Exploring 2,3-Dihydro-4H-1-Benzopyran-4-Ylidene) Hydrazine Derivatives as potential Aurora A kinase inhibitors: Insights from ADMET, Molecular Docking, Dynamics and DFT Studies Reena Singh, Yogesh Murti Research Journal of Biotechnology, 2026 The aurora kinase is an essential enzyme involved in tumor growth. Research revealed that small compounds that target Aurora A kinase have significant effects as anticancer agents. Using Protein Data Bank (PDB ID:3UNZ), the work integrates molecular docking analyses and in silico molecular simulations of these designed compounds with the Aurora A kinase protein. The molecular docking results revealed that two designed compounds, RS3 and RSH4, exhibited substantial binding affinities of -8.2 kcal/mol and -8.8 kcal/mol toward Aurora A kinase respectively. During simulated experiments, these chemicals showed stability in binding to the protein's active site. Based on RMSD analysis, it was found that the complexes typically follow an equilibrium RMSD value between 0.17 and 0.25 nm. ADMET, molecular docking and DFT studies also revealed that the designed compounds RS3 and RSH4 exhibit anticancer activity along with favorable druglikeness properties. ADMET, molecular docking and DFT studies also revealed that the designed compounds RS3 and RSH4 exhibit anticancer activity along with favorable drug-likeness properties. These findings suggest that compounds RS3 and RSH4 may potentially serve as candidates for treating cancers by targeting Aurora A kinase.
Decoding Scopoletin: A Comprehensive Review Krishn Kumar Agrawal, Rahul Deshwal, Yogesh Murti, Sunil Pratap Singh Research Journal of Biotechnology, 2026 A naturally occurring coumarin chemical, scopoletin is present in many plants such as passion flower, stinging nettle and chicory. It has a wide range of biological activities including antibacterial, anti-inflammatory, antioxidant and anti-cancer properties. In silico studies have shown that scopoletin can interact with a number of different proteins including enzymes, receptors and nucleic acids. This suggests that scopoletin may have a number of different mechanisms of action. In vitro studies have shown that scopoletin can inhibit the growth of a variety of bacteria, fungi and viruses. It can also reduce inflammation, it can protect cells from oxidative damage and it can kill cancer cells. In vivo studies have shown that scopoletin can reduce blood pressure, it can improve blood sugar control and it can protect against liver damage. It has also been shown to be effective in the treatment of a number of other conditions, including anxiety, depression and pain. Overall, the results of in silico, in vitro and in vivo studies suggest that scopoletin has a number of potential therapeutic applications. Nevertheless, further investigation is required to comprehensively comprehend the processes by which scopoletin operates.
Depression and COVID-19 Recent Advances in Depression Complications Awareness and Management, 2026
A Contemporary Review of Myocardial Infarction with Emphasis on: Clinical Trials and Therapeutic Approaches Anuj Kumar Sharma, Yogesh Murti, Akash Ved, Karuna Shanker Shukla, Sabeena Anjum, Mayank Kulshreshtha Current Hypertension Reviews, 2026 Myocardial infarction (MI), a major manifestation of coronary artery disease, remains a global health challenge despite significant advances in research and therapy. This review highlights current developments in diagnostic criteria, pathophysiology, treatment strategies, and emerging therapeutic targets. Type 1 MI, driven by atherosclerotic plaque rupture and thrombosis, continues to dominate, but growing recognition of type 2 MI and MINOCA (myocardial infarction with nonobstructive coronary arteries) underscores the need for refined diagnostic and therapeutic approaches. High-sensitivity cardiac troponins and advanced imaging have improved early detection, classification, and risk stratification. The management now emphasizes personalized, evidence-based care, including percutaneous coronary intervention or thrombosis, dual antiplatelet therapy, lipid-lowering agents, and cardioprotective drugs. Despite improved outcomes, challenges, such as late presentation, treatment disparities, recurrent events, and progression to heart failure, persist. A comprehensive literature search was conducted using electronic databases, such as Web of Science, Google Scholar, PubMed, SciFinder, Reaxys, and the Cochrane Library. By identifying persistent gaps, this work aimed to inform clinicians, researchers, and policymakers on innovative strategies for prevention, early detection, and optimal MI management.
