Synthesis, crystal structure and biological properties of a fluorophore-labelled mixed-ligand copper(II) complex incorporating N-hydroxynaphthalene-1,8-dicarboximide Satish Shantaram Bhat, Vitthal A. Kawade, Vidyanand K. Revankar, Vijay Kumbar, Kishore Bhat Acta Crystallographica Section C Structural Chemistry, 2022 The mixed-ligand fluorophore-labelled copper(II) complex aqua[2,4-dioxo-3-azatricyclo[7.3.1.05,13]trideca-1(12),5,7,9(13),10-pentaen-3-olato-κ2 O 2,O 3](1,10-phenanthroline-κ2 N,N′)copper(II) nitrate, [Cu(C12H6NO3)(C12H8N2)(H2O)]NO3·CH3OH or [Cu(L)(phen)(H2O)]NO3·CH3OH (where phen is 1,10-phenanthroline and HL is N-hydroxynaphthalene-1,8-dicarboximide), (1), was synthesized and structurally characterized. The structure of (1) was confirmed by single-crystal X-ray structure determination. The complex crystallized in the triclinic space group P-1. The geometry around the copper centre is distorted square pyramidal, with the apical position occupied by a water molecule. The complex is highly fluorescent in organic and aqueous solutions. It has good anticancer activity, with an IC50 value of 17 µM, which is almost five times greater than cisplatin (IC50 = 82 µM) under identical experimental conditions.
Design, synthesis, crystal structure and spectral characterization of copper (II) complexes of the heterocyclic aroylhydrazones: Antimicrobial and antitubercular activity studies GS Hegde, SS Bhat, S Shaikh, V Kamat, VK Revankar Inorganica Chimica Acta 579, 122568 , 2025 2025 Citations: 6
Dinuclear copper (II) complexes bridged with acetate and nitrate anions: Study of protein binding and in-vitro anticancer activity SA Shaikh, SS Bhat, VK Revankar, S Naveen, NK Lokanath, V Kumbar Inorganica Chimica Acta 559, 121799 , 2024 2024 Citations: 8
Synthesis, crystal structure, DNA and protein binding study of N-(4-pyridyl)-1, 8-naphthalimide copper (II) complex SA Shaikh, SS Bhat, V Kamat, VK Revankar Inorganic Chemistry Communications 158, 111456 , 2023 2023 Citations: 7
Co (II), Ni (II), Cu (II) and Zn (II) complexes of 1, 8-naphthalimide-based ligand: syntheses, characterizations and evaluation of antibacterial activities SA Shaikh, SS Bhat, VK Revankar, N S, Mahesha, NK Loknath, V Kumbar Journal of Coordination Chemistry 76 (13-15), 1586-1603 , 2023 2023 Citations: 2
Influence of counter ions on supramolecular structures of copper (II) complexes derived from 1, 8-naphthalimide tecton SA Shaikh, SS Bhat, PL Hegde, VK Revankar, K Kumara, NK Lokanath, ... Journal of Molecular Structure 1271, 134086 , 2023 2023 Citations: 6
Synthesis, crystal structure and biological properties of a fluorophore-labelled mixed-ligand copper (II) complex incorporating N-hydroxynaphthalene-1, 8-dicarboximide SS Bhat, VA Kawade, VK Revankar, V Kumbar, K Bhat Crystal Structure Communications 78 (12), 755-759 , 2022 2022
Syntheses, structural characterization and evaluation of the anti-tubercular activity of copper (II) complexes containing 3-methoxysalicylaldehyde-4-methylthiosemicarbazone PL Hegde, SS Bhat, VK Revankar, SA Shaikh, K Kumara, L NK Journal of Molecular Structure 1257, 132589 , 2022 2022 Citations: 19
Synthesis, characterization and biological properties of Ruthenium (II) polypyridyl complexes containing 2 (1H)-quinolinone-3 (1H-imidazo [4, 5f][1, 10] phenanthrolin-2-yl SS Bhat, VK Revankar, RV Pinjari, V Kumbar, K Bhat, VA Kawade Inorganic Chemistry Communications 138, 109260 , 2022 2022 Citations: 8
Synthesis, structural characterization and biological properties of cyclometalated iridium (III) complexes containing 2-methyl-3-{(E)-[(quinolin-2-yl) methylidene] amino … RS Vadavi, SS Bhat, VK Revankar, KB Gudasi, NK Lokanath, RV Pinjari, ... Inorganica Chimica Acta 531, 120735 , 2022 2022 Citations: 2
Syntheses and structural characterization of metal complexes of 4-(naphthalen-1-yl)-1-(quinolin-2-yl)methylene)thiosemicarbazide: their in-vitro screening studies … PL Hegde, K Naik, SS Bhat, SA Shaikh, RJ Butcher, N S, NK Lokanath, ... Journal of Coordination Chemistry 74 (17-20), 3018-3030 , 2022 2022
