Mariusz Winiecki

@ukw.edu.pl

Faculty of Materials Engineering
Kazimierz Wielki University

https://researchid.co/winiecki

RESEARCH, TEACHING, or OTHER INTERESTS

Biomaterials, Bioengineering

Scopus Publications

396

Scholar Citations

Scholar h-index

Scholar i10-index

Scopus Publications

Micro-CT Assessment During Embedding of Prototype Ti Alloy Multi-Spiked Connecting Scaffold in Subchondral Trabecular Bone of Osteoarthritic Femoral Heads, Depending on Host BMI
Ryszard Uklejewski, Mariusz Winiecki, Adam Patalas, Patryk Mietliński, Paweł Zawadzki, and Mikołaj Dąbrowski
MDPI AG
The prototype of a biomimetic multi-spiked connecting scaffold (MSC-Scaffold) represents an essential innovation in the fixation in subchondral trabecular bone of components for a new generation of entirely cementless hip resurfacing arthroplasty (RA) endoprostheses. In designing such a functional biomaterial scaffold, identifying the microstructural and mechanical properties of the host bone compromised by degenerative disease is crucial for proper post-operative functioning and long-term maintenance of the endoprosthesis components. This study aimed to explore, depending on the occurrence of obesity, changes in the microstructure and mechanical properties of the subchondral trabecular bone in femoral heads of osteoarthritis (OA) patients caused by the MSC-Scaffold embedding. Computed microtomography (micro-CT) scanning of femoral heads from OA patients was conducted before and after the mechanical embedding of the MSC-Scaffold. Bone morphometric parameters such as bone volume/total volume (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N) for regions surrounding the MSC-Scaffold were computed, and the mechanical properties such as bone density (ρB), bone compressive strength (S), and the Young’s modulus (E) within these regions were calculated. A statistically significant increase in BV/TV (by 15.0% and 24.9%) and Tb.Th (by 13.1% and 42.5%) and a decrease in Tb.N (by 15.2% and 23.6%) were observed, which translates to an increase in ρB (by 15.0% and 24.9%), S (by 28.8% and 49.5%), and E (by 18.0% and 29.8%) in non-obese patients and obese patients, respectively. These changes in properties are favorable for the mechanical loads’ transfer from the artificial joint surface via the MSC-Scaffold to the periarticular trabecular bone of the OA femoral head in the postoperative period.

Advances in Biomimetic Scaffolds for Hard Tissue Surgery
Ryszard Uklejewski and Mariusz Winiecki
MDPI AG
Hard tissues are living mineralized tissues that possess a high degree of hardness and are found in organs such as bones and teeth (enamel, dentin, and cementum) [...]

Effect of Low-Temperature Oxygen Plasma Treatment of Titanium Alloy Surface on Tannic Acid Coating Deposition
Mariusz Winiecki, Magdalena Stepczyńska, Krzysztof Moraczewski, Lukasz Skowronski, Marek Trzcinski, Tomasz Rerek, and Rafał Malinowski
MDPI AG
In this study, the effect of low-temperature oxygen plasma treatment with various powers of a titanium alloy surface on the structural and morphological properties of a substrate and the deposition of a tannic acid coating was investigated. The surface characteristics of the titanium alloy were evaluated by X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), atomic force microscopy (AFM), and contact angle measurements. Following this, the tannic acid coatings were deposited on the titanium alloy substrates and the structural and morphological properties of the tannic acid coatings deposited were subject to characterization by XPS, SEM, and spectroscopic ellipsometry (SE) measurements. The results show that the low-temperature oxygen plasma treatment of titanium alloys leads to the formation of titanium dioxides that contain –OH groups on the surface being accompanied by a reduction in carbon, which imparts hydrophilicity to the titanium substrate, and the effect increases with the applied plasma power. The performed titanium alloy substrate modification translates into the quality of the deposited tannic acid coating standing out by higher uniformity of the coating, lower number of defects indicating delamination or incomplete bonding of the coating with the substrate, lower number of cracks, thinner cracks, and higher thickness of the tannic acid coatings compared to the non-treated titanium alloy substrate. A similar effect is observed as the applied plasma power increases.

