Mechanistic Insights into Chloride-Dependent Uncaging Reaction of Propargyl and Allene-Protected Substrates by Pd-Complexes Thuany M. Ferreira, Claudio D. Navo, Jonathan P. Agnes, Filipe Cardozo, Daniela C. de Oliveira, Alfeu Zanotto‐Filho, Gonzalo Jiménez‐Osés, Josiel B. Domingos Chemistry A European Journal, 2025 This study investigates the effect of chloride levels on the mode of action of palladium complexes for the activation of propargyl‐ and allene‐protected fluorophores and chemotherapeutic drugs through uncaging reactions. Four Pd(II) complexes were synthesized and characterized using various spectroscopic techniques to confirm their structure and electronic properties. Kinetic studies and density functional theory calculations revealed that chloride ions in phosphate buffered saline (PBS) significantly enhance catalytic efficiency, particularly for allenyl‐protected substrates compared to propargylic counterparts. This enhancement is attributed to the neutral charge nature of the Pd complex. The data suggest that neutral complexes are less prone to chloride exchange by water molecules. Additionally, chloride ligands counterbalance the unusually high stability of the key σ‐bound η1‐Pd intermediates in the aquo complexes in PB, leading to an overall higher reactivity. These results highlight the impact of fine‐tuning the electronic properties of the metal center through both designed ligands and environmental factors. Bench evaluations and tests with living breast cancer cells demonstrated that a Pd catalyst complex with a bidentate ligand effectively activates the prodrugs propargyl‐5‐fluorouracil (Prop‐5FU) and allene‐5‐Fluorouracil (Alle‐5FU), the latter being a novel prodrug. The Pd catalyst successfully released the active drug, inducing significant cytotoxicity, especially with Alle‐5FU, which operates at lower catalyst concentrations than Pro‐5FU.
Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions Eloah Latocheski, Gean M. Dal Forno, Thuany M. Ferreira, Bruno L. Oliveira, Gonçalo J. L. Bernardes, Josiel B. Domingos Chemical Society Reviews, 2020 This review assesses the mechanistic aspects of transition metal-mediated uncaging reactions, with the goal of aiding the rational development of new caging groups/catalysts for chemical biology and drug-delivery applications.
Effect of surface and porosity of biochar on water holding capacity aiming indirectly at preservation of the Amazon biome Estela M. C. C. Batista, Juliana Shultz, Tassya T. S. Matos, Mayara R. Fornari, Thuany M. Ferreira, Bruno Szpoganicz, Rilton A. de Freitas, Antonio S. Mangrich Scientific Reports, 2018 As part of efforts to reduce pressure on the Amazon and other biomes, one approach considered by Brazilian authorities and scientists is more intensive use of the soils of the interior of the northeast of the country, which are generally sandy, with low contents of organic matter and low water holding capacity and are frequently affected by severe droughts. In this work, biochars produced from waste biomasses were tested for the improvement of these soils. The highest BET (Brunauer-Emmett-Teller) specific surface areas were observed for all biochars. In the pH range studied, the water hyacinth plants (WH) sample showed the most negative zeta potentials, as well as the highest water holding capacity (WHC) values, while the zeta potentials of two quartzarenic neosol soils were consistent with their WHC values. The results suggested that despite the effect of porosity on water retention, the zeta potential could be associated with the presence of negative charges by which hydrated cationic counterions were absorbed and retained. The surface energy and its polar and dispersive components were associated with water retention, with sugar cane bagasse, orange peel, and water hyacinth biochars presenting higher SE values and larger polar components.
