Francisco Leonardo Torres-Leal

@ufpi.br

Department of Biophysic and Physiology
Federal University of Piauí



              

https://researchid.co/torresleal

RESEARCH, TEACHING, or OTHER INTERESTS

Physiology, Cancer Research, Nutrition and Dietetics, Oncology (nursing)

59

Scopus Publications

1823

Scholar Citations

23

Scholar h-index

38

Scholar i10-index

Scopus Publications

  • Bromelain and liver health: A comprehensive systematic review of preclinical studies
    Irislene Costa Pereira, Álina Mara Carvalho Pedrosa-Santos, Jorddam Almondes Martins, Athanara Alves de Sousa, Taline Alves Nobre, Lucillia Rabelo de Oliveira Torres, Felipe Cavalcanti Carneiro da Silva, Juliana Soares Severo, João Marcelo de Castro e Sousa, and Francisco Leonardo Torres-Leal
    Elsevier BV

  • Physical Exercise as a Therapeutic Approach in Gastrointestinal Diseases
    Juliana Soares Severo, Alda Cássia Alves da Silva, Brenda Lois Barros dos Santos, Thiago Sousa Reinaldo, Aureliano Machado de Oliveira, Rodrigo Soares Pereira Lima, Francisco Leonardo Torres-Leal, Armênio Aguiar dos Santos, and Moisés Tolentino Bento da Silva
    MDPI AG
    Background/Objectives: Physical exercise can have significant consequences for the gastrointestinal tract, which is why there have been studies into its influence on the treatment of conditions such as colorectal cancer, inflammatory bowel diseases (IBD), and irritable bowel syndrome (IBS), being that there is epidemiological evidence that exercise has a protective effect against colon cancer. This review aims to demonstrate the mechanisms of action of physical exercise in the gastrointestinal tract, as well as the benefits of exercise in diseases associated with the digestive system, in addition to gathering training recommendations in treating different gastrointestinal diseases. Results: Physical exercise modulates gastrointestinal motility, permeability, immune responses, and microbiota composition, with both beneficial and adverse effects depending on intensity and duration. Regular moderate exercise is associated with improved quality of life in IBD and IBS, reduced colorectal cancer risk, and potential symptom relief in constipation. However, high-intensity exercise may exacerbate gastroesophageal reflux symptoms and increase the risk of gastrointestinal bleeding. While aerobic exercise has been extensively studied, the effects of resistance training on gastrointestinal health remain underexplored. Conclusions: New methodologies and techniques, such as molecular biology and the study of gastric receptors, have led to advances in understanding the gastrointestinal changes associated with physical exercise. These advances cover different exercise intensities and are being investigated in both experimental models and clinical studies.

  • Buthionine sulfoximine acts synergistically with doxorubicin as a sensitizer molecule on different tumor cell lines
    Joedna Cavalcante Pereira, Rayran Walter Ramos de Sousa, Micaely Lorrana Pereira Conceição, Maria Luísa Lima Barreto do Nascimento, Ana Tárcila Alves de Almeida, Antonielly Campinho dos Reis, Mickael Laudrup de Sousa Cavalcante, Camila dos Reis Oliveira, Italo Rossi Roseno Martins, Francisco Leonardo Torres-Leal,et al.
    Informa UK Limited
    The chemotherapeutic drug doxorubicin (DOX) has been widely used for treating solid tumors attributed to its antiproliferative effectiveness; however, its clinical use is limited due to side effects, including cardiotoxicity, myelosuppression, and drug resistance. Combining DOX with buthionine sulfoximine (BSO), a glutathione (GSH) synthesis inhibitor, showed promising results in overcoming these adverse effects, potentially reducing the required DOX dose while maintaining efficacy. The aim of the present study was to examine the effects of different concentrations of BSO and DOX, both individually and in combination, utilizing B16/F10 (murine melanoma), SNB-19 (human glioblastoma), S180 (murine sarcoma), and SVEC4-10 (murine endothelial) cell lines. Cell viability, migration, and clonogenicity were assessed using the following assays MTT, scratch, and colony formation. Antioxidant levels of GSH, as well as activities catalase (CAT), and superoxide dismutase (SOD) were measured. BSO alone exhibited minimal cytotoxic effects, while DOX alone reduced cell viability significantly. The combination of BSO+DOX decreased IC50 values for most cell lines, demonstrating a synergistic effect, especially in B16/F10, S180, and SVEC4-10 cells. BSO+DOX combination significantly inhibited cell migration and clonogenicity compared to DOX alone. While GSH levels were decreased with BSO+DOX treatment activities of CAT and SOD increased following DOX administration but remained unchanged by BSO. These results suggest that BSO may be considered a valuable tool to improve DOX therapeutic efficacy, particularly in cases of chemotherapy-resistant tumors, as BSO enhances DOX activity while potentially reducing systemic chemotherapeutic drug toxicity.

