SANTOSH KUMAR VERMA

@quantumuniversity.edu.in

Professor, Department of Pharmacy
Quantum University

SANTOSH KUMAR VERMA


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https://researchid.co/verma2us

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacy, Pharmacology, Toxicology and Pharmaceutics
14

Scopus Publications

603

Scholar Citations

11

Scholar h-index

15

Scholar i10-index

Scopus Publications

  • Therapeutic Index of Herbal Medicine in Pandemic COVID-19: A Review
    N. Tyagi, S. Verma, Ajeet
    Letters in Applied Nanobioscience, 2022
    The study of this review focus on effective herbal medicine against COVID-19. There have been many such plants on which a lot of research has been done earlier, and these have been very good for health as we know that the current situation of the whole world is very serious with the novel COVID-19 virus epidemic. Hence, people consume a lot of herbal medicine to increase their immunity, such as kadha (brewing), and it is also very effective against this viral infection. If we take brewing in the proper dose, research should be done from clinical trials. We have been taking many medicines since old times and have been doing research on them which is Antiviral and useful in different types of infection caused by bacteria, viruses, microbes, etc. The plant's diversity included their chemical constituents, showing the promise of their therapeutic level against the antiviral activity, without any toxicity with plasma concentration. Many plants show effectively against viral infections that are Flavonoids, Glycosides, polyphenols, alkaloids, etc.. Still, any clinical trials on humans do not prove their proper research on them, but the Chinese system of medicine claimed that Traditional Chinese medicine improves the COVID-19 patient. According to this review, we aim to collate data of plants the various large in the quantity of natural active constituents from individual medicinal plant species that may have potential therapeutic efficacy. The continuing development of novel antiviral drugs needs to isolate and synthesize more new active constituents.
  • Antihyperglycemic activity of typha elephantina leaves using in vivo and in vitro techniques
    Supriya Agnihotri, Gurvirender Singh, Santosh Kumar Verma
    Research Journal of Pharmacy and Technology, 2021
    Looking at the increasing prevalence and inadequate treatments for diabetes mellitus, this study was carried to trace out hypoglycemic potentials of Typha elephantina leaves using in vitro and in vivo studies. α -amylase and α-glucosidase in vitro enzyme inhibition assay were incorporated to determine percent inhibition of Typha elephantina extracts. Typha elephantina methanol extract (TEME) at 125µg/ml in both α-amylase and α-glucosidase exhibited 57.48±1.42 and 53.64±0.92 percent inhibition in contrast to 66.7±0.94 and 70.31±1.25 of standard Acarbose, respectively. However, results obtained in Typha elephantina petroleum ether and chloroform extracts were insignificant. Further TEME antidiabetic properties were investigated by in vivo study, using Streptozotocin induced diabetic rats. Selected 250mg/kg and 500mg/kg doses of TEME were administered orally, which significantly (𝑃 < 0.001) reduces blood glucose of treated animals in contrast to diabetic control. 500mg/kg dose of TEME reduces blood glucose more efficiently. A significant linear rise of body weight and HDL were observed, while there was also remarkable reduction in cholesterol, TG, LDL, VLDL. Reduction in Liver function SGOT, SGPT along with creatinine and urea levels were observed in contrast to diabetic control group. In addition, antioxidant study of Typha elephantina extracts reflected significant results in comparison to that of ascorbic acid in DPPH and H2O2 assay. The whole study signified that Typha elephantina has hypoglycemic potentials.
  • Gastroprotective and antioxidant mechanism of litchi chinensis leaf extract
    Vivek Srivastava, Babita Viswakarma, Neha Mathur, Santosh Kumar Verma
    Research Journal of Pharmacy and Technology, 2021
    Litchi chinensis has been used to treat gastric ulcers in ayurvedic medicine but its efficacy was not validated yet. The dried leaves of Litchi chinensis were powdered and subjected to extraction with 90% ethanol using soxhlet extraction method. The extract was subjected to preliminary phytochemical analysis and was estimated for antiulcer activity against Ethanol induced ulcer model and cold stress-induced ulcer. The activity was assessed in Wistar rats at a dose of 200mg/kg orally and compared with ranitidine (45mg/kg). The extract showed significant lower the ulcer index in ethanol-induced ulcers as well as showed a significant reduction in cold stress-induced ulcers. Besides, it also shows concomitant attenuation of the level of antioxidant enzyme catalase and SOD. These findings indicate the ethanolic extract of Litchi chinensis exhibits convincing antiulcer action.
