Mirco Vacca

Scopus Publications

Leishmania Infection: A Bioorganic Model Under the Light of Benchtop Low Field Nuclear Magnetic Resonance
Jairo Mendoza-Roldan, Paola Albanese, Carmela Di Spiridione, Mirco Vacca, Matteo Spagnuolo, et al.
Biological Procedures Online, 2026
Semi-industrial scale-up of functional biscuits enriched with wine lees: nutritional enhancement and consumer acceptance
Giusy Rita Caponio, Roberta Miolla, Mirco Vacca, Maria De Angelis, Sara Spinelli, et al.
Applied Food Research, 2026
Clinical trial: Efficacy of a Low FODMAP Diet in Paediatric Irritable Bowel Syndrome—A Randomised Crossover Trial With Exploratory Metabolomic Analysis
Fernanda Cristofori, Giuseppe Celano, Vanessa Nadia Dargenio, Carmen Aurora Apa, Monica Amendolara, et al.
Alimentary Pharmacology and Therapeutics, 2026
Background Evidence supporting the low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet in paediatric irritable bowel syndrome (IBS) remains limited. Mechanisms underlying inter‐individual variability in dietary response in children are poorly understood. Aim To compare the clinical efficacy of a low FODMAP diet (LFD) versus a dietitian‐guided habitual diet (HD; standard FODMAP intake) in children with IBS and to identify faecal and urinary metabolomic signatures associated with treatment response. Methods Single‐centre, randomised assessor‐blinded crossover trial. Children with Rome IV‐defined IBS underwent a 2‐week run‐in, followed by 14 days of LFD or dietitian‐guided HD, a 2‐week washout, and crossover to the alternate diet. The primary outcome was treatment success (≥ 50% reduction in abdominal pain; period‐specific baseline VAS). Secondary outcomes included IBS Severity Scoring System (IBS‐SSS), stool pattern, and metabolomic profiling. Results Sixty‐six children (mean age 10.2 years) completed the trial. Treatment success was achieved in 57.6% during LFD versus 30.3% during HD ( p = 0.024), with the greatest benefit observed in children with severe baseline pain (VAS > 5). LFD was associated with significant reductions in IBS‐SSS scores and bloating. Targeted SCFA analyses showed lower faecal acetic acid during LFD than during HD, while exploratory faecal and urinary volatilome analyses identified candidate features associated with response categories. Conclusion In this randomised crossover trial, a LFD improved abdominal pain and symptom severity in children with IBS, with the greatest benefit in those with severe baseline pain. Exploratory faecal and urinary metabolomic analyses identified candidate features associated with non‐response, warranting further validation. Trial Registration ClinicalTrials.gov identifier: NCT06618677
Genetically Modified Lactic Acid Bacteria in the EU Food Chain: Applications, Benefits, and Risk Assessment
Mirco Vacca, Francesco Maria Calabrese, Pasquale Filannino, Maria De Angelis
International Journal of Molecular Sciences, 2026
Genetically modified (GM) lactic acid bacteria (LAB) are gaining attention as tools for innovation in the food sector, health applications, and industrial processes. LAB have long been used safely due to their GRAS/QPS status, making them suitable for improving fermentation and synthesizing specific and beneficial metabolites. Advances in genomics and gene editing have significantly expanded the available tools, ranging from classical mutagenesis to site-specific recombination, homologous recombination in non-coding regions, CRISPR-based systems, and food-grade chromosomal integration. These approaches enable the insertion of desired genes and the development of engineered strains with tailored functionalities. GM-LAB are also being studied as live delivery systems for therapeutic molecules, including cytokines, hormones, antimicrobial peptides, and vaccine antigens. Engineered strains of Lactococcus lactis and Lactobacillus spp. have yielded promising outcomes in applications such as mucosal immunization, modulation of inflammatory and metabolic responses, and inhibition of pathogenic microorganisms, including multidrug-resistant bacteria. From an industrial perspective, several studies highlight their potential for cost-effective recombinant protein production and the synthesis of high-value metabolites through fermentation. However, within the European Union, their use is subject to stringent regulatory oversight, requiring comprehensive molecular and environmental risk assessments, careful evaluation of horizontal gene transfer, and a preference for markerless chromosomal integrations. Despite these constraints, GM-LAB offer significant potential to improve food quality, sustainability, and human health.
Addressing bacteria with tannins chemistry: an innovative food inspired organic lauryl gallate-based coating to increase probiotics resistance
Mirco Vacca, Mariasimona Cavaliere, Giuseppe Celano, Daniela Pinto, Angelo De Stradis, et al.
International Journal of Biological Macromolecules, 2026
Microbiome preterm birth DREAM challenge: Crowdsourcing machine learning approaches to advance preterm birth research
Jonathan L. Golob, Tomiko T. Oskotsky, Alice S. Tang, Alennie Roldan, Verena Chung, et al.
Cell Reports Medicine, 2025
Comparative Evaluation of Functional Properties of Cow, Goat, and Donkey Milks Fermented with Lactic Acid Bacteria
Giusy Rita Caponio, Alessandro Annunziato, Mirco Vacca, Mariasimona Cavaliere, Ilenia Ceglie, et al.
Antioxidants, 2025
Milk represents not only a source of essential nutrients but also a versatile matrix for the development of functional foods when combined with lactic acid bacteria (LAB) fermentation. While cow milk is the most widely consumed, alternative matrices such as goat and donkey milk possess distinctive compositional features that may influence the bioactivity of fermented products. In this work, fifteen different strains belonging to LAB and bifidobacteria were initially tested for their ability to ferment cow, goat, and donkey milk. Fermented samples showing the best acidification rate were further screened for total phenolic content (TPC), radical scavenging activity (RSA), and effects in human colon epithelial cells and Caco-2 adenocarcinoma cells. The results showed that fermentation modulated TPC in a strain- and matrix-dependent manner, with donkey milk showing the most consistent increases. RSA was significantly enhanced in fermented samples, particularly those inoculated with Lacticaseibacillus casei BGP93 and LC4P1 strains and Limosilactobacillus reuteri ATCC23272. Cell viability assays confirmed the absence of cytotoxicity, and fermented milk extracts reduced ROS under induced oxidative stress. Antimicrobial assay showed that Lactiplantibacillus plantarum LPAL selectively inhibited Listeria monocytogenes, with the strongest effect observed in donkey milk. These findings suggest that LAB-fermented milks from goats and donkeys may represent safe functional foods with improved antioxidant and antimicrobial activities.
Nutritional, rheological, and sensory effect of oat okara enrichment in plant-based ice cream
Giusy Rita Caponio, Davide De Angelis, Lia Mansueto, Mirco Vacca, Roccangelo Silletti, et al.
Lwt, 2025
Phenolic characterization and nutraceutical evaluation of by-products from different globe artichoke cultivars
Giusy Rita Caponio, Mirco Vacca, Laura Scalvenzi, Alessandro Annunziato, Roccangelo Silletti, et al.
Journal of the Science of Food and Agriculture, 2025
BACKGROUNDThe globe artichoke (Cynara cardunculus var. scolymus L.) is extensively cultivated in the Mediterranean region, with Italy being a leading producer. Industrial processing of artichoke plants generates substantial amounts of residual materials, which are discarded annually. This accumulation of biowaste presents environmental challenges. However, these by‐products remain rich in phytochemicals, such as dietary fibers, phenolic acids, sesquiterpene lactones, flavonoids, vitamins and minerals, similar to those found in the edible parts of the plant. The present study aimed to evaluate the potential of artichoke by‐products by analyzing aqueous extracts (AEs) from seven cultivars, comprising two commercial hybrids and five local varieties, focusing on their phenolic content, antioxidant activity, and prebiotic potential.RESULTSThe primary phenolic compounds identified in the AEs were hydroxycinnamates, notably 5‐O‐caffeoylquinic acid and 3,5‐di‐O‐caffeoylquinic acid, and flavonoids, primarily apigenin‐7‐O‐rutinoside, luteolin and luteolin‐7‐O‐rutinoside. These bioactive compounds were more abundant in two of the five local varieties, with concentrations exceeding those in commercial hybrids by more than twofold. Local varieties consistently exhibited higher total phenolic content and greater antioxidant activity, as determined by the DPPH (i.e. 2,2‐diphenyl‐1‐picrilyhydrazil) assay. Furthermore, local varieties demonstrated a remarkable prebiotic potential, supporting more robust probiotic cell growth and resulting in greater acidification compared to commercial hybrids.CONCLUSIONThe findings highlight the potential for valorizing artichoke biowastes as dietary supplements. The rich functional and bioactive properties of these by‐products, particularly in local varieties, offer promising applications in food‐related industries. This approach not only leverages their nutritional benefits, but also addresses environmental concerns by valorizing biowaste. © 2025 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Innovative approaches for the fermentation of black cabbage with improved nutritional and health-promoting traits
Annamaria Tarantini, Leonardo Mancini, Mirco Vacca, Giuseppe Celano, Giuseppe Romano, et al.
