Vedant Kumar Prajapati

@gnsu.ac

assistant professor, Narayan insititute of pharmacy
gopal narayan singh university

Vedant Kumar Prajapati


                        Download Compact PDF  
https://researchid.co/vedant_prajapati

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacy, Pharmaceutical Science, Drug Discovery, Pharmacology, Toxicology and Pharmaceutics
7

Scopus Publications

6

Scholar Citations

2

Scholar h-index

Scopus Publications

  • Analytical and bioactivity-based evaluation of Callistemon citrinus: HPTLC fingerprinting, marker quantification, and antioxidant potential of Hydroalcoholic extracts
    Shankul kumar, Vedant Kumar Prajapati, Shashi Ranjan Singh, Utkarsh Kumar, Sumitra Nain
    Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences, 2026
  • Alkaloids in Cardiovascular Health and Disease Management
    Shankul Kumar, Vedant Kumar Prajapati, Arvind Kumar Patel, Shashi Ranjan Singh, Sumitra Nain
    Alkaloids from Medicinal Plants and their Transformative Applications, 2026
    Alkaloids are significant organic nitrogenous molecules that represent a wealth of information for medication development. Cardiovascular illnesses include congestive heart failure, hypertension, angina pectoris, atherosclerosis, cerebral and peripheral vascular disease, venous insufficiency, and arrhythmia. High mortality and morbidity are related to cardiovascular illnesses linked to hypertension and hyperlipidemia. The most recent and accessible data on alkaloids and their revolutionary role in cardiovascular health and illness prevention were gathered from several sources (PubMed, ScienceDirect, Google Scholar, and Springer Link). This chapter highlights the molecular mechanisms of action of these secondary metabolites, cardiovascular biomarkers, the clinical relevance of cardiovascular biomarkers, and a critical review of the use of naturally occurring alkaloids in treating cardiovascular illness and maintaining cardiovascular health.
  • Extraction and Characterization Techniques for Phenolic Compounds from Medicinal Plants
    Shankul Kumar, Vedant Kumar Prajapati, Arvind Kumar Patel, Shashi Ranjan Singh, Sumitra Nain
    Phenolic Compounds from Medicinal Plants Pharmaceutical and Health Benefts, 2026
    Phenolic compounds are widely present in medicinal plants that are responsible for their medicinal properties. The various extraction and characterization techniques employed to isolate and characterize phenolic compounds from medicinal plants are discussed in this chapter. Traditional methods of extraction, such as hydrodistillation, Soxhlet extraction, and maceration, are discussed, as well as newer methods, including ultrasound-assisted extraction, supercritical fluid extraction, and microwave-assisted extraction. Spectroscopic methods, such as UV–Visible, Fourier transform infrared (FTIR), and nuclear magnetic resonance (NMR) spectroscopy, as well as chromatographic methods like high-performance liquid chromatography (HPLC) and gas chromatography–mass spectrometry (GC–MS), also fall under the umbrella of characterization methods. Supported by a robust framework for the isolation and characterization of phenolic compounds from medicinal plants, this detailed analysis enables researchers and practitioners to utilize these compounds effectively in pharmaceuticals, nutraceuticals, and other health products.
  • Anti-Obesity Activity of Phenolic Compounds
    Sumitra Nain, Arvind Kumar Patel, Omsatyam, Shankul Kumar, Vinod Kumar Singh, Vedant Kumar Prajapati
    Phenolic Compounds from Medicinal Plants Pharmaceutical and Health Benefts, 2026
    The potential anti-obesity properties of phenolic compounds, a diverse group of bioactive compounds commonly found in plant-based foods, have garnered considerable attention. The functions of particular phenolic compounds, including cinnamic acid, quercetin, apigenin, catechins, naringenin, and daidzein, in preventing obesity through different pathways are studied in this chapter. Apigenin and kaempferol have been shown in vitro to decrease fat accumulation in human adipocytes produced from mesenchymal stem cells. By altering the expression of genes linked to triglyceride buildup and adipogenesis, promoting lipolysis, and, in certain situations, preventing lipogenesis, these phenolic compounds lower the triglyceride level of adult adipocytes. Several plants contain polyphenols, which have been demonstrated in animal models to reduce fat storage, block fatty acid production, and promote β-oxidation. Activating the sirtuin 1 and AMPK pathways, resveratrol, another well-researched polyphenol, improves energy metabolism and lowers obesity. In animal research, quercetin has shown promise in lowering body weight increase and increasing insulin sensitivity. There are several obstacles to overcome before the anti-obesity properties of phenolic compounds can be applied to humans, as observed in laboratory and animal models. Inconsistent clinical results are caused by variations in doses, bioavailability, study methods, and individual characteristics, including age, gender, and genetics. Understanding the effectiveness of phenolics is further complicated by the intricate relationships they have with other dietary components and the way the gut flora metabolizes them. To determine uniform dosage schedules, evaluate any adverse effects, and validate the therapeutic potential of these substances in the treatment of obesity, more carefully planned, extended clinical trials are required.