  • Brain Perception of Different Oils on Appetite Regulation: An Anorectic Gene Expression Pattern in the Hypothalamus Dependent on the Vagus Nerve
    Gele de Carvalho Araújo Lopes, Brenda Caroline Rodrigues Miranda, João Orlando Piauilino Ferreira Lima, Jorddam Almondes Martins, Athanara Alves de Sousa, Taline Alves Nobre, Juliana Soares Severo, Tiago Eugênio Oliveira da Silva, Milessa da Silva Afonso, Joana Darc Carola Correia Lima,et al.
    MDPI AG
    (1) Background: We examined the effect of the acute administration of olive oil (EVOO), linseed oil (GLO), soybean oil (SO), and palm oil (PO) on gastric motility and appetite in rats. (2) Methods: We assessed food intake, gastric retention (GR), and gene expression in all groups. (3) Results: Both EVOO and GLO were found to enhance the rate of stomach retention, leading to a decrease in hunger. On the other hand, the reduction in food intake caused by SO was accompanied by delayed effects on stomach retention. PO caused an alteration in the mRNA expression of NPY, POMC, and CART. Although PO increased stomach retention after 180 min, it did not affect food intake. It was subsequently verified that the absence of an autonomic reaction did not nullify the influence of EVOO in reducing food consumption. Moreover, in the absence of parasympathetic responses, animals that received PO exhibited a significant decrease in food consumption, probably mediated by lower NPY expression. (4) Conclusions: This study discovered that different oils induce various effects on parameters related to food consumption. Specifically, EVOO reduces food consumption primarily through its impact on the gastrointestinal tract, making it a recommended adjunct for weight loss. Conversely, the intake of PO limits food consumption in the absence of an autonomic reaction, but it is not advised due to its contribution to the development of cardiometabolic disorders.

  • Dietary restriction and hepatic cancer: Systematic review and meta-analysis of animal studies
    Dallyla Jennifer Morais de Sousa, Kynnara Gabriella Feitosa de Oliveira, Irislene Costa Pereira, Glauto Tuquarre Melo do Nascimento, Clenio Oliveira Barrense, Jorddam Almondes Martins, Beatriz de Mello Pereira Rêgo, Tiago Eugênio Oliveira da Silva, Felipe Cavalcanti Carneiro da Silva, and Francisco Leonardo Torres-Leal
    Elsevier BV

  • Bromelain as a natural anti-inflammatory drug: a systematic review
    Taline Alves Nobre, Athanara Alves de Sousa, Irislene Costa Pereira, Álina Mara Carvalho Pedrosa-Santos, Luana de Oliveira Lopes, Nicole Debia, Heba A. S. El-Nashar, Mohamed El-Shazly, Muhammad Torequl Islam, João Marcelo de Castro e Sousa,et al.
    Informa UK Limited
    Inflammation is a complex and necessary mechanism of an organ's response to biological, chemical and/or physical stimuli. In recent years, investigations on natural compounds with therapeutic actions for the treatment of different diseases have increased. Among these compounds, bromelain is highlighted, as a cysteine protease isolated from the Ananas comosus (pineapple) stem. This review aimed to evaluate the anti-inflammatory activity of bromelain, as well as its pathways on inflammatory mediators, through a systematic review with in vitro studies on different cell lines. The search was performed in PubMed, Science Direct, Scopus, Cochrane Library and Web of Science databases. Bromelain reduced IL-1β, IL-6 and TNF-α secretion when immune cells were already stimulated in an overproduction condition by proinflammatory cytokines, generating a modulation in the inflammatory response through prostaglandins reduction and activation of a cascade reactions that trigger neutrophils and macrophages, in addition to accelerating the healing process.

  • Editorial: Exercise physiology and gastrointestinal disorders
    Moisés Tolentino Bento da Silva, Daniel Moreira-Gonçalves, Francisco Leonardo Torres-Leal, and Arménio Aguiar dos Santos
    Frontiers Media SA

  • Treadmill Exercise Reverses the Adverse Effects of Intermittent Fasting on Behavior and Cortical Spreading Depression in Young Rats
    Amanda Ferraz Braz, Maria Luísa Figueira de Oliveira, Dominique Hellen Silva da Costa, Francisco Leonardo Torres-Leal, and Rubem Carlos Araújo Guedes
    MDPI AG
    Intermittent fasting (IF) and physical exercise (PE) have beneficial psychological and physiological effects, improving memory and anxiety-like behavior. However, the impact of this combination on brain electrophysiological patterns is unknown. We aimed to evaluate the behavior and parameters of a brain excitability-related phenomenon named cortical spreading depression (CSD) in young rats (31–87 days of life) submitted to IF and treadmill PE for eight weeks. Sixty-four male and female Wistar rats aged 24 days were randomized into control, IF, PE, and IF+PE groups. Behavioral tests (open field (OF), object recognition, and elevated plus maze (EPM)) were performed, and the CSD propagation features were recorded. IF caused behavioral responses indicative of anxiety (lower number of entries and time spent in the OF center and EPM open arms). IF also reduced the discrimination index for object recognition memory tests and increased the propagation velocity of CSD. PE rats displayed more entries into the OF center and lowered CSD propagation speed. Data suggest that IF worsens anxiety-like behavior and memory and accelerates CSD in young rats. In contrast, PE reverted the unfavorable effects of IF. The brain effects of IF and PE at younger ages are recommended for study.

