Geriatric Hematology Oncology
Frailty assessment in Hemonc
Applications Invited Colaboration
15
Scopus Publications
190
Scholar Citations
7
Scholar h-index
6
Scholar i10-index
Scopus Publications
Phototherapy in lymphoproliferative and inflammatory diseases associated with human T-lymphotropic virus Brena Andrade de Lima Lobato, João Augusto Gomes de Souza Monteiro de Brito, José Maria de Castro Abreu Junior, Maísa Silva de Sousa, Carlos Augusto Moreira Silva, et al. Transactions of the Royal Society of Tropical Medicine and Hygiene, 2025 Background Dermatological manifestations affect 5% of patients with human T-lymphotropic virus (HTLV). Methods Thirteen patients with inflammatory or lymphoproliferative dermatological diseases, both HTLV-positive and HTLV-negative, were selected for treatment with ultraviolet B narrowband (UVB-NB) phototherapy. Clinical and histopathological evaluations were conducted before and after 120 d of phototherapy. Results All seven HTLV-positive patients evaluated were type 1. Clinical evaluation showed improvement in all 13 patients. In the histopathological examination, all patients with lymphoproliferative diseases and five with inflammatory diseases showed regression in most of the assessed parameters. Conclusions The present research suggests that UVB-NB phototherapy is a promising treatment for lymphoproliferative and inflammatory skin diseases in HTLV-1 patients.
Global Access to Multiple Myeloma Therapies Rawan Atallah, Yara Shatnawi, MD Fathima Shehnaz Ayoobkhan, Md Saiful Islam Saif, Menahil Naeem, et al. JCO Global Oncology, 2025 PURPOSE Initial reports indicate that access to contemporary therapies currently used in North America for the treatment of multiple myeloma (MM) varies internationally. No studies have quantitatively reported the extent of disparities in the access to MM therapies worldwide, with a goal to investigate access to MM therapies and barriers globally. METHODS From June 18 to July 15, 2023, an electronic survey was distributed to 176 oncologists treating MM outside the United States. MM drugs were categorized by accessibility, with the cutoff for adequate access set at 60% of respondents affirming easy/moderate access. RESULTS Ninety-five (54%) respondents from 33 countries completed the survey. Fifty-one percent of the respondents were from university-based academic programs, and 17% of the responders treated only plasma cell disorders. Most respondents had adequate access to noncellular MM therapies, except for isatuximab, ixazomib, selinexor, and elotuzumab. Among the cellular therapies, 17% had access to Chimeric Antigen Receptor T-cell therapy, whereas 23% had access to approved T-cell engagers (TCEs). Financial stress on patients and health care systems has emerged as a primary barrier to global inaccessibility of treatment drugs. CONCLUSION Global access to novel MM therapies remains challenging, and we have identified barriers and suggested strategies to bridge this gap.
Hematological and Biochemical Characteristics Associated with Cytogenetic Findern Alterations in Adult Patients with Acute Lymphoblastic Leukemia (ALL) from the Northern Region of Brazil Dejair da Silva Duarte, Eliel Barbosa Teixeira, Marcelo Braga de Oliveira, Thiago Xavier Carneiro, Lucyana Barbosa Cardoso Leão, et al. Biomedicines, 2024 Acute lymphoblastic leukemia (ALL) is an aggressive neoplasm derived from B and/or T cell lineage (B-ALL; T-ALL). For the first time, this study describes, cytogenetically, the karyotypic alterations in adults with ALL in the northern region of Brazil and their relationship with hematological and biochemical characteristics. Through banding analyses, immunophenotyping, as well as hematological and biochemical examination data obtained directly from patients’ records, we found that chromosome 21 aneuploidy was the most frequent. The cytogenetic structural alterations observed with the highest incidence among the patients were: t(9;22), t(4;11), t(1;19), del(6q), and del(9p). In patients presenting with chromosome alterations, we verified that patients with t(4;11) have elevated red blood cell levels and patients with del(9p) presented with distinct and high values of hematological parameters compared to other patients. Regarding biochemical alterations, we observed that patients with translocations (4;11) and del(6q) presented with elevated urea levels compared to other patients, highlighting its relationship to kidney changes and patient prognosis. Thus, our study highlights that variations in hematological and biochemical data are associated with specific cytogenetic changes and other factors, which may impact the prognosis of adult patients with ALL.