RECENT SCHOLAR PUBLICATIONS
Mechanistic Insights into Chloride‐Dependent Uncaging Reaction of Propargyl and Allene‐Protected Substrates by Pd‐Complexes TM Ferreira, CD Navo, JP Agnes, F Cardozo, DC de Oliveira, ... Chemistry–A European Journal 31 (8), e202403987 , 2025 2025
Possíveis contribuições da série Lessons in Chemistry como ferramenta didática para explorar e discutir desigualdades de gênero no meio acadêmico TM Ferreira Florianópolis, SC. , 2024 2024
Surface active SNS-based dicationic ionic liquids containing amphiphilic anions: Experimental and theoretical studies of their structures and organization in solution MO Vieira, WF Monteiro, TM Ferreira, JB Domingos, J Dupont, ... Journal of Molecular Liquids 344, 117725 , 2021 2021 Citations: 4
Effect of pH on the efficiency of sodium hexametaphosphate as calcium carbonate scale inhibitor at high temperature and high pressure SC de Morais, DF de Lima, TM Ferreira, JB Domingos, MAF de Souza, ... Desalination 491, 114548 , 2020 2020 Citations: 77
Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions E Latocheski, GM Dal Forno, TM Ferreira, BL Oliveira, GJL Bernardes, ... Chemical Society Reviews 49 (21), 7710-7729 , 2020 2020 Citations: 86
Effect of surface and porosity of biochar on water holding capacity aiming indirectly at preservation of the Amazon biome EMCC Batista, J Shultz, TTS Matos, MR Fornari, TM Ferreira, ... Scientific Reports 8 (1), 10677 , 2018 2018 Citations: 462
Estudo de equilíbrio químico entre o ácido húmico e os íons metálicos bivalentes Mn2+, Co2+ e Ni2+ TM Ferreira 2018 Citations: 1
A possible Integrase inhibitor interacts with Mg (II) ion B Szpoganicz, TM Ferreira, BP Szpoganicz, MG Reinecke JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 22, S112-S112 , 2017 2017
ESTUDO DE EQUILÍBRIO ENTRE O ÍON METÁLICO Fe (III) E A TURFA DECOMPOSTA FINA TM FERREIRA 2015
MOST CITED SCHOLAR PUBLICATIONS
Effect of surface and porosity of biochar on water holding capacity aiming indirectly at preservation of the Amazon biome EMCC Batista, J Shultz, TTS Matos, MR Fornari, TM Ferreira, ... Scientific Reports 8 (1), 10677 , 2018 2018 Citations: 462
Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions E Latocheski, GM Dal Forno, TM Ferreira, BL Oliveira, GJL Bernardes, ... Chemical Society Reviews 49 (21), 7710-7729 , 2020 2020 Citations: 86
Effect of pH on the efficiency of sodium hexametaphosphate as calcium carbonate scale inhibitor at high temperature and high pressure SC de Morais, DF de Lima, TM Ferreira, JB Domingos, MAF de Souza, ... Desalination 491, 114548 , 2020 2020 Citations: 77
Surface active SNS-based dicationic ionic liquids containing amphiphilic anions: Experimental and theoretical studies of their structures and organization in solution MO Vieira, WF Monteiro, TM Ferreira, JB Domingos, J Dupont, ... Journal of Molecular Liquids 344, 117725 , 2021 2021 Citations: 4
Estudo de equilíbrio químico entre o ácido húmico e os íons metálicos bivalentes Mn2+, Co2+ e Ni2+ TM Ferreira 2018 Citations: 1
Mechanistic Insights into Chloride‐Dependent Uncaging Reaction of Propargyl and Allene‐Protected Substrates by Pd‐Complexes TM Ferreira, CD Navo, JP Agnes, F Cardozo, DC de Oliveira, ... Chemistry–A European Journal 31 (8), e202403987 , 2025 2025
Possíveis contribuições da série Lessons in Chemistry como ferramenta didática para explorar e discutir desigualdades de gênero no meio acadêmico TM Ferreira Florianópolis, SC. , 2024 2024
A possible Integrase inhibitor interacts with Mg (II) ion B Szpoganicz, TM Ferreira, BP Szpoganicz, MG Reinecke JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 22, S112-S112 , 2017 2017
ESTUDO DE EQUILÍBRIO ENTRE O ÍON METÁLICO Fe (III) E A TURFA DECOMPOSTA FINA TM FERREIRA 2015