Towards the First Generation of Biomimetic Fixation for Resurfacing Arthroplasty Endoprostheses
Ryszard Uklejewski, Mariusz Winiecki, Mikołaj Dąbrowski, and Piotr Rogala
MDPI AG
This paper presents advances in designs of resurfacing arthroplasty endoprostheses that occurred through their historical generations. The critical characteristics of contemporary generation hip resurfacing arthroplasty endoprostheses are given and the failures resulting from the specific generation cemented and short stem fixation of the femoral component are reviewed. On the background of these failures, the critical need arises for an alternative approach to the fixation of components of resurfacing arthroplasty leading towards the first generation of biomimetic fixation for resurfacing arthroplasty endoprostheses. The state of the art of the completed bioengineering research on the first biomimetic fixation for resurfacing arthroplasty endoprostheses is presented. This new design type of completely cementless and stemless resurfacing arthroplasty endoprostheses of the hip joint (and other joints), where endoprosthesis components are embedded in the surrounding bone via the prototype biomimetic multi-spiked connecting scaffold (MSC-Scaffold), initiates the first at all generations of biomimetic endoprostheses of diarthrodial joints.

Prototype of a Biomimetic Multi-Spiked Connecting Scaffold: For a New Generation of Resurfacing Endoprostheses
Ryszard Uklejewski, Piotr Rogala, and Mariusz Winiecki
CRC Press

Subchondral bone relative area and density in human osteoarthritic femoral heads assessed with micro-ct before and after mechanical embedding of the innovative multi-spiked connecting scaffold for resurfacing tha endoprostheses: A pilot study
Mikołaj Dąbrowski, Piotr Rogala, Ryszard Uklejewski, Adam Patalas, Mariusz Winiecki, and Bartosz Gapiński
MDPI AG
The multi-spiked connecting scaffold (MSC-Scaffold) prototype is the essential innovation in the fixation of components of resurfacing total hip arthroplasty (THRA) endoprostheses in the subchondral trabecular bone. We conducted the computed micro-tomography (micro-CT) assessment of the subchondral trabecular bone microarchitecture before and after the MSC-Scaffold embedding in femoral heads removed during long-stem endoprosthesis total hip arthroplasty (THA) of different bone densities from 4 patients with hip osteoarthritis (OA). The embedding of the MSC-Scaffold in subchondral trabecular bone causes the change in its relative area (BA/TA, bone area/total area ratio) ranged from 18.2% to 24.7% (translating to the calculated density ρB relative change 11.1–14.4%, and the compressive strength S relative change 75.3–122.7%) regardless of its initial density (before the MSC-Scaffold embedding). The densification of the trabecular microarchitecture of subchondral trabecular bone due to the MSC-Scaffold initial embedding gradually decreases with the increasing distance from the apexes of the MSC-Scaffold’s spikes while the spatial extent of this subchondral trabecular bone densification ranged from 1.5 to 2.5 mm (which is about half the height of the MSC-Scaffold’s spikes). It may be suggested, despite the limited number of examined femoral heads, that: (1) the magnitude of the effect of the MSC-Scaffold embedding on subchondral trabecular bone densification may be a factor contributing to the maintenance of the MSC-Scaffold also for decreased initial bone density values, (2) the deeper this effect of the subchondral trabecular bone densification, the better strength of subchondral trabecular bone, and as consequence, the better post-operative embedding of the MSC-Scaffold in the bone should be expected.

Titanium-peroxy and peroxide complex functionalities on Ti-6Al-4V alloy effected by modification with active radicals
Mariusz Winiecki and Piotr Krawczyk
Elsevier BV

Bone density micro‐ct assessment during embedding of the innovative multi‐spiked connecting scaffold in periarticular bone to elaborate a validated numerical model for designing biomimetic fixation of resurfacing endoprostheses
Ryszard Uklejewski, Mariusz Winiecki, Adam Patalas, and Piotr Rogala
MDPI AG
Our team has been working for some time on designing a new kind of biomimetic fixation of resurfacing endoprostheses, in which the innovative multi-spiked connecting scaffold (MSC-Scaffold) that mimics the natural interface between articular cartilage and periarticular trabecular bone in human joints is the crucial element. This work aimed to develop a numerical model enabling the design of the considered joint replacement implant that would reflect the mechanics of interacting biomaterials. Thus, quantitative micro-CT analysis of density distribution in bone material during the embedding of MSC-Scaffold in periarticular bone was applied. The performed numerical studies and corresponding mechanical tests revealed, under the embedded MSC-Scaffold, the bone material densification affecting its mechanical properties. On the basis of these findings, the built numerical model was modified by applying a simulated insert of densified bone material. This modification led to a strong correlation between the re-simulation and experimental results (FVU = 0.02). The biomimetism of the MSC-Scaffold prototype that provided physiological load transfer from implant to bone was confirmed based on the Huber–von Mises–Hencky (HMH) stress maps obtained with the validated finite element (FE) model of the problem. The micro-CT bone density assessment performed during the embedding of the MSC-Scaffold prototype in periarticular bone provides insight into the mechanical behaviour of the investigated implant-bone system and validates the numerical model that can be used for the design of material and geometric features of a new kind of resurfacing endoprostheses fixation.

