Dr. M VIJAYA BHASKAR REDDY
@mlrit.ac.in
Associate Professor
MLR Institution of Technology
EDUCATION
1) S.S.C.(1990)
2) Intermediate (1992)
3) B.Sc. (1995)
4) M.Sc. (1998)
5) Ph.D. (2003)
RESEARCH, TEACHING, or OTHER INTERESTS
Organic Chemistry, Plant Science, Pharmaceutical Science, Cancer Research
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Mopur Vijaya Bhaskar Reddy, Hsin-Yi Hung, Ping-Chung Kuo, Guan-Jhong Huang, Yu-Yi Chan, Shiow-Chyn Huang, Shwu-Jen Wu, Susan L. Morris-Natschke, Kuo-Hsiung Lee, and Tian-Shung Wu
Elsevier BV
Meng-Liang Lin, Shih-Shun Chen, Ren-Yu Huang, Yao-Cheng Lu, Yu-Ren Liao, Mopuru Vijaya Bhaskar Reddy, Chuan-Chun Lee, and Tian-Shung Wu
Springer Science and Business Media LLC
Guan-Jhong Huang, M. Vijaya Bhaskar Reddy, Ping-Chung Kuo, Chieh-Hung Huang, Hung-Cheng Shih, E.-Jian Lee, Mei-Lin Yang, Yann-Lii Leu, and Tian-Shung Wu
Elsevier BV
M. Vijaya Bhaskar Reddy, Yuh-Chiang Shen, Emika Ohkoshi, Kenneth F. Bastow, Keduo Qian, Kuo-Hsiung Lee, and Tian-Shung Wu
Elsevier BV
M. Vijaya Bhaskar Reddy, Wei-Jern Tsai, Keduo Qian, Kuo-Hsiung Lee, and Tian-Shung Wu
Elsevier BV
Mopuru Vijaya Bhaskar Reddy, Shih-Shun Chen, Meng-Liang Lin, Hsiu-Hui Chan, Ping-Chung Kuo, and Tian-Shung Wu
Pharmaceutical Society of Japan
The chalcone basic skeleton is a unique template which is associated with widespread biological activities. In the present study, a series of novel bichalcones linked with a 1,4-dimethylenepiperazine moiety was prepared through Mannich reaction and Clasien-Schmidt condensation. The synthetic analogs 2-16 were subjected into the cytotoxicity examinations using a panel of 25 human tumor cell lines. Among the tested compounds, 3 and 4 which possessed the 3-pyridyl and phenyl groups as the substructure, respectively, displayed significant cytotoxicity against all the tumor cell lines. The results suggested that these bichalcones were potential to be the anticancer lead drugs.
Jalli Madhu Sudhana, Rachakunta Munikishore, Mopuru Vijayabhaskar Reddy, Duvvuru Gunasekar, Alain Blond, and Bernard Bodo
SAGE Publications
A new acylated labdane diterpenoid, 14-deoxy-3,19-diacetyl-11,12-didehydroandrographolide (1), together with three known labdane diterpenoids, wightionolide (2), andrographolide (3) and neoandrographolide (4), and three known flavones, echioidinin (5), skullcapflavone I 2′-methyl ether (6) and echioidin (7), were isolated from the whole plant of Andrographis wightiana. The structure of compound 1 was elucidated by 1D and extensive 2D-NMR spectral studies.
Hsiu-Hui Chan, Tsong-Long Hwang, Mopur Vijaya Bhaskar Reddy, Ding-Tzai Li, Keduo Qian, Kenneth F. Bastow, Kuo-Hsiung Lee, and Tian-Shung Wu
American Chemical Society (ACS)
Two new saponins, panajaponol (1) and pseudoginsenoside RT1 butyl ester (2), together with 35 known compounds (3-37), were isolated from the roots of Panax japonicus var. major. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis and chemical methods. Furthermore, a LC-MS/MS method was developed for confirming 2, 3, and 8 as natural compounds containing a butyl ester group. This method should be useful for distinguishing between minor natural and artifactual compounds in Panax species. Moreover, compounds 3, 6, 8, 9, 11, 13, and 15 exhibited strong inhibition of superoxide anion generation and elastase release by human neutrophils in response to formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B (fMLP/CB), with IC(50) values ranging from 0.78 to 43.6 μM. In addition, 1 showed greater than 2- to 3-fold selective cytotoxic activity against KB and DU145 cancer cell lines.
M. Vijaya Bhaskar Reddy, Tsong-Long Hwang, Yann-Lii Leu, Wen-Fei Chiou, and Tian-Shung Wu
Elsevier BV
Hsiu-Hui Chan, Tsong-Long Hwang, Chung-Ren Su, Mopur Vijaya Bhaskar Reddy, and Tian-Shung Wu
Elsevier BV
Hsiu-Hui Chan, Han-Dong Sun, Mopur Vijaya Bhaskar Reddy, and Tian-Shung Wu
Elsevier BV
J. Madhusudhana, R.V. Narahari Reddy, B.A.K. Reddy, M.V.B. Reddy, D. Gunasekar, A. Deville, and B. Bodo
Informa UK Limited
Two new geranyl flavanones, (2S)-5,4′-dihydroxy-7-O-[(E)-3,7-dimethyl-2,6-octadienyl]flavanone (1) and (2S)-5,4′-dihydroxy-7-O-[(E)-3,7-dimethyl-2,6-octa-dienyl]-8-C-[(E)-3,7-dimethyl-2,6-octadienyl]flavanone (2), together with three known compounds, 7-O-methylglabranin (3), tephcalostan (4) and 12a-dehydro-6-hydroxysumatrol (5), were isolated from the roots of Tephrosia villosa. The structures of these compounds were determined by extensive spectral studies.
