Dr. Tharaheswari Mayakrishnan

@pondiuni.ac.in

Assistant Professor, Department of Biochemistry
Pondicherry University

Dr. Tharaheswari Mayakrishnan


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https://researchid.co/tharaheswari

EDUCATION

Ph.D in Biochemistry and Molecular Biology

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry, Genetics and Molecular Biology, Biochemistry, Clinical Biochemistry, Molecular Biology
3

Scopus Publications

239

Scholar Citations

6

Scholar h-index

5

Scholar i10-index

Scopus Publications

  • Transforming oral cancer care: The promise of deep learning in diagnosis
    Durairaj Varalakshmi, Mayakrishnan Tharaheswari, Thirunavukarasou Anand, Konda Mani Saravanan
    Oral Oncology Reports, 2024
    The diagnosis and treatment of oral cancer present significant challenges, including delayed diagnosis at advanced stages and limited access to healthcare. Deep learning (DL), a subset of artificial intelligence, holds promise for transforming medical image analysis and predictive analytics. In this perspective, we examine the applications of DL in oral cancer. Specifically, we explore the efficacy of convolutional neural networks (CNNs) and recurrent neural networks (RNNs) in diagnosing and predicting the prognosis of oral cancer in the last five years. Additionally, we underscore the importance of oral cancer databases in advancing research and clinical practice. However, DL methods face constraints related to input variability and model interpretability. Addressing these issues is crucial to harnessing the full potential of DL in oral cancer treatment. In summary, this article underscores the innovative contributions of DL in revolutionizing oral cancer management and advocating for precision medicine in oncology.
  • Identifying Potent Fat Mass and Obesity-Associated Protein Inhibitors Using Deep Learning-Based Hybrid Procedures
    Kannan Mayuri, Durairaj Varalakshmi, Mayakrishnan Tharaheswari, Chaitanya Sree Somala, Selvaraj Sathya Priya, Nagaraj Bharathkumar, Renganathan Senthil, Raja Babu Singh Kushwah, Sundaram Vickram, Thirunavukarasou Anand, Konda Mani Saravanan
    Biomedinformatics, 2024
    The fat mass and obesity-associated (FTO) protein catalyzes metal-dependent modifications of nucleic acids, namely the demethylation of methyl adenosine inside mRNA molecules. The FTO protein has been identified as a potential target for developing anticancer therapies. Identifying a suitable ligand-targeting FTO protein is crucial to developing chemotherapeutic medicines to combat obesity and cancer. Scientists worldwide have employed many methodologies to discover a potent inhibitor for the FTO protein. This study uses deep learning-based methods and molecular docking techniques to investigate the FTO protein as a target. Our strategy involves systematically screening a database of small chemical compounds. By utilizing the crystal structures of the FTO complexed with ligands, we successfully identified three small-molecule chemical compounds (ZINC000003643476, ZINC000000517415, and ZINC000001562130) as inhibitors of the FTO protein. The identification process was accomplished by employing a combination of screening techniques, specifically deep learning (DeepBindGCN) and Autodock vina, on the ZINC database. These compounds were subjected to comprehensive analysis using 100 nanoseconds of molecular dynamics and binding free energy calculations. The findings of our study indicate the identification of three candidate inhibitors that might effectively target the human fat mass and obesity protein. The results of this study have the potential to facilitate the exploration of other chemicals that can interact with FTO. Conducting biochemical studies to evaluate these compounds’ effectiveness may contribute to improving fat mass and obesity treatment strategies.
  • Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARγ activity in type 2 diabetic rats
    M. Tharaheswari, N. Jayachandra Reddy, R. Kumar, K. C. Varshney, M. Kannan, S. Sudha Rani
    Molecular and Cellular Biochemistry, 2014