Native osseous CaP biomineral coating on a biomimetic multi-spiked connecting scaffold prototype for cementless resurfacing arthroplasty achieved by combined electrochemical deposition
Ryszard Uklejewski, Mariusz Winiecki, Piotr Krawczyk, and Renata Tokłowicz
MDPI AG
The multi-spiked connecting scaffold (MSC-Scaffold) prototype with spikes mimicking the interdigitations of articular subchondral bone is an essential innovation in surgically initiated fixation of resurfacing arthroplasty (RA) endoprosthesis components. This paper aimed to present a determination of the suitable range of conditions for the calcium phosphate (CaP) potentiostatic electrochemical deposition (ECDV=const) on the MSC-Scaffold prototype spikes to achieve a biomineral coating with a native Ca/P ratio. The CaP ECDV=const process on the MSC-Scaffold Ti4Al6V pre-prototypes was investigated for potential VECDfrom −9 to −3 V, and followed by 48 h immersion in a simulated body fluid. An acid–alkaline pretreatment (AAT) was applied for a portion of the pre-prototypes. Scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and X-ray diffraction (XRD) studies of deposited coatings together with coatings weight measurements were performed. Themost suitable VECD range, from −5.25 to −4.75 V, was determined as the native biomineral Ca/P ratio of coatings was achieved. AAT increases the weight of deposited coatings (44% for VECD = −5.25 V, 9% for VECD = −5.00 V and 15% for VECD = −4.75 V) and the coverage degree of the lateral spike surfaces (40% for VECD = −5.25 V, 14% for VECD = −5.00 V and 100% for VECD = −4.75 V). XRD confirmed that the multiphasic CaP coating containing crystalline octacalcium phosphate is produced on the lateral surface of the spikes of the MSC-Scaffold. ECDV=const preceded by AAT prevents micro-cracks on the bone-contacting surfaces of the MSC-Scaffold prototype, increases its spikes’ lateral surface coverage, and results in the best modification effect at VECD = −5.00 V. To conclude, the biomimetic MSC-Scaffold prototype with desired biomineral coating of native Ca/P ratio was obtained for cementless RA endoprostheses.

First Biomimetic Fixation for Resurfacing Arthroplasty: Investigation in Swine of a Prototype Partial Knee Endoprosthesis
Piotr Rogala, Ryszard Uklejewski, Mariusz Winiecki, Mikołaj Dąbrowski, Jacek Gołańczyk, and Adam Patalas
Hindawi Limited
Resurfacing hip and knee endoprostheses are generally embedded in shallow, prepared areas in the bone and secured with cement. Massive cement penetration into periarticular bone, although it provides sufficient primary fixation, leads to the progressive weakening of peri-implant bone and results in failures. The aim of this paper was to investigate in an animal model the first biomimetic fixation of components of resurfacing arthroplasty endoprostheses by means of the innovative multispiked connecting scaffold (MSC-Scaffold). The partial resurfacing knee arthroplasty (RKA) endoprosthesis working prototype with the MSC-Scaffold was designed for biomimetic fixation investigations using reverse engineering methods and manufactured by selective laser melting. After Ca-P surface modification of bone contacting surfaces of the MSC-Scaffold, the working prototypes were implanted in 10 swines. Radiological, histopathological, and micro-CT examinations were performed on retrieved bone-implant specimens. Clinical examination confirmed very good stability (4 in 5-point Likert scale) of the operated knee joints. Radiological examinations showed good implant fixation (radiolucency less than 2 mm) without any signs of migration. Spaces between the MSC-Scaffold spikes were penetrated by bone tissue. The histological sections showed newly formed trabecular bone tissue between the spikes, and the trabeculae of periscaffold bone were seen in contact with the spikes. The micro-CT results showed the highest percentage of bone tissue ingrowths into the MSC-Scaffold at a distance of 2.5÷3.0 mm from the spikes bases. The first biomimetic fixation for resurfacing arthroplasty was successfully verified in 10 swines investigations using RKA endoprosthesis working prototypes. The performed research shows that the MSC-Scaffold allows for cementless and biomimetic fixation of resurfacing endoprosthesis components in periarticular cancellous bone.