Antimicrobial Potential and HPLC Analysis of BGR-34: An Antidiabetic Ayurvedic Formulation Anuj Kumar Sharma, Yogesh Murti, Sachdev Yadav, Akash Ved, Ketan Sharma, Mayank Kulshreshtha Anti Infective Agents, 2026 Background: BGR-34, a polyherbal formulation, has garnered attention for its antimicrobial properties, attributed to its diverse composition of primary and secondary me-tabolites. Objective: The objective of the study was to generate good scientific data regarding BGR -34. Methods: This study was carried out to investigate the phytochemical screening, High Per-formance Liquid Chromatography (HPLC) analysis using Quercetin as a standard, and an-timicrobial efficacy of BGR-34 against significant human pathogens, including Klebsiella pneumoniae, Vibrio cholerae, Staphylococcus epidermidis, Listeria monocytogenes, Esch-erichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella Typhi, Strepto-coccus mutans, Streptococcus pyogenes, Enterococcus faecalis, Bacillus subtilis, and Xan-thomonas oryzae. Results: The findings revealed a dose-dependent antimicrobial effect, with optimal activity observed at 100 mg/mL, highlighting its potential as a therapeutic agent. The phytochemical screening confirmed the presence of various primary and secondary metabolites, such as flavonoids, alkaloids, saponins, carbohydrates, alkaloids, tannins, proteins, terpenoids, etc. HPLC analysis demonstrated the presence of quercetin (2.2974 ug/mL), which is responsi-ble for various pharmacological activities. Antimicrobial potential showed activity of BGR-34 against various microbes that are responsible for various diseases. The bioactive com-pounds in BGR-34, such as phenolics, flavonoids, and terpenoids, exhibit mechanisms like biofilm disruption and microbial membrane interference, underscoring its broad-spectrum efficacy. Furthermore, its potential role in addressing infections related to biofilm-forming pathogens and resistant strains establishes its clinical significance. Conclusion: These results support the continued exploration of BGR-34 as a viable option in combating microbial infections, with implications for managing resistant pathogens, and reducing the burden of infectious diseases.
Antimicrobial Potential of Bempedoic Acid as a Gastroprotective Agent Ketan Sharma, Anuj Kumar Sharma, Yogesh Murti, Sachdev Yadav, Akash Ved, Mayank Kulshreshtha Anti Infective Agents, 2026 Introduction: Bempedoic acid is a well-known lipid-lowering agent which in-hibits the HMG-CoA reductase enzyme. It contains various chemical groups in its struc-ture, which are responsible for antimicrobial potential. The study investigates the antimi-crobial activity of Bempedoic Acid (BA) against pathogenic bacteria, including Bacillus subtilis, Enterococcus faecalis, Salmonella Typhi, and Staphylococcus aureus. Methods: The disc diffusion method was employed for this study. Initially, Mueller Hinton Agar (MHA) was prepared according to the standard formulation provided by Himedia. Specifically, 38 grams of MHA powder was dissolved in 1 liter of distilled water. The medium was then sterilized by autoclaving at 121°C and 15 psi for 15 minutes using an autoclave (Gentek India Pvt. Ltd.). After sterilization, the medium was poured into sterile glass Petri dishes inside a laminar airflow cabinet (Toshiba, India) under aseptic condi-tions, with each plate receiving 30 ml of the medium. The plates were left to solidify in the laminar flow. Once solidified, the bacterial inoculum was evenly spread across the surface of the agar using a sterile cotton swab. Ten minutes after inoculation, discs were placed onto the agar using sterile forceps. Each disc was loaded with 25 μl of sample at three different concentrations: 100 mg/ml, 50 mg/ml, and 25 mg/ml. The samples were allowed to diffuse into the agar, after which the plates were sealed with parafilm and incubated at 37°C for 24 hours. Results: BA lacked significant activity against B. subtilis but exhibited notable inhibition against E. faecalis (zone of inhibition: 11±0.00 mm at 50 mg/kg), S. Typhi (10±0.00 mm at 50 mg/kg and 100 mg/kg), and S. aureus (significant activity at 100 mg/kg). Discussion: Comparative analysis revealed BA exhibited efficacy comparable to that of ciprofloxacin in certain cases. Molecular studies highlighted BA's ability to mitigate bac-terial virulence by disrupting mechanisms, such as pro-inflammatory protein synthesis and mitochondrial genomic integrity, especially in E. faecalis. These findings underscore BA’s selective antimicrobial properties, suggesting its potential for therapeutic application in managing polymicrobial infections, gastrointestinal pathologies, and systemic diseases. Conclusion: The pharmacodynamic profile suggests BA exerts its antimicrobial effects by targeting bacterial virulence mechanisms, including the suppression of pro-inflammatory responses and the disruption of mitochondrial genomic stability. These attributes position BA as a promising candidate for further pharmacological development, especially as a po-tential adjunct to conventional antibiotics for managing drug-resistant and opportunistic infections. Further in vivo validation and clinical studies are warranted to establish its ther-apeutic potential and safety profile.
