Yemisi Adesiji
@lautech.edu.ng
Professor of Medical Microbiology and Parasitology/Clinical Medical Science
Ladoke Akintola University of Technology
Professor Yemisi Adesiji is a distinguished academic and researcher, renowned for her expertise in the field of Medical Microbiology. With a remarkable 21 years of experience in teaching, research, and administration at Lautech's Faculty of Basic Clinical Science, she has left an indelible mark on the institution. Professor Yemisi Adesiji's illustrious career includes notable positions such as Head of Department, Deputy Dean of the Faculty of Basic Medical Sciences, and Faculty Postgraduate Representative. Her research focuses on the Epidemiology of bacterial zoonosis and infection control, garnering her over sixty publications in prestigious journals, edited conference proceedings, and book chapters. She has also successfully mentored over 20 Master's and postgraduate students, while currently guiding two Ph.D. candidates. Professor Yemisi Adesiji's exceptional capabilities have led to her acquisition of multiple research grants, and her membership in numerous professional bodies both
EDUCATION
St. Louis Grammar School, Owo, Ondo state, Nigeria 1984 - 1990
University of Ibadan, Nigeria 1992 - 1998
University of Lagos, Nigeria 2003 - 2004
Ladoke Akintola University of Technology, Ogbomoso 2005 - 2011
College of Veterinary Surgeons, Nigeria 2014- 2020
RESEARCH, TEACHING, or OTHER INTERESTS
Microbiology (medical), Epidemiology, Medicine
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Gbadebo J. Oyedeji, Charles Adeyemo, Affolabi Dissou, Tope Abiodun, Oyebode A.T. Alli, Olakunle J. Onaolapo, Adejoke Y. Onaolapo, Yemisi Adesiji, and Olugbenga A. Olowe
Bentham Science Publishers Ltd.
Background: The development of multidrug-resistant tuberculosis (MDR-TB) poses a considerable threat to tuberculosis control programmes in Nigeria. There is an increase in the prevalence of MDR-TB worldwide both among new tuberculosis cases as well as previously-treated ones. There is also a rise in transmission of resistant strains due to an increase in MDR-TB patients largely due to the poor drug compliance and the impact of Human immunodeficiency virus infection. Therefore, we intend to determine the extent of MDR-TB among attendees of chest clinics in Osun-State, Nigeria. Objectives: The objective of this study was to determine the prevalence of MDR-TB among confirmed tuberculosis patients attending chest clinics in Osun-State, Nigeria. Methods: This study was conducted among 207 attendees of chest clinics in Osun-State between June, 2015 and October 15, 2016. Sputum and blood samples of the participants were collected. GeneXpert test was carried out first on the samples for simultaneous identification of MTB and rifampicin resistance. Sputum samples were cultured on Lowenstein-Jensen (L-J) medium using N-acetyl-Lcysteine- sodium hydroxide (NALC-NaOH) decontamination method. Drug susceptibility testing (DST) to three first-line drugs was carried out using the proportion DST method. Results: The prevalence of MTB was found to be 27.5% while the prevalence of MDR-TB from the fifty-seven isolates was 10.5%. Previously treated and new cases had a prevalence of 7.0% and 3.5% MDR-TB, respectively. Seventy (33.8%) participants were positive for HIV infection, out of which twenty-six (12.6%) had co-infection of tuberculosis and HIV. The mono-resistance rates of the three first-line drugs used were: 5.3% and 8.7% for ethambutol (EMB) and isoniazid (INH), respectively. No isolate had mono-resistance (0%) to rifampicin (RIF). Conclusion: This study observed the prevalence of 27.5% MTB and a prevalence of 10.5% MDR-TB among the MTB isolates. The prevalence of TB is high in Osun State. MDR-TB prevalence is higher compared with the national estimate of MDR-TB (5.1%) of 2017. Resistant TB is a threat to national tuberculosis control and it is recommended that all the facilities be equipped to cater to its diagnosis.
