Vanita Somasekhar

Scopus Publications

Formulation and evaluation of isosorbide dinitrate-loaded flash-release dispersible sublingual wafers
Shivakumar H. Nanjappa, Vanita Somasekhar, Megha Kamath, Sanjana S. Prakash, Avichal Kumar, et al.
Rsc Pharmaceutics, 2026
This study aimed to design flash-release dispersible sublingual wafers of isosorbide dinitrate (ISDN) by lyophilisation (LYO) by applying the principles of Quality by Design (QbD).
Activation-modulated stimuli-responsive systems: an intelligent platform for site-specific gastroretentive delivery of diverse therapeutic agents
H.N. Shivakumar, Rushikesh Shinde, Vanita Somasekhar, M.G. Hariprasad, N.M. Mahesh
International Journal of Pharmaceutics, 2026
Shilajit-analytical study to understand the phyto complex present in shilajit raw material, extract and resin by using hyphenated techniques
Harsimran Kaur Kohli, Vanita Somasekhar, M. Devendra Reddy, N.S. Prakash
Journal of Chromatography A, 2026
A Comprehensive Analysis of Andrographis paniculata Herbal Products Conducted to Enhance Potency and Ensure Safety Through the Application of Pertinent Chromatographic Techniques.
Tamilvanan K, P.V Murali Krishna, Vanita Somasekhar, Rajeshkumar R
Research Journal of Pharmacy and Technology, 2026
The study aimed to identify and quantify andrographolides in various marketed samples of A. Paniculata and detect pesticide residues. It aimed to improve understanding of the composition, purit, and safety.The TLC technique used an aluminium plate with pre-coated silica gel (E. Merck – Silica Gel 60F254). Samples were spotted using a Linomat IV syringe TLC applicator (CAMAG) and a solvent system consisting of acetone, benzene, and chloroform (20:20:10 ratio). With a LiChrospher 100 RP-18e (5μm) column, a quaternary pump, UV detector, auto injector, column oven, and LC-Solution software, the HPLC system comprised a SHIMADZU LC-2030C Liquid Chromatograph. The Agilent Gas Chromatograph with Electron Capture and Nitrogen Phosphorus Detector 7890A-ECD/NPD (EZ Chrome) and associated equipment, along with a Zebron ZB-1 column (30 m in length, 0.25 mm in diameter, and 0.50 m film thickness), made up the GC-ECD system.The TLC results showed well-developed andrographolide spots in all samples, with sample C having the highest percentage. HPLC quantification confirmed this, with sample C exhibiting the highest total andrographolide content. GC-ECD analysis detected pesticide residues in A. paniculata samples. This comprehensive chromatographic analysis enhances our understanding of A. paniculata composition and purity, ensuring potency and safety in herbal products. These findings provide valuable insights for quality control in A. paniculata-based formulations.Our research emphasises the safety and therapeutic potential of Andrographis paniculata, underscoring its importance in contemporary medicine. By using cutting-edge methods for thorough study, we were able to verify its effectiveness against several diseases.
An AQbD driven stability indicating HPLC method for simultaneous estimation of lamivudine, tenofovir disoproxil fumarate and efavirenz in plasma
Avichal Kumar, Vanita Somasekhar, Sumit Dhiman, Shivakumar Hagalavadi Nanjappa, Dhruti Avlani
Analytical Methods, 2025
Advanced AQbD involving D-optimal and Box–Behnken designs for precise analysis of fixed dose combination of antiretrovirals in plasma.
Gymnema sylvestre saponins: Analytical profiling for herbal pharmaceutical standards
Vanita Somasekhar, Raksha Pai, Prakash NS, Devendra Reddy M
Journal of Liquid Chromatography and Related Technologies, 2025
DEVELOPMENT OF A DISCRIMINATORY METHOD FOR DETERMINATION OF IN VITRO DISSOLUTION OF CILNIDIPINE
Vanita Somasekhar, Tejashwini H, Murali krishna PV
Asian Journal of Pharmaceutical and Clinical Research, 2024
Objectives: This study involves the development of a discriminatory method to differentiate the in vitro dissolution of cilnidipine’s mouth-dispersing film from that of a commercial tablet. Methods: The mouth-dispersing film was initially developed using a reported established method. A discriminatory dissolution method was developed to assess the in vitro dissolution of the mouth-dispersing film and compare the same with that of the commercial tablet. Results: The study findings indicated the method employed was able to differentiate the dissolution of the fast-dissolving film from the commercial tablet. About 98.52±0.60% of the drug was found to be released from the oral film in 40 min whereas the tablet took nearly 5 h for 92.06±0.49% of the drug to get released. Conclusion: These results demonstrate that the dissolution media identified was able to create the necessary sink condition that would be able to differentiate the dissolution profile of the mouth-dispersing film from the conventional tablet. The ultrasound spectrophotometric method employed was found to be simple rapid and sensitive enough to estimate the drug release from diverse pharmaceutical dosage forms.