Numerical studies of the influence of various geometrical features of a multispiked connecting scaffold prototype on mechanical stresses in peri-implant bone
Ryszard Uklejewski, Mariusz Winiecki, Adam Patalas, and Piotr Rogala
Informa UK Limited
Abstract The multispiked connecting scaffold (MSC-scaffold) prototype is an essential innovation in the fixation of components of resurfacing arthroplasty (RA) endoprostheses, providing their entirely non-cemented and bone-tissue-preserving fixation in peri-articular bone. An FE study is proposed to evaluate the influence of geometrical features of the MSC-scaffold on the transfer of mechanical load in peri-implant bone. For this study, an FE model of Ti-Alloy MSC-scaffold prototype embedded in a bilinear elastic, transversely isotropic bone material was built. For the compressive load on the MSC-scaffold, maps of Huber-Mises-Hencky (HMH) stress in peri-implant bone were determined. The influence of the distance between the bases of neighbouring spikes, the apex angle of spikes, and the height of the spherical cup of spikes of the MSC-scaffold were analysed. It was found that the changes in the distance between the bases of neighbouring spikes from 0.2 to 0.5 mm cause the HMH stress to increase in bone material by 32%. The changes of the apex angle of spikes from 2° to 4° decrease the HMH stress in bone material by 39%. The changes of height of the spherical cup of spikes from 0 to 0.12 mm increase the HMH stress in bone material by 24%. In conclusion, the spikes’ apex angle and the distance between the bases of spikes of the MSC-scaffold are the key geometrical features determining the appropriate MSC-scaffold prototype design. The built FE model was found to be useful in bioengineering design of the novel fixation system for RA endoprostheses by means of the MSC-scaffold.

Structural-Geometric Functionalization of the Additively Manufactured Prototype of Biomimetic Multispiked Connecting Ti-Alloy Scaffold for Entirely Noncemented Resurfacing Arthroplasty Endoprostheses
Ryszard Uklejewski, Mariusz Winiecki, Piotr Rogala, and Adam Patalas
Hindawi Limited
The multispiked connecting scaffold (MSC-Scaffold) prototype, inspired by the biological system of anchorage of the articular cartilage in the periarticular trabecular bone by means of subchondral bone interdigitations, is the essential innovation in fixation of the bone in resurfacing arthroplasty (RA) endoprostheses. The biomimetic MSC‐Scaffold, due to its complex geometric structure, can be manufactured only using additive technology, for example, selective laser melting (SLM). The major purpose of this work is determination of constructional possibilities for the structural-geometric functionalization of SLM‐manufactured MSC‐Scaffold prototype, compensating the reduced ability—due to the SLM technological limitations—to accommodate the ingrowing bone filling the interspike space of the prototype, which is important for the prototype bioengineering design. Confocal microscopy scanning of components of the SLM‐manufactured prototype of total hip resurfacing arthroplasty (THRA) endoprosthesis with the MSC‐Scaffold was performed. It was followed by the geometric measurements of a variety of specimens designed as the fragments of the MSC-Scaffold of both THRA endoprosthesis components. The reduced ability to accommodate the ingrowing bone tissue in the SLM‐manufactured prototypes versus that in the corresponding CAD models has been quantitatively determined. Obtained results enabled to establish a way of compensatory structural‐geometric functionalization, allowing the MSC‐Scaffold adequate redesigning and manufacturing in additive SLM technology.

Structural and Hydroxyapatite-like Surface Functionalization of Advanced Biomimetic Prototype Interface for RA Endoprostheses to Enhance Osteoconduction and Osteointegration
Ryszard Uklejewski, Ryszard Uklejewski, Piotr Rogala, Mariusz Winiecki, and Mariusz Winiecki
John Wiley & Sons, Inc.