  • IoT-Enabled healthcare ecosystems: innovations in remote monitoring, patient outcomes, and digital transformation
    Shankul Kumar, Vedant Kumar Prajapati, Shashi Ranjan Singh, Arvind Kumar Patel, Pushpraj Singh, Manish Singh
    Informatics for Health and Social Care, 2026
    The monitoring, diagnosis, and treatment of patients has been completely transformed by the Internet of Things (IoT) in healthcare, especially in underprivileged and distant locations. IoT-enabled remote patient monitoring (RPM) makes it possible to gather and transmit health data like heart rate, glucose levels, and blood pressure in real-time, facilitating proactive and individualized care. IoT-enabled smart wearable devices like smartwatches, ECG patches, and fitness bands track physical activity and health parameters provide real-time data to clinicians via mobile apps or cloud servers and empower patients with self-monitoring tools. IoT-enabled RFID tags to locate critical medical equipment (e.g. ventilators, infusion pumps) enhances operational efficiency and reduces loss or theft and assists in hospital inventory and supply chain management. IoT devices facilitate real-time consultation with physicians using health data from patients and bridges the healthcare gap in rural and underserved areas. With a focus on RPM systems, Smart Wearables and RFID tags this chapter examines the architecture, technology, uses, and advantages of IoT in healthcare. The difficulties with interoperability, system integration, security, and data privacy are also covered. IoT has the revolutionary potential to improve healthcare outcomes, lower readmission rates to hospitals, and improve the quality of life for patients with chronic illnesses, as demonstrated by case studies and recent advances.
  • Hydrogel-based gene therapy
    Shweta Kumari, Dipti Jena, Vedant Kumar Prajapati, Shashi Ranjan Singh, Garima Tripathi
    Integration of Biomaterials for Gene Therapy, 2023
    Gene therapy (GT) relies heavily on the adoption of safe delivery vehicles that do not cause any adverse side effects or immunological reactions. Biodegradable and biocompatible polymeric nanocarriers are being used for gene delivery due to their unique properties such as excellent bio-incompatibility, prolonged gene circulation time, prevention of gene degradation, passive targeting, and the ability to modify polymer structure. Biomaterials are playing a pivotal role in medical technologies that aim to transport medicinal chemicals to patients in hospitals and other clinical settings. Recent advances in our understanding of the role biomaterials play in gene therapy have stoked excitement in the generation of several nucleic acid agents for the treatment of numerous diseases. This investigation focuses on the importance of interdisciplinary teams in the development of contemporary hydrogels for performing complex biological activities like cancer immunotherapy, tissue engineering, and immunization. Hydrogels are biocompatible hydrogels that can be used for integrated sensing and therapeutics. They have potential applications in gene transfer, regenerative medicine, genetic diseases, and medication delivery. Hydrogels have high water content and mild gelation conditions, making them useful for gene transfer. They can also be used to promote transplanted or endogenously infiltrating cells, heal or restore the function of damaged or injured tissues, and act as vectors for therapeutic genes. New developments in hydrogel manufacture for distribution have resulted from a greater knowledge of the design aspects, which include physical and biological components, transgene expression, cell engraftment, and cell function.
  • Photodynamic Therapy of Cancer: Quality and Prospective of Therapy based on Photosensitizer
    Rishabha Malviya, Arun Kumar Singh, Ankita Moharana, Vedant Kumar Prajapati, Ashish Kumar Nirmal
    Current Cancer Therapy Reviews, 2023
    To kill cancer cells, photodynamic therapy (PDT) utilizes a light-sensitive medication and light. Light-sensitive drugs are absorbed by cancerous cells. The cells are then illuminated with a specific light or laser by a specialist and oxygen that destroys cancer cells is released. The present study aims to discuss the roles, advancements, and limitations of photodynamic therapy in cancer treatment. Photosensitizers and photosensitizing agents are used in photodynamic treatment to destroy cancer cells. Lasers or other light sources, such as LEDs, may provide illumination. There are reports of a novel nanoplatform for the treatment of HER2-overexpressed breast cancer, as well as other primary and metastatic cancers, using fluorescent electron microscopy PDT/photothermal therapy (PTT) dualtherapy. PDT has a significant benefit over conventional cancer therapies because it may cause fewer adverse effects. PDT-induced immunostimulatory cell death and the production of a robust local inflammatory response might lead to effective local anticancer therapy. PDT has a lower long-term morbidity and recovery time than surgery, chemotherapy, or radiation.