  • Ameliorative effect of Albizzia procera leaves extract against experimentally induced gastric ulcer models in Wistar albino rats
    Vivek Srivastava, Santosh Kumar Verma, Neha Mathur, Kapil Kumar Goel
    Journal of Applied and Natural Science, 2021
    Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model and pylorus ligation model, respectively. Additionally, the extract also prohibited the formation of haemorrhage and edema, significantly lessened catalase activity (p<0.0001) and the lipid peroxidation level (p<0.0001) in the glandular tissue of Wistar albino rats. Furthermore, the extract also significantly diminished the total acidity(p<0.0001) of the gastric fluid by increasing its pH (p<0.0001). The occupancy of different phytoconstituents in the extract, such as flavonoids and tannins were identified that may be responsible for its gastro-protective activity. All these results provide a basis explaining the antiulcer ability of A. procera being useful in the management of gastric ulcers.
  • Favipiravir may acts as covid-19 main protease pdb id 6lu7 inhibitor: Docking analysis
    Ajeet, B. Aggarwal, S. Verma
    Biointerface Research in Applied Chemistry, 2020
    Coronavirus is a well-known threat to the human being in the form of COVID-19. Virus replication may be controlled by inhibition of protease enzyme. Hence, well known 13 antiviral drugs have been observed by docking analysis for understanding the binding pattern of drugs with COVID-19 main protease PDB ID: 6LU7 for any possibilities of protease inhibition. For docking analysis PyRx- Python Prescription 0.8 was used. This analysis reveals that the essential amino acids involved in binding of antiviral drugs to COVID-19 main protease PDB ID: 6LU7 are Glycine (Gly), Serine (Ser), Cysteine (Cys), Leucine (Leu), Asparagine (Asn), Glutamine (Gln), Glutamic acid (Glu) and Threonine (Thr). After docking analysis, it was observed that Favipiravir maybe act as COVID-19 main protease inhibitor despite being vRNA polymerase inhibitor and may further be used in the treatment of COVID-19 infection.
  • Development of solid dispersions of clopidogrel using innate excipient: Synergistic antiplatelet activity
    Chander Pal Singh Verma, Santosh Verma, Mahendra Singh Ashawat, Vinay Pandit
    Indian Journal of Pharmaceutical Education and Research, 2020
    Aim: The present study encompasses on formulation and evaluation of solid dispersion of Clopidogrel, Class II drug-using pectin extracted from mango peel. Materials and Methods: Pectin was extracted from full-grown mango peel grown in the Kangra region. Solid dispersions were prepared using kneading, hot fusion method and solvent wetting method and the solvent wetting method were gauged and optimized. The prepared solid dispersions were subjected to solubility analysis and selected optimized formulation was further subjected to DSC, PXRD, in-vitro Dissolution and in-vitro antiplatelet activity. The in-vitro release studies are subjected to mathematical data analysis using DD Solver 1.0 version. Results: Extracted pectin from mango peel was light brown in color and soluble in water. The screened carriers PVPK30 and extracted pectin showed the enhanced solubility of pure drug. The pectin was further selected for the formulation of solid dispersions by three different methods. The solvent wetting method has given expected results and the formulation SD6 containing drug: pectin ratio 1:2 was selected and evaluated. The in-vitro release has shown 91.2 % in 60 min with a mean dissolution time of 14.64 min and dissolution efficiency of 0.691%. The formulation SD6 has shown 87.1 ±1.8 % antiplatelet activities whereas pure drug has shown 71.9 ±2.1% indicating enhanced activity. Conclusion: It was concluded that the pectin extracted from ripened mango peels can be a suitable carrier for the formulation of solid dispersion of clopidogrel which not only enhances the solubility but also resulted in the enhanced antiplatelet activity. PICTORIAL ABSTRACT Mr. Chander Pal Singh Verma, working as Professor & Head, Department of Pharmacognosy at Laureate Institute of Pharmacy, Kathog, Jawlamukhi. He is currently pursuing his doctoral studies at Motherhood University, Roorkee, UP. Prof. Verma has a keen interest in Herbal medicines and excipients obtained from natural resources. Professor has published and presented a number of research and review articles in a number of reputed national/ international journals. Dr. Santosh Kumar working Uttara Professor has published and presented a number of research and review articles in a number of reputed national/ international journals. His area of research is novel drug delivery systems. has guided more than 40 PG and 2 doctoral research works.