RECENT SCHOLAR PUBLICATIONS

  • Transforming oral cancer care: The promise of deep learning in diagnosis
    D Varalakshmi, M Tharaheswari, T Anand, KM Saravanan
    Oral Oncology Reports 10, 100482 , 2024
    2024.0
    Citations: 19
  • Identifying Potent Fat Mass and Obesity-Associated Protein Inhibitors Using Deep Learning-Based Hybrid Procedures
    K Mayuri, D Varalakshmi, M Tharaheswari, CS Somala, SS Priya, ...
    BioMedInformatics 4 (1), 347-359 , 2024
    2024.0
    Citations: 34
  • Fenugreek seed extract and its phytocompounds-trigonelline and diosgenin arbitrate their hepatoprotective effects through attenuation of endoplasmic reticulum stress and …
    T Mayakrishnan, JR Nakkala, SPK Jeepipalli, K Raja, V Khub Chandra, ...
    European Food Research and Technology 240 (1), 223-232 , 2015
    2015.0
    Citations: 34
  • Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARγ activity in type 2 diabetic rats
    M Tharaheswari, N Jayachandra Reddy, R Kumar, KC Varshney, ...
    Molecular and cellular biochemistry 396 (1), 161-174 , 2014
    2014.0
    Citations: 126
  • Studies on dyslipidemia in diabetic and non diabetic hypertensive patients
    M Tharaheswari, A Yogamoorthi
    Am J Phytomed Clin Therapeutics 2 (5), 636-643 , 2014
    2014.0
    Citations: 7
  • A Comparative Study On The Effect Of Fenugreek Seed Extract And Two Of Its Phytoconstituents-Trigonelline And Diosgenin In Type 2 Diabetic Rats
    M Tharaheswari
    2014.0
  • Cassia auriculata flower extract articulate its antidiabetic effects by regulating antioxidant levels in plasma, liver and pancreas in T2DM rats
    JSP Kumar, M Tharaheswari, S Subhashree, SS Rani
    AJPCT 2, 705-722 , 2014
    2014.0
    Citations: 6
  • Fenugreek seed extract stabilize plasma lipid levels in type 2 diabetes by modulating PPARs and GLUT4 in insulin target tissues
    M Tharaheswari, JSP Kumar, NJ Reddy, S Subhashree, SS Rani
    Am J Phytomed Clin Ther 2, 587-602 , 2014
    2014.0
    Citations: 13
  • A Study of Diabetic Patients in Puducherry after the COVID Lockdown to Measure their Stress and Life Satisfaction
    D Varalakshmi, M Tharaheswari, CS Somala, T Anand, KM Saravanan
  • Assessing spider diversity in Puducherry: Rural richness and urban constraints
    M Tharaheswari, D Varalakshmi, T Anand, KM Saravanan, R Senthil

MOST CITED SCHOLAR PUBLICATIONS

  • Trigonelline and diosgenin attenuate ER stress, oxidative stress-mediated damage in pancreas and enhance adipose tissue PPARγ activity in type 2 diabetic rats
    M Tharaheswari, N Jayachandra Reddy, R Kumar, KC Varshney, ...
    Molecular and cellular biochemistry 396 (1), 161-174 , 2014
    2014.0
    Citations: 126
  • Identifying Potent Fat Mass and Obesity-Associated Protein Inhibitors Using Deep Learning-Based Hybrid Procedures
    K Mayuri, D Varalakshmi, M Tharaheswari, CS Somala, SS Priya, ...
    BioMedInformatics 4 (1), 347-359 , 2024
    2024.0
    Citations: 34
  • Fenugreek seed extract and its phytocompounds-trigonelline and diosgenin arbitrate their hepatoprotective effects through attenuation of endoplasmic reticulum stress and …
    T Mayakrishnan, JR Nakkala, SPK Jeepipalli, K Raja, V Khub Chandra, ...
    European Food Research and Technology 240 (1), 223-232 , 2015
    2015.0
    Citations: 34
  • Transforming oral cancer care: The promise of deep learning in diagnosis
    D Varalakshmi, M Tharaheswari, T Anand, KM Saravanan
    Oral Oncology Reports 10, 100482 , 2024
    2024.0
    Citations: 19
  • Fenugreek seed extract stabilize plasma lipid levels in type 2 diabetes by modulating PPARs and GLUT4 in insulin target tissues
    M Tharaheswari, JSP Kumar, NJ Reddy, S Subhashree, SS Rani
    Am J Phytomed Clin Ther 2, 587-602 , 2014
    2014.0
    Citations: 13
  • Studies on dyslipidemia in diabetic and non diabetic hypertensive patients
    M Tharaheswari, A Yogamoorthi
    Am J Phytomed Clin Therapeutics 2 (5), 636-643 , 2014
    2014.0
    Citations: 7
  • Cassia auriculata flower extract articulate its antidiabetic effects by regulating antioxidant levels in plasma, liver and pancreas in T2DM rats
    JSP Kumar, M Tharaheswari, S Subhashree, SS Rani
    AJPCT 2, 705-722 , 2014
    2014.0
    Citations: 6
  • A Comparative Study On The Effect Of Fenugreek Seed Extract And Two Of Its Phytoconstituents-Trigonelline And Diosgenin In Type 2 Diabetic Rats
    M Tharaheswari
    2014.0
  • A Study of Diabetic Patients in Puducherry after the COVID Lockdown to Measure their Stress and Life Satisfaction
    D Varalakshmi, M Tharaheswari, CS Somala, T Anand, KM Saravanan
  • Assessing spider diversity in Puducherry: Rural richness and urban constraints
    M Tharaheswari, D Varalakshmi, T Anand, KM Saravanan, R Senthil