Ziaur Rahman
@rbu.ac.in
Assistant Professor , Department of Library and Information Science
Rabindra Bharati University
EDUCATION
Ph D Jadavpur University, 2011
MLIS Aligarh Muslim University, 2005
BLIS North Bengal University, 2003
B.Sc North Bengal University, 1999
RESEARCH INTERESTS
Bibliometrics, Scientometrics
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Ziaur Rahman, Madhurima Das, Md. Safiqur Rahaman, and Sabahat Nausheen
Informa UK Limited
Mirza Jawad ul Hasnain, Farhat Amin, Aisha Ghani, Sibtain Ahmad, Ziaur Rehman, Tahera Aslam, and Muhammad Tariq Pervez
Institute of Electrical and Electronics Engineers (IEEE)
Parkinson's disease is the second most common progressive neurodegenerative movement disorder. Mutations in retromer complex subunit and VPS35 represent the second most common cause of late-onset familial Parkinson's disease. The mutation in VPS35 can disrupt the normal protein functions resulting in Parkinson's disease. The aim of this study was the identification of deleterious missense Single Nucleotide Polymorphisms (nsSNPs) and their structural and functional impact on the VPS35 protein. In this study, several insilico tools were used to identify deleterious and disease-associated nsSNPs. 3D structure of VPS35 protein was constructed through MODELLER 9.2, normalized using FOLDX, and evaluated through RAMPAGE and ERRAT whereas, FOLDX was used for mutagenesis. 25 ligands were obtained from literature and docked using PyRx 0.8 software. Based on the binding affinity, five ligands i.e., PG4, MSE, GOL, EDO, and CAF were further analyzed. Molecular Dynamic simulation analysis was performed using GROMACS 5.1.4, where temperature, pressure, density, RMSD, RMSF, Rg, and SASA graphs were analyzed. The results showed that the mutations Y67H, R524W, and D620N had a structural and functional impact on the VPS35 protein. The current findings will help in appropriate drug design against the disease caused by these mutations in a large population using in-vitro study.
Zahidullah, Muhammad Faisal Siddiqui, Shamas Tabraiz, Farhana Maqbool, Fazal Adnan, Ihsan Ullah, Muhammad Ajmal Shah, Waqar Azeem Jadoon, Tariq Mehmood, Sadia Qayyum,et al.
MDPI AG
Finding new biological ways to control biofouling of the membrane in reverse osmosis (RO) is an important substitute for synthetic chemicals in the water industry. Here, the study was focused on the antimicrobial, biofilm formation, and biofilm dispersal potential of rhamnolipids (RLs) (biosurfactants). The MTT assay was also carried out to evaluate the effect of RLs on biofilm viability. Biofilm was qualitatively and quantitatively assessed by crystal violet assay, light microscopy, fluorescence microscopy (bacterial biomass (µm2), surface coverage (%)), and extracellular polymeric substances (EPSs). It was exhibited that RLs can reduce bacterial growth. The higher concentrations (≥100 mg/L) markedly reduced bacterial growth and biofilm formation, while RLs exhibited substantial dispersal effects (89.10% reduction) on preformed biofilms. Further, RLs exhibited 79.24% biomass reduction while polysaccharide was reduced to 60.55 µg/mL (p < 0.05) and protein to 4.67 µg/mL (p < 0.05). Light microscopy revealed biofilm reduction, which was confirmed using fluorescence microscopy. Microscopic images were processed with BioImageL software. It was revealed that biomass surface coverage was reduced to 1.1% at 1000 mg/L of RLs and that 43,245 µm2 of biomass was present for control, while biomass was reduced to 493 µm2 at 1000 mg/L of RLs. Thus, these data suggest that RLs have antimicrobial, biofilm control, and dispersal potential against membrane biofouling.
Aqel Albutti, Muhammad Shoaib Gul, Muhammad Faisal Siddiqui, Farhana Maqbool, Fazal Adnan, Ihsan Ullah, Ziaur Rahman, Sadia Qayyum, Muhammad Ajmal Shah, and Muhammad Salman
MDPI AG
Exploring biological agents to control biofilm is a vital alternative in combating pathogenic bacteria that cause dental plaque. This study was focused on antimicrobial, biofilm formation and biofilm dispersal efficacy of Gallic acid (GA) against bacteria, including Proteus spp., Escherichia coli, Pseudomonas spp., Salmonella spp., Streptococcus mutans, and Staphylococcus aureus and multispecies bacteria. Biofilm was qualitatively and quantitatively assessed by crystal violet assay, florescence microscopy (bacterial biomass (µm2), surface coverage (%)) and extracellular polymeric substances (EPS). It was exhibited that GA (1–200 mg/L) can reduce bacterial growth. However, higher concentrations (100–200 mg/L) markedly reduced (86%) bacterial growth and biofilm formation (85.5%), while GA did not exhibit any substantial dispersal effects on pre-formed biofilm. Further, GA (20–200 mg/L) exhibited 93.43% biomass reduction and 88.6% (p < 0.05) EPS (polysaccharide) reduction. Microscopic images were processed with BioImageL software. It was revealed that biomass surface coverage was reduced to 2% at 200 mg/L of GA and that 13,612 (µm2) biomass was present for control, while it was reduced to 894 (µm2) at 200 mg/L of GA. Thus, this data suggest that GA have antimicrobial and biofilm control potential against single and multispecies bacteria causing dental plaque.