M. Vijaya Bhaskar Reddy, Chung-Ren Su, Wen-Fei Chiou, Yi-Nan Liu, Rosemary Yin-Hwa Chen, Kenneth F. Bastow, Kuo-Hsiung Lee, and Tian-Shung Wu
Elsevier BV
Ramireddy V. Narahari Reddy, Nimmanapalli P. Reddy, Shaik I. Khalivulla, Mopuru V. Bhaskar Reddy, Duvvuru Gunasekar, Alain Blond, and Bernard Bodo
Elsevier BV
Chung-Ren Su, Yune-Fang Ueng, Nguyen Xuan Dung, M. Vijaya Bhaskar Reddy, and Tian-Shung Wu
American Chemical Society (ACS)
Four new furanoditerpenoids, fibrauretin A ( 1), fibrauretinoside A ( 2), epi-fibrauretinoside A ( 3), and epi-12-palmatoside G ( 4), and a new ecdysteroid glucoside, fibraurecdyside A ( 5), together with seven known compounds including two furanoditerpenoids ( 6 and 7), an ecdysteroid ( 8), and four quaternary protoberberine alkaloids ( 9- 12) were isolated from the stems of Fibraurea tinctoria. The structures of 1- 5 were established on the basis of spectroscopic evidence. Among these compounds, palmatine ( 9) and jatrorrhizine ( 10) showed inhibitory effects against cytochrome P450 3A4 (CYP3A4) with IC 50 values of 0.9 and 2.1 microM, respectively.
Li-Shian Shi, Mopur Vijaya Bhaskar Reddy, Hsiu-Ju Yan, Wen-Liang Chang, and Hang-Ching Lin
Wiley
A new ent-trachylobane diterpenoid, saposebifeic acid, together with thirteen known compounds, were isolated from the roots of Sapium sebiferum. Compounds, 5,7,8-trimethoxycoumarin, baccatin, n-alkyl trans-ferulate and 2,6-dimethoxyquinone, were reported for the first time from this plant. The structures of the new and known compounds were established on the basis of extensive 1D and 2D NMR spectral data.
P. Hari Kishore, M. Vijaya Bhaskar Reddy, D. Gunasekar, Cristelle Caux, and Bernard Bodo
Informa UK Limited
A new naphthoquinone, 2,7-dihydroxy-8-formyl-5-isopropyl-3-methyl-1,4-naphthoquinone (1) together with a known naphthoquinone, 8-formyl-7-hydroxy-5-isopropyl-2-methoxy-3-methyl-1,4-naphthoquinone (2), has been isolated from the heartwood of Ceiba pentandra. The structures of 1 and 2 have been elucidated by extensive 1D and 2D NMR experiments.
Pennaka Hari Kishore, Mopuru Vijaya Bhaskar Reddy, Duvvuru Gunasekar, Madugula Marthanda Murthy, Cristelle Caux, and Bernard Bodo
Pharmaceutical Society of Japan
Muntha Kesava Reddy, Mopuru Vijaya Bhaskar Reddy, Galla Jayakrishna, Duvvuru Gunasekar, Cristelle Caux, and Bernard Bodo
Pharmaceutical Society of Japan
Two new flavonoids, 5, 7, 2', 5'-tetramethoxyflavanone (1) and 5-hydroxy-7, 2'-dimethoxyflavone (2), together with two known flavones, skullcapflavone I (3) and echioidin (4) were isolated from the whole plant of Andrographis rothii. The structures of the new compounds were established by extensive one- and two-dimensional (1D- and 2D-) NMR spectral studies.
M. Vijaya Bhaskar Reddy, P. Hari Kishore, C. Venkata Rao, D. Gunasekar, Cristelle Caux, and Bernard Bodo
American Chemical Society (ACS)
Three new 2'-oxygenated flavonoids, (2S)-5,7,2',3',4'-pentamethoxyflavanone (1), 5-hydroxy-7,8,2',5'-tetramethoxyflavone (2), and echioidinin 2'-O-beta-d-(6' '-O-acetyl) glucopyranoside (3), together with four known flavonoids, 7-O-methyldihydrowogonin, 7-O-methylwogonin, skullcapflavone I 2'-methyl ether, and skullcapflavone I, and two diterpenoids, andrograpanin and 14-deoxy-11,12-didehydroandrographolide, were isolated from the whole plant of Andrographis affinis. The structures were elucidated by spectral and chemical studies.
