterized by under-recommended protein consumption and higher caloric intake than the other groups. No differences were observed between both control groups. Further investigations are required to examine the underlying mechanisms and the potential longitudinal changes during surveillance.
Effects of non-surgical periodontal therapy on the cytokine profile in gingival crevicular fluid of breast cancer patients with periodontitis undergoing chemotherapy Kelly R. V. Villafuerte, Felipe T. Dantas, Mario Taba, Michel Messora, Francisco J. Candido dos Reis, et al. Supportive Care in Cancer, 2021 This study evaluated the effect of non-surgical periodontal therapy (NSPT) on the cytokine profile in gingival crevicular fluid (GCF) in patients with breast cancer and periodontitis. Forty patients were allocated into the periodontitis group (P) (n = 20) and breast cancer with periodontitis group (BC/P) (n = 20). Two days before the removal of infectious foci from the oral cavity and NSPT, as well as periodontal reevaluations, C-reactive protein, neutrophils (103μL), and platelets (103μL), were evaluated. The following cytokines in GCF, interleukin (IL)-4, IL-10, IL-2, IL-6, IL-1β, tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and transforming growth factor-β (TGF-β) were evaluated by the Luminex assay at baseline, and 45 and 180 days after therapy. Cytokine levels were analyzed for correlations with the clinical parameters: clinical attachment level (CAL), probing depth (PD), bleeding on probing (BOP), and plaque index (PI). After NSPT, IL-2, TNF-α, and TGF-β were downregulated (p<0.05) in the BC/P. In the P group, INF-γ, IL-2, and TNF-α were downregulated (p<0.05), and TGF-β was increased (p<0.05). At 180 days, IL-6 in GCF was significantly positively correlated with PD and CAL (r=0.45, r=0.56) in the BC/P (p<0.05). In the P group, IL-1β in GCF was positively correlated with PD and CAL (r=0.56, r=0.59) at 45 days (p<0.05). NSPT, before the start of chemotherapy, helps to reduce the inflammatory markers associated with the activity of periodontal disease, favoring a less inflammatory pattern, to avoid the exacerbation of periodontitis.
Metabolic syndrome and unfavorable outcomes on body composition and in visceral adiposities indexes among early breast cancer women post-chemotherapy Bruna Ramos da Silva, Sarah Rufato, Mirele S. Mialich, Loris P. Cruz, Thais Gozzo, et al. Clinical Nutrition Espen, 2021 PURPOSE The study objected to investigate potential changes in metabolic, dietary, and nutritional status in women with stages I-III breast cancer exposed to chemotherapy. METHODS Women who were starting chemotherapy with no previous treatment were recruited. Anthropometrics, bioelectrical impedance analysis, handgrip strength, blood pressure and blood sample were collected. Visceral adiposity index and lipid accumulation product were calculated. Dietary intake was evaluated, and the multiple source methods program was applied. Metabolic syndrome (MetS) was assessed following the NCEP-ATP III criteria (defined as 3 of 5 components of MetS). All data were collected at 2-time points: diagnosis (T0) and after 1 month of completion of therapy (T1). Mean, standard deviation, percentage, and ANOVA in SAS Studio® were used to explore the results. RESULTS 61 women were included. We did not find any changes in anthropometrics and body composition. However, phase angle, extracellular water (EX) and ratio EX to total body water had expressive changes (p < 0.001). The results showed changes in lipid profile (p < 0.001), and greater unfavorable outcomes on adiposities index (p < 0.001). At the end of the study, 68,8% (N = 42) of the women developed MetS post-chemotherapy. CONCLUSION We have found supporting evidence for chemotherapy treatment resulting in worsening of nutritional markers, lipid profile and adiposity markers. After chemotherapy part of the sample developed MetS, even without changes in body weight, fat mass, and food intake. Breast cancer patients may benefit from targeted interventions before starting chemotherapy to prevent MetS post-treatment, and therefore reduce the risk of cardiovascular disease. Further investigation into this theme is needed.