RECENT SCHOLAR PUBLICATIONS

  • Analytical and bioactivity-based evaluation of Callistemon citrinus: HPTLC fingerprinting, marker quantification, and antioxidant potential of Hydroalcoholic extracts
    VK Prajapati, SR Singh, U Kumar, S Nain
    Journal of Chromatography B, 125065 , 2026
    2026.0
  • Alkaloids in Cardiovascular Health and Disease Management
    S Kumar, VK Prajapati, AK Patel, SR Singh, S Nain
    Alkaloids From Medicinal Plants and Their Transformative Applications, 134-145 , 2026
    2026.0
  • IoT-Enabled healthcare ecosystems: innovations in remote monitoring, patient outcomes, and digital transformation
    S Kumar, VK Prajapati, SR Singh, AK Patel, P Singh, M Singh
    Informatics for Health and Social Care, 1-24 , 2026
    2026.0
  • Hydrogel‐Based Gene Therapy
    S Kumari, D Jena, VK Prajapati, SR Singh, G Tripathi
    Integration of Biomaterials for Gene Therapy, 77-115 , 2023
    2023.0
  • Photodynamic Therapy of Cancer: Quality and Prospective of Therapy based on Photosensitizer
    AK Singh, R Malviya, A Moharana, VK Prajapati, AK Nirmal
    Current Cancer Therapy Reviews 19 (3), 223-236 , 2023
    2023.0
    Citations: 3
  • DESIGN AND IN-VITRO EVALUATION OF OSMOTICALLY CONTROLLED RELEASE TABLET OF INDOMETHACIN FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
    VK Prajapati, SR Singh, G Tripathi, V Kumar, GL Patel, G Lal
    Journal of Data Acquisition and Processing 38 (2), 4685 , 2023
    2023.0
  • Development and evaluation of fast dissolving amlodipine besylate tablets
    S Sinha, VK Prajapati
    World J. Pharm. Res 13, 1921-1931 , 2021
    2021.0
    Citations: 1
  • HIGHLIGHTING CONCEPT OF FAST DISSOLVING TABLETS: A
    S Sinha, VK Prajapati, VK Patel
    2021.0
  • A Systematic Review on Ophthalmic Drug Delivery System and its Future Perspective Challenges
    RK Dubey, BK Kumawat, VK Patel, VK Prajapati, G Lal
    World Journal of Pharmaceutical Research 10, 480-497 , 2021
    2021.0
    Citations: 2
  • Anti-Obesity Activity of Phenolic Compounds
    S Nain, AK Patel, S Kumar, VK Singh, VK Prajapati
    Phenolic Compounds from Medicinal Plants, 169-189 , 0
  • Extraction and Characterization Techniques for Phenolic Compounds from Medicinal Plants
    S Kumar, VK Prajapati, AK Patel, SR Singh, S Nain
    Phenolic Compounds from Medicinal Plants, 45-59 , 0
  • Green Synthesis of Silver Nanoparticles of Morus Rubra Leaves Extract
    K Prajapati