Biomimetic multispiked connecting Ti-alloy scaffold prototype for entirely-cementless resurfacing arthroplasty endoprostheses-exemplary results of implantation of the Ca-P surface-modified scaffold prototypes in animal model and osteoblast culture evaluation
Ryszard Uklejewski, Piotr Rogala, Mariusz Winiecki, Renata Tokłowicz, Piotr Ruszkowski, and Maria Wołuń-Cholewa
MDPI AG
We present here—designed, manufactured, and tested by our research team—the Ti-alloy prototype of the multispiked connecting scaffold (MSC-Scaffold) interfacing the components of resurfacing arthroplasty (RA) endoprostheses with bone. The spikes of the MSC-Scaffold prototype mimic the interdigitations of the articular subchondral bone, which is the natural biostructure interfacing the articular cartilage with the periarticular trabecular bone. To enhance the osteoinduction/osteointegration potential of the MSC-Scaffold, the attempts to modify its bone contacting surfaces by the process of electrochemical cathodic deposition of Ca-P was performed with further immersion of the MSC-Scaffold prototypes in SBF in order to transform the amorphous calcium-phosphate coating in hydroxyapatite-like (HA-like) coating. The pilot experimental study of biointegration of unmodified and Ca-P surface-modified MSC-Scaffold prototypes was conducted in an animal model (swine) and in osteoblast cell culture. On the basis of a microscope-histological method the biointegration was proven by the presence of trabeculae in the interspike spaces of the MSC-Scaffold prototype on longitudinal and cross-sections of bone-implant specimens. The percentage of trabeculae in the area between the spikes of specimen containing Ca-P surface modified scaffold prototype observed in microCT reconstructions of the explanted joints was visibly higher than in the case of unmodified MSC-Scaffold prototypes. Significantly higher Alkaline Phosphatase (ALP) activity and the cellular proliferation in the case of Ca-P-modified MSC-Scaffold pre-prototypes, in comparison with unmodified pre-prototypes, was found in osteoblast cell cultures. The obtained results of experimental implantation in an animal model and osteoblast cell culture evaluations of Ca-P surface-modified and non-modified biomimetic MSC-Scaffold prototypes for biomimetic entirely-cementless RA endoprostheses indicate the enhancement of the osteoinduction/osteointegration potential by the Ca-P surface modification of the Ti-alloy MSC-Scaffold prototype. Planned further research on the prototype of this biomimetic MSC-Scaffold for a new generation of RA endoprostheses is also given.

Effectiveness of various deproteinization processes of bovine cancellous bone evaluated via mechano-biostructural properties of produced osteoconductive biomaterials
Ryszard Uklejewski, Mariusz Winiecki, Grzegorz Musielak, and Renata Tokłowicz
Springer Science and Business Media LLC

Preliminary results of implantation in animal model and osteoblast culture evaluation of prototypes of biomimetic multispiked connecting scaffold for noncemented stemless resurfacing hip arthroplasty endoprostheses
Ryszard Uklejewski, Piotr Rogala, Mariusz Winiecki, Andrzej Kędzia, and Piotr Ruszkowski
Hindawi Limited
We present the new fixation method for RHA(resurfacing hip arthroplasty)endoprostheses by means of the biomimetic multispiked connecting scaffold (MSC-Scaffold). Such connecting scaffold can generate new type of RHA endoprostheses, that is stemless and fixed entirely without cement. The preprototypes of this MSC-Scaffold were manufactured with modern additive laser additive technology (SLM). The pilot surgical implantations in animal model (two laboratory swine) of MSC-Scaffold preprototypes have showed after two months neither implant loosening, migration, and nor other early complications. From the results of performed histopathological evaluation of the periscaffold spikes bone tissue and 10-day culture of human osteoblasts (NHOst) we can conclude that (1) the scaffolding effect was obtained and (2) to improve the osseointegration of the scaffold spikes, their material surface should be physicochemically modified (e.g., with hydroxyapatite). Some histopathological findings in the periscaffold domain near the MSC-Scaffold spikes bases (fibrous connective tissue and metallic particles near the MSC-Scaffold spikes bases edges) prompt considering the necessity to optimize the design of the MSC-Scaffold in the regions of its interspike space near the spikes bases edges, to provide more room for new bone formation in this region and for indispensable post-processing (glass pearl blasting) after the SLM manufacturing.

Computer aided stereometric evaluation of porostructural-osteoconductive properties of intra-osseous implant porous coatings
Ryszard Uklejewski, Mariusz Winiecki, and Piotr Rogala
Polish Academy of Sciences Chancellery
Abstract The proper interaction of bone tissue - the natural porous biomaterial - with a porous coated intra-osseous implant is conditioned, among others, by the implant porous coating poroaccessibility for bone tissue adaptive ingrowth. The poroaccessibility is the ability of implant porous coating outer layer to accommodate the ingrowing bone tissue filling in its pore space and effective new formed bone mineralizing in the pores to form a biomechanically functional bone-implant fixation. The functional features of the microtopography of intra-osseous implant porous surfaces together with the porosity of pore space of the outer layer of the porous coating are called by bioengineers the porostructural-osteoconductive properties of the porous coated implant. The properties are crucial for successful adaptive bone tissue ingrowth and further long-term (secondary) biomechanical stability of the boneimplant interface. The poroaccessibility of intra-osseous implants porous coating outer layers is characterized by - the introduced in our previous papers - set of stereometric parameters of poroaccessibility: the effective volumetric porosity fVef, the index of the porous coating space capacity VPM, the representative surface porosity fSrep, the representative pore size pSrep, the representative angle of the poroaccessibility Wrep and the bone-implant interface adhesive surface enlargement index y. Presented in this paper, an original method of evaluation of the porostructural-osteoconductive properties of intra-osseous implant porous coatings outer layer by means of the parameters of poroaccessibility was preliminary verified during experimental tests performed on the representative examples of porous coated femoral stems and acetabular cups of various hip endoprostheses. The computer-aided stereometric evaluation of the microstructure of implant porous coatings outer layer can be now realized by the authoring application software PoroAccess_1.0 elaborated in our research team in Java programming language

