Pharmacology, Toxicology and Pharmaceutics, Physiology
6
Scopus Publications
Scopus Publications
Probiotic Kefir Improves Renal Disorders in Ovariectomized Female SHR with High Fructose Intake–Induced Metabolic Syndrome Leonardo da Silva Escouto, Thatiany Jardim Batista, Pollyana Peixoto, Felipe Tonon Firmino, Silas Nascimento Ronchi, Maria Eduarda de Souza Barroso, Edgar Hell Kampke, Tadeu Uggere de Andrade, Antonio Ferreira de Melo Junior, Nazaré Souza Bissoli Probiotics and Antimicrobial Proteins, 2026 Women in postmenopausal period may present several comorbidities linked to metabolic syndrome (MetS). Our hypothesis is that kefir may prevent the deleterious effects in renal function in an experimental model of metabolic syndrome (MetS) and ovarian hormone deficiency. Young female spontaneously hypertensive rats (SHR) were divided into four groups: ovariectomized (OVX) control, OVX fructose, OVX kefir, and OVX kefir + fructose. They received kefir (5% w/v) via gavage for 8 weeks, while fructose (10% w/v) was available ad libitum. In ponderal parameters and glucose metabolism, we observe that fructose-overloaded groups (OF and OKF) showed increased weight, visceral fat, and fasting blood glucose. However, OKF partially reduced glycemic peak in the glucose tolerance test. Moreover, the standard method for the measurement of renal function showed that OF and OKF groups had a reduction in glomerular filtration rate, and surprisingly OKF exhibited increased renal flow (RBF and RPF) and decreased resistance (RVR). These might be associated with the findings in oxidative stress and nitric oxide (NO) bioavailability, in which kefir in the OKF group was capable of increasing total nitrogen oxides (NOx), attenuate the generation of hydrogen peroxide (DCF) and peroxynitrite (HPF), and also decreased the elevated microalbuminuria promoted by fructose even though the systemic blood pressure between the groups did not differ. Taking together our results, in the present study, kefir showed favorable effects in the model of metabolic syndrome and ovarian hormone deficiency (OKF), potentially protecting the kidney from the deleterious effects of fructose.
Obesity prevalence in Brazilian firefighters and the association of central obesity with personal, occupational and cardiovascular risk factors: a cross-sectional study Fernanda Camargo Damacena, Thatiany Jardim Batista, Lorena Rocha Ayres, Eliana Zandonade, Karla Nívea Sampaio BMJ Open, 2020 Objectives This study aimed to investigate the obesity prevalence in a population of Brazilian firefighters and the association of central obesity (CO) with sociodemographic, occupational, life habits, fitness and health status variables. Design Cross-sectional study. Settings The data were collected during annual health inspections of firefighters from the Military Fire Service of the State of Espírito Santo, a state in Southeast Brazil. Participants The study encompassed 1018 active military firefighters. After exclusion criteria, 892 male firefighters were analysed. Primary and secondary outcome measures The collected data included: sociodemographic, occupational, lifestyle, fitness and health status variables. The associations between these factors and CO were calculated by adjusted OR through a hierarchical logistic regression model. Results Obesity estimation by body mass index indicated that 48.65% of the firefighters were overweight and 10.99% were obese. Concerning the body fat percentage, 26.23% of the participants were considered obese, while 18.61% of the firefighters were considered centrally obese or at risk using the waist circumference measure. After adjusted OR analysis, CO was more likely associated with the age range of 50 to 59 years old (OR 2.93; 95% CI 1.05 to 8.14), low self-reported physical activity (OR 1.95; 95% CI 1.14 to 3.34), low cardiorespiratory fitness (OR 5.15; 95% CI 3.22 to 8.23), hyperglycaemia (OR 1.70; 95% CI 1.07 to 2.72) and hypertriglyceridaemia fasting status (OR 3.12; 95% CI 1.75 to 5.55). Conclusions Our study identified an overall high prevalence of overweight and obese individuals in the examined firefighter population. Age and cardiovascular risk factors were directly associated with CO among the firefighters. Cardiovascular risk factors should be routinely inspected within the Brazilian firefighters’ corporations in order to improve the health condition and wellness of these workers. These endeavours will improve the performance of the services provided to the population.
