nikzamir
@sbmu.ac.ir
at Department of Medical Biochemistry,Faculty of Medicine
shahid Beheshti of University of Medical Sciences,Iran
RESEARCH INTERESTS
clinical biochemistry
Scopus Publications
Scopus Publications
Fatemeh Asgari, Abdolrahim Nikzamir, Kaveh Baghaei, Siamak Salami, Andrea Masotti, and Mohammad Rostami-Nejad
Springer Science and Business Media LLC
Nastaran Asri, Ehsan Nazemalhosseini Mojarad, Mohammad Yaghoob Taleghani, Hamidreza Houri, Mahsa Saeedi Niasar, Mostafa Rezaei-Tavirani, Somayeh Jahani- Sherafat, Amirhossein Shahbazkhani, Abdolrahim Nikzamir, Mohammad Javad Ehsani Ardakani,et al.
EpiSmart Science Vector Ltd
OBJECTIVE
Celiac disease (CD) and colorectal cancer (CRC) are distinct gastrointestinal conditions with a debated association. This study aimed to evaluate the mRNA expression of CD4 and Foxp3 in tissue specimens of CD and CRC patients. The findings can provide valuable insights into the complex connection between these different gastrointestinal conditions.
METHODS
Tissue samples from 100 CRC patients, 50 CD patients, and 50 healthy controls (HCs) were collected. RNA extraction, cDNA synthesis, and quantitative real-time PCR were performed. Statistical analysis was conducted using ANOVA and Pearson's correlation test.
RESULT
CD4 mRNA expression was significantly higher in CRC patients compared to CD patients and HCs (P<0.0001 for both). Foxp3 mRNA expression was significantly higher in CD patients compared to CRC patients and HCs (P<0.0001 for both). Clinicopathological characteristics did not correlate significantly with gene expression levels.
CONCLUSION
This study reveals differential expression patterns of CD4 and Foxp3 mRNA in CRC and CD patients. Upregulated CD4 mRNA suggests its potential role in promoting tumor growth, while increased Foxp3 mRNA expression may reflect an immunosuppressive mechanism in CD pathogenesis. These findings provide insights into the molecular and immunological aspects of CRC and CD, warranting further studies for potential therapeutic strategies.
Shayan Fallah, Nastaran Asri, Abdolrahim Nikzamir, Shokoufeh Ahmadipour, Amir Sadeghi, Kamran Rostami, and Mohammad Rostami-Nejad
MDPI AG
Amino acids (AAs) and vitamin imbalances are observed in celiac disease (CD). This study evaluated the plasma profile of vitamin A and AAs and the expression level of IL-2, IL-4, IL-10, IL-12 and TGFβ in CD patients. A total of 60 children and adults with CD and 40 healthy controls (HCs) were included. The plasma profile of Vitamin A and AAs and the mRNA expression levels of target genes were assessed. Active adult patients exhibited a decrease in Vitamin A levels (p = 0.04) and an increase in IL-2 (p = 0.008) and IL-12 (p = 0.007) mRNA expression compared to the HCs. The treated adult patients showed elevated Serine (p = 0.003) and Glycine (p = 0.04) levels, as well as increased IL-12 (p < 0.0001) mRNA expression, and a decrease in Tryptophan (p = 0.04) levels relative to the controls. Additionally, the treated adult patients had higher plasma levels of Threonine compared to both the active (p = 0.04) and control (p = 0.02) subjects, and the increased mRNA expression of IL-4 (p = 0.01) in comparison to the active patients. In active children with CD, the IL-2 mRNA level was found to be higher than in the controls (p < 0.0001) and in the treated children (p = 0.005). The treated children with CD exhibited decreased plasma levels of Tryptophan (p = 0.01) and Isoleucine (p = 0.01) relative to the controls, and the increased mRNA expression of TGFβ (p = 0.04) relative to the active patients. Elevated levels of specific AAs (Serine, Glycine, Threonine) in the treated CD patients suggested their potential to improve intestinal damage and inflammation, while decreased levels of Tryptophan and Isoleucine highlighted the need for dietary intervention.
Nasrin Amiri-Dashatan, , Zahra Taheri, Niosha Asadi, Farnaz Jahangiri, Nikoo Mozafari, Marzieh Ramandi, Mitra Rezaei, Abdolrahim Nikzamir, Somayeh Jahani Sherafat,et al.
Negah Scientific Publisher
Bisphenol A (BPA), an endocrine disruptor, is associated with metabolic disorders. However, several studies have suggested that exposure to BPA can cause obesity. It has recently got more attention from scientists as a risk factor for obesity due to its ability to mimic natural estrogens and bind to their receptors. Nonetheless, the molecular mechanism underpinning the environmental etiology of metabolic disorders has not been not fully clarified. In this regard, BPA exposure directly disrupts endocrine regulation, neuroimmune and signaling pathways, and gut microbes, resulting in obesity. In addition, epidemiological studies have revealed a significant relationship between BPA exposure and the development of obesity, although conflicting results have been reported. Therefore, this review summarized the possible role and molecular mechanisms associated with BPA exposure that may lead to obesity based on in vivo and in vivo studies.