Lwt, 2025
Incorporating Fresh Durum Wheat Semolina Pasta Fortified with Cardoncello (Pleurotus eryngii) Mushroom Powder as a Mediterranean Diet Staple
Maria Calasso, Alessia Lisi, Arianna Ressa, Giusy Rita Caponio, Graziana Difonzo, et al.
Antioxidants, 2025
Metabolic characterization of selected probiotic consortia during gluten and wheat bread simulated digestion
Mirco Vacca, Giuseppe Celano, Olga Nikoloudaki, Bodo Speckmann, Francesco Maria Calabrese, et al.
Food Science and Human Wellness, 2025
Microencapsulation of Probiotics for Enhanced Stability and Health Benefits in Dairy Functional Foods: A Focus on Pasta Filata Cheese
Vita D’Amico, Mariasimona Cavaliere, Marianna Ivone, Chiara Lacassia, Giuseppe Celano, et al.
Pharmaceutics, 2025
Pasta Filata Cheeses: Traditional Varieties
Mirco Vacca, Francesco Maria Calabrese, Giuseppe Costantino, Maria De Angelis
Cheese Chemistry Physics and Microbiology, 2025
Gut microbiota and fecal volatilome profile inspection in metabolically healthy and unhealthy obesity phenotypes
F. M. Calabrese, V. A. Genchi, N. Serale, G. Celano, M. Vacca, et al.
Journal of Endocrinological Investigation, 2024
Agreeability and gastrointestinal motility responses to fully characterized experimental pasta enriched in wheat by-products
Mirco Vacca, Mohamad Khalil, Antonio Rampino, Giuseppe Celano, Elisa Lanza, et al.
Journal of Functional Foods, 2024
Nutritional, Biochemical, and Functional Properties of Spinach Leaf-Enriched Dough: A Healthier Alternative to Conventional Pasta
Ilaria Iacobellis, Alessia Lisi, Mirco Vacca, Carmen Aurora Apa, Giuseppe Celano, et al.
Foods, 2024
All Bio-Based µ-Beads from Microalgae for Probiotics Delivery
Danilo Vona, Stefania Roberta Cicco, Flavia Maria la Forgia, Mirco Vacca, Annalisa Porrelli, et al.
Advanced Sustainable Systems, 2024
Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study
Mirco Vacca, Eduardo Maria Sommella, Marina Liso, Giulio Verna, Aurelia Scarano, et al.
Food Science and Human Wellness, 2024
Personalized identification of autism-related bacteria in the gut microbiome using explainable artificial intelligence
Pierfrancesco Novielli, Donato Romano, Michele Magarelli, Domenico Diacono, Alfonso Monaco, et al.
Iscience, 2024
Dynamic microbial and metabolic changes during Apulian Caciocavallo cheesemaking and ripening produced according to a standardized protocol
Mirco Vacca, Giuseppe Celano, Nadia Serale, Giuseppe Costantino, Francesco Maria Calabrese, et al.
Journal of Dairy Science, 2024
Enhanced production of xylooligosaccharides from vine shoots and their impact on the nutritional and technological properties of spreadable goat cheese
Graziana Difonzo, Claudia Antonino, Giusy Rita Caponio, Mirco Vacca, Federico Liuzzi, et al.
Lwt, 2024
A Comprehensive Review on the Biogenic Amines in Cheeses: Their Origin, Chemical Characteristics, Hazard and Reduction Strategies
Giuseppe Natrella, Mirco Vacca, Fabio Minervini, Michele Faccia, Maria De Angelis
Foods, 2024
Nutritional, antioxidant and biological activity characterization of orange peel flour to produce nutraceutical gluten-free muffins
Giusy Rita Caponio, Alessandro Annunziato, Mirco Vacca, Graziana Difonzo, Giuseppe Celano, et al.
Food and Function, 2024
Novel probiotic preparation with in vivo gluten-degrading activity and potential modulatory effectson the gut microbiota
Olga Nikoloudaki, Giuseppe Celano, Andrea Polo, Claudia Cappello, Lena Granehäll, et al.
Microbiology Spectrum, 2024
Multistimuli responsive microcapsules produced by the prilling/vibration technique for targeted colonic delivery of probiotics
Vita D'Amico, Antonio Lopalco, Rosa Maria Iacobazzi, Mirco Vacca, Sonya Siragusa, et al.