MOST CITED SCHOLAR PUBLICATIONS

  • Photodynamic Therapy of Cancer: Quality and Prospective of Therapy based on Photosensitizer
    AK Singh, R Malviya, A Moharana, VK Prajapati, AK Nirmal
    Current Cancer Therapy Reviews 19 (3), 223-236 , 2023
    2023.0
    Citations: 3
  • A Systematic Review on Ophthalmic Drug Delivery System and its Future Perspective Challenges
    RK Dubey, BK Kumawat, VK Patel, VK Prajapati, G Lal
    World Journal of Pharmaceutical Research 10, 480-497 , 2021
    2021.0
    Citations: 2
  • Development and evaluation of fast dissolving amlodipine besylate tablets
    S Sinha, VK Prajapati
    World J. Pharm. Res 13, 1921-1931 , 2021
    2021.0
    Citations: 1
  • Analytical and bioactivity-based evaluation of Callistemon citrinus: HPTLC fingerprinting, marker quantification, and antioxidant potential of Hydroalcoholic extracts
    VK Prajapati, SR Singh, U Kumar, S Nain
    Journal of Chromatography B, 125065 , 2026
    2026.0
  • Alkaloids in Cardiovascular Health and Disease Management
    S Kumar, VK Prajapati, AK Patel, SR Singh, S Nain
    Alkaloids From Medicinal Plants and Their Transformative Applications, 134-145 , 2026
    2026.0
  • IoT-Enabled healthcare ecosystems: innovations in remote monitoring, patient outcomes, and digital transformation
    S Kumar, VK Prajapati, SR Singh, AK Patel, P Singh, M Singh
    Informatics for Health and Social Care, 1-24 , 2026
    2026.0
  • Hydrogel‐Based Gene Therapy
    S Kumari, D Jena, VK Prajapati, SR Singh, G Tripathi
    Integration of Biomaterials for Gene Therapy, 77-115 , 2023
    2023.0
  • DESIGN AND IN-VITRO EVALUATION OF OSMOTICALLY CONTROLLED RELEASE TABLET OF INDOMETHACIN FOR THE TREATMENT OF RHEUMATOID ARTHRITIS
    VK Prajapati, SR Singh, G Tripathi, V Kumar, GL Patel, G Lal
    Journal of Data Acquisition and Processing 38 (2), 4685 , 2023
    2023.0
  • HIGHLIGHTING CONCEPT OF FAST DISSOLVING TABLETS: A
    S Sinha, VK Prajapati, VK Patel
    2021.0
  • Anti-Obesity Activity of Phenolic Compounds
    S Nain, AK Patel, S Kumar, VK Singh, VK Prajapati
    Phenolic Compounds from Medicinal Plants, 169-189 , 0
  • Extraction and Characterization Techniques for Phenolic Compounds from Medicinal Plants
    S Kumar, VK Prajapati, AK Patel, SR Singh, S Nain
    Phenolic Compounds from Medicinal Plants, 45-59 , 0
  • Green Synthesis of Silver Nanoparticles of Morus Rubra Leaves Extract
    K Prajapati