Copper (I) complexes with quinolone appended 1, 8-naphthalimide conjugates: structural characterization, DNA and protein binding and cytotoxicity studies SA Shaikh, SS Bhat, VK Revankar, K Kumara, NK Lokanath, RJ Butcher, ... New Journal of Chemistry 46 (35), 16801-16812 , 2022 2022 Citations: 5
Fluorophore tagged mixed ligand copper (II) complexes: synthesis, structural characterization, protein binding, DNA cleavage and anticancer activity SA Shaikh, SS Bhat, VK Revankar, BD Kulkarni, K Kumara, NK Lokanath, ... ChemistrySelect 6 (45), 12666-12676 , 2021 2021 Citations: 4
8-Hydroxyquinoline derived p-halo N4-phenyl substituted thiosemicarbazones: Crystal structures, spectral characterization and in vitro cytotoxic studies of their Co (III), Ni … A Kotian, V Kamat, K Naik, DG Kokare, K Kumara, KL Neratur, V Kumbar, ... Bioorganic Chemistry 112, 104962 , 2021 2021 Citations: 40
The Co (II), Ni (II), Cu (II) and Zn (II) complexes of aroylhydrazone of quinolone core: syntheses, characterization and evaluation of antimicrobial and antitubercular activity GS Hegde, SS Bhat, SP Netalkar, PL Hegde, A Kotian, RJ Butcher, ... Inorganica Chimica Acta 522, 120352 , 2021 2021 Citations: 18
Hydroxyacetone derived N4-methyl substituted thiosemicarbazone: Syntheses, crystal structures and spectroscopic characterization of later first-row transition metal complexes A Kotian, V Kamat, K Naik, DG Kokare, K Kumara, NK Lokanath, ... Journal of Molecular Structure 1224, 129055 , 2021 2021 Citations: 13
Synthesis, structural characterization, protein binding, DNA cleavage and anticancer activity of fluorophore labelled copper (II) complexes based on 1, 8-naphthalimide conjugates SA Shaikh, SS Bhat, PL Hegde, VK Revankar, A Kate, D Kirtani, ... New Journal of Chemistry 45 (35), 16319-16332 , 2021 2021 Citations: 20
Synthesis, Structural Characterization and Hirshfeld Surface Analysis of Mixed Ligand Copper (II) Complex NA Shaikh, SN Rathod, SS Bhat, S Shaikh, VK Revankar, NK Lokanath Chemical Data Collections 28, 100374 , 2020 2020 Citations: 2
Highly sensitive and selective colorimetric probe for detection of Cu2+ in aqueous medium based on rhodamine B SS Bhat, A Kotian, S Shaikh, PL Hegde, RV Pinjari, VK Revankar Chemical data collections 26, 100359 , 2020 2020 Citations: 7
Regio-and diastereoselective synthesis of novel polycyclic pyrrolo [2, 1-a] isoquinolines bearing indeno [1, 2-b] quinoxaline moieties by a three-component [3+ 2]-cycloaddition … FM Moghaddam, A Moafi, B Jafari, A Vilinger, P Langer Synlett 31 (03), 267-271 , 2020 2020 Citations: 15
Synthesis, structural characterization and biological properties of cyclometalated iridium (iii) complexes containing [1, 2, 5]-thiadiazolo-[3, 4-f]-[1, 10]-phenanthroline SS Bhat, S Naveen, VK Revankar, NK Lokanath, RV Pinjari, V Kumbar, ... New Journal of Chemistry 44 (40), 17442-17452 , 2020 2020 Citations: 2
MOST CITED SCHOLAR PUBLICATIONS
Synthesis and antitumor studies on novel Co (II), Ni (II) and Cu (II) metal complexes of bis (3-acetylcoumarin) thiocarbohydrazone MP Sathisha, UN Shetti, VK Revankar, KSR Pai European journal of medicinal chemistry 43 (11), 2338-2346 , 2008 2008 Citations: 136
Transition metal complexes of thiosemicarbazone: Synthesis, structures and invitro antimicrobial studies PP Netalkar, SP Netalkar, VK Revankar Polyhedron 100, 215-222 , 2015 2015 Citations: 126
Synthesis, crystal structures and characterization of late first row transition metal complexes derived from benzothiazole core: Anti-tuberculosis activity and special emphasis … PP Netalkar, SP Netalkar, S Budagumpi, VK Revankar European journal of medicinal chemistry 79, 47-56 , 2014 2014 Citations: 101
Transition metal complexes of thiosemicarbazones with quinoxaline hub: an emphasis on antidiabetic property NV Kulkarni, VK Revankar, BN Kirasur, MH Hugar Medicinal Chemistry Research 21 (5), 663-671 , 2012 2012 Citations: 101
Synthesis, structure, electrochemistry, and spectral characterization of bis‐isatin thiocarbohydrazone metal complexes and their antitumor activity against Ehrlich ascites … MP Sathisha, VK Revankar, KSR Pai Metal‐Based Drugs 2008 (1), 362105 , 2008 2008 Citations: 90