Olukemi Yemisi, Kogaluru Santhosh, Kumar Vijaya, Shivani Girisha, and Karunasagar Indrani
Journal of Biomedical Research
Salmonella enterica has been documented as one of the leading causes of salmonellosis throughout the world and is most commonly associated with the consumption of contaminated food products. Thus, this research was aimed at studying the antimicrobial susceptibility pattern and detection of quinolone resistance in Salmonella spp isolated from food of animal origin. Thirty-six Salmonella isolates comprising 8 from poultry and 28 from seafood (clams) were identified, serotyped and characterized for their antimicrobial susceptibility against 10 different antibiotics. Plasmid DNA was isolated from all the isolates by alkaline lysis, quinolone resistant non-typhoidal S. Weltevreden were examined for mutation in the DNA gyrase coding gene. Among the 36 Salmonella isolates, 20 were S. weltevreden (8 from poultry and 12 from seafood) and 16 were S. Typhimurium (from seafood). All the isolates showed multiple resistance to nalidixic acid, tetracycline, co-trimoxazole and nitrofurantoin, but, interestingly, the isolates were 100% susceptible to ampicillin, chloramphenicol and gentamicin. Resistant isolates from the study carried the genes responsible for resistance to respective antibiotics. The strain S130 isolated in the study showed single point mutation, Asp87Gly, at position 87 in quinolone resistance determining region. It revealed mutation in quinolone resistance determining region as a cause for quinolone resistance in non-typhoidal Salmonellae. The occurrence of genes accountable for plasmid mediated resistance to quinolones (viz., qnrA, qnrB and qnrS) in plasmid of non-typhoidal Salmonellae isolates provides evidence for plasmid mediated quinolone resistance.
Y. Adesiji, N. Ndukwe, and B. Okanlawon
Walter de Gruyter GmbH
AbstractA survey of 104 sexually active young females tested on on cervico-vaginal swabs showed that 26 of the females (25%) had vulvovaginal candidiasis with a species distribution of Candida isolates accounting for 13 (50%) with C. albicans, 6 (23%) with C. glabrata, 1 (4%) with C. krusei, and 6 (23%) with C. tropicalis. Of the 26 (25 %) subjects that were positive for VVC, 8 (7.8 %) were symptomatic and 18 (18.8 %) were asymptomatic. However, distribution among different age groups revealed an increase in the 23–27 age group. The comparative analysis of sensitivity of the given fungi to the number of antimycotic preparations used revealed the following: in fluconazole, 2 (7.8%) isolates were sensitive, 5 (19.2%) were susceptible and dose dependent, and 19 (73%) were resistant. For voriconazole, 4 (18.4%) isolates were sensitive, 6 (23.1%) were susceptible and dose dependent, and 16 (61.5%) were resistant. For nystatin, 5 (19.2%) isolates were sensitive, 10 (38.5%) were susceptible and dose dependent, and 11 (42.3%) were resistant. It appears that Candida isolates have a variable resistance response, but 19 (73%) had maximum resistance of the isolated fungi of the genus Candida to fluconazole. Therefore, further studies on the evaluation of combination therapy should be considered for a better outcome in treatment of vulvovaginal candidiasis.
Y.O. Adesiji, A.O. Coker, and J.K. Oloke
Elsevier BV
Isolation of arcobacters in foods, with the highest prevalence reported in poultry, has underscored its importance as a potential food safety problem in recent years. To estimate its prevalence in live birds, fresh stool samples from healthy chickens were screened by enrichment and plating on Arcobacter selective medium containing cefoperazone, amphotericin B, and teicoplanin. Of 150 fecal samples, only 2 (1.3%) yielded Arcobacter. Species were identified with fluorescence resonance energy transfer PCR. Isolate no. 21 from a local flock shared 99% identity with the complete genome of A. butzleri RM4018 (CP000361.1). Isolate no. 4 from a layer hen shared 100% identity with a partial 16S rRNA gene sequence of A. cryaerophilus (EF064151.1). The low prevalence of Arcobacter in the fecal samples of healthy chickens concurs with earlier studies suggesting that Arcobacter appears to be a transient colonizer of poultry intestines and therefore might not be the major source of chicken carcass contamination.
Yemisi Adesiji
Walter de Gruyter GmbH
AbstractArcobacter spp. are emerging food borne pathogens associated with prolonged diarrhea and occasional systemic infections such as bactereamia and peritonitis in humans. Information on faecal shedding patterns to assess the potential role they play within the intestine however, is lacking. This study was designed to investigate faecal shedding of local isolates of Arcobacter spp. Using real time PCR for confirmation, A. cryaerophilus and A. butzleri were isolated from the stool of healthy chickens. Pathogenicity of the organisms was tested by administering a single oral challenge of 102–109 cfu/ml to 45 healthy adult male albino rats divided equally among 5 groups. Uninfected rats were used as the control group. A. cryaerophilus and A. butzleri produced infection in 100% of the animals. Experimental infection was dose dependent and caused diarrheal illness and faecal shedding was noted up to 5 weeks post infection. The present study demonstrates that rats can act as a reservoir and potential source of Arcobacter infection in humans and animals exposed to this pathogen.
