Thanalakshmi Jagadeesan

Scopus Publications

Effect of selected acupuncture points on lung functions and inflammatory markers in patients with asthma – An interventional study
S. Sasikumar, Thanalakshmi Jagadeesan, Arbind Kumar Choudhary, Sundareswaran Loganathan, V. Venugopal, K. Bincy, Maheshkumar Kuppusamy
Advances in Integrative Medicine, 2025
Comparative Analysis of CGRP, VIP and  PACAP-38 Levels in Migraine with and  Without Aura: A Case–control Study
N. Sreevani, B. Ramesh, K. Maheshkumar, J. Thanalakshmi
Annals of Neurosciences, 2025
Background Migraine pathophysiology involves the release of vasoactive neuropeptides following trigeminovascular system activation. While calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) have been individually studied in migraine, their combined role in differentiating migraine subtypes remains unclear. Purpose The aim of this study was to evaluate serum levels of CGRP, VIP and PACAP-38 in patients with migraine with aura (MA) and without aura (MO) compared to healthy controls (HC), and assess their potential as diagnostic biomarkers. Methods This case–control study included 296 participants (266 females, 30 males) divided into three groups: MA ( n = 101), MO ( n = 98) and HC ( n = 97). Serum neuropeptide levels were measured using enzyme-linked immunosorbent assay (ELISA) under standardised conditions. Clinical characteristics were assessed using attack frequency and Headache Impact Test-6 (HIT-6) scores. Results All three neuropeptides were significantly elevated in migraine patients compared to controls ( p < .001). CGRP levels were highest in MA (45.6 ± 8.2 pg/mL), followed by MO (38.4 ± 7.8 pg/mL) and HC (28.3 ± 6.4 pg/mL). Similar patterns were observed for VIP (MA: 186.4 ± 24.6, MO: 165.8 ± 22.4, HC: 142.3 ± 20.8 pg/mL) and PACAP-38 (MA: 248.6 ± 32.4, MO: 228.5 ± 30.6, HC: 195.4 ± 28.2 pg/mL). MA patients showed marginally higher attack frequency (4.8 ± 2.3 vs. 4.2 ± 2.1 per month, p = .06) and HIT-6 scores (64.8 ± 6.2 vs 62.4 ± 5.8, p = .08) compared to MO patients. Conclusion The significant elevation of all three neuropeptides, particularly in MA patients, suggests their potential utility as biomarkers for migraine diagnosis and subtype differentiation. These findings support the neurogenic inflammation hypothesis in migraine pathophysiology and may have implications for targeted therapeutic approaches.
OM Chanting Reduces Psychological Distress Level in Office Workers During Covid 19 Pandemic
Jagadeesan Thanalakshmi, , Kuppusamy Maheshkumar, Kavia Shree, Mou Pramanik, Karuppasamy Govindasamy, , , , and
Fizicna Reabilitacia Ta Rekreacijno Ozdorovci Tehnologii, 2024
Purpose: psychological stress caused due to the current COVID 19 pandemic lock down may have an adverse impact on the quality of life (QoL) in office shift workers. The purpose of the present study was to investigate the effect of OM chanting on the levels of perceived psychological stress, quality of life and sleep among office workers who are confined at home and work during the global COVID-19 pandemic. Material & Methods: an online OM chanting session was conducted for 20 workers who stayed at home and worked during the pandemic lockdown. Prior to and at the end of the training all the participants finished a battery of self-reported online inventories, including the Depression, Anxiety and Stress Scale with 21 items (DASS-21) and quality of life (WHOQOL-BREF). Results: after ten days of OM chanting, all the participants stated a significant enhancement in all domains of quality of life and a reduction of psychological distress (P<0.05). Conclusions: OM chanting is feasible, safe and has a positive effect on psychological quality of life of participants. Still further studies have to be done to warrant the findings with suitable study design.
Pituitary Adenylate Cyclase-Activating Peptide-38 in migraine: A systematic review and meta-analysis
Sreevani Namani
International Journal of Medical Biochemistry, 2024
M igraine is a complex neurological disorder that impacts a significant portion of the global population [1].It is a condition marked by repeated occurrences of headaches ranging from moderate to severe intensity.These headache episodes frequently co-occur with other symptoms, such as nausea, vomiting, heightened sensitivity to light and sound, and, in certain cases, visual disturbances called auras preceding the headache itself [2].While the precise underlying reason for migraine is still unclear, it is believed to arise from an interplay of genetic influences, environmental triggers, and neurovascular mechanisms in the brain.It is important that the occurrence rates and degree of effects caused by migraine demonstrate variation across different geographic regions and nations [3].Italy, for instance, has been identified as having the highest rate of migraine-related disability, followed closely by Thailand, Norway, Spain, Brazil, and Ethiopia [4,5].These variations in prevalence rates highlight the influence of geographic and cultural factors on the occurrence and management of migraine.In Asia, the estimated average prevalence of migraine is 12.7%, emphasizing the significant impact of the condition on the continent [6].The World Health Organization (WHO) recognizes migraine as the sixth most debilitating disorder Migraine is a complex neurological disorder characterized by recurrent headaches accompanied by sensory disturbances.It involves a combination of genetic, environmental, and neurovascular factors.The objective of this systematic review and meta-analysis was to investigate the correlation between migraine and specific mutant genes by examining the association of Pituitary Adenylate Cyclase-Activating Peptide-38 genes with migraine.A comprehensive search was conducted in major scientific databases, such as PubMed, Scopus, and Embase, to identify relevant studies published up until September 2023.The inclusion criteria encompassed studies that examined the genes (PACAP-38) and various aspects of migraine.Two independent reviewers performed data extraction and quality assessment to ensure the accuracy and reliability of the collected information.Seven studies, comprising 737 patients, were included in the final analysis.The random effects model yielded a standardized mean difference (SMD) of 0.55 (95% CI:-0.15 to 1. 25, t=1.45, p=0.19).Heterogeneity among the studies was substantial, with I indicating 93% variability (95% CI: 84.6% to 96.5%).The heterogeneity was statistically significant (Q= 87.2, df=6, p<0.001).The prediction interval ranged from -1.40 to 2.51.This systematic review and meta-analysis establish a strong link between PACAP-38 and susceptibility to migraine.These findings highlight the significance of genetic factors in migraine development, emphasizing the need for further investigation to elucidate underlying mechanisms and explore the clinical implications of these genetic associations.
Life style changes during lock down period of COVID19 outbreaks in Tamil Nadu, India: A web based survey
Jagadeesan Thanalakshmi, Masilamani Elayaraja, Kaviya Lakshmi, Kuppusamy Maheshkumar, Naima Umar, Mou Pramanik, Rajesh Kumar, Aakash Dhiman, Rakesh Bharati, Dilpreet Kaur, Hemantajit Gogoi, Karuppasamy Govindasamy
Fizjoterapia Polska, 2024
India has been affected by novel coronavirus disease (COVID 19) since January 2020. It was declared as a pandemic outbreak and a nationwide lockdown was implemented to reduce the transmission of infection. As a lack of effective treatment method or vaccine development against the disease, social distancing and home confinement was considered to be the only solution. The COVID 19 has a dangerous effect on the quality of life of the public. The aim of the present study was to assess the lifestyle changes among the public in Tamil Nadu during the outbreak. This web-based survey was initiated to assess and compare the lifestyle changes during the lockdown period of COVID 19 outbreak in Tamil Nadu. By July 10, 2020, a total of 236 participants submitted the responses and the collected data were included for the analysis. The study contained a planned questionnaire that finds out demographic, dietary habits information, screen exposure, sleep time, and lifestyle habits information through an online survey. The present study findings suggest that significant influences of COVID 19 pandemic lockdown on the majority of employed individuals with a history of no comorbidity by decreasing physical activity (60.16%), increase in screen time (52.9%) and sleep per day (43.2%), decrease consumption of vegetables (36.4%) and variation in fruits and meat consumption. This study elicits the importance of various factors to be considered before the commencement and policy about the lockdown and its durations. These findings need to be further confirmed with studies of larger population size to gain higher insight towards healthy lockdown against COVID 19 pandemic.