  • Physical exercise alleviates oxidative stress in brown adipose tissue and causes changes in body composition and nutritional behavior in rats with polycystic ovary syndrome
    Wenna Lúcia Lima Santos, Clailson da Silva Pinheiro, Raisa de Oliveira Santos, Alda Cassia Alves da Silva, Juliana Soares Severo, Pedro Henrique Moraes Mendes, Luiza Carolinda de Sousa, Olga Maria Castro de Sousa, Brenda Lois Barros dos Santos, Kelly Beatriz Vieira de Oliveira,et al.
    Elsevier BV

  • Consumption and supplementation of vitamin E in breast cancer risk, treatment, and outcomes: A systematic review with meta-analysis
    Victor Alves de Oliveira, Iara Katrynne Fonseca Oliveira, Irislene Costa Pereira, Layza Karyne Farias Mendes, Felipe Cavalcanti Carneiro da Silva, Francisco Leonardo Torres–Leal, João Marcelo de Castro e Sousa, and Adriana de Azevedo Paiva
    Elsevier BV

  • Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review
    Maria do Perpetuo Socorro de Sousa Coelho, Irislene Costa Pereira, Kynnara Gabriella Feitosa de Oliveira, Iara Katryne Fonseca Oliveira, Márcia dos Santos Rizzo, Victor Alves de Oliveira, Felipe Cavalcanti Carneiro da Silva, Francisco Leonardo Torres-Leal, and João Marcelo de Castro e Sousa
    Elsevier BV

  • RELATIONSHIP BETWEEN SELENIUM NUTRITIONAL STATUS AND MARKERS OF LOW-GRADE CHRONIC INFLAMMATION IN OBESE WOMEN
    Larissa Cristina Fontenelle, Mickael de Paiva Sousa, Loanne Rocha dos Santos, Bruna Emanuele Pereira Cardoso, Thayanne Gabryelle Visgueira de Sousa, Tamires da Cunha Soares, Stéfany Rodrigues de Sousa Melo, Jennifer Beatriz Silva Morais, Thaline Milany da Silva Dias, Francisco Erasmo de Oliveira,et al.
    Springer Science and Business Media LLC

  • Antimalarials and macrolides: a review of off-label pharmacotherapies during the first wave of the SARS-CoV-2 pandemic
    Paulo Michel Pinheiro Ferreira, Rayran Walter Ramos de Sousa, Dalton Dittz, João Marcelo de Castro e Sousa, Francisco Leonardo Torres-Leal, and Daniel Pereira Bezerra
    FapUNIFESP (SciELO)
    Abstract We critically analyzed clinical trials performed with chloroquine (CQ) and hydroxychloroquine (HCQ) with or without macrolides during the first wave of COVID-19 and discussed the design and limitations of peer-reviewed studies from January to July 2020. Seventeen studies were eligible for the discussion. CQ and HCQ did not demonstrate clinical advantages that justified their inclusion in therapeutic regimens of free prescription for treatment or prophylactic purposes, as suggested by health authorities, including in Brazil, during the first wave. Around August 2020, robust data had already indicated that pharmacological effects of CQ, HCQ and macrolides as anti-SARS-CoV-2 molecules were limited to in vitro conditions and largely based on retrospective trials with low quality and weak internal validity, which made evidence superficial for decision-making. Up to that point, most randomized and nonrandomized clinical trials did not reveal beneficial effects of CQ or HCQ with or without macrolides to reduce lethality, rate of intubation, days of hospitalization, respiratory support/mechanical ventilation requirements, duration, type and number of symptoms, and death and were unsuccessful in increasing virus elimination and/or days alive in hospitalized or ambulatory patients with COVID-19. In addition, many studies have demonstrated that side effects are more common in CQ-or HCQ-treated patients.