  • Synthesis and anti-inflammatory activity of some novel quinazolinone derivatives
    Fabad Journal of Pharmaceutical Sciences, 2020
  • Quinazolinone novel derivatives synthesis and their biological evaluation as antimicrobial and antitubercular agents
    Neha Krishnarth, Santosh Kumar Verma, Anurag
    International Journal of Research in Pharmaceutical Sciences, 2019
    At a global level, tuberculosis (TB) is the disease of human values. It suffers from major health, social and economic burden in many countries. There is an inability of an effective vaccine or the use of vaccine were too long and expensive, have increased risk of spread of this disease. A series of quinazolinone derivatives prepared with the help of 2-Amino-3,4,5-trimethoxy benzoic acid and Vilsmeir reagent. Synthesized compounds were characterized by various spectral methods. Different activity like antimicrobial activity of the synthesised compounds were performed, and the most active compounds of the series were further screened for antitubercular activity against bacteria mycobacterium H37Rv. Results showed that all the synthesized compounds have antimicrobial activity. Compounds IV c, IV f, IV h and IV o showed maximum activity in the synthesized series. These four compounds further screened for antitubercular activity. Compounds IV c, IV f, IV h and IV o showed significant antitubercular activity.
  • Mechanistic role of varuna (Crataeva nurvala) extract on thyroid gland and its histology through iodothyronine deiodinases
    Arshvir Kaur, Santosh Kumar Verma
    Asian Journal of Pharmaceutical and Clinical Research, 2018
    Objective: Crataeva nurvala (CN) is used for its therapeutic effects, but its effect on the thyroid gland in euthyroid conditions and mechanism behind its thyrotropic activity in hypothyroidism is still not explored. This study screened the pharmacological effect of the ethanolic extract of the bark of CN on thyroid hormones, free and total thyroxine (FT4 and T4), triiodothyronine (T3), thyroid-stimulating hormone (TSH) levels, and thyroid histology in normal Swiss albino female mice.Methods: Eighteen animals of 28–33 g were segregated into three groups: Group I treated with vehicle (NOR+VEH), Group II administered CN 400 mg/kg (NOR+CN 400), and Group III given CN 600 mg/kg (NOR+CN 600), for 15 days, per os (p.o.). The variation in the T4, FT4, T3, and TSH levels was recorded using ELISA, 24 h after the last dose, and T3/T4 ratio thus calculated along with the histopathological studies of the thyroid gland.Results: The findings were presented as mean ± standard error of the mean, using one-way ANOVA, followed by Dunnett’s post-tests to compare all columns with the control. NOR+CN 600 has shown thyroid protective effect through retaining euthyroid profile, normal T3/T4 ratio, and near-normal histology. However, NOR+CN 400 had shown the significant decline in T3/T4 ratio and pathological changes in thyroid histology, in comparison with the control and NOR+VEH group.Conclusion: The higher dose of CN was found to sustain the euthyroid levels through retention of iodothyronine deiodinases activity, facilitating the peripheral conversion of T4 to T3, and in retaining normal histoarchitecture of the thyroid gland in contrary to a lower dose.
  • Optimization of extraction protocol of Parmelia perlata and its validation for protective effects against oxalate-induced renal injury in NRK-52E cells
    Parveen Kumar Goyal, Santosh Kumar Verma, Anil Kumar Sharma
    Journal of Herbal Medicine, 2018
  • Evaluation of antiurolithiatic effects of Parmelia perlata against calcium oxalate calculi in hyperoxaluric rats
    P. Goyal, S. Verma, A. Sharma
    Journal of Applied Pharmaceutical Science, 2018
  • Potential thyrotropic and antihypercholesteronemic activity exhibited by ethanolic extract of Crataeva nurvala bark
    Arshvir Kaur, N. Khurana, S. Verma
    Journal of Applied Pharmaceutical Science, 2017
  • Antiurolithiatic potential of neeri against calcium-oxalate stones by crystallization inhibition, free radicals scavenging, and NRK-52E cell protection from oxalate injury
    AnilKumar Sharma, ParveenKumar Goyal, SantoshKumar Verma
    Pharmacognosy Magazine, 2017
  • Nutraceutical Formulations and Challenges
    Raj K. Keservani, Rajesh K. Kesharwani, Anil K. Sharma, Surya P. Gautam, Santosh K. Verma
    Developing New Functional Food and Nutraceutical Products, 2017