Exploring the Insights on Exosomes and their Utility in Treating Ophthalmic Disease: Delving into the Clinical Approval and Present Trials Ashish Ranjan Dwivedi, Yogesh Murti, Pramod Rawat, Shriya Mahajan, Harsimrat Kandhari, Gaurav Joshi, Bhupinder Kumar Current Drug Delivery, 2026 Ophthalmic diseases include a wide array of conditions, each requiring individualized treatment approaches. In ophthalmic research and as therapeutics against potential pharmacological indications, several subtypes of exosomes (EVs) have been reconnoitered, mainly for their regenerative, neuroprotective, and anti-inflammatory characteristics. EVs are recently gaining wider attention as promising vehicles for therapies because of their natural participation in communication between cells and targeted delivery. These small vesicles, derived from cells, transport numerous molecules between cells, thus contributing advantages like low immunogenicity, stability, and the ability to target cells specifically. These inherent advantages of carrying the therapeutic cargo and enabling intercellular signaling make them a captivating avenue for progressing ophthalmic disease treatment options. While research is ongoing, and clinical applications are still emerging, several EV subtypes have shown promise for possible applications in addressing several ophthalmic diseases, such as glaucoma, age-related macular degenerative disorders, retinal degenerative disorders, and ocular inflammatory conditions.
FORMULATION AND IN VITRO ANTI-ULCER EVALUATION OF A HERBAL SYRUP FROM PUNICA GRANATUM (L.) LEAVES , Yogesh Murti, Krishn K. Agrawal, , Alok N. Sharma, , Sunil P. Singh, , Sneha Singh, , Nidhi Chauhan, , Deepali Vij, and Indian Drugs, 2025 The present study was designed to formulate a plant-based solution from the foliage of Punica granatum (L.) and evaluate its in vitro anti-ulcer potential. A decoction of P. granatum leaves was prepared and formulated into simple syrup. The in vitro anti-ulcer activity was assessed using the acid-neutralizing capacity (ANC) method, with a standard antacid (aluminum hydroxide and magnesium hydroxide) used for comparison. The leaf decoction demonstrated significant, concentration-dependent acid-neutralizing effects. At a concentration of 400 mg mL-1, the decoction exhibited an ANC value of 22, which was comparable to the standard antacid’s ANC of 25 at the same concentration. The final syrup formulation was found to be a brown, clear liquid with an aromatic odor, a sweet taste, and a pH of 5.8. These findings suggest that the decoction of P. granatum leaves has promising potential for development as an herbal antacid preparation.