Pyrazole bridged binuclear transition metal complexes: Synthesis, characterization, antimicrobial activity and DNA binding/cleavage studies NV Kulkarni, A Kamath, S Budagumpi, VK Revankar Journal of Molecular structure 1006 (1-3), 580-588 , 2011 2011 Citations: 74
Synthesis and spectroscopy of CoII, NiII, CuII and ZnII complexes derived from 3, 5-disubstituted-1H-pyrazole derivative: A special emphasis on DNA binding and cleavage studies S Budagumpi, NV Kulkarni, GS Kurdekar, MP Sathisha, VK Revankar European journal of medicinal chemistry 45 (2), 455-462 , 2010 2010 Citations: 72
Symmetric binuclear complexes with an ‘end-off’compartmental Schiff base ligand SM Annigeri, AD Naik, UB Gangadharmath, VK Revankar, VB Mahale Transition metal chemistry 27 (3), 316-320 , 2002 2002 Citations: 66
4-Aminoantipyrine-based Schiff-base transition metal complexes as potent anticonvulsant agents GS Kurdekar, MP Sathisha, S Budagumpi, NV Kulkarni, VK Revankar, ... Medicinal Chemistry Research 21 (9), 2273-2279 , 2012 2012 Citations: 60
Synthesis, characterization, antibiogram and DNA binding studies of novel Co (II), Ni (II), Cu (II), and Zn (II) complexes of Schiff base ligands with quinoline core GS Kurdekar, S Mudigoudar Puttanagouda, NV Kulkarni, S Budagumpi, ... Medicinal Chemistry Research 20 (4), 421-429 , 2011 2011 Citations: 56
Spectroscopic studies of bridged binuclear complexes of Co (II), Ni (II), Cu (II) and Zn (II) SM Annigeri, MP Sathisha, VK Revankar Transition Metal Chemistry 32 (1), 81-87 , 2007 2007 Citations: 56
Synthesis, crystal structure and biological properties of a cis-dichloridobis (diimine) copper (II) complex SS Bhat, VK Revankar, V Kumbar, K Bhat, VA Kawade Crystal Structure Communications 74 (2), 146-151 , 2018 2018 Citations: 54
Structural diversity in dinickel (II) complexes of thiosemicarbazones AD Naik, SM Annigeri, UB Gangadharmath, VK Revankar, VB Mahale Journal of molecular structure 616 (1-3), 119-127 , 2002 2002 Citations: 51
Synthesis, structure, electrochemistry and spectral characterization of (D-glucopyranose)-4-phenylthiosemicarbazide metal complexes and their antitumor activity against Ehrlich … MP Sathisha, S Budagumpi, NV Kulkarni, GS Kurdekar, VK Revankar, ... European journal of medicinal chemistry 45 (1), 106-113 , 2010 2010 Citations: 49
Design, synthesis and physico-chemical investigation of a dinuclear zinc (II) complex with a novel ‘end-off’compartmental ligand AD Naik, VK Revankar Journal of Chemical Sciences 113 (4), 285-290 , 2001 2001 Citations: 44
8-Hydroxyquinoline derived p-halo N4-phenyl substituted thiosemicarbazones: Crystal structures, spectral characterization and in vitro cytotoxic studies of their Co (III), Ni … A Kotian, V Kamat, K Naik, DG Kokare, K Kumara, KL Neratur, V Kumbar, ... Bioorganic Chemistry 112, 104962 , 2021 2021 Citations: 40
Anchoring mercapto-triazoles on dicarbonyl backbone to assemble novel binucleating, acyclic SNONS compartmental ligands AD Naik, M Satish, B Umesh, VK Revankar, VB Mahale, VK Reddy Indian Journal of Chemistry Section A 41 (10), 2046-2053 , 2002 2002 Citations: 38
Coordination diversity of new mononucleating hydrazone in 3d metal complexes: synthesis, characterization and structural studies RS Baligar, VK Revankar Journal of the Serbian Chemical Society 71 (12), 1301-1310 , 2006 2006 Citations: 37
Ligational behavior of a bidentate coumarin derivative towards CoII, NiII, and CuII: synthesis, characterization, electrochemistry, and antimicrobial studies S Budagumpi, UN Shetti, NV Kulkarni, VK Revankar Journal of Coordination Chemistry 62 (24), 3961-3968 , 2009 2009 Citations: 36
Synthesis, characterisation and evaluation of molecular-orbital parameters, spin-orbit, dipolar and fermi-contact terms of VO2+ ion in thiosemicarbazone complexes UB Gangadharmath, SM Annigeri, AD Naik, VK Revankar, VB Mahale Journal of Molecular Structure: THEOCHEM 572 (1-3), 61-71 , 2001 2001 Citations: 36