International Journal of Pharmaceutics, 2024
Celiac Disease: The Importance of Studying the Duodenal Mucosa-Associated Microbiota
Alessandro Annunziato, Mirco Vacca, Fernanda Cristofori, Vanessa Nadia Dargenio, Giuseppe Celano, et al.
Nutrients, 2024
Wine lees as functional ingredient to produce biscuits fortified with polyphenols and dietary fibre
Giusy Rita Caponio, Roberta Miolla, Mirco Vacca, Graziana Difonzo, Maria De Angelis
Lwt, 2024
Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
Chiara Porro, Tarek Benameur, Antonia Cianciulli, Mirco Vacca, Margherita Chiarini, et al.
Nutrients, 2024
Nutritional and Physiological Properties of Thymbra spicata: In Vitro Study Using Fecal Fermentation and Intestinal Integrity Models
Mohamad Khalil, Francesca Piccapane, Mirco Vacca, Giuseppe Celano, Laura Mahdi, et al.
Nutrients, 2024
Microbiome preterm birth DREAM challenge: Crowdsourcing machine learning approaches to advance preterm birth research
Jonathan L. Golob, Tomiko T. Oskotsky, Alice S. Tang, Alennie Roldan, Verena Chung, et al.
Cell Reports Medicine, 2024
Maternal Exposure to Endocrine-Disrupting Chemicals: Analysis of Their Impact on Infant Gut Microbiota Composition
Mirco Vacca, Francesco Maria Calabrese, Federica Loperfido, Beatrice Maccarini, Rosa Maria Cerbo, et al.
Biomedicines, 2024
Metabolomic Profiling of Obese Patients with Altered Intestinal Permeability Undergoing a Very Low-Calorie Ketogenic Diet
Francesco Maria Calabrese, Giuseppe Celano, Giuseppe Riezzo, Benedetta D’Attoma, Antonia Ignazzi, et al.
Nutrients, 2023
Correction to: The establishment of the gut microbiota in 1‑year‑aged infants: from birth to family food (European Journal of Nutrition, (2022), 61, 5, (2517-2530), 10.1007/s00394-022-02822-1)
Mirco Vacca, Benedetta Raspini, Francesco Maria Calabrese, Debora Porri, Rachele De Giuseppe, et al.
European Journal of Nutrition, 2023
Effects of a Very-Low-Calorie Ketogenic Diet on the Fecal and Urinary Volatilome in an Obese Patient Cohort: A Preliminary Investigation
Giuseppe Celano, Francesco Maria Calabrese, Giuseppe Riezzo, Benedetta D’Attoma, Antonia Ignazzi, et al.
Nutrients, 2023
Gluten-Free Bread Enriched with Artichoke Leaf Extract In Vitro Exerted Antioxidant and Anti-Inflammatory Properties
Mirco Vacca, Daniela Pinto, Alessandro Annunziato, Arianna Ressa, Maria Calasso, et al.
Antioxidants, 2023
Shelf-life extension of leavened bakery products by using bio-protective cultures and type-III sourdough
Maria Calasso, Marinella Marzano, Giusy Rita Caponio, Giuseppe Celano, Bruno Fosso, et al.
Lwt, 2023
Colonic budesonide delivery by multistimuli alginate/Eudragit® FS 30D/inulin-based microspheres as a paediatric formulation
Vita D'Amico, Ilaria Arduino, Mirco Vacca, Rosa Maria Iacobazzi, Davide Altamura, et al.
Carbohydrate Polymers, 2023
In vivo evaluation of an innovative synbiotics on stage IIIb-IV chronic kidney disease patients
Mirco Vacca, Giuseppe Celano, Francesco Maria Calabrese, Maria Teresa Rocchetti, Ilaria Iacobellis, et al.
Frontiers in Nutrition, 2023
Metabolic framework of spontaneous and synthetic sourdough metacommunities to reveal microbial players responsible for resilience and performance
Francesco Maria Calabrese, Hana Ameur, Olga Nikoloudaki, Giuseppe Celano, Mirco Vacca, et al.
Microbiome, 2022
Phenotyping of Fecal Microbiota of Winnie, a Rodent Model of Spontaneous Chronic Colitis, Reveals Specific Metabolic, Genotoxic, and Pro-inflammatory Properties
Adelfia Talà, Flora Guerra, Silvia Caterina Resta, Matteo Calcagnile, Amilcare Barca, et al.
Inflammation, 2022
Evaluation of the Effects of the Tritordeum-Based Diet Compared to the Low-FODMAPs Diet on the Fecal Metabolome of IBS-D Patients: A Preliminary Investigation
Giusy Caponio, Giuseppe Celano, Francesco Calabrese, Giuseppe Riezzo, Antonella Orlando, et al.