  • α-tocopherol as a selective modulator of toxicogenic damage induced by antineoplastic agents cyclophosphamide and doxorubicin
    Victor Alves de Oliveira, Andressa Naiane Rodrigues Monteiro Fernandes, Lauana Maria dos Santos Leal, Paloma Alves Ferreira Lima, Ana Rafaela Silva Pereira, Irislene Costa Pereira, Helber Alves Negreiros, Joilane Alves Pereira-Freire, Felipe Cavalcanti Carneiro da Silva, Ana Amélia de Carvalho Melo Cavalcante,et al.
    Informa UK Limited
    ABSTRACT The aim of this study was to determine the oxidative/antioxidative effects, modulatory and selective potential of α-tocopherol (vitamin E) on antineoplastic drug-induced toxicogenetic damage. The toxicity, cytotoxicity and genotoxicity induced by antineoplastic agents cyclophosphamide (CPA) and doxorubicin (DOX) was examined utilizing as models Saccharomyces cerevisiae, Allium cepa, Artemia salina and human peripheral blood mononuclear cells (PBMCs) in the presence of α-tocopherol. For these tests, concentrations of α- tocopherol 100 IU/ml (67mg/ml), CPA 20 µg/ml, DOX 2 µg/ml were used. The selectivity of α-tocopherol was assessed by the MTT test using human mammary gland non-tumor (MCF10A) and tumor (MCF-7) cell lines. Data showed cytoplasmic and mitochondrial oxidative damage induced by CPA or DOX was significantly diminished by α-tocopherol in S. cerevisiae. In addition, the toxic effects on A. salina and cytotoxic and mutagenic effects on A. cepa were significantly reduced by α-tocopherol. In PBMCs, α-tocopherol alone did not markedly affect these cells, and when treated in conjunction with CPA or DOX, α-tocopherol reduced the toxicogenetic effects noted after antineoplastic drug administration as evidenced by decreased chromosomal alterations and lowered cell death rate. In human mammary gland non-tumor and tumor cell lines, α-tocopherol produced selective cytotoxicity with 2-fold higher effect in tumor cells. Evidence indicates that vitamin E (1) produced anti-cytotoxic and anti-mutagenic effects against CPA and DOX (2) increased higher selectivity toward tumor cells, and (3) presented chemoprotective activity in PBMCs.

  • Reliability and Validity Estimate of the Pro-Inflammatory/Anti-Inflammatory Food Intake Score in South American Pediatric Population: SAYCARE Study
    Lívia Gabriele Azevedo-Garcia, Francisco Leonardo Torres-Leal, Juan Carlos Aristizabal, Gabriela Berg, Heráclito B. Carvalho, and Augusto César Ferreira De Moraes
    MDPI AG
    Chronic low-grade inflammation may be associated with the development of chronic non-communicable diseases in young populations, often lasting to adulthood. Studies show that the diet is related to chronic inflammation. The Pro-inflammatory/Anti-inflammatory Food Intake Score (PAIFIS) is an indicator that measures the inflammatory potential of the diet, with the help of validated tools that assess food consumption. The validation of tools that assess inflammatory dietary patterns in young populations to produce valid and reliable results is essential to guide disease prevention strategies for adulthood. Methods: This study aimed to estimate the Pro-inflammatory/Anti-inflammatory Food Intake Score (PAIFIS) in children and adolescents in South America and to test its reliability and validity using a food frequency questionnaire (FFQ) and an inflammatory biomarker. This work consists of a validation study in a sample of children and adolescents conducted in South America (SAYCARE Study). The habitual consumption of food contributing to calculating the PAIFIS was obtained through an FFQ and 24 h Dietary Recall (24HDR). Reliability was tested using the FFQ (FFQ1 × FFQ2), using Spearman’s correlation coefficient to estimate the agreement between measurements. The validity of the PAIFIS was tested using 24HDR and the inflammatory biomarker C-reactive protein (CRP) using Spearman’s correlation and multilevel linear regression. Results: For children and adolescents, pro- and anti-inflammatory food groups showed Spearman’s correlation coefficients ranging from 0.31 to 0.66, convergent validity ranging from 0.09 to 0.40, and criterion validity for a reliability range from −0.03 to 0.18. The PAIFIS showed Spearman’s correlation coefficients for reliability ranging from 0.61 to 0.69, convergent validity from 0.16 to 0.23, and criterion validity from −0.03 to 0.24. Conclusion: The PAIFIS showed acceptable reliability, weak convergent validity, and weak criterion validity in children and adolescents.

  • Cellular reprogramming, chemoresistance, and dietary interventions in breast cancer
    Irislene Costa Pereira, Isabele Frazão Mascarenhas, Vinícius Cooper Capetini, Paulo Michel Pinheiro Ferreira, Marcelo Macedo Rogero, and Francisco Leonardo Torres-Leal
    Elsevier BV

  • Improvement of 2,2′-Azobis(2-Methylpropionamidine) Dihydrochloride-Induced Hepatic Redox Imbalance in Swiss Mice and HepG2 Cells by Rutin
    Paula Alexandre de Freitas, Keciany Alves de Oliveira, Laryssa Alves Magalhães, Regina de Jesus das Neves, Carla Soraya Costa Maia, Leonardo Reis Silveira, Tanes Tamamura de Lima, Renata Prado Vasconcelos, Luciana Catunda Brito, Francisco Leonardo Torres-Leal,et al.
    Mary Ann Liebert Inc
    Redox imbalance can lead to irreversible damages to biological functions. In this context, rutin stands out for its antioxidant potential. The objective of this study was to evaluate the acute and chronic effect of rutin on the hepatic redox imbalance. The study was performed according to three different protocols. First, healthy male Swiss mice were divided into two groups: control and rutin, the second of which received chronic oral supplementation of rutin (10 mg/kg). The second involved evaluation of the generation of reactive oxygen species (ROS) by HepG2 cells, incubated or not with rutin (20 and 40 μg/mL) for 3 h. The final protocol involved assessment of the acute effect of rutin (10 mg/kg) in mice with oxidative stress induced by 2,2'-azobis(2-methylpropionamidine) dihydrochloride (ABAP). After the in vivo treatments, the livers were collected to analyze the oxidative damage by thiol, and the antioxidant defense by catalase, superoxide dismutase, and glutathione peroxidase. In the HepG2 cells, the following probes were employed to assess the ROS production: dichlorofluorescein, MitoSOX, dihydroethidium, and Amplex Red. Rutin administered chronically improved the antioxidant defense in healthy animals, and when administered acutely both inhibited the increased production of ROS in HepG2 cells and improved the redox imbalance parameters in mice with induced oxidative stress. This study suggests rutin as a protective agent for restoration of hepatic redox homeostasis in redox injury induced by ABAP in Swiss mice and HelpG2 cells.