Mehdi Koushki, , Nasrin Amiri-Dashatan, Mitra Rezaei, Fatemeh Montazer, Abdolrahim Nikzamir, Reza Vafaee, Vahid Mansouri, Masoumeh Farahani, ,et al.
Negah Scientific Publisher
Background: Ferroptosis, an oxidative and iron-dependent cell death, is a new type of regulated cell death. There are few studies on the mechanisms of ferroptosis in the skin and related diseases. Arsenic is shown to induce ferroptosis cell death. This study aimed to decipher the relationship between arsenic exposure and ferroptosis cell death in the skin. Methods: Arsenic-gene interactions were obtained. Then, skin-specific arsenic-gene interactions were screened. Ferroptosis-related genes were identified. Analysis of functional and biological interactions was performed to identify possible mechanisms. Results: The arsenic-gene interactions and the ferroptosis-related genes showed an overlap of 59 genes. Functional enrichment, protein-protein interaction, and transcription factor (TF)/miRNA target gene interaction analyses were used to look into the mechanism of arsenic-induced ferroptosis in the skin. ACTB, CTNNB1, HSPA8, SRC, RACK1, CD44, and SQSTM1 were identified as key proteins. Gene ontology analysis of these proteins indicated the mitochondrial morphology and functionality changes following arsenic-induced ferroptosis in the skin. HIF1A and SP1 TFs regulate a large number of genes compared to other TFs. Ten miRNAs with high interaction with ferroptosis-associated genes were identified. Conclusion: This work investigated the mechanism of arsenic-induced ferroptosis in the skin and identified key genes and regulators, and functional analysis highlighted the role of mitochondria in this skin exposure.
Nastaran Asri, Mohammad Rostami-Nejad, Abdolrahim Nikzamir, Elham Aghamohamadi, Hamid Asadzadeh-Aghdaei, and Mohammad Reza Zali
Springer Science and Business Media LLC
Unes Sahebi, Hamid Gholami, Behafarid Ghalandari, Farideh Badalkhani-khamseh, Abdolrahim Nikzamir, and Adeleh Divsalar
Elsevier BV
Mohsen Asadolahi, Abdolrahim Nikzamir, Majid Sirati-Sabet, Reza Mirfakhraie, Siamak Salami, Soroush Darbankhales, Kobra Saket-Kisomi, and Saina Ghadiany
Kowsar Medical Institute
Ali J. Jahan‐Abad, Saeed Karima, Somayeh Shateri, Somayeh M. Baram, Shima Rajaei, Parastoo Morteza‐Zadeh, Maryam Borhani‐Haghighi, Ali‐Akbar Salari, Abdolrahim Nikzamir, and Ali Gorji
Wiley
Babak Arjmand, Mostafa Rezaei-Tavirani, Mohammadreza Razzaghi, Mohammad Rostami-Nejad, Mostafa Hamdieh, and Abdolrahim Nikzamir
Maad Rayan Publishing Company
Nastaran Asri, , Mohammad Rostami-Nejad, Mohammad Barzegar, Abdolrahim Nikzamir, Mostafa Rezaei-Tavirani, Mohammadreza Razzaghi, Mohammad Reza Zali, , ,et al.
Armenian Green Publishing Co.
Hamid Asadzadeh-Aghdaei, Farshad Okhovatian, Zahra Razzaghi, Mohammadhossein Heidari, Reza Vafaee, and Abdolrahim Nikzamir
Maad Rayan Publishing Company
Introduction: Radiation therapy (RT) as a common method for cancer treatment could result in some side effects. The molecular investigation is one of the approaches that could assist in decrypting the molecular mechanisms of this incident. For this aim, protein-protein interaction (PPI) network analysis as a complementary study of the proteome is conducted to explore the RT effect on brain cancer after the early stage of exposure prior to the appearance of the skin lesion. Methods: Cytoscape 3.7.2 and its plug-ins were used to analyze the network of differential expression of proteins (DEPs) in the treatment condition, and the centrality and pathway enrichment was conducted by the use of NetworkAnalyzer and ClueGO+CluePedia. Results: A network of 15 DEPs indicated that 6 nodes were key players in the network stability and SERPINC1 and F5 were from the query proteins. The pathways of post-translational protein phosphorylation, platelet degranulation, and complement and coagulation cascades were the most highlighted ones for the central nodes that could be affected in RT. Conclusion: The central proteins of the network of early-stage treatments could have additional importance in the mechanisms of radiotherapy response prior to skin lesions. Introduced biomarkers can be used for the patients’ follow-up. These candidates are worth precise attention for this type of therapy after approving by validation studies.
Zeinab Barartabar, Abdolrahim Nikzamir, Majid Sirati-Sabet, Elham Aghamohammadi, Vahid Chaleshi, Mohammad Rostami Nejad, Hamid Asadzadeh-Aghdaei, and Mohammad Reza Zali
Termedia Sp. z.o.o.
Atousa Moradzadegan, Asad Vaisi-Raygani, Abdolrahim Nikzamir, and Zohreh Rahimi
SAGE Publications
Mohammad Fathi, Abdol Rahim Nikzamir, Alireza Esteghamati, Manouchehr Nakhjavani, and Mir Saeed Yekaninejad
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