RECENT SCHOLAR PUBLICATIONS

  • Transforming India’s dairy landscape: The rise of startups and pathways to sustainable growth
    V Kumar, S Aiswarya, M Gururaj, N Saxena
    Indian Journal of Animal Health 64 (2), 243-254 , 2025
    2025
  • Cancer: Pathology of the century act as big killers: A disease with uncontrolled division of cells
    RKSS Amit Sharma, Santosh Kumar Verma
    Journal of Pharmacognosy and Phytochemistry 14 (1), 272-275 , 2025
    2025
    Citations: 1
  • A qualitative study to understand sociocultural beliefs around
    A Ahuja, M Duggal, JY Liu, P Sharma, D Hosapatna Basavarajappa, ...
    Social Determinants of Women's Health in Low and Middle Income Countries, 47 , 2024
    2024
    Citations: 2
  • Targeted Sequencing of Regulatory Regions Shows Potential Snvs Affecting FXN Gene Expression in Friedreich's Ataxia Patients
    V Swarup, H Singh, V Kumar, D Gupta, A Ahuja, I Singh, R Rajan, ...
    MOVEMENT DISORDERS 38, S317-S317 , 2023
    2023
  • Molecular drivers of prostate cancer pathogenesis and therapy resistance
    GK Patel, SK Verma, S Misra, G Chand, RN Rao
    Frontiers in Cell and Developmental Biology 11, 1239478 , 2023
    2023
    Citations: 3
  • An attention mechanism-based LSTM network for cancer kinase activity prediction
    Danishuddin, V Kumar, G Lee, J Yoo, HS Ro, KW Lee
    SAR and QSAR in Environmental Research 33 (8), 631-647 , 2022
    2022
    Citations: 3
  • D, Zeb A, Singh P, Lee G, Jung TS, Lee KW and Ha MW (2022) 3D-QSAR-Based Pharmacophore Modeling, Virtual Screening, and Molecular Dynamics Simulations for the Identification of …
    V Kumar, S Parate
    Front. Cell. Infect. Microbiol. 12: 909111. doi: 10.3389/fcimb , 2022
    2022
  • The supply is there. So why can’t pregnant and breastfeeding women in rural India get the COVID-19 vaccine? PLOS Glob Public Health 2 (12): e0001321
    NG Diamond-Smith, P Sharma, M Duggal, N Gill, J Gupta, V Kumar
    2022
    Citations: 1
  • Floristic diversity of angiosperms in aquatic and marshy habitats within floodplain and residual relieves of ranipur wild life sanctuary, UP, India.
    RB Yadav, A Kumar, SK Verma, LJ Singh
    Plant Archives (09725210) 21 (2) , 2021
    2021
    Citations: 1
  • Effect of Ethanolic Extract of Crataeva nurvala Bark on Iodothyronine Deiodinases Oxidative Stress and Thyroid Histology in 6-Propyl-2-Thiouracil Induced Hypothyroid Mice Model.
    AKSK Verma