Nanotherapeutics in ocular infections Sonia Singh, Yogesh Murti Applications of Nanotherapeutics and Nanotheranostics in Managing Infectious Diseases, 2025
Nanotherapeutics in gastric infections Yogesh Murti, Krishn Kumar Agrawal Applications of Nanotherapeutics and Nanotheranostics in Managing Infectious Diseases, 2025
Lipid-based nanoparticles for topical and transdermal drug delivery Lipid Based Nanocarriers for Drug Delivery, 2024
Tinospora cordifolia (Willd.) Miers: A review on medicinal aromatic plant with industrial and therapeutical utilization Advances in Medicinal and Aromatic Plants Production Processing and Pharmaceutics 2 Volume Set, 2024
Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma Divya Jain, Yogesh Murti, Wasi Ullah Khan, Rajib Hossain, Mohammad Nabil Hossain, Krishn Kumar Agrawal, Rana Azeem Ashraf, Muhammad Torequl Islam, Pracheta Janmeda, Yasaman Taheri, Mohammed M. Alshehri, Sevgi Durna Daştan, Balakyz Yeskaliyeva, Aliya Kipchakbayeva, Javad Sharifi-Rad, William C. Cho Oxidative Medicine and Cellular Longevity, 2021
In vitro cytotoxicity of chromatographic elutes of Calotropis procera (Ait.) R Br. leaves against human hepatoma cell line (HEPG2) Indian Drugs, 2016
Expeditious synthesis and evaluation of heterocyclic chalcones and flavanones as anticancer agents Indian Journal of Heterocyclic Chemistry, 2016
In vitro Anthelminthic activity of Calotropis procera (AIT.) R. BR. Leaves Asian Journal of Pharmaceutical and Clinical Research, 2015
Nuclear pharmacist: As a health care services provider Pharma Times, 2014
Flavanone: A versatile heterocyclic nucleus International Journal of Chemtech Research, 2014
Synthesis and evaluation of flavanones as anticancer agents Indian Journal of Pharmaceutical Sciences, 2014
Synthesis and antioxidant activity of some chalcones and flavanoids International Journal of Pharmtech Research, 2013
In-vitro anthelmintic & cytotoxic potential of different extracts of calotropis procera leaves Asian Journal of Pharmaceutical and Clinical Research, 2013
Antimicrobial activity of leaf callus of Bacopa monnieri L. Der Pharmacia Lettre, 2011
Marine derived pharmaceuticals- development of natural health products from marine biodiversity International Journal of Chemtech Research, 2010
Synthesis, characterization and in vivo anthelmintic activity of some novel N-Mannich bases of benzimidazoles Journal of the Indian Chemical Society, 2010
Synthesis and anticonvulsant activity of substituted benzaldehyde-4-aryl-3- thiosemicarbazones Indian Drugs, 2010
Synthesis of newer steroidal pyrazoles as prospective h antimicrobial and antiinflammatory agents Indian Journal of Heterocyclic Chemistry, 2009
RECENT SCHOLAR PUBLICATIONS
Retraction Note to: Calotropis procera attenuates chronic unpredictable mild stress-induced depression in experimental animals D Garabadu, N Srivastava, Y Murti Metabolic Brain Disease 41 (1), 95 , 2026 2026
A Review on Models for Wound Healing. D Dubey, Y Murti, A Ved, S Yadav, KS Shukla, M Kulshreshtha Infectious Disorders Drug Targets , 2026 2026
Antimicrobial Potential and HPLC Analysis of BGR-34: An Antidiabetic Ayurvedic Formulation AK Sharma, Y Murti, S Yadav, A Ved, K Sharma, M Kulshreshtha Anti-Infective Agents 24 (2), E22113525393510 , 2026 2026
A Contemporary Review of Myocardial Infarction with Emphasis on: Clinical Trials and Therapeutic Approaches AK Sharma, Y Murti, A Ved, KS Shukla, S Anjum, M Kulshreshtha Current Hypertension Reviews , 2026 2026