Almando Geraldi, Fatiha Khairunnisa, Nadya Farah, Le Bui, and Ziaur Rahman
MDPI AG
Microbes have been the preferred hosts for producing high-value chemicals from cheap raw materials. However, metabolic flux imbalance, the presence of competing pathways, and toxic intermediates often lead to low production efficiency. The spatial organization of the substrates, intermediates, and enzymes is critical to ensuring efficient metabolic activity by microorganisms. One of the most common approaches for bringing the key components of biosynthetic pathways together is through molecular scaffolds, which involves the clustering of pathway enzymes on engineered molecules via different interacting mechanisms. In particular, synthetic scaffold systems have been applied to improve the efficiency of various heterologous and synthetic pathways in Escherichia coli and Saccharomyces cerevisiae, with varying degrees of success. Herein, we review the recent developments and applications of protein-based and nucleic acid-based scaffold systems and discuss current challenges and future directions in the use of such approaches.
Miao Liu, Yuxin Xu, Javed Nawab, Ziaur Rahman, Sardar Khan, Muhammad Idress, Zia Ud din, Abid Ali, Riaz Ahmad, Said Akbar Khan,et al.
Elsevier BV
Muhammad Faisal Siddiqui, Lakhveer Singh, Farhana Maqbool, Ziaur Rahman, Abdul Rehman, Fazal Adnan, Sadia Qayyum, and Ajmal Khan
Springer International Publishing
Muhammad Faisal Siddiqui, Zahid Ullah, Lakhveer Singh, Farhana Maqbool, Sadia Qayyum, Ihsan Ullah, Ziaur Rahman, and Fazal Adnan
Elsevier
Ziaur Rahman, Bong Hyun Sung, Javed Nawab, Muhammad Faisal Siddiqui, Abid Ali, Almando Geraldi, and Sun Chang Kim
MDPI AG
Biodiesel, or fatty acid ethyl ester (FAEE), is an environmentally safe, next-generation biofuel. Conventionally, FAEE is produced by the conversion of oil/fats, obtained from plants, animals, and microorganisms, by transesterification. Recently, metabolic engineering of bacteria for ready-to-use biodiesel was developed. In Escherichia coli, it is produced by fatty acyl-carrier proteins and ethanol, with the help of thioesterase (TesB) and wax synthase (WS) enzymes. One of the foremost barriers in microbial FAEE production is the feedback inhibition of the fatty acid (FA) operon (fabHDG). Here, we studied the effect of biodiesel biosynthesis in E. coli with an engineered fabHDG operon. With a basic FAEE producing BD1 strain harboring tes and ws genes, biodiesel of 32 mg/L were produced. Optimal FAEE biosynthesis was achieved in the BD2 strain that carries an overexpressed operon (fabH, fabD, and fabG genes) and achieved up to 1291 mg/L of biodiesel, a 40-fold rise compared to the BD1 strain. The composition of FAEE obtained from the BD2 strain was 65% (C10:C2, decanoic acid ethyl ester) and 35% (C12:C2, dodecanoic acid ethyl ester). Our findings indicate that overexpression of the native FA operon, along with FAEE biosynthesis enzymes, improved biodiesel biosynthesis in E. coli.
Ziaur Rahman, Naim Rashid, Javed Nawab, Muhammad Ilyas, Bong Hyun Sung, and Sun Chang Kim
Springer Science and Business Media LLC
Javed Nawab, Sardar Khan, Sharafat Ali, Hassan Sher, Ziaur Rahman, Kifayatullah Khan, Jianfeng Tang, and Aziz Ahmad
Springer Science and Business Media LLC
Le Minh Bui, Ju Young Lee, Almando Geraldi, Ziaur Rahman, Jun Hyoung Lee, and Sun Chang Kim
Elsevier BV
Ziaur Rahman, Bong Hyun Sung, Ji-Yeun Yi, Le Minh Bui, Jun Hyoung Lee, and Sun Chang Kim
Elsevier BV