    Bioscience Biotechnology Research Communications 14 (9), 58-163 , 2021
    2021
  • Seasonal and temporal variations of ambient aerosols in a deciduous broadleaf forest from northern Japan: Contributions of biomass burning and biological particles
    MM Haque, SK Verma, DK Deshmukh, B Kunwar, Y Miyazaki, ...
    Chemosphere 279, 130540 , 2021
    2021
    Citations: 9
  • Thin Layer Chromatography of Solanum Xanthocarpum Schard. Wendl.(Ethanolic, Hydroalcoholic and aqueous extracts).
    N Tyagi, A Kumar, S Verma
    Annals of the Romanian Society for Cell Biology 25 (7) , 2021
    2021
  • Fifatrol, An Ayurvedic Formulation- A Prospective Multi-Center Observational Study On The Symptoms of Upper Respiratory Tract Infections
    MCS Santosh Kumar Verma, Abdul Haye, Shubham Saxena, Mohammad Junaid
    International Research Journal of Ayurveda & Yoga 4 (6), 21-30 , 2021
    2021
  • Covid The Third Wave
    A Sharma, SK Verma, MN Tyagi, S Sharma, OP Yadav
    International journal of innovative research in technology, 198-200 , 2021
    2021
    Citations: 4
  • Ameliorative effect of Albizzia procera leaves extract against experimentally induced gastric ulcer models in Wistar albino rats
    KKG Vivek Srivastava, Santosh Kumar Verma, Neha Mathur
    Journal of Applied and Natural Science 13 (1), 308-315 , 2021
    2021
    Citations: 2
  • Gastroprotective and Antioxidant mechanism of Litchi chinensis Leaf extract
    V Srivastava, B Viswakarma, N Mathur, SK Verma
    Research Journal of Pharmacy and Technology 14 (3), 1705-1710 , 2021
    2021
  • BN Sugarcane Bagasse as a Co-Substrate with Oil-Refinery Biological Sludge for Biogas Production Using Batch Mesophilic Anaerobic Co-Digestion Technology: Effect of Carbon …
    AAS Ghaleb, SRM Kutty, GHA Salih, AH Jagaba, A Noor, V Kumar, ...
    s Note: MDPI stays neutral with regard to jurisdictional claims in published … , 2021
    2021
    Citations: 3
  • Black Fungus “Pandemic With In the Pandemic”
    A Sharma, SK Verma, MS Sharma, OP Yadav
    International Journal of All Research Education and Scientific Methods 9 (5 … , 2021
    2021
    Citations: 6
  • Pharmacognostical & phytochemical standardization of Solanum xanthocarpum (whole plant).
    N Tyagi, A Kumar, S Verma
    2021
  • CNS Acting Potential of Natural Products with Special Reference to Family Solanaceae
    N Tyagi, A Sharma, KS Verma, MS Sharma
    Systematic Reviews in Pharmacy 12 (4), 219-223 , 2021
    2021
    Citations: 1

MOST CITED SCHOLAR PUBLICATIONS

  • Anti-inflammatory activity of Aconitum heterophyllum on cotton pellet-induced granuloma in rats
    SOMR Santosh Verma
    Journal of Medicinal Plants Research 4 (15), 1566-1569 , 2010
    2010
    Citations: 107
  • Nutraceutical Formulations and Challenges
    SKV Raj K. Keservani, Rajesh K. Kesharwani, Anil K. Sharma, Surya P. Gautam
    Developing New Functional Food and Nutraceutical Products 1, 161-177 , 2017
    2017
    Citations: 55
  • Plant derived alkaloids in major neurodegenerative diseases: from animal models to clinical trials
    DP Shikha Girdhar, Amit Girdhar, Santosh Kumar Verma, Viney Lather
    Journal of Ayurvedic and Herbal Medicine 1 (3), 91-100 , 2015
    2015
    Citations: 44
  • PHARMACOLOGICAL AND PHYTOCHEMICAL ASPECTS OF LICHEN PARMELIA PERLATA: A REVIEW
    SAK Goyal Parveen Kumar, Verma Santosh Kumar
    International Journal of Research in Ayurveda and Pharmacy 7 (Suppl 1), 102-107 , 2016
    2016
    Citations: 31
  • Antilithiatic potential of Vernonia cinerea against calcium oxalate calculi in experimental rats
    AKS Parveen Kumar Goyal, Santosh Kumar Verma
    The Journal of Phytopharmacology 6 (2), 149-155 , 2017
    2017
    Citations: 15
  • Quantification of Total Phenolic and Flavonoid Contents, and Evaluation of Free Radical Scavenging Potential of Vernonia cinerea
    AKS Parveen Kumar Goyal, Santosh Kumar Verma
    Asian Pacific Journal of Health Sciences 4 (3), 279-287 , 2017
    2017
    Citations: 14
  • A brief review on phytopharmacological reports on Albizia procera
    SV Vivek Srivastava, Santosh kumar Verma, Surbhi Panwar, Prakash Deep
    Asian Journal of Pharmacy and Pharmacology 6 (2), 144-149 , 2020
    2020
    Citations: 13
  • In vitro antioxidant activity of different extract of Ganoderma lucidum
    K Agarwal, GS Chakarborthy, S Verma
    DHR Int J Pharm Sci 3, 48-54 , 2012
    2012
    Citations: 13
  • A Review on Different Types of Animal Models for Pharmacological Evaluation of Antidiabetic Drugs
    AKS Sangeeta Saini, Savita Kumari, Santosh Kumar Verma
    International Journal of Pharmaceutical and Phytopharmacological Research 3 … , 2013
    2013
    Citations: 12
  • An overview of carcinogenic pollutants in groundwater of India. Biocatal Agric Biotechnol 21: 101288
    SK Malyan, R Singh, M Rawat, M Kumar, A Pugazhendhi, A Kumar, ...
    2019
    Citations: 11
  • Antiurolithiatic potential of neeri against calcium-oxalate stones by crystallization inhibition, free radicals scavenging, and NRK-52E cell protection from oxalate injury
    AKS Parveen Kumar Goyal, Santosh Kumar Verma
    Pharmacognosy Magazine 13 (51), 549-554 , 2017
    2017
    Citations: 11
  • Synthesis and anti-inflammatory activity of some novel quinazolinone derivatives
    N Krishnarth, SK Verma, A Chaudhary
    FABAD Journal of Pharmaceutical Sciences 45 (3), 205-210 , 2020
    2020
    Citations: 10
  • Favipiravir May Acts as COVID-19 Main Protease PDB ID 6LU7 Inhibitor: Docking Analysis
    SKV Ajeet , Babita Aggarwal
    Biointerface Research in Applied Chemistry 10 (06), 6821 - 6828 , 2020
    2020
    Citations: 10
  • Prevalence and seasonal variation in ixodid ticks on buffaloes of Mathura district, Uttar Pradesh, India
    G Patel, D Shanker, AK Jaiswal, V Sudan, SK Verma
    Buffalo Bull 34 (1), 21-28 , 2015
    2015
    Citations: 10
  • Measurement of memory in children: construction of a simple clinical tool in Hindi
    A Kohli, M Mohanty, R Malhotra, SK Verma
    Behav Med J 1 (1), 34-42 , 1998
    1998
    Citations: 10
  • Seasonal and temporal variations of ambient aerosols in a deciduous broadleaf forest from northern Japan: Contributions of biomass burning and biological particles
    MM Haque, SK Verma, DK Deshmukh, B Kunwar, Y Miyazaki, ...
    Chemosphere 279, 130540 , 2021
    2021
    Citations: 9
  • Quinazolinone novel derivatives synthesis and their Biological Evaluation as Antimicrobial and Antitubercular agents
    A Neha Krishnarth, Santosh Kumar Verma
    International Journal of Research in Pharmaceutical Sciences 10 (4), 3026-3034 , 2019
    2019
    Citations: 9
  • Characterisation of molecular beam epitaxy-grown InGaAs multilayer structures using photoluminescence
    T Srinivasan, R Muralidharan, SK Mehta, BP Jain, SN Singh, RK Jain, ...
    Vacuum 60 (4), 425-429 , 2001
    2001
    Citations: 9
  • Political economy of inequality in ownership holdings in India: An analysis of 70th round NSS data
    S Verma, R Roy
    Man & Development 41 (3), 1-20 , 2019
    2019
    Citations: 8
  • Foreign body bronchus—presenting with asthma
    AS Khurana, SK Verma, BS Sohal
    Indian Journal of Otolaryngology and Head and Neck Surgery 52 (1), 107-108 , 1999
    1999
    Citations: 8