Selective laser melted prototype of original minimally invasive resurfacing hip endoprosthesis
Ryszard Uklejewski, Mariusz Winiecki, Piotr Rogala, and Janusz Mielniczuk
Emerald
PurposeThe aim of this paper is to present the main results of a research project finished in 2008 which concerned the selective laser melted (SLM) prototype of a new kind of minimally invasive resurfacing hip arthroplasty (RHA) endoprosthesis with the original multi‐spiked connecting scaffold (MSC‐Scaffold). Previous attempts performed in pre‐Direct Metal Manufacturing (DMM) era demonstrated that it was impossible to manufacture suitable prototypes of this RHA endoprosthesis (especially of the MSC‐Scaffold) using traditional machining technologies. Owing to an extensive development of DMM technologies observed in recent years the manufacturing of such prototypes has become possible.Design/methodology/approachComputer aided design models of pre‐prototypes and the prototype of the RHA endoprosthesis with MSC‐Scaffold were designed and initially optimized within the claims and the general assumptions of international patents by Rogala. Prototyping in SLM technology was subcontracted to SLM Tech Center (Paderborn, Germany). Macroscopic and SEM microscopic evaluation of the MSC‐Scaffold was performed using SLM manufactured prototypes and paying special attention to the quality and precision of manufacturing.FindingsIt was found that SLM can be successfully applied to manufacturing of prototypes of the original minimally invasive RHA endoprosthesis. The manufacturing quality of the 3D spikes system of the MSC‐Scaffold, which mimics the interdigitations of articular subchondral bone, has been proved to be geometrically corresponding to the biological original. Nevertheless, some pores and non‐melted zones were found in SLM prototyped RHA endoprosthesis cross‐sections which need to be eliminated to minimize the potential risk of clinical failure.Research limitations/implicationsThe presented case study was performed with a limited number of samples. More research needs to be performed on the rapid prototyped samples including microstructural and mechanical tests. The results may enable the optimization of the SLM manufacturing process of the prototypes of the minimally invasive RHA endoprosthesis with MSC‐Scaffold.Practical implicationsThe SLM can be considered as potentially suitable for the fabrication of patient‐fitted minimally invasive RHA endoprostheses with MSC‐Scaffold.Originality/valueFor the first time, largely owing to SLM technology, it was possible to manufacture the prototype of the original minimally invasive RHA endoprosthesis with MSC‐Scaffold suitable for further research.

Prototype of minimally invasive hip resurfacing endoprosthesis - Bioengineering design and manufacturing

The poroaccessibility parameters for three-dimensional characterization of orthopaedic implants porous coatings

RECENT SCHOLAR PUBLICATIONS

Biomimetic Scaffolds for Hard Tissue Surgery
R Uklejewski, M Winiecki
MDPI-Multidisciplinary Digital Publishing Institute 2024

Advances in Biomimetic Scaffolds for Hard Tissue Surgery
R Uklejewski, M Winiecki
Biomimetics 9 (5), 279 2024

Effect of Low-Temperature Oxygen Plasma Treatment of Titanium Alloy Surface on Tannic Acid Coating Deposition
M Winiecki, M Stepczyńska, K Moraczewski, L Skowronski, M Trzcinski, ...
Materials 17 (5), 1065 2024

Towards the First Generation of Biomimetic Fixation for Resurfacing Arthroplasty Endoprostheses
R Uklejewski, M Winiecki, M Dąbrowski, P Rogala
Biomimetics 9 (2), 99 2024

Laser functionalization of medical silicone surface microstructure and investigation of its anisotropic tribological properties
A Patalas, M Winiecki, P Zawadzki, R Uklejewski
Engineering of Biomaterials 2023 (171), 23-29 2023

