Tushar Emran

Tushar Emran is a dedicated pharmaceutical professional and researcher with an M.Pharm in Pharmacology and Clinical Pharmacy from North South University. He is currently serving as a laboratory officer in the Department of Pharmaceutical Sciences at North South University, where he has gained extensive experience in animal studies, molecular biology techniques, biochemical analysis, and pharmaceutical laboratory instrumentation. He has contributed to several peer-reviewed international research publications focusing on oxidative stress, inflammation, hepatotoxicity, cardiovascular diseases, and natural product pharmacology. Tushar possesses strong analytical, communication, and teamwork skills, with a passion for academic research and pharmaceutical sciences.

EDUCATION

I have completed my Master of Pharmacy in Pharmacology and Clinical Pharmacy (M.Pharm) and Bachelor of Pharmacy (B.Pharm) from North South University, Dhaka 1212, Bangladesh. I did my Higher Secondary Certificate (HSC) from Narsingdi Model College and my Secondary School Certificate (SSC) from Mutiullah Bhuiya High School, Narsingdi 1600, Dhaka, Bangladesh.

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology, Toxicology and Pharmaceutics, Drug Discovery, Biotechnology, Molecular Biology

Scopus Publications

Coenzyme Q10 alleviates oxidative stress, inflammation and fibrosis via activation of TGFβ1/TNF-α in FCA-Salt hypertensive rats
Nusrat Hossain, Sadia Shabnam, Tushar Emran, Zahidul Islam Zahid, Shaiful Alam, et al.
Archives of Biochemistry and Biophysics, 2025
Transforming Growth Factor-β-mediated attenuation of cardio-renal oxidative stress, inflammation and fibrosis by L-arginine in fludrocortisone acetate induced-hypertensive rats
Astrid Mukta Biswas, Tushar Emran, Sabrin Islam Khan, Sadia Shabnam, Preeti Jain, et al.
European Journal of Pharmacology, 2025
XAI-Enhanced Hybrid Models for Effective Chronic Kidney Disease Prediction
Pijush Kanti Roy Partho, Suchi Karmoker, Tushar Emran, Dipraj Sarker, Delowar Hossain, et al.
Proceedings of 2025 International Conference on Sustainable Technology and Engineering I Coste 2025, 2025
Astaxanthin protects fludrocortisone acetate-induced cardiac injury by attenuating oxidative stress, fibrosis, and inflammation through TGF-β/Smad signaling pathway
Manoneeta Sarker, Nowreen Chowdhury, Anika Tabassum Bristy, Tushar Emran, Reatul Karim, et al.
Biomedicine and Pharmacotherapy, 2024
Anti-obesity effects and underlying molecular mechanisms of the ethanolic extract of figs from Ficus hispida using high fat-fed wister rats
Anika Tabassum Shama, Luluin Maknun Shova, Anika Tabassum Bristy, Tushar Emran, Sadia Shabnam, et al.
Heliyon, 2024
Amelioration of CCl4-induced oxidative stress and hepatotoxicity by Ganoderma lucidum in long evans rats
Fatima Tuj Johra, Sukria Hossain, Preeti Jain, Anika Tabassum Bristy, Tushar Emran, et al.
Scientific Reports, 2023
Liver disease is a serious health problem affecting people worldwide at an alarming rate. The present study aimed to investigate the protective effects ofGanoderma lucidumagainst CCl4-induced liver toxicity in rats. The experimental Long Evans rats were divided into five groups, of which four groups were treated with carbon tetrachloride (CCl4). Among the CCl4treated groups, one of the groups was treated with silymarin and two of them with ethanolic extract ofG. lucidumat 100 and 200 mg/Kg body weight. The oxidative stress parameters and endogenous antioxidant enzyme concentrations were assessed by biochemical tests. Liver enzymes ALT, AST, and ALP were determined spectrophotometrically. Histopathological examinations were carried out to assess hepatic tissue damage and fibrosis. Reverse transcription PCR (RT-PCR) was performed to determine the expression of IL-1β, IL-6, IL-10, TNF-α, and TGF-β genes. Gas Chromatography-Mass Spectroscopy (GC–MS) analysis revealed thatG. lucidumis rich in several phytochemicals including 6-Octadecanoic acid (55.81%), l-( +)-Ascorbic acid 2,6-dihexadecanoate (18.72%), Cis-11-Eicosenamide (5.76%), and Octadecanoic acid (5.26%). Treatment with theG. lucidumextract reduced the elevated ALT, AST, ALP levels, and cellular oxidative stress markers and increased the endogenous antioxidant levels. Histopathology observations revealed that the inflammation, infiltration of immune cells, and aberration of collagen fibers in the hepatocytes were altered by theG. lucidumtreatment. The increased expression of inflammatory cytokines TNF-α, TGF-β, IL-1 β, and IL-6 were markedly suppressed byG. lucidumextract treatment.G. lucidumalso prevented the suppression of protective IL-10 expression by CCl4. This study strongly suggests thatG. lucidumextract possesses significant hepatoprotective activity as evidenced by reduced oxidative stress and inflammation mediated by suppression in inflammatory cytokine expression and increased protective IL-10 cytokine expression.
QbD Approach towards Robust Design Space for Flutamide/PiperineSelf-Emulsifying Drug Delivery System with Reduced Liver Injury
Mithun Saha, Pallabi Sikder, Aditi Saha, Sharha Shah, Sharmin Sultana, et al.
AAPS Pharmscitech, 2022
L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against isoproterenol-induced myocardial infarction
Tushar Emran, Nowreen Islam Chowdhury, Manoneeta Sarker, Asim Kumar Bepari, Murad Hossain, et al.
Biomedicine and Pharmacotherapy, 2021
Coenzyme Q10 and silymarin reduce ccl4-induced oxidative stress and liver and kidney injury in ovariectomized rats-implications for protective therapy in chronic liver and kidney diseases
Samanta Sifat Lamia, Tushar Emran, Jubaida Khatun Rikta, Nowreen Islam Chowdhury, Manoneeta Sarker, et al.
Pathophysiology, 2021
Oxidative stress is one of the key factors in the pathophysiology of liver disease. The present study aimed to evaluate the potential impact of two antioxidants, namely coenzyme Q10 (CoQ10) and silymarin, on carbon tetrachloride (CCl4)-induced oxidative stress and hepatic damage in ovariectomized rats. Female Long Evans rats were divided into six groups (n = 6): control, CCl4, CCl4 + CoQ10 (200 mg/kg), CCl4 + silymarin (140 mg/kg), Control + CoQ10, and Control + silymarin. Plasma and tissues from liver and kidney were analyzed for oxidative stress parameters and antioxidant enzyme activities using biochemical assays. Infiltration of inflammatory cells and fibrosis were assessed by histological staining of tissue sections. Both CoQ10 and silymarin significantly lowered serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels that were detected to be higher in CCl4 rats compared to controls. Significant reduction in CCl4-induced elevated levels of oxidative stress markers malondialdehyde (MDA), nitric oxide (NO), and advanced protein oxidation product (APOP) was observed with both antioxidants. However, in control rats, CoQ10 and silymarin did not produce a significant effect. Histological analysis revealed that CCl4 markedly increased the level of inflammatory cells infiltration and fibrosis in liver and kidney tissues, but this was significantly reduced in CCl4 + CoQ10 and CCl4 + silymarin groups. Taken together, our results suggest that CoQ10 and silymarin can protect the liver against oxidative damage through improved antioxidant enzyme activities and reduced lipid peroxidation. Thus, supplementation of the aforementioned antioxidants may be useful as a therapeutic intervention to protect liver health in chronic liver diseases.

RECENT SCHOLAR PUBLICATIONS

Coenzyme Q10 alleviates oxidative stress, inflammation and fibrosis via activation of TGFβ1/TNF-α in FCA-Salt hypertensive rats
N Hossain, S Shabnam, T Emran, ZI Zahid, S Alam, AK Bepari, ...
Archives of Biochemistry and Biophysics 769, 110444 , 2025
2025
Citations: 1
Transforming Growth Factor-β-mediated attenuation of cardio-renal oxidative stress, inflammation and fibrosis by L-arginine in fludrocortisone acetate induced-hypertensive rats
AM Biswas, T Emran, SI Khan, S Shabnam, P Jain, AK Bepari, MC Shill, ...
European Journal of Pharmacology 996, 177559 , 2025
2025
Citations: 2
Astaxanthin protects fludrocortisone acetate-induced cardiac injury by attenuating oxidative stress, fibrosis, and inflammation through TGF-β/Smad signaling pathway
M Sarker, N Chowdhury, AT Bristy, T Emran, R Karim, R Ahmed, ...
Biomedicine & Pharmacotherapy 181, 117703 , 2024
2024
Citations: 16
Anti-obesity effects and underlying molecular mechanisms of the ethanolic extract of figs from Ficus hispida using high fat-fed wister rats
AT Shama, LM Shova, AT Bristy, T Emran, S Shabnam, MC Shill, ...
Heliyon 10 (15) , 2024
2024
Citations: 8
Amelioration of CCl 4 -induced oxidative stress and hepatotoxicity by Ganoderma lucidum in Long Evans rats
FT Johra, S Hossain, P Jain, AT Bristy, T Emran, R Ahmed, SM Sharker, ...
Scientific Reports 13 (1), 9909 , 2023
2023
Citations: 55
QbD approach towards robust design space for flutamide/piperine self-emulsifying drug delivery system with reduced liver injury
M Saha, P Sikder, A Saha, S Shah, S Sultana, T Emran, A Banik, Z Islam, ...
AAPS PharmSciTech 23 (1), 62 , 2022
2022
Citations: 10
L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against …
T Emran, NI Chowdhury, M Sarker, AK Bepari, M Hossain, GMS Rahman, ...
Biomedicine & Pharmacotherapy 143, 112139 , 2021
2021
Citations: 59
Coenzyme Q10 and Silymarin Reduce CCl 4 -Induced Oxidative Stress and Liver and Kidney Injury in Ovariectomized Rats—Implications for Protective Therapy in …
SS Lamia, T Emran, JK Rikta, NI Chowdhury, M Sarker, P Jain, T Islam, ...
Pathophysiology 28 (1), 50-63 , 2021
2021
Citations: 55

MOST CITED SCHOLAR PUBLICATIONS

L-carnitine protects cardiac damage by reducing oxidative stress and inflammatory response via inhibition of tumor necrosis factor-alpha and interleukin-1beta against …
T Emran, NI Chowdhury, M Sarker, AK Bepari, M Hossain, GMS Rahman, ...
Biomedicine & Pharmacotherapy 143, 112139 , 2021
2021
Citations: 59
Amelioration of CCl 4 -induced oxidative stress and hepatotoxicity by Ganoderma lucidum in Long Evans rats
FT Johra, S Hossain, P Jain, AT Bristy, T Emran, R Ahmed, SM Sharker, ...
Scientific Reports 13 (1), 9909 , 2023
2023
Citations: 55
Coenzyme Q10 and Silymarin Reduce CCl 4 -Induced Oxidative Stress and Liver and Kidney Injury in Ovariectomized Rats—Implications for Protective Therapy in …
SS Lamia, T Emran, JK Rikta, NI Chowdhury, M Sarker, P Jain, T Islam, ...
Pathophysiology 28 (1), 50-63 , 2021
2021
Citations: 55
Astaxanthin protects fludrocortisone acetate-induced cardiac injury by attenuating oxidative stress, fibrosis, and inflammation through TGF-β/Smad signaling pathway
M Sarker, N Chowdhury, AT Bristy, T Emran, R Karim, R Ahmed, ...
Biomedicine & Pharmacotherapy 181, 117703 , 2024
2024
Citations: 16
QbD approach towards robust design space for flutamide/piperine self-emulsifying drug delivery system with reduced liver injury
M Saha, P Sikder, A Saha, S Shah, S Sultana, T Emran, A Banik, Z Islam, ...
AAPS PharmSciTech 23 (1), 62 , 2022
2022
Citations: 10
Anti-obesity effects and underlying molecular mechanisms of the ethanolic extract of figs from Ficus hispida using high fat-fed wister rats
AT Shama, LM Shova, AT Bristy, T Emran, S Shabnam, MC Shill, ...
Heliyon 10 (15) , 2024
2024
Citations: 8
Transforming Growth Factor-β-mediated attenuation of cardio-renal oxidative stress, inflammation and fibrosis by L-arginine in fludrocortisone acetate induced-hypertensive rats
AM Biswas, T Emran, SI Khan, S Shabnam, P Jain, AK Bepari, MC Shill, ...
European Journal of Pharmacology 996, 177559 , 2025
2025
Citations: 2
Coenzyme Q10 alleviates oxidative stress, inflammation and fibrosis via activation of TGFβ1/TNF-α in FCA-Salt hypertensive rats
N Hossain, S Shabnam, T Emran, ZI Zahid, S Alam, AK Bepari, ...
Archives of Biochemistry and Biophysics 769, 110444 , 2025
2025
Citations: 1

Industry, Institute, or Organisation Collaboration

North South University, Dhaka 1212, Bangladesh

INDUSTRY EXPERIENCE

2 weeks of internship in Essential Drugs Company Limited, Tejgaon I/A, Dhaka 1208, Bangladesh