Antimicrobial Potential of Bempedoic Acid as a Gastroprotective Agent K Sharma, AK Sharma, Y Murti, S Yadav, A Ved, M Kulshreshtha Anti-Infective Agents 24 (1), E22113525391531 , 2026 2026
Exploring the Insights on Exosomes and their Utility in Treating Ophthalmic Disease: Delving into the Clinical Approval and Present Trials AR Dwivedi, Y Murti, P Rawat, S Mahajan, H Kandhari, G Joshi, B Kumar Current Drug Delivery 23 (1), 56-72 , 2026 2026 Citations: 2
Medicinal Plants in the Treatment of Tuberculosis: A Systematic Review R Agrawal, Y Murti, M Mangla, M Sanduja, AK Sharma, V Kumari, ... Central Nervous System Agents in Medicinal Chemistry 25 (4), 513-543 , 2025 2025
FORMULATION AND IN VITRO ANTI-ULCER EVALUATION OF A HERBAL SYRUP FROM PUNICA GRANATUM (L.) LEAVES. Y Murti, KK Agrawal, AN Sharma, SP Singh, S Singh, N Chauhan, D Vij Indian Drugs 62 (9) , 2025 2025
Lead Phytomolecules for Treating Parkinson’s Disease KK Agrawal, C Veer, Y Murti, SP Singh Central Nervous System Agents in Medicinal Chemistry 25 (3), 337-361 , 2025 2025 Citations: 1
Advancements in targeting tumor suppressor genes (p53 and BRCA 1/2) in breast cancer therapy Chahat, N Nainwal, Y Murti, S Yadav, P Rawat, S Dhiman, B Kumar Molecular diversity 29 (3), 2691-2716 , 2025 2025 Citations: 11
Formulation and Comparison of Herbal Gels Containing Essential Oils and their Antimicrobial Evaluation K Agrawal, Vibha, Y Murti, M Agrawal, M Kulshreshtha Infectious Disorders-Drug Targets 25 (3), E18715265293665 , 2025 2025
Synthesis and Antimicrobial Screening of Some Thiazolidin-4-one Derivatives M Yadav, A Kumar, Y Murti, A Jain, R Dinkar, SN Mali Russian Journal of Bioorganic Chemistry 51 (2), 683-692 , 2025 2025 Citations: 1
Safeguarding Neuronal Integrity: Unveiling Possible Role of NFκB in the Neuroprotective Efficacy of Andrographolide Contrary to Aluminium Chloride-induced Neurotoxicity and … A Kumar, M Agrawal, Y Murti, S Behl, S Kumar, H Chaudhary, K Singh, ... Central Nervous System Agents in Medicinal Chemistry 25 (2), 157-168 , 2025 2025 Citations: 3
Development of New N-{4-[(7-Chloro-5-methylpyrrolo [2, 1-f][1, 2, 4] triazin-4-yl) oxy]-3-fluorophenyl} benzenesulfonamide Analogues: Exploring Anticancer Potential through … BD Sathe, M Meenakshi, Y Murti, MS Mane, SK Pandey, S Mahajan, ... Synlett 36 (05), 522-530 , 2025 2025 Citations: 1
Depression and COVID-19 A Ahuja, Y Murti, S Singh, R Ramankutty 2025
Nanotherapeutics in ocular infections S Singh, Y Murti Applications of Nanotherapeutics and Nanotheranostics in Managing Infectious … , 2025 2025 Citations: 1
Nanotherapeutics in gastric infections Y Murti, KK Agrawal Applications of Nanotherapeutics and Nanotheranostics in Managing Infectious … , 2025 2025
Artificial intelligence for cardiovascular diseases MQ Lari, D Kumar, A Kumar, Y Murti, PK Yadav, D Kumar Recent Advances in Computer Science and Communications , 2024 2024 Citations: 1
UROLITHIATIC ACTIVITY OF KIGELIA AFRICANA (L.). A Yadav, M Saraswat, SP Singh, Y Murti, KK Agrawal Indian Drugs 61 (12) , 2024 2024
Exploring the potential of artificial intelligence in medical research: applications, regulatory concerns, opportunities and future outlook-a mini review A Ahuja, Y Murti, S Singh Letters in Drug Design & Discovery 21 (18), 4205-4220 , 2024 2024 Citations: 5
MOST CITED SCHOLAR PUBLICATIONS
Pharmacognostic standardization of leaves of Calotropis procera (Ait.) R. Br.(Asclepiadaceae) Y Murti, B Yogi, D Pathak International journal of Ayurveda research 1 (1), 14-17 , 2010 2010 Citations: 154
Marine derived pharmaceuticals-development of natural health products from marine biodiversity Y Murti, T Agrawal International Journal of Chem Tech Research 2 (4), 2198-2217 , 2010 2010 Citations: 89
