Pharmaceutical Science, Pharmacy, Pharmacology, Toxicology and Pharmaceutics, Multidisciplinary
6
Scopus Publications
Scopus Publications
COMPARATIVE STUDY OF FORMULATED WOUND HEALING OINTMENTS WITH THE MARKETED PRODUCT BY IN-VIVO METHOD S. Valarmathi, M. Sathish Kumar, P Shrinithy, V. Sivasankari, A. Syed, et al. Chinese Journal of Epidemiology, 2023 A wound is a breakthrough of skin; it disrupts the normal functioning of skin.So, the wound healing process is important to repair the skin.It restores the normal function and structure of the skin.There are several phases of the wound healing process: inflammation, re-epithelization, vascularization, and granulation tissue formation and maturation.The wound healing process can be studied using invitro and in-vivo methods.There are many in-vivo methods to study the wound healing process.In-vivo method uses laboratory animals for the study.Animals used are mice, rats, rabbits, and pigs.Recently, Zebrafish have been used as a model to study the wound healing process.Zebrafish are used because it has similar wound closure properties as mammalian embryos.The wound healing can be studied by amputating the caudal fin of fish and recording the regeneration of the fin on days 5th, 7th and 9th post-amputation.This study compares various wound healing agents with the market product (neomycin cream).The various wound healing agents used in this study are pomegranate peel powder, Aloe vera powder, potash alum powder, lavender oil, and sesame oil.The wound-healing effects of these agents are studied using Zebrafish as an in-vivo wound-healing model. INTRODUCTION:A wound is a breakthrough of the skin; it can disrupt the anatomical and functional continuity of the skin.It can be caused by heat, radiation, microbial, chemical, etc. Wounds can be classified based on location, etiology, presenting symptoms or type of injury, wound depth, and tissue loss or clinical appearance 1 .The structure of the skin is restored by a process called wound healing.Wound healing is a process to respond to tissue damage integrity of damaged skin tissue.Wound healing is a series of processes carried out in an orderly manner.It is a dynamic process that takes place by
Sterility testing procedure of ophthalmic ocusert aciclovir used for treating herpes simplex virus Shanmugam S, Valarmathi S, Satheesh Kumars Asian Journal of Pharmaceutical and Clinical Research, 2017 Objective: The present work focuses on sterility studies of prepared aciclovir ocusert which is so essential for ophthalmic preparations. According to Indian Pharmacopoeia, the sterility test was performed. Ocuserts are sterile preparations which are placed into cul-de-sac or conjunctival sac. Ophthalmic inserts offer many advantages over conventional dosage forms such as increased ocular residence time, possibility of releasing drugs at a slow and constant rate and accurate dosing. Ocuserts are formulated for treating external ocular diseases such as conjuctivitis, corneal ulcer, and keratoconjuctivitis. Ophthalmic preparations contaminated with microorganisms cause corneal damage and finally blindness, especially if the microorganism is Pseudomonas aeruginosa. Ophthalmic preparations should be manufactured in aseptic condition and to be sterilized before packing.Methods: According to Indian Pharmacopoeia, the official sterility test for ocusert was performed for detecting the presence of microbes. The selected F2 formulation which shows controlled drug release after 24 hrs was selected for the sterility test. The F2 formulation was subjected to ultraviolet radiation for sterilization. The sterilized ocusert and unsterilized ocusert were placed in fluid thioglycollate medium and incubated for 7 days at 20-25oC.Results: After 7 days of incubation, the sterilized ocusert shows no microbial growth and unsterilized ocusert shows microbial growth. The prepared aciclovir ocuserts were found to be sterile after the completion of official sterility test.Conclusion: The sterility studies conclude after 7 days of incubation period; there was no appearance of turbidity which indicates the prepared formulation F2 was found to be sterile.
In vivo studies of ophthalmic ocular insert containing aciclovir S. Valarmathi, S. Shanmugam, S. Satheesh Kumar, P. Shanmugasundaram Research Journal of Pharmacy and Technology, 2017 Aciclovir is an antiviral drug used to treat viral infections like herpes simplex virus. The aim of the present research work was to develop ocular inserts of aciclovir and evaluate their drug release for both in vitro and in vivo. The draw backs of other ophthalmic formulations (solutions, suspensions, ointment) like poor bioavailability, patient non compliance, quick drug elimination was overcome by formulating the drug in ocusert formulation.1, 2 The ocuserts was prepared by solvent casting technique using hydrophilic and hydrophobic polymers. Eight formulations was prepared with formulation code of F1, F2, F3, F4, F5, F6, F7, F8. The satisfied drug release was achieved in F2 formulation. The selected formulation F2 was subjected to sterilization before performing in vivo studies.3, 46 healthy rabbits are used for in vivo study. Draize irritation studies are carried out to check the compatibility of ocusert in the eyes. After 21 days of irritation study the eyes are examined. Drug content of the ocuserts are calculated at predetermined time intervals and subtracted from the initial value.5Theinvivo drug release results are correlating with invitro drug release, which shows better therapeutic efficacy.
Formulation development and evaluation of opthalmic ocusert containing aciclovir S. Shanmugam, S. Valarmathi, S. Satheesh Kumar, P. Shanmugasundaram, M. Senthilkumar Research Journal of Pharmacy and Technology, 2016 The aim of formulating aciclovir occusert was to prolong the drug residence time after ocular administration to achieve the controlled release of drug. Aciclovir is a antiviral agent and its use in the treatment of viral infections like herpes simplex infections. Ocular inserts were prepared by solvent casting method. Drug reservoir and rate controlling membrane were prepared using different hydrophilic and hydrophobic polymers respectively with polyethylene glycol 400 as the plasticizer.DSC and IR spectral studies were performed to confirm the interaction of drug and polymers in formulation. The ocusert were evaluated for their physical and chemical and in vitro – release characteristics. The developed formulation was stable sterile and non irritant. The final formulation F2 was subjected to UV irritation for sterilization. In the present work it was concluded that the F2 formulation shows 99.16% controlled release upto 8 hrs when compared to other formulations.
Mucoadhesive buccal drug delivery system - an overview International Journal of Pharmacy and Technology, 2012
Quantum dots International Journal of Pharmacy and Technology, 2012