Muntha Kesava Reddy, Mopuru Vijaya Bhaskar Reddy, Bandi Anil Kumar Reddy, Duvvuru Gunasekar, Cristelle Caux, and Bernard Bodo
Pharmaceutical Society of Japan
Two new flavonoids, 2',4',6',2,3,4-hexamethoxychalcone (1) and 5-hydroxy-7,2',5'-trimethoxyflavone (2) together with a known flavone glycoside, echioidinin 5-O-beta-D-glucopyranoside (3) were isolated from the whole plant of Andrographis neesiana, and the structures were elucidated by electrospray ionization tandem mass spectrometry (ESI-MS/MS) and one- and two-dimensional (1D- and 2D)-NMR spectral studies including 1H-1H correlation spectroscopy (COSY), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond connectivity (HMBC) and nuclear Overhauser enhancement spectroscopy (NOESY) experiments.
Mopuru Vijaya Bhaskar Reddy, Muntha Kesava Reddy, Duvvuru Gunasekar, Madugula Marthanda Murthy, Cristelle Caux, and Bernard Bodo
Pharmaceutical Society of Japan
A new sesquiterpene lactone, 5-isopropyl-3-methyl-2,4,7-trimethoxy-8,1-naphthalene carbolactone (1) together with a known naphthoquinone, 8-formyl-7-hydroxy-5-isopropyl-2-methoxy-3-methyl-1,4-naphthoquinone (2) were isolated from the root bark of Bombax malabaricum. The structures of these two compounds were established by extensive one- and two-dimensional (1D- and 2D)-NMR spectral studies.
Mopuru V.B Reddy, Muntha K Reddy, Duvvuru Gunasekar, Cristelle Caux, and Bernard Bodo
Elsevier BV
P. Hari Kishore, M. Vijaya Bhaskar Reddy, M. Kesava Reddy, D. Gunasekar, Cristelle Caux, and Bernard Bodo
Elsevier BV
RECENT SCHOLAR PUBLICATIONS
MOST CITED SCHOLAR PUBLICATIONS
RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)
1) Patent filed on the topic on “DEVELOPMENT OF IMAGE PROCESSING BASED FRUIT SPOILED DETECTION SYSTEM” with the application number 202141008722A. (2001).
2) Patent filed on the topic on “SYNTHESI AND BIOLOGICAL EVALUATION OF CINNAMIC ACID DERIVATIVE AS POTENT ANTIMICROBIAL AGENTS” with the application number 202341070550 (2003).
Industry, Institute, or Organisation Collaboration
7) Associate Professor, Department of Chemistry, MLRIT
6). Associate Professor, Department of Chemistry, Malla Reddy Engineering College (autonomous), Maisammaguda, Secunderabad, Telangana. 08/07/2016 to 30/04/2024. (Ratified as Associate Professor by JNTUH).
5). Associate Professor, Holymary Institute of Technology & Science, Keesara, Hyderabad, Telangana. 10/11.2014 to 30/06/2016. (Ratified as Associate Professor by JNTUH).
4). Senior Executive Scientist, Cavinkare Pvt, Ltd., Chennai, T.N. 26/03/2012 to 31/12/2013.
3). Research scholar, Plant and Soil Sciences Building, Michigan State University, East Lansing, Mchigan, USA, 48824, 01/09/2011 to 31-12-2011.
2). Postdoctoral Fellow, Department of Chemistry, National Cheng Kung University, Tainan 701,Taiwan, R.O.C. 01/06/ 2006 to 31/03/2011.
1). Postdoctoral Fellow, School of Pharmacy, National Defence Medical Center, Taipei, Taiwan, R.O.C. 19/02/ 2004 to 30/05/ 2006.
SOCIAL, ECONOMIC, or ACADEMIC BENEFITS
NPTEL COURSES COMPLETED:
1) Online NPTEL course completed in the duration of July-December-2019 on the topic of “Bioenergy” in Biotechnology discipline with “Elite Silver” (77%).
2) Online NPTEL course completed in the duration of July-December-2020 on the topic of “Coordination compounds and transition metals” in chemistry discipline with 65%.
3) Online NPTEL workshop completed in the duration of July- 2022 on the topic of “High Resolution NMR Spectroscopy in Liquids and Solids: Principles and Analysis of organised by IISC Bangalore.
4) Online NPTEL course completed in the duration of July-December-2023 on the topic of “Hydrogen energy: Production, Storage, Transportation and Safety” in chemistry discipline with “Elite Silver” (78%).
5) Online NPTEL course completed in the duration of January-April-2024 on the topic of “Industrial Inorganic Chemistry” in chemistry discipline with “Elite Silver” (78%).
6) Online NPTEL course completed in the duration of January-April-2024 on the topic of “NBA Accreditation and Teaching Learning in Engineering (NATE)” in multidiscipline with “Elite Silver” (78%).
IMPORTANT FDP’S ATTENDED:
1. AICTE Training and Learning (ATAL) Academy FDP successfully completed on the topic on "Capacity Building" from 2020-10-12 to 2020-10-16 at University of Petroleum and Energy Studies.
2. AICTE Training and Learning (ATAL) Academy FDP successfully completed on the topic on "Waste Technology" from 2020-11-2 to 2020-11-6 at L.D.COLLEGE OF ENGINE