Prototype of a Biomimetic Multi-spiked Connecting Scaffold for a New Generation of Resurfacing Endoprostheses
R Uklejewski, P Rogala, M Winiecki
Taylor & Francis / CRC Press 2023

Prototyp biomimetycznego rusztowania łączącego z kością komponenty nowej generacji bezcementowych powierzchniowych endoprotez stawowych – projektowanie, badania bioinżynierskie
R Uklejewski, P Rogala, M Winiecki
Akademicka Oficyna Wydawnicza EXIT; ISBN 978-83-7837-115-1 2021

Subchondral Bone Relative Area and Density in Human Osteoarthritic Femoral Heads Assessed with Micro-CT before and after Mechanical Embedding of the Innovative Multi-Spiked
M Dąbrowski, P Rogala, R Uklejewski, A Patalas, M Winiecki, B Gapiński
Journal of Clinical Medicine 10 (13), 2937 2021

Titanium-peroxy and peroxide complex functionalities on Ti-6Al-4V alloy effected by modification with active radicals
M Winiecki, P Krawczyk
Chemical Engineering Science 237, 116543 2021

Biomimetic Multi-Spiked Connecting Scaffold Prototype for Cementless Resurfacing Arthroplasty Achieved by Combined Electrochemical Deposition
R Uklejewski, M Winiecki, P Krawczyk, R Tokłowicz
Bio-Inspired Materials for Biomedical Applications 27, 15 2021

Bio-Inspired Materials for Biomedical Applications
M Pollini, F Paladini
MDPI 2021

Gapi nski, B. Subchondral Bone Relative Area and Density in Human Osteoarthritic Femoral Heads Assessed with Micro-CT before and after Mechanical Embedding of the Innovative
M Dabrowski, P Rogala, R Uklejewski, A Patalas, M Winiecki
J. Clin. Med 10, 2937 2021

Design of initial fixation in bone of customized innovative hip resurfacing endoprosthesis based on validated numerical model of the biomimetic multi-spiked connecting scaffold
R Uklejewski, A Patalas, M Winiecki, P Rogala
Engineering of Biomaterials 24 (163) 2021

Bone Density Micro-CT Assessment during Embedding of the Innovative Multi-Spiked Connecting Scaffold in Periarticular Bone to Elaborate a Validated Numerical Model for
R Uklejewski, M Winiecki, A Patalas, P Rogala
Materials 14 (6), 1384 2021

Stalag XXI B/H Thure. Jeńcy wojenni w Turze w latach II wojny światowej / Prisoners of war in Tur during World War II
J Daniluk, M Winiecki
Polish-American Foundation for the Commemoration of POW Camps in Szubin 2020

Stalag XXI B/H Thure: jeńcy wojenni w Turze w latach II wojny światowej
J Daniluk, M Winiecki
Polsko-Amerykańska Fundacja Upamiętnienia Obozw Jenieckich w Szubinie 2020

Native Osseous CaP Biomineral Coating on a Biomimetic Multi-Spiked Connecting Scaffold Prototype for Cementless Resurfacing Arthroplasty Achieved by Combined Electrochemical
R Uklejewski, M Winiecki, P Krawczyk, R Tokłowicz
Materials 12 (23), 3994 2019

First biomimetic fixation for resurfacing arthroplasty: investigation in swine of a prototype partial knee endoprosthesis
P Rogala, R Uklejewski, M Winiecki, M Dąbrowski, J Gołańczyk, A Patalas
BioMed Research International 2019 (1), 6952649 2019

Numerical studies of the influence of various geometrical features of a multispiked connecting scaffold prototype on mechanical stresses in peri-implant bone
R Uklejewski, M Winiecki, A Patalas, P Rogala
Computer methods in biomechanics and biomedical engineering 21 (9), 541-547 2018

MOST CITED SCHOLAR PUBLICATIONS

Selective laser melted prototype of original minimally invasive resurfacing hip endoprosthesis
R Uklejewski, M Winiecki, P Rogala, J Mielniczuk
Rapid Prototyping Journal 17 (1), 76-85 2011
Citations: 42

Biomimetic Multispiked Connecting Ti-Alloy Scaffold Prototype for Entirely-Cementless Resurfacing Arthroplasty Endoprostheses—Exemplary Results of Implantation of the Ca-P
R Uklejewski, P Rogala, M Winiecki, R Tokłowicz, P Ruszkowski, ...
Materials 9 (7), 532 2016
Citations: 22