Chronic Myelogenous Leukemia with Double Philadelphia Chromosome and Coexpression of p210 and p190 Fusion Transcripts Samara Silveira da Cruz, Aline Damasceno Seabra, Lais Helena Rescinho Macambira, Débora Monteiro Carneiro, Patrícia Ferreira Nunes, et al. Genes, 2022 The Philadelphia (Ph+) chromosome, t(9;22)(q34;q11.2), originates from a chimeric gene called BCR-ABL and is present in more than 90% of CML patients. Most patients with CML express the protein p210 BCR-ABL and, with a frequency lower than 5%, express rare isoforms, the main one being p190. In the transition from the chronic phase to the blast phase (BP), additional chromosomal abnormalities, such as the presence of the double Ph+ chromosome, are revealed. Of the 1132 patients analyzed via molecular biology in this study, two patients (0.17%) showed the co-expression of the p210 and p190 isoforms for the BCR-ABL transcript, with the concomitant presence of a double Ph+ chromosome, which was observed via conventional cytogenetics and confirmed by fluorescent in situ hybridization. The BCR-ABL/ABL% p210 and p190 ratio increased in these two patients from diagnosis to progression to blast crisis. To our knowledge, this is the first report in the literature of patients who co-expressed the two main BCR-ABL transcript isoforms and concomitantly presented Ph+ chromosome duplication. The evolution from the chronic phase to BP often occurs within 5 to 7 years, and, in this study, the evolution to BP was earlier, since disease-free survival was on average 4.5 months and overall survival was on average 9.5 months. The presence of the p190 transcript and the double Ph+ chromosome in CML may be related to the vertiginous progression of the disease.
Safety and feasibility of outpatient high dose cytarabine for acute myeloid leukemia in the Brazilian amazon International Journal of Hematology Oncology and Stem Cell Research, 2020
Does Down syndrome affect the prognosis of acute lymphoblastic leukemia? A systematic review and meta-analysis FCA de Moraes, A de Oliveira Macena Lôbo, VKT Sano, CRM Pereira, ... Expert Review of Hematology 18 (11), 961-970 , 2025 2025
ATRASOS E BARREIRAS NO ACESSO AO TRANSPLANTE DE MEDULA ÓSSEA EM PACIENTES COM LEUCEMIA MIELOIDE AGUDA: ANÁLISE DE UM CENTRO NA AMAZÔNIA VF Ribeiro, CRM Reis, RM Silva, JV Tavares, LBC Leão, TX Carneiro Hematology, Transfusion and Cell Therapy 47, 104500 , 2025 2025
Guia de exercícios terapêuticos desenvolvido para pacientes com mieloma múltiplo CP de Almeida, GA da Silva Dias, TX Carneiro Revista Práxis 17 (31) , 2025 2025
Phototherapy in lymphoproliferative and inflammatory diseases associated with human T-lymphotropic virus BA de Lima Lobato, JAGSM de Brito, JMC Abreu Junior, MS de Sousa, ... Transactions of The Royal Society of Tropical Medicine and Hygiene 119 (7 … , 2025 2025
Manual de transplante de medula óssea para pacientes de um hospital público no norte do Brasil LBC Leão, TX Carneiro REVISTA DELOS 18 (68), e5593-e5593 , 2025 2025
Global access to multiple myeloma therapies R Atallah, Y Shatnawi, MDFS Ayoobkhan, MSI Saif, M Naeem, E Logan, ... JCO Global Oncology 11, e2400441 , 2025 2025 Citations: 7
Hematological and Biochemical Characteristics Associated with Cytogenetic Findern Alterations in Adult Patients with Acute Lymphoblastic Leukemia (ALL) from the Northern Region … DS Duarte, EB Teixeira, MB de Oliveira, TX Carneiro, LBC Leão, ... Biomedicines 12 (12), 2739 , 2024 2024 Citations: 1
Unraveling the protective genetic architecture of COVID-19 in the Brazilian Amazon MC Barros, JES de Souza, DHF Gomes, CT Pinho, CS Silva, ... Scientific Reports 14 (1), 27332 , 2024 2024
Safety and efficacy of venetoclax, cytarabine and metformin for relapsed-refractory and induction-ineligible acute myeloid leukemia MP de Lacerda, E Nunes, G Steffenello, TX Carneiro, IS Boettcher, ... Blood 144, 1524 , 2024 2024 Citations: 3