Exploring cardiovascular risk: The significance of neck circumference in predicting upper body obesity and metabolic health
K. Kavitha, Masilamani Elayaraja, Kuppusamy Maheshkumar, Sunil Kumar, Anurag Pathak, Aakash Dhiman, Rajesh Kumar, Jagadeesan Thanalakshmi, Dilara Kamaldeen, Dilpreet Kaur, Kavita Marwah, Rakesh Bharti, Hemantajit Gogoi, Karuppasamy Govindasamy
Fizjoterapia Polska, 2024
Anthropometric measurements play a crucial role in assessing metabolic variables and predicting cardiovascular risk. Neck circumference (NC), a simple and time-saving measure, has emerged as a potential indicator of central obesity and a predictor for cardiovascular risk factors. This study aims to explore the correlation between NC and lipid profile, emphasizing its significance as a screening tool for overweight individuals. The primary objectives of this cross-sectional study are to determine whether NC alone can predict overweight and obesity and to assess the association between NC and cardiovascular risk factors. Ethical clearance was obtained, and written consent was obtained from 100 subjects (50 males and 50 females) aged 25 to 50 years undergoing master health checkups. Exclusion criteria included systemic diseases, smoking, alcohol consumption, medication, and diet restrictions. Anthropometric measurements, including NC, BMI, and lipid profile, were recorded. Significant gender-based differences were observed in NC, with males having higher values. NC correlated positively with BMI, weight, cholesterol, LDL, and triglycerides in both genders. NC > 38 cm for males and > 34 cm for females were identified as optimal cutoff points for determining overweight/obesity. The study also revealed associations between NC and blood pressure, heart rate, and lipid profile. Neck circumference demonstrates a strong correlation with lipid profile factors and cardiovascular risk, making it a potential screening tool for upper-body obesity. Gender-specific cutoff values were established for identifying overweight and obese subjects. NC's simplicity, cultural acceptability, and ease of measurement suggest its utility in primary care settings for obesity assessment and cardiovascular risk prediction. Further research is warranted to establish standardized NC cutoff values for the Indian population.
In-silico Studies of Active Phytochemicals from Siddha Medicinal Herbs of Karisalai Chooranam against SARS-CoV-2 main Protease (3CLpro), RNA Dependent RNA Polymerase and Angiotensin-Converting Enzyme II Receptor
Mariappan. A, Thanalakshmi. J, S. Sundar, Radha S, Meenakumari R, Kaaruniya. G
Research Journal of Pharmacy and Technology, 2023
Aim: The contagious disease COVID 19 is a recently out-broken pandemic situation which threatens humankind all over the world. Siddha system of medicine is one of the traditional medical systems of India, which has provided a novel remedy for many epidemics like Dengue, Chicken guinea earlier. On evaluating the literature evidence and considering the mortality and severity of the disease, we have attempted to identify the possible inhibition of viral replication by "Karisalai Chooranam" - a polyherbal Siddha formulation which contains herbs like Karisalai (Wedelia chinensis), Thoodhuvelai (Solanum trilobatum), Musumusukai (Melothria maderaspatana) and Seeragam (Cuminum cyminum). The aim of this study was to identify the bioactive components present in Karisalai chooranam and pin down the components that inhibit COVID 19 protease by In Silico molecular docking analysis. Material and methods: The study was performed for the active compounds present in the herbs (Wedelia chinensis - Benzoic acid, Solanum trilobatum- Disogenin, Melothria maderaspatana- β–sitosterol, Cuminum cyminum L- Coumaric acid and Limonene) with three potential targets, PDB id: 6LU7 3-chymotrypsin-like protease (3CLpro), PDB id: 6-NUR RNA dependent RNA polymerase and PDB id: 2AJF Angiotensin-converting enzyme II (ACE2) receptor using Autodock Vina. Key findings: The active phytocomponents present in “Karisalai chooranam” was found to inhibit the target 3CL proenzyme and hereby halt the formation of 16 non-structural proteins (nsp1-nsp16) that are highly essential for viral replication and there by prevents viral survival in the host environment. The phytocomponents also inhibited the target RNA dependent RNA polymerase (PDB)-6NUR RdRp which possess versatile action in mediating nonstructural protein (nsp 12) essential for viral replication. A significant binding against the target Angiotensin-converting enzyme II (ACE2) receptors - PDB- 2AJF was found which was recognized as a binding site for novel coronavirus to cause its pathogenesis. Among the five active components present in the herb, the binding ability of Disogenin and β–sitosterol with COVID19 protease suggests a possible mechanism of protease inhibition and thus preventing viral replication. Significance: The results strongly suggest that phytocomponents of “Karisalai chooranam” may act as a potential therapeutic agent for the management of COVID-19 and related symptoms. Further, the efficacy of the active compounds should be tested in vitro before being recommended as a drug.