Development and Validation of High-Performance Thin Layer Chromatographic Method for Estimation of Acyclovir
Pai Raksha, Somasekhar Vanita, Purushottaman Vijayanthimala, Chandran Athira
Indian Journal of Pharmaceutical Education and Research, 2024
Background: The antiviral medication genre comprises the synthetic purine nucleoside analogue acyclovir, which particularly is used to treat varicella-zoster and herpes simplex virus infections. By incorporating into viral DNA to stop further synthesis, acyclovir limits DNA synthesis and viral multiplication. The investigation of an economical alternative was spurred by the existence of the currently used HPLC and UV techniques for acyclovir analysis, which are recognized for their solvent-intensive character. The innovation offers a more cost-effective method of pharmaceutical analysis along with improving sustainability. Materials and Methods: Using a CAMAG Linomat 5 sampler, the samples were spotted in the form of bands on a precoated silica gel plate using a CAMAG microliter syringe. The application rate was kept constant at 100 nL/sec and the spacing between the tracks was set. Chloroform, ethanol, isopropyl alcohol and strong ammonia (2:4:3:1 v/v/v/v) constitute the mobile phase. The development process was linear ascending in a twin trough glass chamber that was saturated with a mobile phase. To estimate acyclovir, densitometric scanning was carried out in the absorbance mode at 254 nm. Results: With r 2 =0.9974, the calibration plots' linear regression analysis results demonstrated a strong linear association. The limit of quantification was 11.7726 µg/mL, whereas the limit of detection was 3.884 µg/mL. Conclusion: According to statistical analysis of the data, the approach was found to be precise, accurate, repeatable, sensitive and selective for the analysis of acyclovir. The technique will work well for routine quality control when estimating acyclovir as a bulk medication.
RP-HPLC Method Development and Validation of Choline Salicylate and Lignocaine HCl in Mouth Ulcer Gel
Sivanathan Boopalan, Palla Venkata Murali Krishna, Vanita Somasekhar, Venketesh Dubalgundi, Shruthi Devadiga
Indian Journal of Pharmaceutical Education and Research, 2024
Preparation and characterization of directly compressible spherical agglomerates of etoricoxib
Hagalavadi Nanjappa Shivakumar, Vanita Somasekhar, Anwesha Roy
Indian Journal of Pharmaceutical Education and Research, 2020
Comparative antioxidant and bioavailability studies of vitamin C in Phyllanthus emblica Linn. And its combinations with piper nigrum Linn. and Zingiber officinale Roscoe
Vanita Somasekhar, Purnima Ashok, Sri Adibatla Renuka Kameswari, Ramaswamy Rajendran, Rajpreet Singh
Brazilian Journal of Pharmaceutical Sciences, 2016
Optimization and validation of an RP-HPLC method for the estimation of 6-mercaptopurine in bulk and pharmaceutical formulations
Vanita Somasekhar
Brazilian Journal of Pharmaceutical Sciences, 2014
HPLC method for the simultaneous determination of paracetamol, aceclofenac and tizanidine hydrochloride
Asian Journal of Chemistry, 2011
Development and validation of a rapid RP-HPLC method for the estimation of esmolol hydrochloride in bulk and pharmaceutical dosage forms
Vanita Somasekhar, D. Gowri Sankar
E Journal of Chemistry, 2010
Development and validation of a rapid RP-HPLC method for the determination of venlafaxine hydrochloride in pharmaceutical dosage forms using experimental design
Vanita Somasekhar, Dannana Gowrisankar, H. N. Shivakumar
E Journal of Chemistry, 2009
Screening of venlafaxine hydrochloride for transdermal delivery: Passive diffusion and iontophoresis
Gursharanjit Singh, Bijaya Ghosh, Dave Kaushalkumar, Vanita Somsekhar
AAPS Pharmscitech, 2008
Synthesis of 2-N-acylamino-4-arylthiazole-5-acetic acids/esters for their anti-inflammatory and analgesic activities
Asian Journal of Chemistry, 2004
An unexpected reaction in the synthesis of 3-substituted thienoazetidinones
Asian Journal of Chemistry, 2003
An oxidative spectrophotometric method for the determination of clprofloxacln in pharmaceutical preparations
Indian Drugs, 1997