Diagnosis and management of acute promyelocytic leukemia: Brazilian consensus guidelines 2024 on behalf of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy LL de Figueiredo-Pontes, LFB Catto, MLLF Chauffaille, KBB Pagnano, ... Hematology, Transfusion and Cell Therapy 46 (4), 553-569 , 2024 2024 Citations: 11
IMPLEMENTAÇÃO DE UM MODELO DE NAVEGAÇÃO PARA PACIENTES ONCOLÓGICOS NO ESTADO DO PARÁ JCP Saraiva Filho, TX Carneiro RECISATEC-REVISTA CIENTÍFICA SAÚDE E TECNOLOGIA-ISSN 2763-8405 4 (2), e42367 … , 2024 2024 Citations: 1
Current perspectives on the management of refractory or relapsed classic hodgkin lymphoma in brazil: Balancing efficacy, safety, and tolerability FD Xavier, DLC de Farias, AEH Neto, GN Ribeiro, MAS de Araujo, ... Oncotarget 14, 977 , 2023 2023 Citations: 2
EE227 Waldenstrom's Macroglobulinemia: An Overview of Treatment Patterns, Resource Use, and Costs From the Brazilian Private Healthcare Perspective M Macedo, M Resende, J Genre, J Martins, RA Fernandes, AC Pereira, ... Value in Health 26 (12), S95 , 2023 2023
The GLAMM1 study-global access to myeloma medications: potential barriers to chimeric antigen receptors (CART) and T-cell-engaging bispecific antibodies (TCE) globally R Atallah, Y Shatnawi, A Mammadzadeh, SK Hashmi, SK Rana, ... Blood 142, 3327 , 2023 2023 Citations: 8
Global Access to Multiple Myeloma Medications (GLAMM-2 Study): Access and Barriers to Chemoimmunotherapies and Transplant A Mammadzadeh, Y Shatnawi, R Atallah, B Mohamed, N Desai, ... Blood 142 (Supplement 1), 4727-4727 , 2023 2023 Citations: 1
FRAILTY ASSESSMENT IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA TREATED WITH THE COMBINATION OF VENETOCLAX AND IBRUTINIB TX Carneiro, JLS Sales, JS Tavares, IJM Wanderley, JKD Santos, ... Hematology, Transfusion and Cell Therapy 45, S178 , 2023 2023 Citations: 1
FRAILTY ASSESSMENT IN PATIENTS WITH LYMPHOMA. TX Carneiro, NS Moraes, LDS Pimentel, IF Lemos, MED Veiga, VR Lopes Hematology, Transfusion and Cell Therapy 45, S329 , 2023 2023
SAFETY OF DARATUMUMAB IN FRAIL PATIENTS WITH MULTIPLE MYELOMA TX Carneiro, JLS Sales, LDS Pimentel, LG Fonseca, LBC Leão, ... Hematology, Transfusion and Cell Therapy 45, S425 , 2023 2023
FRAILTY ASSESSMENT AS PREDICTOR OF BLEEDING FOR PATIENTS TREATED WITH ACALABRUTINIB TX Carneiro, JLS Sales, JS Tavares, IJM Wanderley, JKD Santos, ... Hematology, Transfusion and Cell Therapy 45, S177-S178 , 2023 2023
Equity program: strategies on clinical studies as an aggregating potential E de Queiroz Crusoe, AEH Neto, DF Nantes, EFO Ribeiro, FMC Pinto, ... Hematology, Transfusion and Cell Therapy 45 (4), 417-418 , 2023 2023
MOST CITED SCHOLAR PUBLICATIONS
Copaiba oil effect on urea and creatinine serum levels in rats submitted to kidney ischemia and reperfusion syndrome MVH Brito, RJ Moreira, MLC Tavares, MCS Carballo, TX Carneiro, ... Acta Cirurgica Brasileira 20, 243-246 , 2005 2005 Citations: 34
Association between sarcopenia and diabetes in community dwelling elderly in the Amazon region–Viver Mais Project ABF Souza, DAC Nascimento, IJM Rodrigues, CCO Charone, GL Lopes, ... Archives of gerontology and geriatrics 83, 121-125 , 2019 2019 Citations: 33
Efeito do óleo de copaíba nos níveis séricos de uréia e creatinina em ratos submetidos à síndrome de isquemia e reperfusão renal MVH Brito, RJ Moreira, MLC Tavares, MCS Carballo, TX Carneiro, ... Acta Cirúrgica Brasileira 20 (3), 243-246 , 2005 2005 Citations: 25
Diversidade genética e eficiência de DNA microssatélites para o controle genealógico da raça Nelore TX Carneiro, EC Gonçalves, MPC Schneider, A Silva Arquivo Brasileiro de Medicina Veterinária e Zootecnia 59 (5), 1257-1262 , 2007 2007 Citations: 15