Antihyperglycemic activity of root of Berberis aristata D. C. in alloxan-induced diabetic rats YKMG Bhupesh Chandra Semwal, Jitendra Gupta, Sonia Singh International Journal of Green Pharmacy 3 (3), 259-262 , 2009 2009 Citations: 71
Light-driven photocatalysis as an effective tool for degradation of antibiotics PP Singh, G Pandey, Y Murti, J Gairola, S Mahajan, H Kandhari, S Tivari, ... RSC advances 14 (29), 20492-20515 , 2024 2024 Citations: 58
Synthesis and evaluation of flavanones as anticancer agents Y Murti, P Mishra Indian Journal of Pharmaceutical Sciences 76 (2), 163 , 2014 2014 Citations: 58
Synthesis and antioxidant activity of some chalcones and flavanoids Y Murti, A Goswam, P Mishra Inter J Pharm Tech Res 5, 811-818 , 2013 2013 Citations: 40
Synthesis, characterization and pharmacological screening of some substituted 1, 2, 3-& 1, 2, 4-triazoles Y Murti, R Agnihotri, D Pathak Am. J. Chem 1 (2), 42-46 , 2011 2011 Citations: 35
Roles of therapeutic bioactive compounds in hepatocellular carcinoma D Jain, Y Murti, WU Khan, R Hossain, MN Hossain, KK Agrawal, ... Oxidative Medicine and Cellular Longevity 2021 (1), 9068850 , 2021 2021 Citations: 29
Innovative methods for extraction of essential oils from medicinal plants Y Murti, D Jain, BC Semwal, S Sıngh, P Janmeda, P Bhaskar International Journal of Secondary Metabolite 10 (2), 190-230 , 2023 2023 Citations: 28
RETRACTED ARTICLE: Calotropis procera attenuates chronic unpredictable mild stress-induced depression in experimental animals D Garabadu, N Srivastava, Y Murti Metabolic Brain Disease 34 (6), 1635-1647 , 2019 2019 Citations: 28
Anticonvulsant activity of substituted benzaldehyde-4-aryl-3-thiosemicarbazones TADP Yogesh Murti Indian Drugs 47 (10), 19-27 , 2010 2010 Citations: 26
Antimicrobial activity of leaf callus of Bacopa monnieri L K Alam, N Parvez, S Yadav, K Molvi, N Hwisa, S Sharif, D Pathak, Y Murti, ... Der. Pharm. Lett 3, 287-291 , 2011 2011 Citations: 21
Green chemistry approaches to the synthesis of flavonoids Y Murti, D Pathak, K Pathak Current Organic Chemistry 25 (17), 2005-2027 , 2021 2021 Citations: 19
In vitro anthelmintic and cytotoxic potential of different extracts of Calotropis procera leaves Y Murti, A Singh, D Pathak Asian J Pharm Clin Res 6 (1), 14-16 , 2013 2013 Citations: 17
Visible-light photocatalysed synthesis of coumarin derivatives A Kashyap, PP Singh, Y Murti, P Gahtori, S Mahajan, H Kandhari, ... Tetrahedron Letters 142, 155099 , 2024 2024 Citations: 16
Phyto‐Pharmacological Review on Murraya koenigii (L.) Spreng: As an Indigenous Plant of India with High Medicinal Potential S Singh, A Ahuja, Y Murti, A Khaliq Chemistry & Biodiversity 20 (7), e202300483 , 2023 2023 Citations: 16
Exploring the therapeutic potential of Moringa oleifera Lam S Kumar, Y Murti, S Arora, W Akram, H Bhardwaj, K Gupta, A Sachdev, ... Traditional Chinese Medicine: A Comprehensive Review. Pharmacological Res … , 2024 2024 Citations: 15
A review on novel herbal drug delivery system and its application Y Murti, KK Agrawal, BC Semwal, J Gupta, R Gupta Current Traditional Medicine 9 (2), 43-55 , 2023 2023 Citations: 15
Flavanone: A Versatile Heterocyclic Nucleus Y Murti, P Mishra International Journal of ChemTech Research 6 (5), 3160-3178 , 2014 2014 Citations: 13
Recent advances of 9, 10-phenanthrenequinone (PQ) in photoredox catalysis R Kumar, PP Singh, Y Murti, J Gairola, S Mahajan, H Kandhari, PK Singh, ... Synthetic Communications 54 (14), 1129-1146 , 2024 2024 Citations: 12