S. S. Taiwo, Y. O. Adesiji, and D. A. Adekanle
BMJ
Objective: To determine the seroprevalence rate of syphilis among pregnant women attending the antenatal clinics of a teaching and a state specialist hospital in Nigeria, in order to ascertain whether maternal screening should be incorporated into routine antenatal care of our hospitals. Methods: A screening for syphilis for 505 newly registered pregnant women was carried out using the qualitative rapid plasma reagin (RPR) test. All reactive sera were then subjected to the quantitative RPR test to estimate the titre of each sample. The Treponema pallidum haemagglutination antibody (TPHA) test was used as confirmatory test of all positive RPR sera. Results: A total of 50 women (9.9%) were positive for RPR; 15 (2.97%) were positive for TPHA, giving a seroprevalence rate of 2.97%. A total of 32 women (6.34%) were RPR positive at 1:2, 7 (1.39%) at 1:4 and 11 (2.2%) at 1:8. Of the women positive for RPR at 1:2, 2 were also TPHA positive, 2 of the 7 positive at 1:4 were TPHA positive, while all 11 positive women at 1:8 were TPHA positive. In all, 70% of all RPR positive women screened were biological false positives. Eleven of the 15 women had high titre active syphilis (RPR ⩾1:8, TPHA+) while 4 had low titre active syphilis (RPR <1:8, TPHA+). Conclusions: The 2.97% seroprevalence rate obtained after accounting for biological false positives was considered high. Screening for syphilis in pregnancy should be incorporated into routine antenatal practice in Nigerian hospitals.
Yemisi Olukemi Adesiji, Rofiat Omolabake Lawal, Samuel Sunday Taiwo, Sunday Adetona Fayemiwo, and Oluwaseyi Adegboyega Adeyeba
Modestum Publishing Ltd
Aim: Although cryptosporidiosis is said to be rare among adult HIV
patients in certain parts of Nigeria, there are no documented studies
on the occurrence of this parasite among HIV patients in Southwestern
Nigeria. Methods: We conducted a cross sectional study involving 150
patients (100 HIV infected and 50 HIV negative) with diarrhoea from two
tertiary and one secondary health institutions in Southwestern Nigeria.
Concentrated stool sample from each patient was screened for
cryptosporidium oocysts with the modified cold Ziehl Neelsen method
while direct sample was screened for other enteric parasites. Results:
The overall parasite prevalence rate in the diarrhoea patients is
79.3% (119/150) with Cryptosporidium parvum 52.7%, Ascaris
lumbricoides 11.3%, Hookworm 3.3%, Trichuris trichura 2% and
Entamoeba histolytica 10%. The parasite prevalence rate in HIV
infected patients is 97% while in HIV-negative patients, the rate is
44%. The rate is significantly higher among HIVinfected patients with
diarrhoea than among HIV-negative patients with diarrhoea (OR=41.152,
95%CI=11.467-147.68, P<0.0001). However this difference is
attributed to Cryptosporidium which was found exclusively among
HIV-infected patients. When Cryptosporidium prevalence was excluded
from analysis, the parasite prevalence rates between the two groups was
not significantly different (X2=0.8002, df=3, P=0.8494). Conclusion:
Contrary to a previous report of apparent rarity of cryptosporidium
infections in certain parts of Nigeria, this study revealed a high
prevalence of this parasitosis among HIV infected patients in
Southwestern Nigeria.
O O Opaleye, Y O Adesiji, O A Olowe, and A H Fagbami
SAGE Publications
Factors responsible for the continued endemicity of rabies in Nigeria were determined by carrying out a knowledge, attitude and practice study among residents of Osun State. Structured questionnaires were administered to 679 individuals comprising students, traders and civil servants. Only 33.4% of the respondents knew rabies could be prevented by vaccination, while 38.7% believed that the infection could be treated with herbs. Of the 387 victims of dog bite, 240 (62%) never sought prophylactic postexposure treatment. Of the 10 people who received postexposure treatment, only one received the appropriate treatment consisting of washing, disinfection of wounds, tetanus toxoid and complete antirabies immunization.