  • Evaluation of the Validity of a Food Frequency Questionnaire and 24-Hour Dietary Recall to Assess Dietary Iron Intake in Children and Adolescents from the South American Youth/Child Cardiovascular and Environmental Study
    Tatiana Sadalla Collese, Augusto César F. De Moraes, Tara Rendo-Urteaga, Laura I. Gonzalez-Zapata, Diego Alejandro Gaitán Charry, Carlos A. Delgado, Gabriela Berg, Francisco Leonardo Torres-Leal, and Heráclito B. Carvalho
    Journal of the Academy of Nutrition and Dietetics Elsevier BV

  • Reliability and validity of the dutch eating behavior questionnaire in an online format for university students from low-income regions in a pandemic context: A 24 hour MESYN study
    Millena Vaz de Carvalho, Antonio Gibran de Almeida Cardoso, Shirley Cunha Feuerstein, Rosana Rodrigues de Sousa, Tatiana Sadalla Collese, Francisco Leonardo Torres-Leal, Marcus Vinicius Nascimento-Ferreira, and Augusto Cesar Ferreira De Moraes
    Frontiers Media SA
    ObjectiveTo test the reliability and validity of the Dutch Eating Behavior Questionnaire (DEBQ) in an online format in university students from low-income regions.MethodsWe applied the questionnaire to a sample of 195 and 117 university students from a low-income region (Gini index of 0.56) to study validity and reliability, respectively. The DEBQ consists of 33 items on eating behavior in three dimensions/factors: emotional eating, restrained eating and external eating. The questionnaire was administered twice at 2-week intervals. We tested the reliability via temporal stability and internal consistency and construct validity via exploratory and confirmatory factor analysis.ResultsFor reliability, we identified an acceptable Spearman correlation coefficient (rho > 0.30 and p < 0.05) and Cronbach's alpha (α ≥ 0.70) for all DEBQ items. In the exploratory analysis, we identified 6 factors representing a mix of original and additional factors, with an explained variance of 69.1%. In the confirmatory analysis with structural equation modeling, we observed better global model adjustment for the 6-factor model with the Tucker–Lewis index and comparative fit index closer to one, as well as root mean square error of approximation closer to zero than the original (3-factor) model. Using generalized structural equation modeling, we also observed a better fit in latent class modeling for the 6-factor model (AIC: 16990.67; BIC. 17874.38) than for the 3-factor model (AIC: 17904.09; BIC: 18342.67).ConclusionThe online format of the DEBQ has acceptable reliability and validity for measuring eating behavior in university students from low-income regions.

  • 24 h movement behavior and metabolic syndrome study protocol: A prospective cohort study on lifestyle and risk of developing metabolic syndrome in undergraduate students from low-income regions during a pandemic
    Marcus Vinicius Nascimento-Ferreira, Kliver Antonio Marin, Ruhena Kelber Abrão Ferreira, Luiz Fernando Oliveira, Ana Caroline Bandeira, Paula Silva Sousa, Josilene Miranda de Sousa, Antonio Gibran de Almeida Cardoso, Lorrane Cristine Conceição da Silva, Ana Clara Arrais Rosa,et al.
    Frontiers Media SA
    IntroductionObesity and its comorbidities are increasingly prevalent in Latin America, with a more rapid growth in individuals with lower income. The composition of movement behaviors within a 24 h period may have important implications for obesity, metabolic and mental health in cross-sectional data. However, a longitudinal study is needed to confirm the findings from the primarily cross-sectional evidence. The COVID-19 pandemic has been associated with cardiometabolic outcomes and has impeded healthy behavior.ObjectivesThe first objective is to evaluate the time elapsed since the diagnosis of not meeting 24 h movement guidelines and the potential subsequent onset of metabolic syndrome in undergraduate students from low-income regions within 4 years of follow up. The second objective is to test the association between 24 h movement, mental wellbeing, eating behaviors, and abdominal obesity in the period of this pandemic.MethodsThe 24 h movement behavior and metabolic syndrome (24 h-MESYN) study is a multicentre cohort study that will include participants from two Brazilian cities within the 2022–2025 period to asses the first objective, and also a nested case-control study at the baseline will be carried out to evaluate the second objective. Previously, we conducted a feasibility study in the academic year of 2021 to assessing the psychometric properties of subjective tools, refine our study protocol, and adjust the epidemiological conditions of the cohort's subsequent phases (like as prevalence of exposure of interest, sampling process, and study adherence). Statistical tests as Cohen's kappa agreement; factorial analysis; logistic, Poisson and linear regression; and Kaplan-Meier analysis will be performed, in accordance with the objectives.