Nutrients, 2022
Inulin from Globe Artichoke Roots: A Promising Ingredient for the Production of Functional Fresh Pasta
Graziana Difonzo, Giuditta de Gennaro, Giusy Rita Caponio, Mirco Vacca, Giovanni dal Poggetto, et al.
Foods, 2022
Extension of the shelf-life of fresh pasta using modified atmosphere packaging and bioprotective cultures
Marinella Marzano, Maria Calasso, Giusy Rita Caponio, Giuseppe Celano, Bruno Fosso, et al.
Frontiers in Microbiology, 2022
Effect of Seasonality on Microbiological Variability of Raw Cow Milk from Apulian Dairy Farms in Italy
Giuseppe Celano, Maria Calasso, Giuseppe Costantino, Mirco Vacca, Arianna Ressa, et al.
Microbiology Spectrum, 2022
Vineyard establishment under exacerbated summer stress: effects of mycorrhization on rootstock agronomical parameters, leaf element composition and root-associated bacterial microbiota
Massimiliano Cardinale, Fabio Minervini, Maria De Angelis, Paride Papadia, Danilo Migoni, et al.
Plant and Soil, 2022
The establishment of the gut microbiota in 1-year-aged infants: from birth to family food
Mirco Vacca, Benedetta Raspini, Francesco Maria Calabrese, Debora Porri, Rachele De Giuseppe, et al.
European Journal of Nutrition, 2022
How Metabolomics Provides Novel Insights on Celiac Disease and Gluten-Free Diet: A Narrative Review
Mirco Vacca, Annalisa Porrelli, Francesco Maria Calabrese, Tamara Lippolis, Ilaria Iacobellis, et al.
Frontiers in Microbiology, 2022
A Low Glycemic Index Mediterranean Diet Combined with Aerobic Physical Activity Rearranges the Gut Microbiota Signature in NAFLD Patients
Francesco Calabrese, Vittoria Disciglio, Isabella Franco, Paolo Sorino, Caterina Bonfiglio, et al.
Nutrients, 2022
Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis
Piero Portincasa, Leonilde Bonfrate, Mirco Vacca, Maria De Angelis, Ilaria Farella, et al.
International Journal of Molecular Sciences, 2022
Metaproteomics approach and pathway modulation in obesity and diabetes: A narrative review
Francesco Maria Calabrese, Annalisa Porrelli, Mirco Vacca, Blandine Comte, Katharina Nimptsch, et al.
Nutrients, 2022
WHOLE-meal ancient wheat-based diet: Effect on metabolic parameters and microbiota
Antonio Carroccio, Giuseppe Celano, Carmelo Cottone, Giuseppe Di Sclafani, Lucia Vannini, et al.
Digestive and Liver Disease, 2021
Fecal Microbiota Transplantation Modulates Renal Phenotype in the Humanized Mouse Model of IgA Nephropathy
Gabriella Lauriero, Lilia Abbad, Mirco Vacca, Giuseppe Celano, Jonathan M. Chemouny, et al.
Frontiers in Immunology, 2021
In vitro selection of probiotics, prebiotics, and antioxidants to develop an innovative synbiotic (Naturen g) and testing its effect in reducing uremic toxins in fecal batches from ckd patients
Mirco Vacca, Giuseppe Celano, Marcello Salvatore Lenucci, Sergio Fontana, Flavia Maria la Forgia, et al.
Microorganisms, 2021
Early Life Microbiota Colonization at Six Months of Age: A Transitional Time Point
Benedetta Raspini, Mirco Vacca, Debora Porri, Rachele De Giuseppe, Francesco Maria Calabrese, et al.
Frontiers in Cellular and Infection Microbiology, 2021
Selection of gut-resistant bacteria and construction of microbial consortia for improving gluten digestion under simulated gastrointestinal conditions
Maria De Angelis, Sonya Siragusa, Mirco Vacca, Raffaella Di Cagno, Fernanda Cristofori, et al.
Nutrients, 2021
Ketoanalogs’ effects on intestinal microbiota modulation and uremic toxins serum levels in chronic kidney disease (Medika2 study)
Maria Teresa Rocchetti, Biagio Raffaele Di Iorio, Mirco Vacca, Carmela Cosola, Stefania Marzocco, et al.
Journal of Clinical Medicine, 2021
Dysbiosis triggers ACF development in genetically predisposed subjects
Stefania De Santis, Marina Liso, Mirco Vacca, Giulio Verna, Elisabetta Cavalcanti, et al.