Preliminary Results of Implantation in Animal Model and Osteoblast Culture Evaluation of Prototypes of Biomimetic Multispiked Connecting Scaffold for Noncemented Stemless
R Uklejewski, P Rogala, M Winiecki, A Kędzia, P Ruszkowski
BioMed Research International 2013 (doi:10.1155/2013/689089), 10 pages 2013
Citations: 22

On the structural-adaptive compatibility of bone with porous coated implants on the base of the traditional one-phase and the modern two-phase poroelastic biomechanical model
R Uklejewski, M Winiecki, P Rogala
Eng. Biomat 9 (54-55), 1-13 2006
Citations: 21

Prototype of minimally invasive hip resurfacing endoprosthesis—bioengineering design and manufacturing
R Uklejewski, P Rogala, M Winiecki, J Mielniczuk
Acta of Bioengineering and Biomechanics 11 (2), 65-70 2009
Citations: 19

Advanced Surface Engineering Materials
A Tiwari, R Wang, B Wei
John Wiley & Sons 2016
Citations: 18

Effectiveness of various deproteinization processes of bovine cancellous bone evaluated via mechano-biostructural properties of produced osteoconductive
R Uklejewski, M Winiecki, G Musielak, R Tokłowicz
Biotechnology and Bioprocess Engineering 20, 259-266 2015
Citations: 16

The poroparameters for evaluation of structural-osteoinductive and mechanical properties of bone-implant porous coating interface. Part 1. Theoretical background on the basis
J Mielniczuk, R Uklejewski, M Winiecki, P Rogala
Journal of Biomechanics 39 (Suppl.1), S14 2006
Citations: 14

The investigation on the microgeometrical constructional properties of porous endoosseous implants and the influence of these properties on the strength of the bone-implant
M Winiecki
PhD Thesis, Poznan University of Technology, Faculty of Working Machines and 2006
Citations: 14

Structural‐Geometric Functionalization of the Additively Manufactured Prototype of Biomimetic Multispiked Connecting Ti‐Alloy Scaffold for Entirely Noncemented Resurfacing
R Uklejewski, M Winiecki, P Rogala, A Patalas
Applied Bionics and Biomechanics 2017 (1), 5638680 2017
Citations: 13

Prototype of innovating bone tissue preserving thra endoprosthesis with multi-spiked connecting scaffold manufactured in selective laser melting technology
JM Ryszard Uklejewski, Piotr Rogala, Mariusz Winiecki
Engineering of Biomaterials 12 (87), 2-6 2009
Citations: g bone tissue preserving thra endoprosthesis with multi-spiked connecting scaffold manufactured in selective laser melting technology

Prototype of innovating bone tissue preserving THRA endoprosthesis with multi-spiked connecting scaffold manufactured in selective laser melting technology
R Uklejewski, P Rogala, M Winiecki, J Mielniczuk
Engineering of Biomaterials 12 (87), 2-6 2009
Citations: 13

Structural and biomechanical biocompatibility in bone-porous implant fixation region-on the basis of two-phase poroelastic biomechanical model of bone tissue
R Uklejewski, M Winiecki, P Rogala, J Mielniczuk, A Auguściński, W Stryła
Eng. Biomat 10 (69-72), 93-95 2007
Citations: 13

The poroaccessibility parameters for three-dimensional characterization of orthopaedic implants porous coatings
R Uklejewski, M Winiecki, J Mielniczuk, P Rogala, A Auguściński
Metrology and Measurement Systems 15 (2), 215-226 2008
Citations: 11

Modelling of the needle-palisade fixation system for the total hip resurfacing arthroplasty endoprosthesis
J Mielniczuk, P Rogala, R Uklejewski, M Winiecki, G Jokś, A Auguściński, ...
Vysok škola bňsk-Technick univerzita Ostrava 2008
Citations: e-palisade fixation system for the total hip resurfacing arthroplasty endoprosthesis

Modern trends in bioengineering design of low-invasive joint endoprostheses
R Uklejewski, P Rogala, M Winiecki, J Mielniczuk, A Auguściński, ...
Inżynieria biomateriałw 11 (77-80), 32-33 2008
Citations: 9

Modelling of the needle-palisade fixation system for the total hip resurfacing arthroplasty endoprosthesis
J Mielniczuk, P Rogala, R Uklejewski, M Winiecki, G Jokś, A Auguściński, ...
Trans VŠB-TU Ostrava, Metallurgical Series 51 (1), 160-166 2008
Citations: 9