  • Probiotics in sports and physical exercise
    Juliana Soares Severo, Alda Cássia Alves da Silva, Irislene Costa Pereira, Francisco Leonardo Torres-Leal, and Moisés Tolentino Bento da Silva
    Elsevier

  • Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner
    Mar Quiñones, René Hernández-Bautista, Daniel Beiroa, Violeta Heras, Francisco L. Torres-Leal, Brian Y.H. Lam, Ana Senra, Johan Fernø, Alicia García Gómez-Valadés, Markus Schwaninger,et al.
    Elsevier BV

  • Acute strength exercise decreases satiety by modifying blood cytokines levels in physically active men
    Thamires Mendonça de Carvalho, Juliana Soares Severo, Felipe Giovanni de Sousa e Silva Santos, Ana Karolina Martins Cavalcante, Alexandre Havt, Armênio Aguiar dos Santos, Francisco Leonardo Torres-Leal, and Moisés Tolentino
    FapUNIFESP (SciELO)
    Aim: Exercise elicits adaptations in several physiological systems, such as the gastrointestinal tract. We evaluated the effects of an acute strength exercise (acute-SE) on gastric satiety and its correlation with creatinine kinase (CK), lactate, and plasma cytokine levels in humans. Methods: Anthropometric parameters, body composition, muscular strength, and satiety (drink test protocol) at rest and exercise were assessed. Results: In the squat, bench press, and T-bar row exercises, we observed a significant decrease (p<0.05) in muscular strength in the second, third, and fourth sets compared with that in the first set. Compared with rest, we observed a significant increase (p<0.05) in CK and lactate levels after acute-SE. In the drink test, acute-SE significantly increased (p <0.05) the total intake, calories ingested, and a total time of ingestion. Concerning cytokines, there was a significant increase (p<0.05) after acute-SE of IL-1β and IL-6 levels at the beginning of the test and a decrease in IL-6, -10, -13, and TNF-α levels after acute-SE at the end of the test (p<0.05). There was a correlation between CK, lactate, and total intake after acute-SE (p<0.05) as well as between IL-6, 13, TNF-α, and volume ingested in the last score of the drink test after acute-SE (p<0.05). Conclusion: Acute-SE decreases satiety associated with changes in lactate, CK, and plasma cytokine levels in healthy humans.

  • Food consumption of branched chain amino acids and insulin resistance: A systematic review of observational studies in humans
    Eduardo Emanuel Sátiro Vieira, Irislene Costa Pereira, Amanda Ferraz Braz, Marcus Vinicius Nascimento-Ferreira, Lucillia Rabelo de Oliveira Torres, Aline de Freitas Brito, Dilina do Nascimento Marreiro, João Marcelo de Castro e Sousa, Felipe Cavalcanti Carneiro da Silva, and Francisco Leonardo Torres-Leal
    Clinical Nutrition ESPEN Elsevier BV

  • Sampling and processing blood samples within the South American Youth/Child cARdiovascular and Environmental (SAYCARE) Study
    Graciela López, Raphael Assali Serruya, Magalí Barchuk, Diego Gaitan-Charry, Francisco Leonardo Torres-Leal, Luis Alberto Moreno, Carlos Alberto Delgado, Heráclito Barbosa Carvalho, Augusto César Ferreira De Moraes, and Gabriela Berg
    Scientific Reports Springer Science and Business Media LLC

RECENT SCHOLAR PUBLICATIONS

  • Physical Exercise Alleviates Oxidative Stress and Autonomic Dysregulation in a Rat Model of Inflammatory Bowel Disease
    BLB dos Santos, ACA da Silva, JS Severo, B de Sousa Barbosa, ...
    Antioxidants 14 (3), 328 2025

  • Bromelain as a natural anti-inflammatory drug: a systematic review
    T Alves Nobre, AA de Sousa, IC Pereira, M Carvalho Pedrosa-Santos, ...
    Natural Product Research 39 (5), 1258-1271 2025

  • Physical Exercise as a Therapeutic Approach in Gastrointestinal Diseases
    JS Severo, ACA Silva, BLB Santos, TS Reinaldo, AM Oliveira, RSP Lima, ...
    Journal of Clinical Medicine 14 (5), 1708 2025

  • BROMELAIN AND LIVER HEALTH: A COMPREHENSIVE SYSTEMATIC REVIEW OF PRECLINICAL STUDIES
    IC Pereira, MC Pedrosa-Santos, JA Martins, AA de Sousa, TA Nobre, ...
    Clinical Nutrition ESPEN 2025

  • Buthionine sulfoximine acts synergistically with doxorubicin as a sensitizer molecule on different tumor cell lines
    JC Pereira, RWR de Sousa, MLP Conceio, MLLB do Nascimento, ...
    Journal of Toxicology and Environmental Health, Part A, 1-23 2025

  • Brain Perception of Different Oils on Appetite Regulation: An Anorectic Gene Expression Pattern in the Hypothalamus Dependent on the Vagus Nerve
    GCA Lopes, BCR Miranda, JOPF Lima, JA Martins, AA de Sousa, ...
    Nutrients 16 (15), 2397 2024

  • Exercise physiology and gastrointestinal disorders
    MTB Silva, D Moreira-Gonalves, FL Torres-Leal, AA Santos
    Frontiers in Sports and Active Living 6, 1404388 2024

  • Dietary restriction and hepatic cancer: Systematic review and meta-analysis of animal studies
    DJM de Sousa, KGF de Oliveira, IC Pereira, GTM do Nascimento, ...
    Critical Reviews in Oncology/Hematology 196, 104264 2024

  • Treadmill Exercise reverses the adverse effects of intermittent fasting on behavior and cortical spreading depression in young rats
    AF Braz, ML Figueira de Oliveira, DHS Costa, FL Torres-Leal, ...
    Brain Sciences 13 (12), 1726 2023

  • Physical exercise alleviates oxidative stress in brown adipose tissue and causes changes in body composition and nutritional behavior in rats with polycystic ovary syndrome
    WLL Santos, C da Silva Pinheiro, R de Oliveira Santos, ACA da Silva, ...
    Life Sciences 325, 121754 2023

  • Bromelain supplementation and inflammatory markers: A systematic review of clinical trials
    IC Pereira, EES Vieira, LR de Oliveira Torres, FCC da Silva, JMC e Sousa, ...
    Clinical Nutrition Espen 55, 116-127 2023

  • Antimalarials and macrolides: a review of off-label pharmacotherapies during the first wave of the SARS-CoV-2 pandemic
    PMP Ferreira, RWR Sousa, D Dittz, FL Torres-Leal, DP Bezerra
    Brazilian Journal of Pharmaceutical Sciences 59, e21067 2023

  • Consumption and supplementation of vitamin E in breast cancer risk, treatment, and outcomes: A systematic review with meta-analysis
    VA de Oliveira, IKF Oliveira, IC Pereira, LKF Mendes, FCC da Silva, ...
    Clinical Nutrition ESPEN 54, 215-226 2023

  • α-tocopherol as a selective modulator of toxicogenic damage induced by antineoplastic agents cyclophosphamide and doxorubicin
    VA de Oliveira, ANR Monteiro Fernandes, LM dos Santos Leal, ...
    Journal of Toxicology and Environmental Health, Part A 86 (4), 87-102 2023

  • Chemopreventive and anti-tumor potential of vitamin E in preclinical breast cancer studies: A systematic review
    MPS de Sousa, IC Pereira, KGF de Oliveira, IKF Oliveira, ...
    Clinical Nutrition ESPEN 53, 60-73 2023

  • Relationship between selenium nutritional status and markers of low-grade chronic inflammation in obese women
    LC Fontenelle, M de Paiva Sousa, LR Dos Santos, BEP Cardoso, ...
    Biological Trace Element Research 201 (2), 663-676 2023

  • Reliability and validity of the dutch eating behavior questionnaire in an online format for university students from low-income regions in a pandemic context: A 24
    MV de Carvalho, AGA Cardoso, SC Feuerstein, RR Sousa, TS Collese, ...
    Frontiers in Epidemiology 2, 1036631 2023

  • Reliability and validity estimate of the pro-inflammatory/anti-inflammatory food intake score in South American pediatric population: SAYCARE study
    LG Azevedo-Garcia, FL Torres-Leal, JC Aristizabal, G Berg, HB Carvalho, ...
    International Journal of Environmental Research and Public Health 20 (2), 1038 2023

  • Cellular reprogramming, chemoresistance, and dietary interventions in breast cancer
    IC Pereira, IF Mascarenhas, VC Capetini, PMP Ferreira, MM Rogero, ...
    Critical Reviews in Oncology/Hematology 179, 103796 2022

  • 24 h movement behavior and metabolic syndrome study protocol: A prospective cohort study on lifestyle and risk of developing metabolic syndrome in undergraduate students from
    MV Nascimento-Ferreira, KA Marin, RK Abro Ferreira, LF Oliveira, ...
    Frontiers in Epidemiology 2, 1010832 2022

MOST CITED SCHOLAR PUBLICATIONS

  • Thyroid function in human obesity: underlying mechanisms
    LC Fontenelle, MM Feitosa, JS Severo, TEC Freitas, JBS Morais, ...
    Hormone and Metabolic Research 48 (12), 787-794 2016
    Citations: 158

  • The role of inflamed adipose tissue in the insulin resistance
    FL Torres‐Leal, MH Fonseca‐Alaniz, MM Rogero, J Tirapegui
    Cell biochemistry and function 28 (8), 623-631 2010
    Citations: 108

  • Pequi (Caryocar brasiliense Camb.) almond oil attenuates carbon tetrachloride-induced acute hepatic injury in rats: Antioxidant and anti-inflammatory effects
    LRO Torres, FC de Santana, FL Torres-Leal, ILP de Melo, LT Yoshime, ...
    Food and Chemical Toxicology 97, 205-216 2016
    Citations: 97

  • Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content in a PPARα-dependent manner
    A Bolsoni-Lopes, WT Festuccia, TSM Farias, P Chimin, FL Torres-Leal, ...
    American Journal of Physiology-Endocrinology and Metabolism 305 (9), E1093-E1102 2013
    Citations: 93

  • Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation
    A Bolsoni-Lopes, WT Festuccia, P Chimin, TSM Farias, FL Torres-Leal, ...
    Lipids in Health and Disease 13, 1-10 2014
    Citations: 87

  • The lipid accumulation product is a powerful tool to predict metabolic syndrome in undiagnosed Brazilian adults
    MV Nascimento-Ferreira, T Rendo-Urteaga, RC Vilanova-Campelo, ...
    Clinical nutrition 36 (6), 1693-1700 2017
    Citations: 80

  • Leucine supplementation improves adiponectin and total cholesterol concentrations despite the lack of changes in adiposity or glucose homeostasis in rats previously exposed to
    FL Torres-Leal, MH Fonseca-Alaniz, GFR Teodoro, MD de Capitani, ...
    Nutrition & Metabolism 8, 1-10 2011
    Citations: 78

  • Pinealectomy interferes with the circadian clock genes expression in white adipose tissue
    TSM de Farias, AC de Oliveira, S Andreotti, FG do Amaral, P Chimin, ...
    Journal of Pineal Research 58 (3), 251-261 2015
    Citations: 71

  • Metabolic disorders and adipose tissue insulin responsiveness in neonatally STZ-induced diabetic rats are improved by long-term melatonin treatment
    AC de Oliveira, S Andreotti, TSM Farias, FL Torres-Leal, ARG de Proena, ...
    Endocrinology 153 (5), 2178-2188 2012
    Citations: 66

  • Leucine is essential for attenuating fetal growth restriction caused by a protein-restricted diet in rats
    GFR Teodoro, D Vianna, FL Torres-Leal, LC Pantaleao, EM Matos-Neto, ...
    The Journal of nutrition 142 (5), 924-930 2012
    Citations: 66

  • Chronic glucocorticoid treatment enhances lipogenic activity in visceral adipocytes of male Wistar rats
    P Chimin, TSM Farias, FL Torres‐Leal, A Bolsoni‐Lopes, AB Campaa, ...
    Acta Physiologica 211 (2), 409-420 2014
    Citations: 64

  • Long-term leucine supplementation reduces fat mass gain without changing body protein status of aging rats
    D Vianna, GFT Resende, FL Torres-Leal, LC Pantaleo, J Donato Jr, ...
    Nutrition 28 (2), 182-189 2012
    Citations: 60

  • Influence of magnesium on insulin resistance in obese women
    KJC Cruz, ARS de Oliveira, DP Pinto, JBS Morais, F da Silva Lima, C Colli, ...
    Biological trace element research 160, 305-310 2014
    Citations: 59

  • p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1
    M Quinones, O Al-Massadi, C Folgueira, S Bremser, R Gallego, ...
    Nature communications 9 (1), 3432 2018
    Citations: 56

  • Is self-reported physical fitness useful for estimating fitness levels in children and adolescents? A reliability and validity study
    ACF De Moraes, RC Vilanova-Campelo, FL Torres-Leal, HB Carvalho
    Medicina 55 (6), 286 2019
    Citations: 46

  • Obesity, inflammation, and insulin resistance
    LM Martins, ARS Oliveira, KJC Cruz, FL Torres-Leal, DN Marreiro
    Brazilian Journal of Pharmaceutical Sciences 50 (4), 677-692 2014
    Citations: 44

  • Magnesium status and its relationship with C-reactive protein in obese women
    ARS de Oliveira, KJC Cruz, JBS Morais, JS Severo, TEC Freitas, ...
    Biological trace element research 168, 296-302 2015
    Citations: 40

  • Protein synthesis regulation by leucine
    D Vianna, GFR Teodoro, FL Torres-Leal, J Tirapegui
    Brazilian Journal of Pharmaceutical Sciences 46, 29-36 2010
    Citations: 38

  • Design and objectives of the south American youth/child cardiovascular and environmental (SAYCARE) study
    HB Carvalho, LA Moreno, AM Silva, G Berg, A Estrada‐Restrepo, ...
    Obesity 26, S5-S13 2018
    Citations: 37

  • Prevalence of cardiovascular risk factors, the association with socioeconomic variables in adolescents from low-income region
    MV Nascimento-Ferreira, ACF De Moraes, HB Carvalho, LA Moreno, ...
    Nutricion hospitalaria 31 (1), 217-224 2015
    Citations: 34