Diagnosis and management of acute promyelocytic leukemia: Brazilian consensus guidelines 2024 on behalf of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy LL de Figueiredo-Pontes, LFB Catto, MLLF Chauffaille, KBB Pagnano, ... Hematology, Transfusion and Cell Therapy 46 (4), 553-569 , 2024 2024 Citations: 11
EZH2 expression is dependent on MYC and TP53 regulation in diffuse large B‐cell lymphoma EH Neves Filho, CG Hirth, IA Frederico, RM Burbano, T Carneiro, ... Apmis 128 (4), 308-315 , 2020 2020 Citations: 11
The GLAMM1 study-global access to myeloma medications: potential barriers to chimeric antigen receptors (CART) and T-cell-engaging bispecific antibodies (TCE) globally R Atallah, Y Shatnawi, A Mammadzadeh, SK Hashmi, SK Rana, ... Blood 142, 3327 , 2023 2023 Citations: 8
Global access to multiple myeloma therapies R Atallah, Y Shatnawi, MDFS Ayoobkhan, MSI Saif, M Naeem, E Logan, ... JCO Global Oncology 11, e2400441 , 2025 2025 Citations: 7
Safety and feasibility of outpatient high dose cytarabine for acute myeloid leukemia in the Brazilian Amazon ALM Rodrigues, DM do Nascimento, JM de Lima, MLP Reis, LBC Leão, ... International journal of hematology-oncology and stem cell research 14 (3), 151 , 2020 2020 Citations: 7
Chronic myelogenous leukemia with double Philadelphia chromosome and coexpression of p210 and p190 fusion transcripts SS Cruz, AD Seabra, LHR Macambira, DM Carneiro, PF Nunes, ... Genes 13 (4), 580 , 2022 2022 Citations: 6
INTERAÇÃO MEDICAMENTOSA EM PACIENTES COM CÂNCER: REVISÃO INTEGRATIVA DA LITERATURA/DRUG INTERACTION IN CANCER PATIENTS: AN INTEGRATIVE LITERATURE REVIEW RED Lobo, BPG Bahia, GEA Silva, L CRUZ, EDS SARGES, A PRETE, ... Brazilian Journal of Development 7 (3), 32289-32303 , 2021 2021 Citations: 5
Circulating extracellular vesicles as a predictive biomarker for acute graft-versus-host disease TX Carneiro, DG Marrese, MG Dos Santos, MV Gonçalves, YAS Novis, ... Experimental hematology 117, 15-23 , 2023 2023 Citations: 4
Tissue expression of TGF-β1 in uterine cervical samples from HIV/AIDS patients TX Carneiro, JT Pacheco, MB Xavier, JAS Quaresma Microbial pathogenesis 53 (1), 44-48 , 2012 2012 Citations: 4
Safety and efficacy of venetoclax, cytarabine and metformin for relapsed-refractory and induction-ineligible acute myeloid leukemia MP de Lacerda, E Nunes, G Steffenello, TX Carneiro, IS Boettcher, ... Blood 144, 1524 , 2024 2024 Citations: 3
8. CRISE E TRABALHO NO DISTRITO FEDERAL S Dal Rosso, FM Bueno, AA de Azevedo, E da Silva Rêses, PC de Souza, ... Trabalho na Capital. Brasília: Ministério do Trabalho e Emprego, 124-149 , 2011 2011 Citations: 3
Current perspectives on the management of refractory or relapsed classic hodgkin lymphoma in brazil: Balancing efficacy, safety, and tolerability FD Xavier, DLC de Farias, AEH Neto, GN Ribeiro, MAS de Araujo, ... Oncotarget 14, 977 , 2023 2023 Citations: 2
Circulating microparticles as predictive biomarkers of acute graft versus host disease TX Carneiro, DG Marrese, MG dos Santos, MV Gonçalves, YS Novis, ... Blood 128 (22), 5778 , 2016 2016 Citations: 2
Low Counts Of Natural Killer Cells CD56 bright CD16 negative After Engraftment Are Associated With Worse Survival In Patients Receiving Allogeneic … M Vescovi Gonçalves, M Yamamoto, EYS Kimura, VA Renzi Colturato, ... Blood, The Journal of the American Society of Hematology 122 (21), 4625-4625 , 2013 2013 Citations: 2
Hematological and Biochemical Characteristics Associated with Cytogenetic Findern Alterations in Adult Patients with Acute Lymphoblastic Leukemia (ALL) from the Northern Region … DS Duarte, EB Teixeira, MB de Oliveira, TX Carneiro, LBC Leão, ... Biomedicines 12 (12), 2739 , 2024 2024 Citations: 1
IMPLEMENTAÇÃO DE UM MODELO DE NAVEGAÇÃO PARA PACIENTES ONCOLÓGICOS NO ESTADO DO PARÁ JCP Saraiva Filho, TX Carneiro RECISATEC-REVISTA CIENTÍFICA SAÚDE E TECNOLOGIA-ISSN 2763-8405 4 (2), e42367 … , 2024 2024 Citations: 1