RECENT SCHOLAR PUBLICATIONS

Activation-modulated stimuli-responsive systems: an intelligent platform for site-specific gastroretentive delivery of diverse therapeutic agents
HN Shivakumar, R Shinde, V Somasekhar, MG Hariprasad, NM Mahesh
International Journal of Pharmaceutics, 126599 , 2026
2026
Formulation and evaluation of isosorbide dinitrate-loaded flash-release dispersible sublingual wafers
SH Nanjappa, V Somasekhar, M Kamath, SS Prakash, A Kumar, R Pai, ...
RSC Pharmaceutics , 2026
2026
Gymnema sylvestre saponins: Analytical profiling for herbal pharmaceutical standards
V Somasekhar, R Pai, P Ns, D Reddy M
Journal of Liquid Chromatography & Related Technologies 48 (16-20), 558-564 , 2025
2025
Shilajit-analytical study to understand the phyto complex present in shilajit raw material, extract and resin by using hyphenated techniques
HK Kohli, V Somasekhar, MD Reddy, NS Prakash
Journal of Chromatography A, 466570 , 2025
2025
An AQbD driven stability indicating HPLC method for simultaneous estimation of lamivudine, tenofovir disoproxil fumarate and efavirenz in plasma
A Kumar, V Somasekhar, S Dhiman, SH Nanjappa, D Avlani
Analytical Methods 17 (9), 2094-2111 , 2025
2025
Citations: 2
Development and Validation of High-Performance Thin Layer Chromatographic Method for Estimation of Acyclovir.
P Raksha, S Vanita, P Vijayanthimala, C Athira
Indian Journal of Pharmaceutical Education & Research 58 , 2024
2024
RP-HPLC Method Development and Validation of Choline Salicylate and Lignocaine HCl in Mouth Ulcer Gel.
S Boopalan, PVM Krishna, V Somasekhar, V Dubalgundi, S Devadiga
Indian Journal of Pharmaceutical Education & Research 58 , 2024
2024
Citations: 1
DEVELOPMENT OF A DISCRIMINATORY METHOD FOR DETERMINATION OF IN VITRO DISSOLUTION OF CILNIDIPINE
V SOMASEKHAR, H TEJASHWINI, MK PV
DEVELOPMENT 17 (2) , 2024
2024
Preparation and Characterization of Directly Compressible Spherical Agglomerates of Etoricoxib.
HN Shivakumar, V Somasekhar, A Roy
Indian Journal of Pharmaceutical Education & Research 54 (4) , 2020
2020
Citations: 3
SYNTHESIS AND EVALUATION OF ANTI-PROLIFERATIVE ACTIVITY OF NOVEL THIAZOLIDINONE DERIVATIVES
V Somasekhar, R Udainiya, S Kumar
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH 9 (8), 3449-3453 , 2018
2018
Comparative antioxidant and bioavailability studies of Vitamin C in Phyllanthus emblica Linn. and its combinations with Piper nigrum Linn. and Zingiber officinale Roscoe
V Somasekhar, P Ashok, SAR Kameswari, R Rajendran, R Singh
Brazilian Journal of Pharmaceutical Sciences 52, 35-43 , 2016
2016
Citations: 13
Optimization and validation of an RP-HPLC method for the estimation of 6-mercaptopurine in bulk and pharmaceutical formulations
V Somasekhar
Brazilian Journal of Pharmaceutical Sciences 50, 793-797 , 2014
2014
Citations: 8
HPLC Method for the simultaneous determination of paracetamol, aceclofenac and tizanidine hydrochloride
V Somasekhar, D Gowrisankar
Asian Journal of Research in Chemistry 23 (4), 1651-1654 , 2011
2011
Citations: 9
Development and validation of an RP-HPLC method for estimation of famciclovir in bulk and pharmaceutical formulations
V Somasekhar, D Gowrisankar
Current Pharma Research 1 (3), 227-231 , 2011
2011
Citations: 2
Isolation, characterization and pharmacological studies of a flavonol glucoside from trichilia connaroides (w. &a.) Bentilizen
D Meharoon
KLE University, Belagavi, Karnataka , 2011
2011
Development and Validation of a Rapid RP‐HPLC Method for the Estimation of Esmolol Hydrochloride in Bulk and Pharmaceutical Dosage Forms
V Somasekhar, DG Sankar
Journal of Chemistry 7 (3), 807-812 , 2010
2010
Citations: 5
Development and Validation of a Rapid RP‐HPLC Method for the Determination of Venlafaxine Hydrochloride in Pharmaceutical Dosage forms using Experimental Design
V Somasekhar, D Gowrisankar, HN Shivakumar
Journal of Chemistry 6 (4), 1091-1102 , 2009
2009
Citations: 23
Screening of Venlafaxine Hydrochloride for Transdermal Delivery : Passive Diffusion and Iontophoresis
VS 7. Gurusharanjit Sigh, Bijaya Ghosh, Dave Kaushalkumar D
AAPSPharmSciTech 9 (3), 791-797 , 2008
2008
Citations: 31
Synthesis of 2-N-Acylamino-4-Arylthiazole-5-Acetic acids/esters for Their Anti-inflammatory and Analgesic Activities
M Attimarad, V Somasekhar, S Mohan
Asian Journal of Chemistry 16 (1), 179 , 2004
2004
Citations: 1
An unexpected reaction in the synthesis of 3-substituted thienoazetidinones
J Saravanan, V Somasekhar, S Mohan
Asian Journal of Chemistry 15 (3), 1749 , 2003
2003
Citations: 2