Cancers, 2021
Bile acids and gpbar-1: Dynamic interaction involving genes, environment and gut microbiome
Piero Portincasa, Agostino Di Ciaula, Gabriella Garruti, Mirco Vacca, Maria De Angelis, et al.
Nutrients, 2020
Advances in understanding the potential therapeutic applications of gut microbiota and probiotic mediated therapies in celiac disease
Ruggiero Francavilla, Fernanda Cristofori, Mirco Vacca, Michele Barone, Maria De Angelis
Expert Review of Gastroenterology and Hepatology, 2020
Prenatal and postnatal determinants in shaping offspring's microbiome in the first 1000 days: Study protocol and preliminary results at one month of life
Benedetta Raspini, Debora Porri, Rachele De Giuseppe, Marcello Chieppa, Marina Liso, et al.
Italian Journal of Pediatrics, 2020
The controversial role of human gut lachnospiraceae
Mirco Vacca, Giuseppe Celano, Francesco Maria Calabrese, Piero Portincasa, Marco Gobbetti, et al.
Microorganisms, 2020
Nutritional therapy modulates intestinal microbiota and reduces serum levels of total and free indoxyl sulfate and p-cresyl sulfate in chronic kidney disease (Medika study)
Biagio Raffaele Di Iorio, Maria Teresa Rocchetti, Maria De Angelis, Carmela Cosola, Stefania Marzocco, et al.
Journal of Clinical Medicine, 2019
A bronze-tomato enriched diet affects the intestinal microbiome under homeostatic and inflammatory conditions
Marina Liso, Stefania De Santis, Aurelia Scarano, Giulio Verna, Manuela Dicarlo, et al.
Nutrients, 2018

RECENT SCHOLAR PUBLICATIONS

Genetically Modified Lactic Acid Bacteria in the EU Food Chain: Applications, Benefits, and Risk Assessment
M Vacca, FM Calabrese, P Filannino, M De Angelis
International Journal of Molecular Sciences 27 (9), 3759 , 2026
2026
Semi-industrial scale-up of functional biscuits enriched with wine lees: nutritional enhancement and consumer acceptance
GR Caponio, R Miolla, M Vacca, M De Angelis, S Spinelli, G Difonzo
Applied Food Research, 101983 , 2026
2026
Leishmania Infection: A Bioorganic Model Under the Light of Benchtop Low Field Nuclear Magnetic Resonance
J Mendoza-Roldan, P Albanese, C Di Spiridione, M Vacca, M Spagnuolo, ...
Biological Procedures Online , 2026
2026
Addressing bacteria with tannins chemistry: an innovative food inspired organic lauryl-gallate-based coating to increase probiotics resistance
M Vacca, M Cavaliere, G Celano, D Pinto, A De Stradis, M Spagnuolo, ...
International Journal of Biological Macromolecules, 150164 , 2026
2026
Citations: 1
Clinical trial: Efficacy of a Low FODMAP Diet in Paediatric Irritable Bowel Syndrome-A Randomised Crossover Trial With Exploratory Metabolomic Analysis
F Cristofori, G Celano, VN Dargenio, CA Apa, M Amendolara, M Stella, ...
Alimentary pharmacology & therapeutics , 2026
2026
Cholesterol‐Lowering and Radical Scavenging Potential of Fermented Black Kale ( Brassica oleracea var. acephala ): From Pilot‐Scale Production to in Vivo Study
M Vacca, A Tarantini, M Khalil, D Vona, FM Calabrese, G Celano, CA Apa, ...
ChemFoodChem 1 (2), e00035 , 2025
2025
Citations: 2
Comparative Evaluation of Functional Properties of Cow, Goat, and Donkey Milks Fermented with Lactic Acid Bacteria
GR Caponio, A Annunziato, M Vacca, M Cavaliere, I Ceglie, M Ranieri, ...
Antioxidants 14 (11), 1331 , 2025
2025
Citations: 2
Nutritional, Rheological, and Sensory Effect of Oat Okara Enrichment in Plant-Based Ice Cream
GR Caponio, D De Angelis, L Mansueto, M Vacca, R Silletti, M De Angelis, ...
LWT, 118490 , 2025
2025
Citations: 3
Phenolic characterization and nutraceutical evaluation of by‐products from different globe artichoke cultivars
GR Caponio, M Vacca, L Scalvenzi, A Annunziato, R Silletti, C Ruta, ...
Journal of the Science of Food and Agriculture 105 (9), 5062-5073 , 2025
2025
Citations: 6
Innovative approaches for the fermentation of black cabbage with improved nutritional and health-promoting traits
A Tarantini, L Mancini, M Vacca, G Celano, G Romano, L D'Amico, ...
LWT 226, 117961 , 2025
2025
Citations: 3
Incorporating Fresh Durum Wheat Semolina Pasta Fortified with Cardoncello ( Pleurotus eryngii ) Mushroom Powder as a Mediterranean Diet Staple
M Calasso, A Lisi, A Ressa, GR Caponio, G Difonzo, F Minervini, ...
Antioxidants 14 (3), 284 , 2025
2025
Citations: 5
Microencapsulation of Probiotics for Enhanced Stability and Health Benefits in Dairy Functional Foods: A Focus on Pasta Filata Cheese
V D’Amico, M Cavaliere, M Ivone, C Lacassia, G Celano, M Vacca, ...
Pharmaceutics 17 (2), 185 , 2025
2025
Citations: 56
Pasta Filata Cheeses: Traditional Varieties
M Vacca, FM Calabrese, G Costantino, M De Angelis
Cheese, 1093-1107 , 2025
2025
Citations: 1
Agreeability and gastrointestinal motility responses to fully characterized experimental pasta enriched in wheat by-products
M Vacca, M Khalil, A Rampino, G Celano, E Lanza, GR Caponio, ...
Journal of Functional Foods 123, 106598 , 2024
2024
Citations: 9
Gut microbiota and fecal volatilome profile inspection in metabolically healthy and unhealthy obesity phenotypes
FM Calabrese, VA Genchi, N Serale, G Celano, M Vacca, G Palma, ...
Journal of Endocrinological Investigation 47 (12), 3077-3090 , 2024
2024
Citations: 10
Nutritional, Biochemical, and Functional Properties of Spinach Leaf-Enriched Dough: A Healthier Alternative to Conventional Pasta
I Iacobellis, A Lisi, M Vacca, CA Apa, G Celano, L Mancini, F Minervini, ...
Foods 13 (22), 3608 , 2024
2024
Citations: 12
Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study
M Vacca, EM Sommella, M Liso, G Verna, A Scarano, A Sila, M Curlo, ...
Food Science and Human Wellness 13 (6), 3536-3543 , 2024
2024
Citations: 8
All Bio‐Based µ‐Beads from Microalgae for Probiotics Delivery
D Vona, SR Cicco, FM la Forgia, M Vacca, A Porrelli, G Caggiano, ...
Advanced Sustainable Systems 8 (11), 2400384 , 2024
2024
Citations: 10
Personalized identification of autism-related bacteria in the gut microbiome using explainable artificial intelligence
P Novielli, D Romano, M Magarelli, D Diacono, A Monaco, N Amoroso, ...
Iscience 27 (9) , 2024
2024
Citations: 23
Dynamic microbial and metabolic changes during Apulian Caciocavallo cheesemaking and ripening produced according to a standardized protocol
M Vacca, G Celano, N Serale, G Costantino, FM Calabrese, M Calasso, ...
Journal of Dairy Science 107 (9), 6541-6557 , 2024
2024
Citations: 14

MOST CITED SCHOLAR PUBLICATIONS

The Controversial Role of Human Gut Lachnospiraceae
M Vacca, G Celano, FM Calabrese, P Portincasa, M Gobbetti, ...
Microorganisms 8 (4), 573 , 2020
2020
Citations: 1792
Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis
P Portincasa, L Bonfrate, M Vacca, M De Angelis, I Farella, E Lanza, ...
International Journal of Molecular Sciences 23 (3), 1105 , 2022
2022
Citations: 1086
Nutritional Therapy Modulates Intestinal Microbiota and Reduces Serum Levels of Total and Free Indoxyl Sulfate and P-Cresyl Sulfate in Chronic Kidney Disease (Medika Study)
BR Di Iorio, MT Rocchetti, M De Angelis, C Cosola, S Marzocco, ...
Journal of clinical medicine 8 (9), 1424 , 2019
2019
Citations: 154
Fecal microbiota transplantation modulates renal phenotype in the humanized mouse model of IgA nephropathy
G Lauriero, L Abbad, M Vacca, G Celano, JM Chemouny, M Calasso, ...
Frontiers in Immunology 12, 694787 , 2021
2021
Citations: 81
Metabolic framework of spontaneous and synthetic sourdough metacommunities to reveal microbial players responsible for resilience and performance
FM Calabrese, H Ameur, O Nikoloudaki, G Celano, M Vacca, WJFL Junior, ...