Effect of Bhramari Pranayama intervention on stress, anxiety, depression and sleep quality among COVID 19 patients in home isolation
Thanalakshmi Jagadeesan, Archana R, Kannan R, Timsi Jain, Aadhyyanth R. Allu, Tamil Selvi G, M. Maveeran, Maheshkumar Kuppusamy
Journal of Ayurveda and Integrative Medicine, 2022
COVID-19 outbreak is considered to be a major public health concern as it has a negative impact on the patient’s psychological health. In addition, patients under home isolation might be more panic and in stress. In this study, we examined the effect of Bhramari Pranayama (Bhr.P) intervention on patients’ psychological distress during home isolation. Ninety-two asymptomatic COVID-19 patients were recruited from the host hospital and willing patients who satisfied the inclusion criteria (n = 42) were selected for the study. The patients were given Bhr.P intervention (20 min) through online for 15 days. Participants were assessed with Depression Anxiety and Stress Scale-21 (DASS-21), Pittsburgh Sleep Quality Index (PSQI), and Quality of life (WHOQOL-BREF) at baseline and post-intervention. Bhr.P practice has shown a significant (P < 0.05) reduction in DASS-21 score of depression, anxiety and stress. In addition, the patients stated significant improvement in quality of sleep (PSQI; p < 0.05) and quality of life (WHOQOL-BREF; p < 0.05) after the intervention. Our findings indicate that Bhr.P intervention had a positive impact on psychological health as well as quality of sleep among the COVID-19 patients during home isolation. However, it needs to be confirmed by multi-site randomized controlled trials. Clinical trial registration: CTRI/2021/04/032845.
Vestibular stimulation: A noninvasive brain stimulation in Parkinson's disease & its implications
Thanalakshmi Jagadeesan, Archana Rajagopal, Senthilkumar Sivanesan
Journal of Complementary and Integrative Medicine, 2021
Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease, and it is characterized by both motor and neuropsychiatric problems. Effective treatment of PD requires a combination of pharmacotherapy and physiotherapy; however, existing treatment generally involves one medical discipline most probably interpretation by neurologist. This pharmacotherapy relay on dopaminergic medications which is not capable of bringing sufficient alleviation of all motor symptoms in PD. Implementing positive lifestyle activities can support patients to improve the quality of life, symptoms, and possibly slow down the disease progression. In far effective management of PD, clinics are trying to execute and promote the use of additional integrative approaches of care among PD patients. Notably, vestibular stimulation like noisy galvanic vestibular stimulation (nGVS) is being studied as a potential treatment for PD, and a number of studies have presented scientific evidence in support of this concept. In this review paper, we highlight the importance of vestibular stimulation in both human and animal studies as one of the promising interventional approaches for PD. All the existing studies are heterogeneous in study design, so further studies have to be conducted which meets the standards of randomized control trial with proper sample size to validate the findings of vestibular stimulation.
Yoga practice (Sheetali Pranayama) on cognition in patients with hypertension: A randomized controlled study
Thanalakshmi Jagadeesan, Arbind Kumar Choudhary, Sundareswaran Loganathan, Kannan Rajendran, Aadhyyanth R. Allu, Maheshkumar Kuppusamy
Integrative Medicine Research, 2021
Role of caloric vestibular stimulation in improvement of motor symptoms and inhibition of neuronal degeneration in rotenone model of Parkinson’s disease – An experimental study
J. Thanalakshmi, R. Archana, S. Senthilkumar, R. Shakila, N. Pazhanivel, S. Subhashini
Physiology International, 2020
Beneficial effects of long term caloric vestibular stimulation on changes in brain neurotransmitter dopamine and locomotor activity in parkinson’s disease induced rats
Thanalakshmi J, Archana R, Senthil Kumar S
International Journal of Research in Pharmaceutical Sciences, 2020
Effect of Sheetali pranayama on cardiac autonomic function among patients with primary hypertension - A randomized controlled trial
J. Thanalakshmi, K. Maheshkumar, R. Kannan, L. Sundareswaran, V. Venugopal, S. Poonguzhali
Complementary Therapies in Clinical Practice, 2020
Prevalence of menstrual symptoms and primary dysmenorrhea among medical undergraduates in south indian population.
Pavithra B, Sangeetha A, Anuja A V, Samuel Sundar Doss, Thanalakshmi J, Vijayalakshmi B
International Journal of Research in Pharmaceutical Sciences, 2020
The immediate effect of sheethali and sheethkari pranayama on blood pressure and cardiovascular changes among hypertensive patients
Naveen Kumar M, J Thanalakshmi, R. Jagadeesh Kannan, Mahesh Kumar K, Aadhyyanth R Allu, et al.
International Journal of Research in Pharmaceutical Sciences, 2018

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