MOST CITED SCHOLAR PUBLICATIONS

Screening of Venlafaxine Hydrochloride for Transdermal Delivery : Passive Diffusion and Iontophoresis
VS 7. Gurusharanjit Sigh, Bijaya Ghosh, Dave Kaushalkumar D
AAPSPharmSciTech 9 (3), 791-797 , 2008
2008
Citations: 31
Development and Validation of a Rapid RP‐HPLC Method for the Determination of Venlafaxine Hydrochloride in Pharmaceutical Dosage forms using Experimental Design
V Somasekhar, D Gowrisankar, HN Shivakumar
Journal of Chemistry 6 (4), 1091-1102 , 2009
2009
Citations: 23
Comparative antioxidant and bioavailability studies of Vitamin C in Phyllanthus emblica Linn. and its combinations with Piper nigrum Linn. and Zingiber officinale Roscoe
V Somasekhar, P Ashok, SAR Kameswari, R Rajendran, R Singh
Brazilian Journal of Pharmaceutical Sciences 52, 35-43 , 2016
2016
Citations: 13
HPLC Method for the simultaneous determination of paracetamol, aceclofenac and tizanidine hydrochloride
V Somasekhar, D Gowrisankar
Asian Journal of Research in Chemistry 23 (4), 1651-1654 , 2011
2011
Citations: 9
Optimization and validation of an RP-HPLC method for the estimation of 6-mercaptopurine in bulk and pharmaceutical formulations
V Somasekhar
Brazilian Journal of Pharmaceutical Sciences 50, 793-797 , 2014
2014
Citations: 8
Development and Validation of a Rapid RP‐HPLC Method for the Estimation of Esmolol Hydrochloride in Bulk and Pharmaceutical Dosage Forms
V Somasekhar, DG Sankar
Journal of Chemistry 7 (3), 807-812 , 2010
2010
Citations: 5
Preparation and Characterization of Directly Compressible Spherical Agglomerates of Etoricoxib.
HN Shivakumar, V Somasekhar, A Roy
Indian Journal of Pharmaceutical Education & Research 54 (4) , 2020
2020
Citations: 3
An AQbD driven stability indicating HPLC method for simultaneous estimation of lamivudine, tenofovir disoproxil fumarate and efavirenz in plasma
A Kumar, V Somasekhar, S Dhiman, SH Nanjappa, D Avlani
Analytical Methods 17 (9), 2094-2111 , 2025
2025
Citations: 2
Development and validation of an RP-HPLC method for estimation of famciclovir in bulk and pharmaceutical formulations
V Somasekhar, D Gowrisankar
Current Pharma Research 1 (3), 227-231 , 2011
2011
Citations: 2
An unexpected reaction in the synthesis of 3-substituted thienoazetidinones
J Saravanan, V Somasekhar, S Mohan