Microbiome 10 (1), 1-37 , 2022
2022
Citations: 71
A Low Glycemic Index Mediterranean Diet Combined with Aerobic Physical Activity Rearranges the Gut Microbiota Signature in NAFLD Patients
FM Calabrese, V Disciglio, I Franco, P Sorino, C Bonfiglio, A Bianco, ...
Nutrients 14 (9), 1773 , 2022
2022
Citations: 67
Effect of Seasonality on Microbiological Variability of Raw Cow Milk from Apulian Dairy Farms in Italy
G Celano, M Calasso, G Costantino, M Vacca, A Ressa, O Nikoloudaki, ...
Microbiology spectrum 10 (5), e00514-22 , 2022
2022
Citations: 62
Bile Acids and GPBAR-1: Dynamic Interaction Involving Genes, Environment and Gut Microbiome
P Portincasa, A Di Ciaula, G Garruti, M Vacca, M De Angelis, DQH Wang
Nutrients 12 (12), 3709 , 2020
2020
Citations: 61
Microbiome preterm birth DREAM challenge: Crowdsourcing machine learning approaches to advance preterm birth research
JL Golob, TT Oskotsky, AS Tang, A Roldan, V Chung, CWY Ha, RJ Wong, ...
Cell Reports Medicine 5 (1) , 2024
2024
Citations: 59
Microencapsulation of Probiotics for Enhanced Stability and Health Benefits in Dairy Functional Foods: A Focus on Pasta Filata Cheese
V D’Amico, M Cavaliere, M Ivone, C Lacassia, G Celano, M Vacca, ...
Pharmaceutics 17 (2), 185 , 2025
2025
Citations: 56
Prenatal and postnatal determinants in shaping offspring’s microbiome in the first 1000 days: study protocol and preliminary results at one month of life
B Raspini, D Porri, R De Giuseppe, M Chieppa, M Liso, RM Cerbo, ...
Italian Journal of Pediatrics 46, 1-14 , 2020
2020
Citations: 55
Early life microbiota colonization at six months of age: a transitional time point
B Raspini, M Vacca, D Porri, R De Giuseppe, FM Calabrese, M Chieppa, ...
Frontiers in cellular and infection microbiology 11, 590202 , 2021
2021
Citations: 47
Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
C Porro, T Benameur, A Cianciulli, M Vacca, M Chiarini, M De Angelis, ...
Nutrients 16 (6), 872 , 2024
2024
Citations: 46
A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions
M Liso, S De Santis, A Scarano, G Verna, M Dicarlo, V Galleggiante, ...
Nutrients 10 (12), 1862 , 2018
2018
Citations: 46
The establishment of the gut microbiota in 1-year-aged infants: from birth to family food
M Vacca, B Raspini, FM Calabrese, D Porri, R De Giuseppe, M Chieppa, ...
European Journal of Nutrition 61 (5), 2517-2530 , 2022
2022
Citations: 43
Selection of Gut-Resistant Bacteria and Construction of Microbial Consortia for Improving Gluten Digestion under Simulated Gastrointestinal Conditions
M De Angelis, S Siragusa, M Vacca, R Di Cagno, F Cristofori, M Schwarm, ...
Nutrients 13 (3), 992 , 2021
2021
Citations: 43
Ketoanalogs’ effects on intestinal microbiota modulation and uremic toxins serum levels in chronic kidney disease (Medika2 Study)
MT Rocchetti, BR Di Iorio, M Vacca, C Cosola, S Marzocco, I di Bari, ...
Journal of clinical medicine 10 (4), 840 , 2021
2021
Citations: 42
Advances in understanding the potential therapeutic applications of gut microbiota and probiotic mediated therapies in celiac disease
R Francavilla, F Cristofori, M Vacca, M Barone, M De Angelis
Expert review of gastroenterology & hepatology 14 (5), 323-333 , 2020
2020
Citations: 40
Wine lees as functional ingredient to produce biscuits fortified with polyphenols and dietary fibre
GR Caponio, R Miolla, M Vacca, G Difonzo, M De Angelis
LWT 198, 115943 , 2024
2024
Citations: 38
A Comprehensive Review on the Biogenic Amines in Cheeses: Their Origin, Chemical Characteristics, Hazard and Reduction Strategies
G Natrella, M Vacca, F Minervini, M Faccia, M De Angelis
Foods 13 (16), 2583 , 2024
2024
Citations: 37

Mirco Vacca

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