Asian Journal of Chemistry 15 (3), 1749 , 2003
2003
Citations: 2
RP-HPLC Method Development and Validation of Choline Salicylate and Lignocaine HCl in Mouth Ulcer Gel.
S Boopalan, PVM Krishna, V Somasekhar, V Dubalgundi, S Devadiga
Indian Journal of Pharmaceutical Education & Research 58 , 2024
2024
Citations: 1
Synthesis of 2-N-Acylamino-4-Arylthiazole-5-Acetic acids/esters for Their Anti-inflammatory and Analgesic Activities
M Attimarad, V Somasekhar, S Mohan
Asian Journal of Chemistry 16 (1), 179 , 2004
2004
Citations: 1
Activation-modulated stimuli-responsive systems: an intelligent platform for site-specific gastroretentive delivery of diverse therapeutic agents
HN Shivakumar, R Shinde, V Somasekhar, MG Hariprasad, NM Mahesh
International Journal of Pharmaceutics, 126599 , 2026
2026
Formulation and evaluation of isosorbide dinitrate-loaded flash-release dispersible sublingual wafers
SH Nanjappa, V Somasekhar, M Kamath, SS Prakash, A Kumar, R Pai, ...
RSC Pharmaceutics , 2026
2026
Gymnema sylvestre saponins: Analytical profiling for herbal pharmaceutical standards
V Somasekhar, R Pai, P Ns, D Reddy M
Journal of Liquid Chromatography & Related Technologies 48 (16-20), 558-564 , 2025
2025
Shilajit-analytical study to understand the phyto complex present in shilajit raw material, extract and resin by using hyphenated techniques
HK Kohli, V Somasekhar, MD Reddy, NS Prakash
Journal of Chromatography A, 466570 , 2025
2025
Development and Validation of High-Performance Thin Layer Chromatographic Method for Estimation of Acyclovir.
P Raksha, S Vanita, P Vijayanthimala, C Athira
Indian Journal of Pharmaceutical Education & Research 58 , 2024
2024
DEVELOPMENT OF A DISCRIMINATORY METHOD FOR DETERMINATION OF IN VITRO DISSOLUTION OF CILNIDIPINE
V SOMASEKHAR, H TEJASHWINI, MK PV
DEVELOPMENT 17 (2) , 2024
2024
SYNTHESIS AND EVALUATION OF ANTI-PROLIFERATIVE ACTIVITY OF NOVEL THIAZOLIDINONE DERIVATIVES
V Somasekhar, R Udainiya, S Kumar
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH 9 (8), 3449-3453 , 2018
2018
Isolation, characterization and pharmacological studies of a flavonol glucoside from trichilia connaroides (w. &a.) Bentilizen
D Meharoon
KLE University, Belagavi, Karnataka , 2011
2011

Vanita Somasekhar

EDUCATION

RESEARCH INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS